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Information on EC 3.5.4.1 - cytosine deaminase and Organism(s) Mus musculus and UniProt Accession Q99J72

for references in articles please use BRENDA:EC3.5.4.1
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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.1 cytosine deaminase
IUBMB Comments
Also acts on 5-methylcytosine.
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Select one or more organisms in this record:
This record set is specific for:
Mus musculus
UNIPROT: Q99J72
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
The taxonomic range for the selected organisms is: Mus musculus
Reaction Schemes
Synonyms
A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, CodA protein, Cytosine aminohydrolase, cytosine deaminase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
APOBEC1
297960
-
APOBEC3
297961
-
Cytosine aminohydrolase
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-
-
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isocytosine deaminase
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-
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-
SYSTEMATIC NAME
IUBMB Comments
cytosine aminohydrolase
Also acts on 5-methylcytosine.
CAS REGISTRY NUMBER
COMMENTARY hide
9025-05-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
for woodchuck hepatitis virus mAPOBEC3 is operative
physiological function
mHBV (mouse transgenic model of HBV replication) is edited in vivo by mAPOBEC1 (mA1) and not mAPOBEC3
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
ABEC3_MOUSE
440
0
52213
Swiss-Prot
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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inhibition of tumor growth in mice treated with gene transfer of interleukin IL-12 plus enzyme/5-fluorcytosine is significantly greater than in mice treated with enzyme or IL-12 alone. Combined gene transfer increases splenic natural killer cell activity and interferon-gamma production by slenocytes and increases tumor growth inhibition and mean animal survival time
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hwang, K.; Cho, W.; Yoo, J.; Yun, H.; Kim, S.; Im, D.
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
BMC Cancer
5
51
2005
Mus musculus
Manually annotated by BRENDA team
Renard, M.; Henry, M.; Guetard, D.; Vartanian, J.P.; Wain-Hobson, S.
APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo
J. Mol. Biol.
400
323-334
2010
Mus musculus, Mus musculus (P51908), Mus musculus (Q99J72)
Manually annotated by BRENDA team
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