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cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
5-methylcytosine in single-stranded DNA + H2O
?
the enzyme exhibits low activity toward 5-methylcytosine n single-stranded DNA
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state in DNA
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
high deaminase activities on cytosine and methylated cytosine with relatively high selectivity for methylated cytosine
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
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-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
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-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
-
-
-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
-
-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
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-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
activation-induced cytidine deaminase (AID) produces DNA breaks in immunoglobulin genes during antibody diversification. Double-stranded breaks in the switch region mediate class switch recombination, and contribute to gene conversion and somatic hypermutation in the variable regions. Among potential highly transcribed genes in mouse hybridoma cells, the immunoglobulin heavy and light chain genes are important AID targets, with the immunoglobulin mu switch region being preferred compared to other genomic sites
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
activation-induced deaminase is the initiator for somatic hypermutation (SHM) and class switch recombination (CSR). The enzyme targets the highly repetitive switch regions of the immunoglobulin heavy chain locus to induce DNA double-strand breaks (DSBs), which can be rejoined, leading to switch of constant regions of antibody. When targeting to variable region exons of IgH and IgL loci, the enzyme predominantly induces point mutations, termed SHM, resulting in increased affinity of antibody for antigen. While somatic hypermutation and class switch recombination (CSR) enhance antibody diversity, activation-induced deaminase initiated double-strand breaks and mutations may predispose B cells to carcinogenesis
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
AID mediates hypermutation by deaminating single stranded DNA. In vivo, single stranded DNA may arise transiently during transcription
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme can act on transcribing DNA. It is required for the maturation of antibodies in higher vertebrates, where it promotes somatic hypermutation
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme deaminates cytidine residues in the DNA of the variable and the switch regions of the immunoglobulin locus. The resulting uracil induces error-prone DNA synthesis in the case of hypermutation or DNA breaks that activate nonhomologous recombination in the case of class-switch recombination
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme deaminates DNA at transcribed Ig genes. Expressed immunoglobulin genes undergo alterations in sequence and genomic structure in order to optimize antibody function. A single B cell-specific factor, activation-induced deaminase (AID), initiates these changes by deamination of cytosine to uracil. At the Ig loci of B-cells, AID-initiated damage is processed to produce three distinct outcomes: somatic hypermutation, class switch recombination and gene conversion
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
activation-induced cytidine deaminase initiates secondary antibody diversification processes by deaminating cytidines on single-stranded DNA. AID preferentially deaminates cytidines preceded by W(A/T)R(A/G) dinucleotides, a sequence specificity that is evolutionarily conserved from bony fish to humans. AID preferentially deaminates bubble substrates of five to seven nucleotides rather than larger bubbles and preferentially binds to bubble-type rather than to single-stranded DNA substrates, suggesting that the natural targets of AID are either transcription bubbles or stem-loop structures. AID displays high affinity for single-stranded DNA. All substrates used in activity assays contain a single cytidine within the bubble and differ in the dinucleotide immediately upstream of the target cytidine constituting either WRC motifs (hot spots) or non-WRC motifs (cold spots)
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
among potential highly transcribed genes in mouse hybridoma cells, the immunoglobulin heavy and light chain genes are important targets, with the immunoglobulin mu switch region being preferred compared to other genomic sites
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
exclusively catalyses deamination of cytidine in single-stranded DNA. It shows minimal activity on stem-loop structures and preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G). WRC preference involves the recognition of a purine in the R position and that the carbonyl or amino side chains of guanosine negatively influence specificity at the W position
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
no detectable activity on double-stranded DNA. The enzyme catalyzes deoxycytidine to deoxyuridine deamination activity on double-stranded DNA substrates containing a small transcription-like single-stranded DNA bubble. Enzyme activity depends on sequence context
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme deaminates cytidine residues in the DNA of the variable and the switch regions of the immunoglobulin locus. The resulting uracil induces error-prone DNA synthesis in the case of hypermutation or DNA breaks that activate nonhomologous recombination in the case of class-switch recombination. The enzyme deaminates single-stranded but not double-stranded substrates unless it is in a complex with replication protein A (RPA) and the substrate is actively undergoing transcription
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme preferentially deaminates cytosine to uracil in single-stranded and not double-stranded DNA the enzyme deaminates DNA at transcribed Ig genes
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the purified, tetrameric enzyme can deaminate cytidine residues in single-stranded DNA, but not in RNA. It deaminates only single-stranded DNA. Neither cytidine nor CTP (or dCTP) are good substrates for the enzyme in vitro
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
conformational equilibrium of the APOBEC3B active site loops, skewed toward being closed, controls enzymatic activity by regulating binding to ssDNA substrates
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state
-
-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state in DNA
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-
?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzymes must access single-stranded DNA during the dynamic processes of DNA replication or transcription. The ability of an APOBEC3 to cycle between DNA substrates determines whether it is able to efficiently deaminate single-stranded DNA produced by replication and single-stranded DNA bound by replication protein A. APOBEC3 deaminase activity during transcription has a size limitation that inhibits APOBEC3B tetramers
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
deamination activity of methylated cytosine is demonstrated APOBEC3B
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
high deaminase activities on cytosine and methylated cytosine with relatively high selectivity for methylated cytosine
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
relatively low deaminase activity and selectivity for methylated cytosine
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
RNA binding is integral to APOBEC3H function. RNA-mediated dimerization alters the interactions of the enzyme with ssDNA and other RNA molecules
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?
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
the enzyme preferentially converts cytidine to uridine at the third position of triplet cytosine (CCC) hotspots. The phosphate backbone is required for C-terminal domain of the enzyme to slide along the DNA strand and to exert the 3'->5' polarity. The higher the salt cncentration, the less prominent is the 3'->5' polarity
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Acquired Immunodeficiency Syndrome
APOBEC3B deletion and risk of HIV-1 acquisition.
Acquired Immunodeficiency Syndrome
APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese.
Acquired Immunodeficiency Syndrome
No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations.
Adenocarcinoma
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Adenocarcinoma of Lung
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.
Adrenocortical Carcinoma
GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Asthma
Familial Success in Allergen Desensitization.
Asthma
Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.
Breast Neoplasms
Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.
Breast Neoplasms
APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion.
Breast Neoplasms
APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry.
Breast Neoplasms
APOBEC3A is a prominent cytidine deaminase in breast cancer.
Breast Neoplasms
APOBEC3B expression and its prognostic potential in breast cancer.
Breast Neoplasms
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
Breast Neoplasms
APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation.
Breast Neoplasms
APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines.
Breast Neoplasms
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.
Breast Neoplasms
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
Breast Neoplasms
APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers.
Breast Neoplasms
APOBEC3B is an enzymatic source of mutation in breast cancer.
Breast Neoplasms
APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.
Breast Neoplasms
Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.
Breast Neoplasms
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.
Breast Neoplasms
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
Breast Neoplasms
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B.
Breast Neoplasms
Clinical implications of APOBEC3A and 3B expression in patients with breast cancer.
Breast Neoplasms
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
Breast Neoplasms
DNA replication stress: a source of APOBEC3B expression in breast cancer.
Breast Neoplasms
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.
Breast Neoplasms
Evidence for APOBEC3B mutagenesis in multiple human cancers.
Breast Neoplasms
Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women.
Breast Neoplasms
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Breast Neoplasms
Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations, and immune activation.
Breast Neoplasms
Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort.
Breast Neoplasms
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Breast Neoplasms
Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.
Breast Neoplasms
Immune gene expression profiling reveals heterogeneity in luminal breast tumors.
Breast Neoplasms
Impact of functional germline variants and a deletion polymorphism in APOBEC3A and APOBEC3B on breast cancer risk and survival in a Swedish study population.
Breast Neoplasms
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
Breast Neoplasms
PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.
Breast Neoplasms
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Breast Neoplasms
The 29.5 kb APOBEC3B Deletion Polymorphism Is Not Associated with Clinical Outcome of Breast Cancer.
Breast Neoplasms
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.
Carcinogenesis
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
Carcinogenesis
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
Carcinogenesis
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
Carcinogenesis
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Carcinogenesis
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Carcinogenesis
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Carcinogenesis
Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.
Carcinogenesis
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Carcinogenesis
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Carcinogenesis
In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction.
Carcinogenesis
Phosphorylation Directly Regulates the Intrinsic DNA Cytidine Deaminase Activity of Activation-induced Deaminase and APOBEC3G Protein.
Carcinogenesis
Progesterone inhibits activation-induced deaminase by binding to the promoter.
Carcinogenesis
Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes.
Carcinogenesis
Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.
Carcinogenesis
The emerging role of estrogen in B cell malignancies.
Carcinogenesis
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.
Carcinoma
APOBEC3A Expression in Penile Squamous Cell Carcinoma.
Carcinoma
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Carcinoma
APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression.
Carcinoma
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
Carcinoma
APOBEC3B protein expression and mRNA analyses in patients with high-grade serous ovarian carcinoma.
Carcinoma
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
Carcinoma
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
Carcinoma
High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma.
Carcinoma
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Carcinoma
Involvement of APOBEC3B in mutation induction by irradiation.
Carcinoma
Prognostic Impact of APOBEC3B Expression in Metastatic Urothelial Carcinoma and Its Association with Tumor-Infiltrating Cytotoxic T Cells.
Carcinoma, Ductal
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
Carcinoma, Hepatocellular
APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.
Carcinoma, Hepatocellular
APOBEC3B: A Potential Factor Suppressing Growth of Human Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population.
Carcinoma, Hepatocellular
Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.
Carcinoma, Hepatocellular
Evidence of associations of APOBEC3B gene deletion with susceptibility to persistent HBV infection and hepatocellular carcinoma.
Carcinoma, Hepatocellular
HBx-elevated MSL2 Modulates HBV cccDNA through Inducing Degradation of APOBEC3B to Enhance Hepatocarcinogenesis.
Carcinoma, Hepatocellular
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.
Carcinoma, Hepatocellular
Long non-coding RNA HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
Carcinoma, Non-Small-Cell Lung
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Carcinoma, Renal Cell
High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
APOBEC3A Expression in Penile Squamous Cell Carcinoma.
Chondrosarcoma
The role of APOBEC3B in chondrosarcoma.
Coinfection
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Communicable Diseases
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Condylomata Acuminata
Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?
COVID-19
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
Esophageal Squamous Cell Carcinoma
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
Glioma
APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.
Glioma
Correlation Between APOBEC3B Expression and Clinical Characterization in Lower-Grade Gliomas.
Glioma
Development of a prognostic model of glioma based on immune-related genes.
Head and Neck Neoplasms
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers.
Head and Neck Neoplasms
GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Hepatitis B
APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.
Hepatitis B
Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular Carcinoma.
Hepatitis B
Cell-specific regulation of APOBEC3F by interferons.
Hepatitis B
Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression.
Hepatitis B
Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.
Hepatitis B
Effects of point mutations in the cytidine deaminase domains of APOBEC3B on replication and hypermutation of hepatitis B virus in vitro.
Hepatitis B
Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C.
Hepatitis B
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.
Hepatitis B
Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Hepatitis B
Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication.
Hepatitis B
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Hepatitis B
Virology. Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Hepatitis B, Chronic
Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population.
Hepatitis B, Chronic
Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Hepatitis B, Chronic
Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Hepatitis B, Chronic
Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.
Hepatitis C
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Herpes Simplex
Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.
Herpes Simplex
Human Herpes Simplex Virus-1 depletes APOBEC3A from nuclei.
Herpes Simplex
In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.
HIV Infections
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
HIV Infections
APOBEC3B deletion impacts on susceptibility to acquire HIV-1 and its advancement among individuals in western India.
HIV Infections
No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations.
HIV Infections
Stably expressed APOBEC3F has negligible antiviral activity.
Hypersensitivity
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Hypertension
A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data.
Infections
A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein.
Infections
A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection.
Infections
Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections.
Infections
Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.
Infections
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
Infections
APOBEC proteins and intrinsic resistance to HIV-1 infection.
Infections
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
Infections
APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription.
Infections
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Infections
APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo.
Infections
APOBEC3H haplotypes and HIV-1 pro-viral vif DNA sequence diversity in early untreated human immunodeficiency virus-1 infection.
Infections
APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population.
Infections
APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese.
Infections
Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle.
Infections
Candida albicans Delays HIV-1 Replication in Macrophages.
Infections
Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.
Infections
Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.
Infections
Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Infections
Evidence of associations of APOBEC3B gene deletion with susceptibility to persistent HBV infection and hepatocellular carcinoma.
Infections
Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.
Infections
Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.
Infections
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Infections
Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.
Infections
Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.
Infections
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Infections
Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.
Infections
Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.
Infections
Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk.
Infections
Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.
Infections
Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.
Infections
Relationship between human immunodeficiency type 1 infection and expression of human APOBEC3G and APOBEC3F.
Infections
The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.
Infections
The Range of Human APOBEC3H Sensitivity to Lentiviral Vif Proteins.
Infections
The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain.
Infections
The Role of Amino-Terminal Sequences in Cellular Localization and Antiviral Activity of APOBEC3B.
Infections
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.
Infectious Mononucleosis
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.
Influenza, Human
Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients.
Leukemia
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Leukemia
Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.
Leukemia
Murine leukemia virus resists producer cell APOBEC3A by its Glycosylated Gag but not target cell APOBEC3A.
Leukemia, Feline
Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections.
Leukemia, Lymphocytic, Chronic, B-Cell
Activation-induced deaminase and its splice variants associate with trisomy 12 in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
Leukemia, Lymphocytic, Chronic, B-Cell
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Leukemia, Lymphocytic, Chronic, B-Cell
Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Leukemia, Myeloid, Acute
Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications.
Leukemia, T-Cell
Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.
Liver Neoplasms
A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.
Liver Neoplasms
Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.
Lung Neoplasms
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.
Lung Neoplasms
APOBEC3B deletion polymorphism and lung cancer risk in the southern Chinese population.
Lung Neoplasms
APOBEC3B gene overexpression in non-small-cell lung cancer.
Lung Neoplasms
High CEP55 expression is associated with poor prognosis in non-small-cell lung cancer.
Lung Neoplasms
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Lung Neoplasms
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Lung Neoplasms
Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer.
Lung Neoplasms
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.
Lung Neoplasms
The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.
Lupus Nephritis
Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis.
Lupus Nephritis
The role of activation-induced deaminase in lupus nephritis.
Lymphatic Metastasis
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
Lymphatic Metastasis
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Lymphatic Metastasis
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Lymphocytic Choriomeningitis
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.
Lymphoma
Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein.
Lymphoma
G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas.
Lymphoma
Identification of APOBEC3B as a potential target for the graft-versus-lymphoma effect by SEREX in a patient with mantle cell lymphoma.
Lymphoma
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.
Lymphoma
Mechanisms of human lymphoid chromosomal translocations.
Lymphoma
PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas.
Lymphoma
Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.
Lymphoma
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
Lymphoma
Speckled-like pattern in the germinal center (SLIP-GC): A nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.
Lymphoma, B-Cell
Whole genome sequencing demonstrates substantial pathophysiological differences of MYC rearrangements in patients with plasma cell myeloma and B-cell lymphoma.
Lymphoma, Follicular
Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.
Lymphoma, Mantle-Cell
Identification of APOBEC3B as a potential target for the graft-versus-lymphoma effect by SEREX in a patient with mantle cell lymphoma.
Malaria
Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria.
Melanoma
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.
Melanoma
Expression of AID in malignant melanoma with BRAF(V) (600E) mutation.
Meningioma
APOBEC3B expression in human leptomeninges and meningiomas.
Mouth Neoplasms
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Multiple Myeloma
Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells.
Nasopharyngeal Carcinoma
The Prognostic Significance of APOBEC3B and PD-L1/PD-1 in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
Neoplasm Metastasis
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
Neoplasm Metastasis
APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.
Neoplasm Metastasis
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Neoplasm Metastasis
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
Neoplasm Metastasis
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Neoplasm Metastasis
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
Neoplasm Metastasis
The Prognostic Significance of APOBEC3B and PD-L1/PD-1 in Nasopharyngeal Carcinoma.
Neoplasms
A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers.
Neoplasms
A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.
Neoplasms
A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B.
Neoplasms
A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils.
Neoplasms
Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.
Neoplasms
Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B.
Neoplasms
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
Neoplasms
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.
Neoplasms
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Neoplasms
An extended APOBEC3A mutation signature in cancer.
Neoplasms
Analysis of APOBEC3A/3B germline deletion polymorphism in breast, cervical and oral cancers from South India and its impact on miRNA regulation.
Neoplasms
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
Neoplasms
APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.
Neoplasms
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.
Neoplasms
APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.
Neoplasms
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.
Neoplasms
APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
Neoplasms
APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.
Neoplasms
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
Neoplasms
APOBEC3A Expression in Penile Squamous Cell Carcinoma.
Neoplasms
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Neoplasms
APOBEC3B expression and its prognostic potential in breast cancer.
Neoplasms
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
Neoplasms
APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation.
Neoplasms
APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines.
Neoplasms
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.
Neoplasms
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
Neoplasms
APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers.
Neoplasms
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.
Neoplasms
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
Neoplasms
APOBEC3B is an enzymatic source of mutation in breast cancer.
Neoplasms
APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.
Neoplasms
APOBEC3B mutagenesis in cancer.
Neoplasms
APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.
Neoplasms
APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.
Neoplasms
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Neoplasms
APOBEC3B, a molecular driver of mutagenesis in human cancers.
Neoplasms
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.
Neoplasms
APOBEC3B: A Potential Factor Suppressing Growth of Human Hepatocellular Carcinoma Cells.
Neoplasms
APOBEC3B: Pathological Consequences of an Innate Immune DNA Mutator.
Neoplasms
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma.
Neoplasms
APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction.
Neoplasms
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Neoplasms
Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma.
Neoplasms
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
Neoplasms
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers.
Neoplasms
Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate.
Neoplasms
Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.
Neoplasms
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B.
Neoplasms
Classical NF-?B pathway is responsible for APOBEC3B expression in cancer cells.
Neoplasms
Clinical implications of APOBEC3A and 3B expression in patients with breast cancer.
Neoplasms
Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression.
Neoplasms
Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Neoplasms
Correlation Between APOBEC3B Expression and Clinical Characterization in Lower-Grade Gliomas.
Neoplasms
Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment.
Neoplasms
Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.
Neoplasms
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Neoplasms
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Neoplasms
Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif.
Neoplasms
Determinants of Oligonucleotide Selectivity of APOBEC3B.
Neoplasms
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Neoplasms
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.
Neoplasms
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Neoplasms
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers.
Neoplasms
Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.
Neoplasms
Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates.
Neoplasms
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
Neoplasms
Evidence for APOBEC3B mutagenesis in multiple human cancers.
Neoplasms
Expression of AID in malignant melanoma with BRAF(V) (600E) mutation.
Neoplasms
Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women.
Neoplasms
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Neoplasms
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Neoplasms
Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network.
Neoplasms
GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Neoplasms
Genomic Instability Signature of Palindromic Non-Coding Somatic Mutations in Bladder Cancer.
Neoplasms
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways.
Neoplasms
Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort.
Neoplasms
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Neoplasms
High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma.
Neoplasms
Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death.
Neoplasms
Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells.
Neoplasms
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Neoplasms
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.
Neoplasms
Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.
Neoplasms
Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.
Neoplasms
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Neoplasms
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Neoplasms
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Neoplasms
Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-?B.
Neoplasms
Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate.
Neoplasms
Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.
Neoplasms
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
Neoplasms
Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types.
Neoplasms
Integrative genomic analysis reveals functional diversification of APOBEC gene family in breast cancer.
Neoplasms
Involvement of APOBEC3B in mutation induction by irradiation.
Neoplasms
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells.
Neoplasms
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.
Neoplasms
Mechanisms of base substitution mutagenesis in cancer genomes.
Neoplasms
Mechanisms shaping the mutational landscape of the FRA3B/FHIT-deficient cancer genome.
Neoplasms
Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies.
Neoplasms
Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme.
Neoplasms
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
Neoplasms
Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.
Neoplasms
Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.
Neoplasms
Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes.
Neoplasms
Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B.
Neoplasms
Onset of deaminase APOBEC3B induction in response to DNA double-strand breaks.
Neoplasms
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
Neoplasms
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Neoplasms
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases.
Neoplasms
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.
Neoplasms
PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas.
Neoplasms
Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism.
Neoplasms
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Neoplasms
Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.
Neoplasms
Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots.
Neoplasms
Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.
Neoplasms
Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity.
Neoplasms
RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.
Neoplasms
Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer.
Neoplasms
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
Neoplasms
Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2'-deoxyzebularine.
Neoplasms
Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.
Neoplasms
Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer.
Neoplasms
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.
Neoplasms
Structural Characterization of a Minimal Antibody against Human APOBEC3B.
Neoplasms
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Neoplasms
Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.
Neoplasms
Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment.
Neoplasms
The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.
Neoplasms
The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase.
Neoplasms
The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer.
Neoplasms
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.
Neoplasms
The emerging role of estrogen in B cell malignancies.
Neoplasms
The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.
Neoplasms
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.
Neoplasms
The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.
Neoplasms
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
Neoplasms
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.
Neoplasms
The roles of APOBEC3B in gastric cancer.
Neoplasms
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Neoplasms
Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.
Neoplasms
Upregulation of MTA1 expression by human papillomavirus infection promotes CDDP resistance in cervical cancer cells via modulation of NF-?B/APOBEC3B cascade.
Oropharyngeal Neoplasms
APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers.
Ovarian Neoplasms
APOBEC3B protein expression and mRNA analyses in patients with high-grade serous ovarian carcinoma.
Ovarian Neoplasms
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Ovarian Neoplasms
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
Ovarian Neoplasms
The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer.
Papilloma
Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?
Papillomavirus Infections
In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction.
Papillomavirus Infections
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
Papillomavirus Infections
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
Persistent Infection
Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and chronic infections.
Pneumonia, Pneumocystis
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology.
Prostatic Neoplasms
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Retroviridae Infections
Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.
Sialadenitis
Ductal cells of minor salivary glands in Sjögren's syndrome express LINE-1 ORF2p and APOBEC3B.
single-stranded dna cytosine deaminase deficiency
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Skin Neoplasms
A Biochemical Analysis Linking APOBEC3A to Disparate HIV-1 Restriction and Skin Cancer.
Squamous Cell Carcinoma of Head and Neck
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Squamous Cell Carcinoma of Head and Neck
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Involvement of APOBEC3B in mutation induction by irradiation.
Squamous Cell Carcinoma of Head and Neck
Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma.
Stomach Neoplasms
CagA increases DNA methylation and decreases PTEN expression in human gastric cancer.
Stomach Neoplasms
The roles of APOBEC3B in gastric cancer.
Thrombosis
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Urinary Bladder Neoplasms
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
Urinary Bladder Neoplasms
Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
Uterine Cervical Neoplasms
APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer.
Uterine Cervical Neoplasms
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Uterine Cervical Neoplasms
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Uterine Cervical Neoplasms
Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.
Uterine Cervical Neoplasms
Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression.
Uterine Cervical Neoplasms
Involvement of APOBEC3B in mutation induction by irradiation.
Uterine Cervical Neoplasms
Upregulation of MTA1 expression by human papillomavirus infection promotes CDDP resistance in cervical cancer cells via modulation of NF-?B/APOBEC3B cascade.
Viremia
APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count.
Viremia
Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation.
Virus Diseases
Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections.
Virus Diseases
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Virus Diseases
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.
Virus Diseases
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways.
Virus Diseases
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Virus Diseases
Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination.
Virus Diseases
Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.
Virus Diseases
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
Virus Diseases
Structural Characterization of a Minimal Antibody against Human APOBEC3B.
Wasting Syndrome
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.
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Larijani, M.;Petrov, A.P.; Kolenchenko, O.; Berru, M.; Krylov, S.N.; Martin, A.
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner
Mol. Cell. Biol.
27
20-30
2007
Homo sapiens (Q9GZX7)
brenda
Vallur, A.C.; Yabuki, M.; Larson, E.D.; Maizels, N.
AID in antibody perfection
Cell. Mol. Life Sci.
64
555-565
2007
Homo sapiens (Q9GZX7)
brenda
Brar, S.S.; Sacho, E.J.; Tessmer, I.; Croteau, D.L.; Erie, D.A.; Diaz, M.
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA
DNA Repair
7
77-87
2007
Homo sapiens (Q9GZX7)
brenda
Carpenter, M.A.; Rajagurubandara, E.; Wijesinghe, P.; Bhagwat, A.S.
Determinants of sequence-specificity within human AID and APOBEC3G
DNA Repair
9
579-587
2010
Homo sapiens (Q9GZX7), Homo sapiens
brenda
Lee, S.A.; Parsa, J.Y.; Martin, A.; Baker, M.D.
Activation-induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome
Eur. J. Immunol.
37
3529-3539
2007
Homo sapiens (Q9GZX7)
brenda
Wang, J.H.
The role of activation-induced deaminase in antibody diversification and genomic instability
Immunol. Res.
55
287-297
2013
Homo sapiens (Q9GZX7), Mus musculus (Q9WVE0)
brenda
Dickerson, S.K.; Market, E.; Besmer, E.; Papavasiliou, F.N.
AID mediates hypermutation by deaminating single stranded DNA
J. Exp. Med.
197
1291-1296
2003
Homo sapiens (Q9GZX7)
brenda
Aoufouchi, S.; Faili, A.; Zober, C.; D'Orlando, O.; Weller, S.; Weill, J.C.; Reynaud, C.A.
Proteasomal degradation restricts the nuclear lifespan of AID
J. Exp. Med.
205
1357-1368
2008
Homo sapiens (Q9GZX7)
brenda
Miyazaki, Y.; Inoue, H.; Kikuchi, K.; Ochiai, K.; Kusama, K.
Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines
J. Oral Sci.
54
71-75
2012
Homo sapiens (Q9GZX7)
brenda
Larijani, M.; Martin, A.
Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID
Mol. Cell. Biol.
27
8038-8048
2007
Homo sapiens (Q9GZX7)
brenda
Sohail, A.; Klapacz, J.; Samaranayake, M.; Ullah, A.; Bhagwat, A.S.
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
Nucleic Acids Res.
31
2990-2994
2003
Homo sapiens (Q9GZX7)
brenda
Bransteitter, R.; Pham, P.; Scharff, M.D.; Goodman, M.F.
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
Proc. Natl. Acad. Sci. USA
100
4102-4107
2003
Homo sapiens (Q9GZX7)
brenda
Pasqualucci, L.; Kitaura, Y.; Gu, H.; Dalla-Favera, R.
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
Proc. Natl. Acad. Sci. USA
103
395-400
2005
Homo sapiens (Q9GZX7)
brenda
Meyers, G.; Ng, Y.S.; Bannock, J.M.; Lavoie, A.; Walter, J.E.; Notarangelo, L.D.; Kilic, S.S.; Aksu, G.; Debre, M.; Rieux-Laucat, F.; Conley, M.E.; Cunningham-Rundles, C.; Durandy, A.; Meffre, E.
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans
Proc. Natl. Acad. Sci. USA
108
11554-11559
2011
Homo sapiens
brenda
Hou, S.; Silvas, T.V.; Leidner, F.; Nalivaika, E.A.; Matsuo, H.; Kurt Yilmaz, N.; Schiffer, C.A.
Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B
J. Chem. Theory Comput.
15
637-647
2019
Homo sapiens (Q9UH17), Homo sapiens
brenda
Sharma, S.; Patnaik, S.K.; Taggart, R.T.; Kannisto, E.D.; Enriquez, S.M.; Gollnick, P.; Baysal, B.E.
APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
Nat. Commun.
6
6881
2015
Homo sapiens (P31941)
brenda
Hu, W.; Begum, N.A.; Mondal, S.; Stanlie, A.; Honjo, T.
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
Proc. Natl. Acad. Sci. USA
112
5791-5796
2015
Homo sapiens (Q9GZX7)
brenda
Marx, A.; Galilee, M.; Alian, A.
Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes
Sci. Rep.
5
18191
2015
Homo sapiens (P31941), Homo sapiens (Q9HC16)
brenda
Sharma, S.; Patnaik, S.K.; Taggart, R.T.; Baysal, B.E.
The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme
Sci. Rep.
6
39100
2016
Homo sapiens (Q9HC16)
brenda
King, J.J.; Manuel, C.A.; Barrett, C.V.; Raber, S.; Lucas, H.; Sutter, P.; Larijani, M.
Catalytic pocket inaccessibility of activation-induced cytidine deaminase is a safeguard against excessive mutagenic activity
Structure
23
615-627
2015
Homo sapiens, Homo sapiens (P31941)
brenda
Adolph, M.B.; Love, R.P.; Chelico, L.
Biochemical basis of APOBEC3 deoxycytidine deaminase activity on diverse DNA substrates
ACS Infect. Dis.
4
224-238
2018
Homo sapiens (P31941), Homo sapiens (Q6NTF7), Homo sapiens (Q8IUX4), Homo sapiens (Q96AK3), Homo sapiens (Q9HC16), Homo sapiens (Q9NRW3), Homo sapiens (Q9UH17)
brenda
Shi, K.; Carpenter, M.A.; Kurahashi, K.; Harris, R.S.; Aihara, H.
Crystal structure of the DNA deaminase APOBEC3B catalytic domain
J. Biol. Chem.
290
28120-28130
2015
Homo sapiens (Q9UH17)
brenda
Ito, F.; Fu, Y.; Kao, S.A.; Yang, H.; Chen, X.S.
Family-wide comparative analysis of cytidine and methylcytidine deamination by eleven human APOBEC proteins
J. Mol. Biol.
429
1787-1799
2017
Homo sapiens (P31941), Homo sapiens (Q6NTF7), Homo sapiens (Q8IUX4), Homo sapiens (Q96AK3), Homo sapiens (Q9HC16), Homo sapiens (Q9NRW3), Homo sapiens (Q9UH17), Homo sapiens
brenda
Feng, Y.; Wong, L.; Morse, M.; Rouzina, I.; Williams, M.C.; Chelico, L.
RNA-mediated dimerization of the human deoxycytidine deaminase APOBEC3H influences enzyme activity and interaction with nucleic acids
J. Mol. Biol.
430
4891-4907
2018
Homo sapiens (Q6NTF7), Homo sapiens
brenda
Fang, Y.; Xiao, X.; Li, S.X.; Wolfe, A.; Chen, X.S.
Molecular interactions of a DNA modifying enzyme APOBEC3F catalytic domain with a single-stranded DNA
J. Mol. Biol.
430
87-101
2018
Homo sapiens (Q8IUX4)
brenda
Maiti, A.; Myint, W.; Kanai, T.; Delviks-Frankenberry, K.; Sierra Rodriguez, C.; Pathak, V.K.; Schiffer, C.A.; Matsuo, H.
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with sDNA
Nat. Commun.
9
2460
2018
Homo sapiens (Q9HC16)
brenda
Adolph, M.B.; Love, R.P.; Feng, Y.; Chelico, L.
Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
Nucleic Acids Res.
45
11925-11940
2017
Homo sapiens (Q9UH17)
brenda
Wang, Y.; Wu, S.; Zheng, S.; Wang, S.; Wali, A.; Ezhilarasan, R.; Sulman, E.P.; Koul, D.; Alfred Yung, W.K.
APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death
Oncotarget
8
54285-54296
2017
Homo sapiens (Q9HC16)
brenda
Kamba, K.; Nagata, T.; Katahira, M.
Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination
PLoS ONE
10
e0124142
2015
Homo sapiens (Q9HC16)
brenda
Shi, K.; Demir, O.e.; Carpenter, M.A.; Wagner, J.; Kurahashi, K.; Harris, R.S.; Amaro, R.E.; Aihara, H.
Conformational switch regulates the DNA cytosine deaminase activity of human APOBEC3B
Sci. Rep.
7
17415
2017
Homo sapiens (Q9UH17), Homo sapiens
brenda