Information on EC 220.127.116.11 - cytosine deaminase and Organism(s) Mus musculus and UniProt Accession Q99J72for references in articles please use BRENDA:EC18.104.22.168
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The taxonomic range for the selected organisms is: Mus musculus
A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, CodA protein, Cytosine aminohydrolase, cytosine deaminase,
Also acts on 5-methylcytosine.
for woodchuck hepatitis virus mAPOBEC3 is operative
mHBV (mouse transgenic model of HBV replication) is edited in vivo by mAPOBEC1 (mA1) and not mAPOBEC3
inhibition of tumor growth in mice treated with gene transfer of interleukin IL-12 plus enzyme/5-fluorcytosine is significantly greater than in mice treated with enzyme or IL-12 alone. Combined gene transfer increases splenic natural killer cell activity and interferon-gamma production by slenocytes and increases tumor growth inhibition and mean animal survival time
Hwang, K.; Cho, W.; Yoo, J.; Yun, H.; Kim, S.; Im, D.
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
Renard, M.; Henry, M.; Guetard, D.; Vartanian, J.P.; Wain-Hobson, S.
APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo
J. Mol. Biol.
Mus musculus, Mus musculus (P51908), Mus musculus (Q99J72)
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