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Information on EC 3.5.4.36 - mRNA(cytosine6666) deaminase and Organism(s) Monodelphis domestica and UniProt Accession Q9TUI7

for references in articles please use BRENDA:EC3.5.4.36
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EC Tree
IUBMB Comments
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site .
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This record set is specific for:
Monodelphis domestica
UNIPROT: Q9TUI7
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Word Map
  • 3.5.4.36
  • cytidine
  • polypeptide-like
  • deamination
  • deaminases
  • apobecs
  • hypermutation
  • editosome
  • c-to-u
  • mooring
  • apob48
  • apob100
  • rna-specific
  • unedited
  • mcardle
The taxonomic range for the selected organisms is: Monodelphis domestica
The expected taxonomic range for this enzyme is: Tetrapoda
Reaction Schemes
cytosine6666 in apolipoprotein B mRNA
+
=
uracil6666 in apolipoprotein B mRNA
+
Synonyms
apobec-1, apolipoprotein b mrna editing enzyme, apob mrna-editing enzyme catalytic polypeptide 1, apo b messenger rna editing protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
APOBEC1
catalytic component of an RNA-editing complex
SYSTEMATIC NAME
IUBMB Comments
mRNA(cytosine6666) aminohydrolase
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
no APOBEC1 is expresed in liver
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ABEC1_MONDO
235
0
28062
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli, the opossum APOBEC-1 gene has the same intron/exon organisation in the coding sequence as the eutherian gene
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujino, T.; Navaratnam, N.; Jarmuz, A.; von Haeseler, A.; Scott, J.
C->U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica
Nucleic Acids Res.
27
2662-2671
1999
Monodelphis domestica (Q9TUI7)
Manually annotated by BRENDA team