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Information on EC 3.5.4.34 - tRNAAla(adenine37) deaminase and Organism(s) Homo sapiens and UniProt Accession Q9BUB4

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EC Tree
IUBMB Comments
The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla . tRNA editing is strictly dependent on Mg2+ .
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This record set is specific for:
Homo sapiens
UNIPROT: Q9BUB4
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
adenine37 in tRNAAla
+
=
hypoxanthine37 in tRNAAla
+
Synonyms
adat1, hadat1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
tRNAAla(adenine37) aminohydrolase
The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
adenine37 in tRNAAla + H2O
hypoxanthine37 in tRNAAla + NH3
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenine37 in tRNAAla + H2O
hypoxanthine37 in tRNAAla + NH3
show the reaction diagram
specifically deaminates adenosine 37 to inosine in eukaryotic tRNAAla. This unique modification in tRNAAla is conserved from yeast to man
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ADAT1_HUMAN
502
0
55392
Swiss-Prot
other Location (Reliability: 1)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maas, S.; Gerber, A.P.; Rich, A.
Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes
Proc. Natl. Acad. Sci. USA
96
8895-8900
1999
Homo sapiens (Q9BUB4), Homo sapiens
Manually annotated by BRENDA team