Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-methylguanine + H2O
1-methylxanthine + NH3
-
-
-
?
2,6-diaminopurine + H2O
?
-
the native enzyme shows 107% activity and the recombinant enzyme 98% activity compared to guanine
-
-
?
2,6-diaminopurine + H2O
xanthine + NH3
-
-
-
-
?
2-amino-6-chloropurine + H2O
6-chloro-3,9-dihydro-2H-purin-2-one + NH3
-
-
-
-
?
2-amino-6-chloropurine + H2O
6-chloro-9H-purin-2-ol + NH3
-
the native enzyme shows 93% activity and the recombinant enzyme 88% activity compared to guanine
-
-
?
2-amino-6-methoxypurine + H2O
6-methoxy-3,9-dihydro-2H-purin-2-one + NH3
-
-
-
-
?
6-thioguanine + H2O
6-thioxanthine + NH3
7,8-dihydropterin + H2O
7,8-dihydrolumazine + NH3
8-azaguanine + H2O
8-azaxanthine + NH3
8-azaxanthine + H2O
8-azaxanthine + HCl
-
-
-
-
?
8-azaxanthine + H2O
?
-
the native enzyme shows 95% activity and the recombinant enzyme 88% activity compared to guanine
-
-
?
adenine + H2O
allopurinol + NH3
adenosine + H2O
inosine + NH3
ammelide + H2O
cyanuric acid + NH3
the absolute activity toward ammelide is 7 orders of magnitude lower than the activity of wild type GDA for guanine
-
-
?
ammeline + H2O
ammelide + NH3
AMP + H2O
IMP + NH3
-
-
-
-
?
cytidine + H2O
uridine + NH3
-
-
-
-
?
cytosine + H2O
6-hydroxy-1H-pyrimidin-2-one + NH3
-
-
-
-
?
GMP + H2O
XMP + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
guanosine + H2O
xanthosine + NH3
-
-
-
-
?
hypoxanthine + H2O
?
-
the native enzyme shows 100% activity and the recombinant enzyme 87% activity compared to guanine
-
-
?
xanthine + H2O
?
-
the native enzyme shows 01% activity and the recombinant enzyme 87% activity compared to guanine
-
-
?
additional information
?
-
6-thioguanine + H2O
6-thioxanthine + NH3
-
-
-
-
?
6-thioguanine + H2O
6-thioxanthine + NH3
-
-
-
-
?
6-thioguanine + H2O
6-thioxanthine + NH3
-
-
-
-
?
7,8-dihydropterin + H2O
7,8-dihydrolumazine + NH3
-
the enzyme exhibits 40fold higher activity for guanine than for 7,8-dihydropterin. Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin
-
-
?
7,8-dihydropterin + H2O
7,8-dihydrolumazine + NH3
-
the enzyme exhibits 40fold higher activity for guanine than for 7,8-dihydropterin. Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
the native enzyme shows 99% activity and the recombinant enzyme 95% activity compared to guanine
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
the native enzyme shows 99% activity and the recombinant enzyme 95% activity compared to guanine
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
-
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
high substrate specificity, only 60% of the reaction rate with the natural substrate guanine
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
-
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
-
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
-
-
-
?
8-azaguanine + H2O
8-azaxanthine + NH3
-
-
-
-
?
8-azaguanine + H2O
?
-
the enzyme shows 60% activity for 8-azaguanine relative to 7,8-dihydropterin
-
-
?
8-azaguanine + H2O
?
-
the enzyme shows 60% activity for 8-azaguanine relative to 7,8-dihydropterin
-
-
?
adenine + H2O
allopurinol + NH3
-
the native enzyme shows 102% activity and the recombinant enzyme 85% activity compared to guanine
-
-
?
adenine + H2O
allopurinol + NH3
-
the native enzyme shows 102% activity and the recombinant enzyme 85% activity compared to guanine
-
-
?
adenine + H2O
allopurinol + NH3
-
-
-
-
?
adenine + H2O
allopurinol + NH3
-
-
-
-
?
adenosine + H2O
inosine + NH3
-
the native enzyme shows 98% activity and the recombinant enzyme 91% activity compared to guanine
-
-
?
adenosine + H2O
inosine + NH3
-
the native enzyme shows 98% activity and the recombinant enzyme 91% activity compared to guanine
-
-
?
adenosine + H2O
inosine + NH3
-
-
-
-
?
ammeline + H2O
? + NH3
-
-
-
?
ammeline + H2O
? + NH3
-
-
-
?
ammeline + H2O
ammelide + NH3
-
-
-
-
ir
ammeline + H2O
ammelide + NH3
-
-
-
-
ir
ammeline + H2O
ammelide + NH3
-
-
-
-
ir
ammeline + H2O
ammelide + NH3
-
-
-
ir
ammeline + H2O
ammelide + NH3
-
-
-
-
ir
ammeline + H2O
ammelide + NH3
-
-
-
-
ir
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
substrate binding structure and tautomerization of the bound guanine, reaction steps in a detailed overview
-
-
?
guanine + H2O
xanthine + NH3
-
100% activity
-
-
r
guanine + H2O
xanthine + NH3
-
100% activity
-
-
r
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
ir
guanine + H2O
xanthine + NH3
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
ir
guanine + H2O
xanthine + NH3
-
enzyme shows activity toward guanine not toward adenine
-
-
?
guanine + H2O
xanthine + NH3
-
preferred substrate
-
-
?
guanine + H2O
xanthine + NH3
-
preferred substrate
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
ir
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
209584, 209586, 209587, 209591, 209592, 209593, 209594, 209595, 209601, 667985, 711469, 733480, 733496 -
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
ir
guanine + H2O
xanthine + NH3
-
reaction via tetrahedral intermediate
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
nucleotide metabolism
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
209539, 209584, 209586, 209588, 209589, 209593, 209594, 209595, 209596, 209598, 689944, 711469 -
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
ir
guanine + H2O
xanthine + NH3
-
the enzyme plays a central role in neuronal development, and an active role in regulating dendrite branching in hippocampal neurons, cypin-promoted increases in dendrite number are dependent on its zinc-dependent guanine deaminase activity, overview
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
?
guanine + H2O
xanthine + NH3
-
-
-
-
ir
guanosine + H2O
?
-
the native enzyme shows 48% activity and the recombinant enzyme 70% activity compared to guanine
-
-
?
guanosine + H2O
?
-
the enzyme shows 5% activity for guanosine relative to 7,8-dihydropterin
-
-
?
guanosine + H2O
?
-
the enzyme shows 5% activity for guanosine relative to 7,8-dihydropterin
-
-
?
uric acid + H2O
?
-
the native enzyme shows 89% activity and the recombinant enzyme 86% activity compared to guanine
-
-
?
uric acid + H2O
?
-
the native enzyme shows 89% activity and the recombinant enzyme 86% activity compared to guanine
-
-
?
additional information
?
-
-
the enzyme does not metabolize ammelide or melamine
-
-
?
additional information
?
-
-
the enzyme does not metabolize ammelide or melamine
-
-
?
additional information
?
-
-
isoguanine is no substrate
-
-
?
additional information
?
-
-
the enzyme has no deaminase activities for other dihydropteridines such as 7,8-dihydrobiopterin, 7,8-dihydroneopterin, and sepiapterin, it also does not show deaminase activity with fully oxidized pteridines such as pterin, biopterin, neopterin, monapterin, xanthopterin, isoxanthopterin, aminopterin, 6-formylpterin, 6-carboxypterin, and 6-hydroxymethylpterin. Moreover the enzyme does not use folic acid, pyrimidodiazepine, drosopterin, or isodrosopterin as a substrate. No activity is found for adenine and adenosine
-
-
?
additional information
?
-
-
the enzyme has no deaminase activities for other dihydropteridines such as 7,8-dihydrobiopterin, 7,8-dihydroneopterin, and sepiapterin, it also does not show deaminase activity with fully oxidized pteridines such as pterin, biopterin, neopterin, monapterin, xanthopterin, isoxanthopterin, aminopterin, 6-formylpterin, 6-carboxypterin, and 6-hydroxymethylpterin. Moreover the enzyme does not use folic acid, pyrimidodiazepine, drosopterin, or isodrosopterin as a substrate. No activity is found for adenine and adenosine
-
-
?
additional information
?
-
-
the enzyme does not metabolize ammelide or melamine
-
-
?
additional information
?
-
9-methylguanine, 6-O-methylguanine, 6-thioguanine, and 2,6-diaminopurine, also exhibit measurable activity but turn over very slowly, i.e. below 0.001 per s
-
-
?
additional information
?
-
-
9-methylguanine, 6-O-methylguanine, 6-thioguanine, and 2,6-diaminopurine, also exhibit measurable activity but turn over very slowly, i.e. below 0.001 per s
-
-
?
additional information
?
-
-
nedasin, an enzyme involved in synaptic connections between neurons binding to neuronal and endocrine lethal discs large, might be an isozyme of guanase, overview
-
-
?
additional information
?
-
the enzyme does not metabolize ammelide or melamine
-
-
?
additional information
?
-
-
the enzyme does not metabolize ammelide or melamine
-
-
?
additional information
?
-
-
the enzyme does not metabolize ammelide or melamine
-
-
?
additional information
?
-
-
high specificity towards guanine, 2-amino-6-chloropurine, 8-bromoguanine, 7-methylguanine, thioguanine, guanosine, guanosine 5'-monophosphate, guanilic acid, adenosine and 2-aminopurine are no substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(6R)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
competitive inhibition
(6S)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
competitive inhibition
1-(4-methoxybenzyl)-4-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8-(1H)-one
-
-
1-(4-methoxybenzyl)-4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
-
-
3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-(4-methoxybenzyl)-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-(4-methoxybenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-benzyl-5-butoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-benzyl-5-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group
3-Deazaguanine
-
competitive inhibitor
4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
-
4-chloromercuribenzoate
-
the deaminase activities for both 7,8-dihydropterin and guanine are completely inhibited in the presence of 1 mM 4-chloromercuribenzoate
5-amino-4-imidazole carboxamide
5-aminoimidazole-4-carboxamide
5-aminoimidazole-4-carboxamide ribonucleoside
5-methoxy-1-(4-methoxybenzyl)-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
-
-
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group
6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
i.e. azepinomycin
9-(p-aminoethoxyphenyl)guanine
-
strong inhibitor
Ag+
-
6.5% inhibition at 2 mM
allopurinol
-
at concentrations of 1 and 10 mM, potassium fluoride shows weak inhibitory effect on both, guanine deaminase activity (5.2 and 11% inhibition) and dihydropterin deaminase activity (6.2 and 10.1% inhibition)
Cd(CH3COO)2
-
relative activity 7.4%
CuSO4
-
relative activity 25.8%
Fe2+
-
0.1 mM FeSO4, 82% inhibition
guanidine hydrochloride
-
-
guanosine
-
at concentrations of 1 and 10 mM, guanosine shows weak inhibitory effect on both, guanine deaminase activity (1.8 and 12.5% inhibition) and dihydropterin deaminase activity (3.8 and 5.1% inhibition)
Hg2+
-
98.6% inhibition at 2 mM
HgCl2
-
69% inhibition in 5 min
KCN
-
KCN inhibits dihydropterin deaminase activity strongly 98.6% inhibition at 10 mM whereas it has almost no inhibitory effect on guanine deaminase activity at the same concentration
lumazine
-
at concentrations of 1 and 10 mM, allopurinol shows weak inhibitory effect on both, guanine deaminase activity (4.5 and 17.8% inhibition) and dihydropterin deaminase activity (3.2 and 10% inhibition)
natural inhibitor protein
-
Pb2+
-
55.5% inhibition at 2 mM
PCMB
-
relative activity 34.7%
potassium fluoride
-
at concentrations of 1 and 10 mM, potassium fluoride shows weak inhibitory effect on both, guanine deaminase activity (3.6 and 8.1% inhibition) and dihydropterin deaminase activity (0 and 1.2% inhibition)
pterin
-
pterin strongly inhibits guanine deaminase activity (57.8% inhibition at 1 mM), whereas it has a weak effect on dihydropterin deaminase activity
Urea
-
8 M, both isoenzymes
additional information
-
not inhibited by EDTA, 1,10-phenanthroline, dithiothreitol, L-cysteine, and phenylmethylsulfonyl fluoride
-
2,6-diaminopurine
-
5-amino-4-imidazole carboxamide
-
5-amino-4-imidazole carboxamide
-
-
5-amino-4-imidazole carboxamide
-
-
5-aminoimidazole-4-carboxamide
-
AICA, competitive inhibition
5-aminoimidazole-4-carboxamide
-
29% inhibition
5-aminoimidazole-4-carboxamide
-
-
5-aminoimidazole-4-carboxamide
-
AICA, competitive inhibition
5-aminoimidazole-4-carboxamide
-
-
5-aminoimidazole-4-carboxamide
-
AICA, competitive inhibition
5-aminoimidazole-4-carboxamide
-
-
5-aminoimidazole-4-carboxamide ribonucleoside
-
-
5-aminoimidazole-4-carboxamide ribonucleoside
-
-
5-aminoimidazole-4-carboxamide ribonucleoside
-
AICAR
5-aminoimidazole-4-carboxamide ribonucleoside
-
-
7-methylguanine
-
adenine
-
at concentrations of 1 and 10 mM, adenine shows weak inhibitory effect on both, guanine deaminase activity (7.1 and 24% inhibition) and dihydropterin deaminase activity (10.3 and 14.1% inhibition)
adenosine
-
at concentrations of 1 and 10 mM, adenosine shows weak inhibitory effec on both, guanine deaminase activity (5.6 and 22.7% inhibition) and dihydropterin deaminase activity (11.5 and 16.7% inhibition)
azepinomycin
-
naturally occuring guanase inhibitor, antitumor antibiotic
azepinomycin
-
competitive inhibition
Caffeine
-
F-
-
inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5
F-
-
inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5
F-
-
inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5
Fe3+
-
-
Fe3+
-
0.25 mM FeCl3, 82% inhibition
HClO4
-
-
hypoxanthine
-
-
hypoxanthine
-
slight inhibition of 8%
Inosine
-
-
Inosine
-
slight inhibition of 5%
iodoacetamide
-
2 mM mildly inhibitory
iodoacetic acid
-
0.1 mM 7% loss in the activity, 1 mM 29% loss in the activity after 30 min incubation
N-2-acetylguanine
-
natural inhibitor protein
-
-
-
natural inhibitor protein
-
-
-
natural inhibitor protein
-
heat labile proteinous mitochondrial inhibitor for liver and brain enzyme
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
noncompetitive inhibitor, 0.1 mM, 37°C, rapid inactivation
p-hydroxymercuribenzoate
-
0.0001 M 91% loss of activity after 30 min incubation
p-hydroxymercuribenzoate
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
isoenzyme B more rapidly inactivated and the inhibition is less effectively reversed by thiol supplements than isoenzyme A
Rose bengal
-
photo-oxidation, 0.00025% at acidic pH
Rose bengal
-
photo-oxidation, 0.00025% at acidic pH
tetrahydrofolic acid
-
-
tetrahydrofolic acid
-
competitive inhibitor
uric acid
-
xanthine
-
-
Zn2+
-
1 mM ZnSO4, complete inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Anaphylaxis
[Changes in the guanase activity in the lungs and blood serum of guinea pigs in anaphylactic shock]
Anemia
Guanase in reticulocytes and other rat tissues.
Balkan Nephropathy
Guanase activity in endemic Balkan nephropathy.
Brain Injuries
Cypin: A novel target for traumatic brain injury.
Brain Injuries, Traumatic
Cypin: A novel target for traumatic brain injury.
Carcinoma
Clinical evaluation of serum guanase activity in liver diseases.
Carcinoma, Hepatocellular
Clinical evaluation of serum guanase activity in liver diseases.
Carcinoma, Hepatocellular
Clinical significance of serum guanase activity in various liver diseases.
Carcinoma, Hepatocellular
Estimation of guanine deaminase using guanosine as a "prosubstrate".
Diabetes Mellitus, Experimental
[Characteristics of purine and nucleotide metabolism in juvenile rats with alloxan diabetes]
Fatty Liver
Evaluation of serum guanase in hepatic diseases.
Glomerulonephritis
[Guanine deaminase and adenosine deaminase activity in chronic glomerulonephritis]
Gout
Effects of plumbous ion on guanine metabolism.
Heart Failure
Clinical and experimental studies of the determination of serum guanase activity in acute myocardial infarction.
Hepatitis
A sensitive spectrophotometric assay for guanase activity.
Hepatitis
Clinical evaluation of serum guanase activity in liver diseases.
Hepatitis
Clinical significance of serum guanase activity in various liver diseases.
Hepatitis
Clinical value of the guanase screening test in donor blood for prevention of posttransfusional non-A, non-B hepatitis.
Hepatitis
Cytochemical demonstration of guanase in human liver using yellow tetrazolium.
Hepatitis
Evaluation of serum guanase in hepatic diseases.
Hepatitis
Guanase activity in the donor serum and the incidence of posttransfusion hepatitis non-A, non-B.
Hepatitis
Prevention of posttransfusional non-A, non-B hepatitis using the screening test for guanase activity of donor blood.
Hepatitis
Relationship between guanase activity in donor blood and the incidence of posttransfusional non-A, non-B hepatitis, and a possible method for preventing posttransfusional hepatitis.
Hepatitis
Serum guanase activity in viral hepatitis and some other hepatic and extrahepatic diseases.
Hepatitis
[Activity of cobalt-activated acylase and guanase in the serum of patients with viral hepatitis]
Hepatitis
[Experiences and significance of the determination of guanase in acute hepatitis]
Hepatitis
[Guanase activity of human blood in viral hepatitis and other liver diseases]
Hepatitis
[Measurement of serum guanase activity and prevention of non-A, non-B hepatitis]
Hepatitis
[Screening of the donor's blood by measuring the serum guanase level for the prevention of posttransfusion hepatitis in cardiac surgery]
Hepatitis
[Studies on the diagnostic value of various enzymatic activties in icterogenic hepatitis of infancy. II. Sorbitol dehydrogenase, guanase and argininosuccinate lyase]
Hepatitis
[The prevention of post-transfusional hepatitis using measurement of guanase activity]
Hepatitis
[The relationship between the guanase activity of donor and incidence of posttransfusion hepatitis]
Hepatitis A
[Determination of guanine deaminase activity in infectious hepatitis]
Hepatitis C
Clinical value of the determination of serum guanase activity in patients with chronic hepatitis type C.
Hepatitis C
Estimation of guanine deaminase using guanosine as a "prosubstrate".
Hepatitis C
Serum guanase activity in hepatitis C virus infection.
Hepatitis, Chronic
Clinical evaluation of serum guanase activity in liver diseases.
Hepatitis, Chronic
Clinical significance of serum guanase activity in various liver diseases.
Hepatitis, Chronic
Clinical value of the determination of serum guanase activity in patients with chronic hepatitis type C.
Hepatitis, Chronic
Evaluation of serum guanase in hepatic diseases.
Hepatitis, Chronic
[Activity of guanase in serum and liver function tests in HBe antigen-positive chronic hepatitis]
Herpes Zoster
A novel role for snapin in dendrite patterning: interaction with cypin.
Infections
Purine pathway enzymes in a cyst forming strain of Toxoplasma gondii.
Intellectual Disability
Deficiency of a naturally occurring protein inhibitor in brain of clinically 'brain damaged' newborn human infants - A possible cause of mental retardation?
Keratosis
Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.
Kidney Diseases
Serum guanase in kidney diseases.
Leukemia
Value of ribonuclease and guanase activity for the diagnosis of leukemias.
Liver Cirrhosis
Clinical evaluation of serum guanase activity in liver diseases.
Liver Cirrhosis
Clinical significance of serum guanase activity in various liver diseases.
Liver Cirrhosis
Evaluation of serum guanase in hepatic diseases.
Liver Cirrhosis, Alcoholic
Histochemical demonstration of guanase in human liver with guanine in bicine buffer as substrate.
Liver Cirrhosis, Biliary
Histochemical demonstration of guanase in human liver with guanine in bicine buffer as substrate.
Liver Diseases
A simple and sensitive radiochemical assay for plasma guanase.
Liver Diseases
Clinical evaluation of serum guanase activity in liver diseases.
Liver Diseases
Clinical significance of serum guanase activity in various liver diseases.
Liver Diseases
Determination of guanase activity in normal and pathological sera by high-performance liquid chromatography.
Liver Diseases
Enzymological aspects of disorders in purine metabolism.
Liver Diseases
Evaluation of the spectrophotometric assay of guanase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen.
Liver Diseases
Guanase activity in the donor serum and the incidence of posttransfusion hepatitis non-A, non-B.
Liver Diseases
Serum guanase in diagnosis of liver disease.
Liver Diseases
[Activity of guanase and ornithine carbamyl transferase in blood serum of patients with liver disease]
Liver Diseases
[Clinical and laboratory-based evaluation of serum guanase activity in liver diseases]
Liver Diseases
[Clinical values of guanase activity in liver disease]
Liver Diseases
[Guanase activity of human blood in viral hepatitis and other liver diseases]
Liver Diseases
[Serum guanase in liver diseases]
Liver Diseases
[The value of the determinations of guanase and ornithine carbamyl-transferase activities in diagnosis of liver diseases]
Liver Diseases, Alcoholic
Clinical value of serum guanase in alcoholic liver disease.
Lung Neoplasms
Effect of TEI-6720, a xanthine oxidase inhibitor, on the nucleoside transport in the lung cancer cell line A549.
Melanosis
Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation.
Multiple Sclerosis
[Clinical significance of CSF guanase activity in patient with multiple sclerosis]
Multiple Sclerosis
[Determination of CSF guanase activity in multiple sclerosis: a comparative study on various parameters to monitor the disease activity]
Myocardial Infarction
Clinical and experimental studies of the determination of serum guanase activity in acute myocardial infarction.
Myocardial Infarction
Clinical evaluation of measurement of serum guanase activity as a screening test of liver damage.
Myocardial Infarction
Clinical value of the determination of serum guanase activity in acute myocardial infarction.
Myocardial Infarction
Clinical value of the determination of serum guanase activity. Studies on patients and experimental data from mongrel dogs and cultured rat hepatocytes.
Myocardial Infarction
Serum guanase activities after myocardial infarction.
Neoplasms
Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.
Neoplasms
Enzymes and cancer. Preparation and some properties of guanase from rabbit liver.
Neoplasms
Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.
Neoplasms
Short anogenital distance is associated with testicular germ cell tumour development.
Neoplasms
Uridine kinase, adenylate kinase, and guanase in human lung tumors.
Neoplasms, Germ Cell and Embryonal
Short anogenital distance is associated with testicular germ cell tumour development.
Neuroblastoma
A comparison of purine metabolism and nucleotide pools in normal and hypoxanthine-guanine phosphoribosyltransferase-deficient neuroblastoma cells.
Obesity
Target identification of the novel antiobesity agent tungstate in adipose tissue from obese rats.
Papillomavirus Infections
Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.
Premature Ejaculation
The relationship between anogenital distance and lifelong premature ejaculation.
Prostatic Neoplasms
Assesment of anogenital distance as a marker in diagnosis of prostate cancer.
Starvation
Guanine deaminase in the developing rat brain: effect of starvation.
Stomach Neoplasms
Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer.
Virus Diseases
Serum guanase activity in hepatitis C virus infection.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.129
(6R)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.119
(6S)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.0438
1-(4-methoxybenzyl)-4-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8-(1H)-one
-
at 25°C and pH 7.4
0.0265
1-(4-methoxybenzyl)-4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
-
at 25°C and pH 7.4
0.00188
2,6-diaminopurine
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.0397
3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.0334
3-(4-methoxybenzyl)-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.021
3-benzyl-5-butoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.054
3-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.04
3-benzyl-5-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.047
3-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.00201 - 0.02
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
0.0088
4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
at 25°C and pH 7.4
0.00444
5-amino-4-imidazole carboxamide
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.0475
5-methoxy-1-(4-methoxybenzyl)-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
-
at 25°C and pH 7.4
0.00536 - 0.054
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
0.0005
6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
pH 7.4, 25°C
0.00555
7-methylguanine
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.0025 - 2.5
azepinomycin
0.0102
Caffeine
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.00344
N-2-acetylguanine
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.00434
uric acid
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.00196
xanthine
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
0.00201
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
pH 7.4, 25°C
0.02
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
pH 7.4, 25°C
0.00536
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
pH 7.4, 25°C
0.054
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
-
pH 7.4, 25°C
0.0025
azepinomycin
-
at 25°C and pH 7.4
2.5
azepinomycin
-
at 25°C and pH 7.4
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Negishi, O.; Ozawa, T.; Imagawa, H.
Guanosine deaminase and guanine deaminase from tea leaves
Biosci. Biotechnol. Biochem.
58
1277-1281
1994
Camellia sinensis, Clostridium sp., Nicotiana tabacum, Rattus norvegicus
-
brenda
Kimm, S.W.; Park, J.B.; Kim, H.L.
The physicochemical properties of guanine aminohydrolase purified from human liver
Korean J. Biochem.
19
39-46
1987
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus sp.
-
brenda
Kimm, S.W.; Park, J.B.; Lee, I.S.
Purification and characterization of guanine aminohydrolase from human liver
Korean J. Biochem.
17
139-148
1985
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
-
brenda
Gupta, N.K.; Glantz, M.D.
Isolation and characterization of human liver guanine deaminase
Arch. Biochem. Biophys.
236
266-276
1985
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus sp.
brenda
Pugh, M.E.; Bieber, A.L.
Studies of rabbit brain, intestine and liver guanine aminohydrolase
Comp. Biochem. Physiol. B
77
619-627
1984
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Ovis ammon, Sus sp.
brenda
Kim, C.J.; Kimm, S.W.
Enzymatic evidence for a mitochondrial inhibitor of guanine aminohydrolase in rat liver
Korean J. Biochem.
14
77-93
1982
Clostridium sp., Homo sapiens, Mus musculus, Ophiodon elongatus, Rattus norvegicus, Rattus norvegicus Sprague Dawley
-
brenda
Miyamoto, S.; Ogawa, H.; Shiraki, H.; Nakagawa, H.
Guanine deaminase from rat brain. Purification, characteristics, and contribution to ammoniagenesis in the brain
J. Biochem.
91
167-176
1982
Rattus norvegicus, Rattus norvegicus Wistar, Sus sp.
brenda
Kuzmits, R.; Stemberger, H.; Muller, M.M.
Guanase from human liver - purification and characterization
Adv. Exp. Med. Biol.
122B
183-188
1980
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Bergstrom, J.D.; Bieber, A.L.
Characterization of purified guanine aminohydrolase
Arch. Biochem. Biophys.
194
107-116
1979
Oryctolagus cuniculus
brenda
Glantz, M.D.; Lewis, A.S.
Guanine deaminase from rabbit liver
Methods Enzymol.
51
512-517
1978
Oryctolagus cuniculus
brenda
Rossi, C.A.; Hakim, G.; Solaini, G.
Purification and properties of pig brain guanine deaminase
Biochim. Biophys. Acta
526
235-246
1978
Oryctolagus cuniculus, Platyrrhini, Mus musculus, Ovis ammon, Rattus norvegicus, Sus sp.
brenda
Fogle, P.J.; Bieber, A.L.
Purification of rabbit liver guanine aminohydrolase
Prep. Biochem.
5
59-77
1975
Oryctolagus cuniculus, Homo sapiens, Ophiodon elongatus, Rattus norvegicus
brenda
Lewis, A.S.; Glantz, M.D.
Rabbit liver guanine deaminase. Chemical, physical, and kinetic properties
J. Biol. Chem.
249
3862-3866
1974
Oryctolagus cuniculus, Rattus norvegicus
brenda
Kumar, K.S.; Sitaramayya, A.; Krishnan, P.S.
Guanine deaminase in rat liver and mouse liver and brain
Biochem. J.
128
1079-1088
1972
Mus musculus, Rattus norvegicus
brenda
Rabinowitz, J.C.; Barker, H.A.
Purine fermentation by Clostridium cylindrosporum
J. Biol. Chem.
218
161-173
1956
Clostridium sp.
brenda
Ito, S.; Maeda, T.; Iwasaki, A.; Fujikawa, H.; Okahisa, T.; Saijyou, T.; II, K.; Sano, N.; Matsuda, Y.; Endo, H.
Histochemical and biochemical studies on guanase in the human and rat kidney
Acta Histochem.
24
591-596
1991
Homo sapiens, Mus musculus, Rattus norvegicus
-
brenda
Canbolat, O.; Durak, I.; Cetin, R.; Kavutcu, M.; Demirci, S.; Oeztuerk, S.
Activities of adenosine deaminase, 5'-nucleotidase, guanase, and cytidine deaminase enzymes in cancerous and non-cancerous human breast tissues
Breast Cancer Res. Treat.
37
189-193
1996
Homo sapiens
brenda
Rajappan, V.P.; Hosmane, R.
Analogues of azepinomycin as inhibitors of guanase
Nucleosides Nucleotides
17
1141-1151
1998
Oryctolagus cuniculus, Homo sapiens
brenda
Yuan, G.; Bin, J.C.; McKay, D.J.; Snyder, F.F.
Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein
J. Biol. Chem.
274
8175-8180
1999
Mus musculus, Sus sp., Homo sapiens (Q9Y2T3), Homo sapiens
brenda
Maynes, J.T.; Yuan, R.G.; Snyder, F.F.
Identification, expression and characterization of Escherichia coli guanine deaminase
J. Bacteriol.
8
4658-4660
2000
Escherichia coli, Homo sapiens (Q9Y2T3), Homo sapiens
brenda
Liaw, S.H.; Chang, Y.J.; Lai, C.T.; Chang, H.C.; Chang, G.G.
Crystal structure of Bacillus subtilis guanine deaminase: the first domain-swapped structure in the cytidine deaminase superfamily
J. Biol. Chem.
279
35479-35485
2004
Bacillus subtilis (O34598), Bacillus subtilis
brenda
Chang Yu Ju, C.Y.; Huang Chun Hsian, H.C.; Hu Chih Yun, H.C.; Liaw Shwu Hue, L.S.
Crystallization and preliminary crystallographic analysis of Bacillus subtilis guanine deaminase
Acta Crystallogr. Sect. D
60
1152-1154
2004
Bacillus subtilis
brenda
Roberts, E.L.; Newton, R.P.
Estimation of guanine deaminase using guanosine as a "prosubstrate"
Anal. Biochem.
324
250-257
2004
Homo sapiens
brenda
Ujjinamatada, R.K.; Bhan, A.; Hosmane, R.S.
Design of inhibitors against guanase: Synthesis and biochemical evaluation of analogues of azepinomycin
Bioorg. Med. Chem. Lett.
16
5551-5554
2006
Oryctolagus cuniculus
brenda
Saint-Marc, C.; Daignan-Fornier, B.
GUD1 (YDL238c) encodes Saccharomyces cerevisiae guanine deaminase, an enzyme expressed during post-diauxic growth
Yeast
21
1359-1363
2004
Saccharomyces cerevisiae
brenda
Sannomiya, K.; Honda, H.; Kubo, K.; Ii, K.; Yuan, Y.; Aoyagi, E.; Muguruma, N.; Shimizu, I.; Ito, S.
A histochemical and immunohistochemical investigation of guanase and nedasin in rat and human tissues
J. Med. Invest.
53
246-254
2006
Homo sapiens, Rattus norvegicus
brenda
Kubo, K.; Honda, H.; Honda, H.; Sannomiya, K.; Aying, Y.; Mei, W.; Mi, S.; Aoyagi, E.; Simizu, I.; Ii, K.; Ito, S.
Histochemical and immunohistochemical investigation of guanase and nedasin in human tissues
J. Med. Invest.
53
264-270
2006
Homo sapiens
brenda
Yao, L.; Cukier, R.I.; Yan, H.
Catalytic mechanism of guanine deaminase: an ONIOM and molecular dynamics study
J. Phys. Chem. B
111
4200-4210
2007
Bacillus subtilis
brenda
Fernandez, J.R.; Welsh, W.J.; Firestein, B.L.
Structural characterization of the zinc binding domain in cytosolic PSD-95 interactor (cypin): Role of zinc binding in guanine deamination and dendrite branching
Proteins
70
873-881
2008
Rattus norvegicus
brenda
Medici, R.; Lewkowicz, E.S.; Iribarren, A.M.
Arthrobacter oxydans as a biocatalyst for purine deamination
FEMS Microbiol. Lett.
289
20-26
2008
Pseudarthrobacter oxydans
brenda
Fernandez, J.R.; Sweet, E.S.; Welsh, W.J.; Firestein, B.L.
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine
Bioorg. Med. Chem.
18
6748-6755
2010
Oryctolagus cuniculus, Rattus norvegicus, Homo sapiens (Q9Y2T3), Homo sapiens
brenda
Seffernick, J.L.; Dodge, A.G.; Sadowsky, M.J.; Bumpus, J.A.; Wackett, L.P.
Bacterial ammeline metabolism via guanine deaminase
J. Bacteriol.
192
1106-1112
2010
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110, Escherichia coli, Homo sapiens (Q9Y2T3), Pseudomonas putida, Pseudomonas putida KT 2240
brenda
Kim, J.; Park, S.I.; Ahn, C.; Kim, H.; Yim, J.
Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila
J. Biol. Chem.
284
23426-23435
2009
Drosophila melanogaster, Drosophila melanogaster Oregon-R
brenda
Murphy, P.M.; Bolduc, J.M.; Gallaher, J.L.; Stoddard, B.L.; Baker, D.
Alteration of enzyme specificity by computational loop remodeling and design
Proc. Natl. Acad. Sci. USA
106
9215-9220
2009
Homo sapiens (Q9Y2T3), Homo sapiens
brenda
Guzman, K.; Badia, J.; Gimenez, R.; Aguilar, J.; Baldoma, L.
Transcriptional regulation of the gene cluster encoding allantoinase and guanine deaminase in Klebsiella pneumoniae
J. Bacteriol.
193
2197-2207
2011
Klebsiella pneumoniae
brenda
Bitra, A.; Hussain, B.; Tanwar, A.S.; Anand, R.
Identification of function and mechanistic insights of guanine deaminase from Nitrosomonas europaea: role of the C-terminal loop in catalysis
Biochemistry
52
3512-3522
2013
Nitrosomonas europaea (Q82Y41), Nitrosomonas europaea
brenda
Chakraborty, S.; Shah, N.H.; Fishbein, J.C.; Hosmane, R.S.
Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
Bioorg. Med. Chem. Lett.
22
7214-7218
2012
Oryctolagus cuniculus
brenda
Tantravedi, S.; Chakraborty, S.; Shah, N.H.; Fishbein, J.C.; Hosmane, R.S.
Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines
Bioorg. Med. Chem.
21
4893-4903
2013
Oryctolagus cuniculus
brenda
Stuer-Lauridsen, B.; Nygaard, P.
Purine salvage in two halophilic archaea: characterization of salvage pathways and isolation of mutants resistant to purine analogs
J. Bacteriol.
180
457-463
1998
Halobacterium salinarum, Haloferax volcanii
brenda
Trautwein-Schult, A.; Jankowska, D.; Cordes, A.; Hoferichter, P.; Klein, C.; Matros, A.; Mock, H.P.; Baronian, K.; Bode, R.; Kunze, G.
Arxula adeninivorans recombinant guanine deaminase and its application in the production of food with low purine content
J. Mol. Microbiol. Biotechnol.
24
67-81
2014
Blastobotrys adeninivorans, Blastobotrys adeninivorans LS3
brenda
Shek, R.; Hilaire, T.; Sim, J.; French, J.B.
Structural determinants for substrate selectivity in guanine deaminase enzymes of the amidohydrolase superfamily
Biochemistry
58
3280-3292
2019
Escherichia coli (P76641), Escherichia coli, Saccharomyces cerevisiae (Q07729), Saccharomyces cerevisiae
brenda
Slater, P.G.; Cammarata, G.M.; Monahan, C.; Bowers, J.T.; Yan, O.; Lee, S.; Lowery, L.A.
Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney
Dev. Dyn.
248
296-305
2019
Xenopus laevis
brenda
Mahor, D.; Prasad, G.S.
Biochemical characterization of Kluyveromyces lactis adenine deaminase and guanine deaminase and their potential application in lowering purine content in beer
Front. Bioeng. Biotechnol.
6
180
2018
Kluyveromyces lactis, Kluyveromyces lactis MTCC 458
brenda