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2-amino-3,5-dihydropteridine-4,6-dione + H2O
1,5-dihydropteridine-2,4,6(3H)-trione + NH3
-
i.e. xanthopterin
-
-
?
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + H2O
2,4-dihydroxy-6-hydroxymethyl-7,8-dihydropteridine + NH3
2-amino-4-hydroxypteridine + H2O
2,4-dihydroxypteridine + NH3
2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid + H2O
2,4-dioxo-1,2,3,4-tetrahydropteridine-6-carboxylic acid + NH3
2-amino-5,6,7,8-tetrahydropteridin-4(1H)-one + H2O
5,6,7,8-tetrahydropteridine-2,4(1H,3H)-dione + NH3
-
the enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin
-
-
?
2-amino-6-hydroxypteridin-4(3H)-one + H2O
6-hydroxypteridine-2,4(1H,3H)-dione + NH3
-
i.e. 6-hydroxypterin
-
-
?
2-amino-6-methylpteridin-4(3H)-one + H2O
6-methylpteridine-2,4(1H,3H)-dione + NH3
-
i.e. 6-methylpterin
-
-
?
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(8H)-one + H2O
6-[(1R,2S)-1,2-dihydroxypropyl]pteridine-2,4(1H,3H)-dione + NH3
-
i.e. biopterin
-
-
?
2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydropteridin-4(1H)-one + H2O
6-[(2S)-2-hydroxypropanoyl]-7,8-dihydropteridine-2,4(1H,3H)-dione + NH3
-
i.e. sepiapterin
-
-
?
2-amino-7-methylpteridin-4(3H)-one + H2O
7-methylpteridine-2,4(1H,3H)-dione + NH3
-
i.e. 7-methylpterin
-
-
?
2-aminopteridin-4(1H)-one + H2O
2-hydroxypteridin-4(1H)-one + NH3
2-aminopteridin-4(3H)-one + H2O
2-hydroxypteridin-4(3H)-one + NH3
2-aminopteridine-4,7(1H,8H)-dione + H2O
7-hydroxypteridine-2,4(1H,3H)-dione + NH3
additional information
?
-
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + H2O
2,4-dihydroxy-6-hydroxymethyl-7,8-dihydropteridine + NH3
-
-
-
?
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + H2O
2,4-dihydroxy-6-hydroxymethyl-7,8-dihydropteridine + NH3
-
-
-
?
2-amino-4-hydroxypteridine + H2O
2,4-dihydroxypteridine + NH3
Alcaligenes metalcaligenes
-
i.e. pterin
i.e. lumazine
-
ir
2-amino-4-hydroxypteridine + H2O
2,4-dihydroxypteridine + NH3
-
i.e. pterin
i.e. lumazine
-
?
2-amino-4-hydroxypteridine + H2O
2,4-dihydroxypteridine + NH3
-
i.e. pterin. The enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin
i.e. lumazine
-
?
2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid + H2O
2,4-dioxo-1,2,3,4-tetrahydropteridine-6-carboxylic acid + NH3
-
i.e. pterin 6-carboxylate
i.e. 2,4-dioxo-pteridine-6-carboxylate
-
?
2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid + H2O
2,4-dioxo-1,2,3,4-tetrahydropteridine-6-carboxylic acid + NH3
i.e. pterin 6-carboxylate
i.e. 2,4-dioxo-pteridine-6-carboxylate
-
?
2-aminopteridin-4(1H)-one + H2O
2-hydroxypteridin-4(1H)-one + NH3
-
-
-
?
2-aminopteridin-4(1H)-one + H2O
2-hydroxypteridin-4(1H)-one + NH3
-
-
-
?
2-aminopteridin-4(3H)-one + H2O
2-hydroxypteridin-4(3H)-one + NH3
-
-
-
?
2-aminopteridin-4(3H)-one + H2O
2-hydroxypteridin-4(3H)-one + NH3
-
-
-
?
2-aminopteridine-4,7(1H,8H)-dione + H2O
7-hydroxypteridine-2,4(1H,3H)-dione + NH3
-
i.e. isoxanthopterin. The enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin
i.e. 7-hydroxylumazine
-
?
2-aminopteridine-4,7(1H,8H)-dione + H2O
7-hydroxypteridine-2,4(1H,3H)-dione + NH3
i.e. isoxanthopterin. The enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin
i.e. 7-hydroxylumazine
-
?
additional information
?
-
Alcaligenes metalcaligenes
-
Only pteridines possessing the pterin structure (i.e. the 2-amino and 4-hydroxyl functional groups) are deaminated. The nature of the substitution at carbon 6 is relatively unimportant. However, an hydroxyl group at this position results in an inactive substance. Carbon 7 must be unsubstituted, since blocking of this position by a methyl or carboxyl function destroys the ability of the pterin to serve as a substrate. An N-5-formylated and reduced pterin is not deaminated
-
-
?
additional information
?
-
-
guanine, 7-carboxypterin, leucopterin, isoxanthopterin, and 6-methylisoxanthopterin do not serve as substrates
-
-
?
additional information
?
-
-
guanine, 7-carboxypterin, leucopterin, isoxanthopterin, and 6-methylisoxanthopterin do not serve as substrates
-
-
?
additional information
?
-
-
xanthopterin, biopterin, neopterin, pterin-6-carboxylic acid, and 6-hydroxymethylpterin are not deaminated
-
-
?
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Tsusue, M.; Takikawa, S.; Yokokawa, C.K.
The bacterial catabolism of pteridines
Dev. Biochem.
4
153-158
1978
Priestia megaterium
-
brenda
Takikawa, S.; Kitayama-Yokokawa, C.; Tsusue, M.
Pterin deaminase from Bacillus megaterium
J. Biochem.
85
785-790
1979
Priestia megaterium
brenda
Rembold.H.; Simmersbach, F.
Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver
Biochim. Biophys. Acta
184
589-596
1969
Apis mellifera, Rattus norvegicus
brenda
Hall, R.S.; Agarwal, R.; Hitchcock, D.; Sauder, J.M.; Burley, S.K.; Swaminathan, S.; Raushel, F.M.
Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase
Biochemistry
49
4374-4382
2010
unidentified prokaryotic organism (P0CI72)
brenda
Levenberg, B.; Hayaishi, O.
A bacterial pterin deaminase
J. Biol. Chem.
234
955-961
1959
Alcaligenes metalcaligenes
brenda
Fan, H.; Hitchcock, D.S.; Seidel, R.D.; Hillerich, B.; Lin, H.; Almo, S.C.; Sali, A.; Shoichet, B.K.; Raushel, F.M.
Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking
J. Am. Chem. Soc.
135
795-803
2013
Agrobacterium tumefaciens (B9J850), Agrobacterium tumefaciens K84 (B9J850)
brenda
Jayaraman, A.; Thandeeswaran, M.; Priyadarsini, U.; Sabarathinam, S.; Nawaz, K.A.; Palaniswamy, M.
Characterization of unexplored amidohydrolase enzyme-pterin deaminase
Appl. Microbiol. Biotechnol.
100
4779-4789
2016
Dictyostelium discoideum, Rattus norvegicus, Alcaligenes metalcaligenes
brenda