Reference on EC 3.5.3.18 - dimethylargininase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Leiper, J.M.; Santa Maria, J.; Chubb, A.; MacAllister, R.J.; Charles, I.G.
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
Biochem. J.
343
209-214
1999
Homo sapiens, Homo sapiens (O95865)
Manually annotated by BRENDA team
Kimoto, M.; Sasakawa, T.; Tsuji, H.; Miyatake, S.; Oka, T.
Cloning and sequencing of cDNA encoding NG,NG-dimethylarginine dimethylaminohydrolase from rat kidnes
Biochim. Biophys. Acta
1337
6-10
1997
Rattus norvegicus
Manually annotated by BRENDA team
Santa Maria, J.; Vallance, P.; Charles, I.G.; Leiper, J.M.
Identification of microbial dimethylarginine dimethylaminohydrolase enzymes
Mol. Microbiol.
33
1278-1279
1999
Homo sapiens, Mus musculus, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Rattus norvegicus, Streptomyces coelicolor
Manually annotated by BRENDA team
Birdsey, G.M.; Leiper, J.M.; Vallance, P.
Intramolecular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line
Acta Physiol. Scand.
168
73-79
2000
Homo sapiens
Manually annotated by BRENDA team
Bogumil, R.; Knipp, M.; Fundel, S.M.; Vasak, M.
Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site
Biochemistry
37
4791-4798
1998
Bos taurus
Manually annotated by BRENDA team
MacAllister, R.J.; Parry, H.; Kimoto, M.; Ogawa, T.; Russell, R.J.; Hodson, H.; Whiteley, G.St.J.; Vallance, P.
Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase
Br. J. Pharmacol.
119
1533-1540
1996
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Ogawa, T.; Kimoto, M.; Sasaoka, K.
Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase from rat kidney
J. Biol. Chem.
264
10205-10209
1989
Rattus norvegicus
Manually annotated by BRENDA team
Kimoto, M.; Whiteley, G.St.J.; Tsuji, H.; Ogawa, T.
Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissue using a monoclonal antibody
J. Biochem.
117
237-238
1995
Homo sapiens
Manually annotated by BRENDA team
Kimoto, M.; Tsuji, H.; Ogawa, T.; Sasaoka, K.
Detection of NG,NG-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody
Arch. Biochem. Biophys.
300
657-662
1993
Rattus norvegicus
Manually annotated by BRENDA team
Knipp, M.; Charnock, J.M.; Garner, C.D.; Vasak, M.
Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain. Zn(II) release activates DDAH-1
J. Biol. Chem.
276
40449-40456
2001
Bos taurus
Manually annotated by BRENDA team
Knipp, M.; Braun, O.; Gehrig, P.M.; Sack, R.; Vasak, M.
Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation
J. Biol. Chem.
278
3410-3416
2003
Bos taurus
Manually annotated by BRENDA team
Plevin, M.J.; Magalhaes, B.S.; Harris, R.; Sankar, A.; Perkins, S.J.; Driscoll, P.C.
Characterization and manipulation of the Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase monomer--dimer equilibrium
J. Mol. Biol.
341
171-184
2004
Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9I4E3)
Manually annotated by BRENDA team
Leiper, J.; Murray-Rust, J.; McDonald, N.; Vallance, P.
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase
Proc. Natl. Acad. Sci. USA
99
13527-13532
2002
Homo sapiens, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Stone, E.M.; Schaller, T.H.; Bianchi, H.; Person, M.D.; Fast, W.
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase
Biochemistry
44
13744-13752
2005
Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9I4E3)
Manually annotated by BRENDA team
Chen, Y.; Li, Y.; Zhang, P.; Traverse, J.H.; Hou, M.; Xu, X.; Kimoto, M.; Bache, R.J.
Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts
Am. J. Physiol. Heart Circ. Physiol.
289
H2212-2219
2005
Canis lupus familiaris, Homo sapiens
Manually annotated by BRENDA team
Billecke, S.S.; Kitzmiller, L.A.; Northrup, J.J.; Whitesall, S.E.; Kimoto, M.; Hinz, A.V.; D'Alecy, L.G.
Contribution of whole blood to the control of plasma asymmetrical dimethylarginine
Am. J. Physiol. Heart Circ. Physiol.
291
H1788-1796
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hasegawa, K.; Wakino, S.; Tanaka, T.; Kimoto, M.; Tatematsu, S.; Kanda, T.; Yoshioka, K.; Homma, K.; Sugano, N.; Kurabayashi, M.; Saruta, T.; Hayashi, K.
Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells
Arterioscler. Thromb. Vasc. Biol.
26
1488-1494
2006
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Yin, Q.; Fu, S.; He, P.; Xiong, Y.
Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: Effects of aminoguanidine
Atherosclerosis
190
53-61
2006
Rattus norvegicus
Manually annotated by BRENDA team
Stone, E.M.; Person, M.D.; Costello, N.J.; Fast, W.
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis
Biochemistry
44
7069 - 7078
2005
Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9I4E3)
Manually annotated by BRENDA team
Stone, E.M.; Costello, A.L.; Tierney, D.L.; Fast, W.
Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa
Biochemistry
45
5618-5630
2006
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Mishima, T.; Hamada, T.; Ui-Tei, K.; Miyata, Y.; Imaki, J.; Suzuki, H.; Yamashita K.
Expression of DDAH1 in chick and rat embryos
Brain Res. Dev. Brain Res.
148
223-232
2004
Gallus gallus, Rattus norvegicus
Manually annotated by BRENDA team
Jiang, J.L.; Zhang, X.H.; Li, N.S.; Rang, W.Q; Feng-Ye, W.Q.; Hu, C.P.; Li, Y.J.; Deng, H.W.
Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity
Cardiovasc. Drugs Ther.
20
281-294
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Vallance, P.; Bush, H.D.; Mok, B.J.; Hurtado-Guerrero, R.; Gill, H.; Rossiter, S.; Wilden, J.D.; Caddick, S.
Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates
Chem. Commun. (Camb.)
2005
5563-5565
2005
Pseudomonas sp.
Manually annotated by BRENDA team
Wakino, S.; Hayashi, K.; Tatematsu, S.; Hasegawa, K.; Takamatsu, I.; Kanda, T.; Homma, K.; Yoshioka, K.; Sugano, N.; Saruta, T.
Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats
Hypertens. Res.
28
255-262
2005
Rattus norvegicus
Manually annotated by BRENDA team
Scalera, F.; Kielstein, J.T.; Martens-Lobenhoffer, J.; Postel, S.C.; Tager, M.; Bode-Boger, S.M.
Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase
J. Am. Soc. Nephrol.
16
892-898
2005
Homo sapiens
Manually annotated by BRENDA team
Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L.
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
J. Med. Chem.
48
4670-4678
2005
Rattus norvegicus
Manually annotated by BRENDA team
Frey, D.; Braun, O.; Briand, C.; Vašák, M.; Grütter, M.G.
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: a basis for the design of specific inhibitors
Structure
14
901-911
2006
Bos taurus, Bos taurus (P56965)
Manually annotated by BRENDA team
Braun, O.; Knipp, M.; Chesnov, S.; Vasak, M.
Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase
Protein Sci.
16
1522-1534
2007
Bos taurus (P56965)
Manually annotated by BRENDA team
Sasaki, A.; Doi, S.; Mizutani, S.; Azuma, H.
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L1480-L1487
2007
Rattus norvegicus
Manually annotated by BRENDA team
Forbes, S.P.; Druhan, L.J.; Guzman, J.E.; Parinandi, N.; Zhang, L.; Green-Church, K.B.; Cardounel, A.J.
Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation
Biochemistry
47
1819-1826
2008
Homo sapiens
Manually annotated by BRENDA team
Wang, J.; Sim, A.S.; Wang, X.L.; Wilcken, D.E.
L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells
Cell. Mol. Life Sci.
63
2838-2846
2006
Homo sapiens
Manually annotated by BRENDA team
Wang, D.; Gill, P.S.; Chabrashvili, T.; Onozato, M.L.; Raggio, J.; Mendonca, M.; Dennehy, K.; Li, M.; Modlinger, P.; Leiper, J.; Vallance, P.; Adler, O.; Leone, A.; Tojo, A.; Welch, W.J.; Wilcox, C.S.
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO
Circ. Res.
101
627-635
2007
Rattus norvegicus (Q6MG60)
Manually annotated by BRENDA team
Siroen, M.P.; Teerlink, T.; Bolte, A.C.; van Elburg, R.M.; Richir, M.C.; Nijveldt, R.J.; van der Hoven, B.; van Leeuwen, P.A.
No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia
Gynecol. Obstet. Invest.
62
7-13
2006
Homo sapiens
Manually annotated by BRENDA team
Hong, L.; Fast, W.
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia
J. Biol. Chem.
282
34684-34692
2007
Homo sapiens
Manually annotated by BRENDA team
Slaghekke, F.; Dekker, G.; Jeffries, B.
Endogenous inhibitors of nitric oxide and preeclampsia: a review
J. Matern. Fetal. Neonatal. Med.
19
447-452
2006
Homo sapiens, Homo sapiens (O95865)
Manually annotated by BRENDA team
Tain, Y.L.; Baylis, C.
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney
Kidney Int.
72
886-889
2007
Rattus norvegicus
Manually annotated by BRENDA team
Mizuno, Y.; Isotani, E.; Ohno, K.; Nagai, A.; Imamura, M.; Azuma, H.
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit
Vascul. Pharmacol.
48
21-31
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Dayal, S.; Rodionov, R.N.; Arning, E.; Bottiglieri, T.; Kimoto, M.; Murry, D.J.; Cooke, J.P.; Faraci, F.M.; Lentz, S.R.
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia
Am. J. Physiol. Heart Circ. Physiol.
295
H816-H825
2008
Mus musculus
Manually annotated by BRENDA team
Sydow, K.; Mondon, C.E.; Schrader, J.; Konishi, H.; Cooke, J.P.
Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity
Arterioscler. Thromb. Vasc. Biol.
28
692-697
2008
Homo sapiens
Manually annotated by BRENDA team
Kotthaus, J.; Schade, D.; Muschick, N.; Beitz, E.; Clement, B.
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads
Bioorg. Med. Chem.
16
10205-10209
2008
Homo sapiens
Manually annotated by BRENDA team
Xiao, J.; Xiao, Z.J.; Liu, Z.G.; Gong, H.Y.; Yuan, Q.; Wang, S.; Li, Y.J.; Jiang, D.J.
Involvement of dimethylarginine dimethylaminohydrolase-2 in visfatin-enhanced angiogenic function of endothelial cells
Diabetes Metab. Res. Rev.
25
242-249
2009
Homo sapiens
Manually annotated by BRENDA team
Ellger, B.; Richir, M.C.; van Leeuwen, P.A.; Debaveye, Y.; Langouche, L.; Vanhorebeek, I.; Teerlink, T.; Van den Berghe, G.
Glycemic control modulates arginine and asymmetrical-dimethylarginine levels during critical illness by preserving dimethylarginine-dimethylaminohydrolase activity
Endocrinology
149
3148-3157
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Wadham, C.; Mangoni, A.A.
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease
Expert. Opin. Drug Metab. Toxicol.
5
303-319
2009
Bos taurus, Bos taurus (Q3SX44), Homo sapiens (O94760), Homo sapiens (O95865), Mus musculus (Q99LD8), Mus musculus (Q9CWS0), Oryctolagus cuniculus, Rattus norvegicus (O08557), Rattus norvegicus (Q6MG60)
Manually annotated by BRENDA team
Sakurada, M.; Shichiri, M.; Imamura, M.; Azuma, H.; Hirata, Y.
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells
Hypertension
52
903-909
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Wang, S.; Hu, C.P.; Jiang, D.J.; Peng, J.; Zhou, Z.; Yuan, Q.; Nie, S.D.; Jiang, J.L.; Li, Y.J.; Huang, K.L.
All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway
J. Neurosci. Res.
87
1938-1946
2009
Homo sapiens
Manually annotated by BRENDA team
Ueda, S.; Yamagishi, S.I.; Matsumoto, Y.; Kaida, Y.; Fujimi-Hayashida, A.; Koike, K.; Tanaka, H.; Fukami, K.; Okuda, S.
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD)
Life Sci.
84
853-860
2009
Homo sapiens
Manually annotated by BRENDA team
Gray, G.A.; Patrizio, M.; Sherry, L.; Miller, A.A.; Malaki, M.; Wallace, A.F.; Leiper, J.M.; Vallance, P.
Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction
Acta Histochem.
112
413-423
2010
Rattus norvegicus
Manually annotated by BRENDA team
Lee, W.J.; Kim, S.H.; Kim, G.H.; Han, S.M.; Won, J.C.; Jung, C.H.; Park, H.S.; Choi, d.o..S.; Lee, K.U.; Park, J.Y.
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells
Biochem. Biophys. Res. Commun.
398
653-658
2010
Mus musculus
Manually annotated by BRENDA team
Wang, Y.; Monzingo, A.F.; Hu, S.; Schaller, T.H.; Robertus, J.D.; Fast, W.
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide
Biochemistry
48
8624-8635
2009
Homo sapiens, Homo sapiens (O94760)
Manually annotated by BRENDA team
Rodionov, R.N.; Dayoub, H.; Lynch, C.M.; Wilson, K.M.; Stevens, J.W.; Murry, D.J.; Kimoto, M.; Arning, E.; Bottiglieri, T.; Cooke, J.P.; Baumbach, G.L.; Faraci, F.M.; Lentz, S.R.
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia
Circ. Res.
106
551-558
2010
Homo sapiens
Manually annotated by BRENDA team
Breckenridge, R.A.; Kelly, P.; Nandi, M.; Vallance, P.J.; Ohun, T.J.; Leiper, J.
A role for dimethylarginine dimethylaminohydrolase 1 (DDAH1) in mammalian development
Int. J. Dev. Biol.
54
215-220
2010
Mus musculus
Manually annotated by BRENDA team
Wang, Y.; Hu, S.; Fast, W.
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase
J. Am. Chem. Soc.
131
15096-15097
2009
Homo sapiens
Manually annotated by BRENDA team
Pope, A.J.; Karrupiah, K.; Kearns, P.N.; Xia, Y.; Cardounel, A.J.
Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production
J. Biol. Chem.
284
35338-35347
2009
Bos taurus (P56965), Bos taurus (Q3SX44)
Manually annotated by BRENDA team
Li, J.; Wilson, A.; Gao, X.; Kuruba, R.; Liu, Y.; Poloyac, S.; Pitt, B.; Xie, W.; Li, S.
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine
J. Pharmacol. Exp. Ther.
331
234-243
2009
Mus musculus
Manually annotated by BRENDA team
Hu, X.; Atzler, D.; Xu, X.; Zhang, P.; Guo, H.; Lu, Z.; Fassett, J.; Schwedhelm, E.; Boeger, R.H.; Bache, R.J.; Chen, Y.
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine
Arterioscler. Thromb. Vasc. Biol.
31
1540-1546
2011
Mus musculus
Manually annotated by BRENDA team
Zhang, P.; Hu, X.; Xu, X.; Chen, Y.; Bache, R.J.
Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt
Arterioscler. Thromb. Vasc. Biol.
31
890-897
2011
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Cillero-Pastor, B.; Mateos, J.; Fernandez-Lopez, C.; Oreiro, N.; Ruiz-Romero, C.; Blanco, F.J.
Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes
Arthritis Rheum.
64
204-212
2012
Homo sapiens
Manually annotated by BRENDA team
Johnson, C.M.; Linsky, T.W.; Yoon, D.W.; Person, M.D.; Fast, W.
Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase
J. Am. Chem. Soc.
133
1553-1562
2011
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Kotthaus, J.; Schade, D.; Kotthaus, J.; Clement, B.
Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase
J. Enzyme Inhib. Med. Chem.
27
24-28
2012
Homo sapiens
Manually annotated by BRENDA team
Davids, M.; Richir, M.C.; Visser, M.; Ellger, B.; van den Berghe, G.; van Leeuwen, P.A.; Teerlink, T.
Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness
Metab. Clin. Exp.
61
482-490
2012
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ghebremariam, Y.T.; Erlanson, D.A.; Cooke, J.P.
A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide
J. Pharmacol. Exp. Ther.
348
69-76
2014
Homo sapiens, Homo sapiens (O94760)
Manually annotated by BRENDA team
Sydow, K.; Schmitz, C.; von Leitner, E.C.; von Leitner, R.; Klinke, A.; Atzler, D.; Krebs, C.; Wieboldt, H.; Ehmke, H.; Schwedhelm, E.; Meinertz, T.; Blankenberg, S.; Boeger, R.H.; Magnus, T.; Baldus, S.; Wenzel, U.
Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension
PLoS ONE
7
e48150
2012
Homo sapiens (O94760)
Manually annotated by BRENDA team