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Information on EC 3.5.3.4 - allantoicase and Organism(s) Dictyostelium discoideum and UniProt Accession Q54VL5

for references in articles please use BRENDA:EC3.5.3.4
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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.4 allantoicase
IUBMB Comments
Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.
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This record set is specific for:
Dictyostelium discoideum
UNIPROT: Q54VL5
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
allantoicase, allantoate amidohydrolase, allantoate amidinohydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Allantoate amidinohydrolase
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-
-
-
Allantoine amidinohydrolase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of linear amidines
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
allantoate amidinohydrolase
Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.
CAS REGISTRY NUMBER
COMMENTARY hide
9025-21-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
allantoate + H2O
(S)-ureidoglycolate + urea
show the reaction diagram
-
-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
allantoate + H2O
(S)-ureidoglycolate + urea
show the reaction diagram
-
-
-
r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
downregulation of enzyme expression leads to a shortened cell cycle, a reduction in cell size relative to wild type cells and interrupted development
physiological function
normal functions of the enzyme include retarding cell division until a specific cell size is reached and coordinating the progression of development
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ALLC_DICDI
369
0
41778
Swiss-Prot
other Location (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xue, D.M.; Hou, L.S.
Shortening of the cell cycle and developmental interruption in a Dictyostelium discoideum cell line due to RNAi-silenced expression of allantoicase
Genet. Mol. Res.
11
1923-1933
2012
Dictyostelium discoideum (Q54VL5), Dictyostelium discoideum, Dictyostelium discoideum KAx3 (Q54VL5)
Manually annotated by BRENDA team