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Information on EC 3.5.3.4 - allantoicase and Organism(s) Escherichia coli and UniProt Accession P77425

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.4 allantoicase
IUBMB Comments
Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.
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This record set is specific for:
Escherichia coli
UNIPROT: P77425
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Word Map
The taxonomic range for the selected organisms is: Escherichia coli
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
allantoicase, allantoate amidohydrolase, allantoate amidinohydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Allantoate amidinohydrolase
-
-
-
-
allantoate amidohydrolase
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Allantoine amidinohydrolase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of linear amidines
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
allantoate amidinohydrolase
Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.
CAS REGISTRY NUMBER
COMMENTARY hide
9025-21-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
allantoate + H2O
(S)-ureidoglycolate + urea
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
allantoate + H2O
(S)-ureidoglycolate + urea
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
required for maximum activity
Mn2+
required for maximum activity
Ni2+
required for maximum activity
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with allantoate, sitting drop vapor diffusion method, using 0.1 M sodium citrate (pH 5.6), 20% (w/v) polyethylene glycol 4000, 20%(v/v) isopropanol, 1 mMMnCl2, and 5 mM allantoate
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E126A
inactive
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shin, I.; Han, K.; Rhee, S.
Structural insights into the substrate specificity of (S)-ureidoglycolate amidohydrolase and its comparison with allantoate amidohydrolase
J. Mol. Biol.
426
3028-3040
2014
Escherichia coli (P77425), Escherichia coli
Manually annotated by BRENDA team