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Information on EC 3.5.4.36 - mRNA(cytosine6666) deaminase and Organism(s) Mus musculus and UniProt Accession P51908

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EC Tree
IUBMB Comments
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site .
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This record set is specific for:
Mus musculus
UNIPROT: P51908
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Word Map
  • 3.5.4.36
  • cytidine
  • polypeptide-like
  • deamination
  • deaminases
  • apobecs
  • hypermutation
  • editosome
  • c-to-u
  • mooring
  • apob48
  • apob100
  • rna-specific
  • unedited
  • mcardle
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Tetrapoda
Reaction Schemes
cytosine6666 in apolipoprotein B mRNA
+
=
uracil6666 in apolipoprotein B mRNA
+
Synonyms
apobec-1, apolipoprotein b mrna editing enzyme, apob mrna-editing enzyme catalytic polypeptide 1, apo b messenger rna editing protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
apoB mRNA-editing enzyme catalytic polypeptide 1
catalytic subunit of the apoB mRNA editing complex
APOBEC-1
catalytic subunit of the apoB mRNA editing complex
APOBEC1
catalytic component of an RNA-editing complex
SYSTEMATIC NAME
IUBMB Comments
mRNA(cytosine6666) aminohydrolase
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cytosine in RNA + H2O
uracil in RNA + NH3
show the reaction diagram
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
show the reaction diagram
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
show the reaction diagram
additional information
?
-
APOBEC1 possesses antiviral activity. It is capable of inhibiting the infectivity of various lentiviruses in tissue culture models
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cytosine in RNA + H2O
uracil in RNA + NH3
show the reaction diagram
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
show the reaction diagram
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo
-
-
?
cytosine6666 in apolipoprotein B mRNA + H2O
uracil6666 in apolipoprotein B mRNA + NH3
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low level
Manually annotated by BRENDA team
low level
Manually annotated by BRENDA team
low level
Manually annotated by BRENDA team
low level
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
unlike their human counterparts, APOBEC1 in a wide range of mammalian species may function as a defense mechanism regulating retroelements
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ABEC1_MOUSE
229
0
27522
Swiss-Prot
other Location (Reliability: 4)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Innerarity, T.L.; Boren, J.; Yamanaka, S.; Olofsson, S.O.
Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms
J. Biol. Chem.
271
2353-2536
1996
Rattus norvegicus (P38483), Mus musculus (P51908)
Manually annotated by BRENDA team
Blanc, V.; Xie, Y.; Luo, J.; Kennedy, S.; Davidson, N.O.
Intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1-/- mice
J. Lipid Res.
53
2643-2655
2012
Mus musculus (P51908)
Manually annotated by BRENDA team
Petit, V.; Guetard, D.; Renard, M.; Keriel, A.; Sitbon, M.; Wain-Hobson, S.; Vartanian, J.P.
Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo
J. Mol. Biol.
385
65-78
2008
Homo sapiens (P41238), Mus musculus (P51908)
Manually annotated by BRENDA team
Rosenberg, B.R.; Hamilton, C.E.; Mwangi, M.M.; Dewell, S.; Papavasiliou, F.N.
Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs
Nat. Struct. Mol. Biol.
18
230-236
2011
Mus musculus (P51908)
Manually annotated by BRENDA team
Ikeda, T.; Ohsugi, T.; Kimura, T.; Matsushita, S.; Maeda, Y.; Harada, S.; Koito, A.
The antiretroviral potency of APOBEC1 deaminase from small animal species
Nucleic Acids Res.
36
6859-6871
2008
Mesocricetus auratus (Q9EQP0), Mus musculus (P51908), Mustela putorius furo (B2NIW5), Oryctolagus cuniculus (P47855), Rattus norvegicus (P38483)
Manually annotated by BRENDA team