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Disease on EC 3.5.3.15 - protein-arginine deiminase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
ATP induces PAD4 in renal proximal tubule cells via P2X7 receptor activation to exacerbate ischemic AKI.
Divergent roles for kidney proximal tubule and granulocyte PAD4 in ischemic AKI.
Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury.
Adenocarcinoma
DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Investigating the pathogenic role of PADI4 in oesophageal cancer.
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
Putative Roles for Peptidylarginine Deiminases in COVID-19.
Adenocarcinoma of Lung
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Adenocarcinoma, Papillary
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Adenoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Alopecia
Autosomal-Dominant Mutation in PADI3 Responsible for up to 25% of Central Centrifugal Cicatricial Alopecia Cases.
Comprehensive analysis of protein expression levels and phosphorylation levels in host skin in response to tick (Haemaphysalis longicornis) bite.
Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles.
Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Alveolar Bone Loss
Induction of immune response and prevention of alveolar bone loss with recombinant Porphyromonas gingivalis peptidylarginine deiminase.
Alzheimer Disease
A two-stage case-control association study of PADI2 with schizophrenia.
Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.
Arginine Metabolising Enzymes as Therapeutic Tools for Alzheimer's Disease: Peptidyl Arginine Deiminase Catalyses Fibrillogenesis of beta-amyloid Peptides.
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Peptidyl arginine deiminase 4 and its potential role in Alzheimer's disease.
Anemia, Sickle Cell
Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso-occlusive crisis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Significance of serum peptidylarginine deiminase type 4 in ANCA-associated vasculitis.
Aortic Aneurysm, Abdominal
Inhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice.
Appendicitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Arthritis
Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.
Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.
Extracellular citrullination inhibits the function of matrix associated TGF-?.
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis.
Genetics of arthritis severity: A genome-wide and species-wide dissection in HS mice.
Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: comment on the article by Shelef et al.
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis.
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) Gene Polymorphisms and Polyarticular Juvenile Idiopathic Arthritis.
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
Peptidyl arginine deiminase inhibition suppresses arthritis via decreased protein citrullination in joints and serum with the downregulation of interlukin-6.
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.
Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis.
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.
Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin.
Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD).
Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis.
Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans.
The relationship of the immune response mediator genes polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis.
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Arthritis, Experimental
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats.
N-{alpha}-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis.
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.
The regulation of macrophage polarization by hypoxia-PADI4 coordination in Rheumatoid arthritis.
Arthritis, Juvenile
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) Gene Polymorphisms and Polyarticular Juvenile Idiopathic Arthritis.
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
The relationship of the immune response mediator genes polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population.
A fluopol-ABPP HTS assay to identify PAD inhibitors.
A functional haplotype and expression of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Chinese.
A Functional Haplotype of PADI4 Gene in Rheumatoid Arthritis: Positive Correlation in a French Population.
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans.
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population.
Active site cysteine is protonated in the PAD4 Michaelis complex: evidence from Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis.
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system.
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate.
Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis.
Antibodies against transglutaminases, peptidylarginine deiminase and citrulline in rheumatoid arthritis - new pathways to epitope spreading.
Antibodies targeting protein-arginine deiminase 4 (PAD4) demonstrate diagnostic value in rheumatoid arthritis.
Association between PADI4 and rheumatoid arthritis: a meta-analysis.
Association between PADI4 and rheumatoid arthritis: a replication study.
Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort.
Association between peptidyl arginine deiminase 4 (PADI4)-104C/T polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population.
Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran.
Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis.
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population.
Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis.
Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans.
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
Association of baseline peptidylarginine deiminase 4 autoantibodies with favorable response to treatment escalation in rheumatoid arthritis.
Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.
Association of MiRNA-146a, MiRNA-499, IRAK1 and PADI4 Polymorphisms with Rheumatoid Arthritis in Egyptian Population.
Association of PADI4 and rheumatoid arthritis: a successful multidisciplinary approach.
Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population.
Associations Between PADI4 Gene Polymorphisms and Rheumatoid Arthritis: An Updated Meta-analysis.
Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis.
Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine.
Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis.
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.
Citrullination by peptidylarginine deiminase in rheumatoid arthritis.
Citrullination in the periodontium-a possible link between periodontitis and rheumatoid arthritis.
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
Citrullination of fibronectin in rheumatoid arthritis synovial tissue.
Citrulline Not a Major Determinant in the Recognition of Peptidylarginine Deiminase 2 and 4 by Autoantibodies in Rheumatoid Arthritis.
Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides.
Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features.
Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes.
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.
Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology.
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen.
Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study.
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Erratum to: PADI4 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
Estrogen-enhanced peptidylarginine deiminase type IV gene (PADI4) expression in MCF-7 cells is mediated by estrogen receptor-alpha-promoted transfactors activator protein-1, nuclear factor-Y, and Sp1.
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Evaluation of allele frequencies in the PADI4 gene and anti-cyclic citrullinated peptide antibodies of patients with rheumatoid arthritis in a Japanese population.
Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis.
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats.
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.
Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies.
Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes.
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay.
Genetic and genomic studies of PADI4 in rheumatoid arthritis.
Genetic background of anticyclic citrullinated Peptide autoantibody production in hungarian patients with rheumatoid arthritis.
Genomic modulators of gene expression in human neutrophils.
Great Therapeutic Potential of Peptidylarginine Deiminase 4 (PAD4) Inhibitors: Treatment of Rheumatoid Arthritis, Epigenetic Tools, Regulation of Pluripotency in Stem Cells, and More.
Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population.
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
Heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to tuberculosis in Koreans.
High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach.
High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4.
Hypoxia?induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast?like synoviocytes in rheumatoid arthritis.
Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.
Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers.
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.
Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases.
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis.
Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.
Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis.
Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients.
Lack of association between PADI4 polymorphisms and rheumatoid arthritis in the Tunisian population.
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis.
Matrix-assisted laser desorption ionization-time of flight mass spectrometry identification of peptide citrullination site using Br signature.
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population.
Meta-analysis: diagnostic accuracy of antibody against peptidylarginine deiminase 4 by ELISA for rheumatoid arthritis.
Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV.
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.
PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis.
PADI2 is significantly associated with rheumatoid arthritis.
PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico.
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) Gene Polymorphisms and Polyarticular Juvenile Idiopathic Arthritis.
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients.
PADI4 Gene Polymorphism is not Associated with Ankylosing Spondylitis in Chinese Han Population.
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population.
PADI4 haplotypes in association with RA Mexican patients, a new prospect for antigen modulation.
PADI4 polymorphism predisposes male smokers to rheumatoid arthritis.
PADI4 polymorphisms and related haplotype in rheumatoid arthritis patients.
PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.
PADI4 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
PADI4 polymorphisms and the functional haplotype are associated with increased rheumatoid arthritis susceptibility: A replication study in a Southern Mexican population.
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population.
PADI4 Polymorphisms in Iranian Patients with Rheumatoid Arthritis.
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Peptidyl arginine deiminase autoimmunity and the development of ACPA in rheumatoid arthritis. The "hapten carrier" model.
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.
Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis.
Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis.
Peptidyl-arginine deiminase: an additional marker of rheumatoid arthritis.
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis.
Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis.
Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis.
Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations.
Peptidylarginine deiminase 4 and citrullination in health and disease.
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and ?-enolase: implications for autoimmunity in rheumatoid arthritis.
Peptidylarginine deiminase type 2 and 4 generate distinct patterns of rheumatoid arthritis autoantigens during perforin-induced cell damage.
Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis.
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Peptidylarginine deiminase type 4, anticitrullinated peptide antibodies, and rheumatoid arthritis.
Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.
Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome.
Periodontal Treatment Decreases Levels of Antibodies to Porphyromonas Gingivalis and Citrulline in Patients With Rheumatoid Arthritis and Periodontitis.
Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.
Polymorphisms and functional haplotype in PADI4: Further evidence for contribution on rheumatoid arthritis susceptibility and anti-cyclic citrullinated peptide antibodies in a western Mexican population.
Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.
Predominance of IgG1 and IgG3 subclasses of autoantibodies to peptidylarginine deiminase 4 in rheumatoid arthritis.
Prevalence of functional haplotypes of the peptidylarginine deiminase citrullinating enzyme gene in patients with rheumatoid arthritis: no influence of the presence of anti-citrullinated peptide antibodies.
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4.
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis.
Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans.
Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3.
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis - a systematic review and meta-analysis.
Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity.
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents.
Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis.
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.
The development of N-?-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-?-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
The expression of mRNA for peptidylarginine deiminase type 2 and type 4 in bone marrow CD34+ cells in rheumatoid arthritis.
The expression of PADI4 in synovium of rheumatoid arthritis.
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells.
The inhibition of antithrombin by peptidylarginine deiminase 4 may contribute to pathogenesis of rheumatoid arthritis.
The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin.
The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population.
The regulation of macrophage polarization by hypoxia-PADI4 coordination in Rheumatoid arthritis.
The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis.
Theoretical insights into the protonation states of active site cysteine and citrullination mechanism of Porphyromonas gingivalis peptidylarginine deiminase.
There's no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis.
Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis.
Zinc is the modulator of the calcium-dependent activation of post-translationally acting thiol-enzymes in autoimmune diseases.
[Association between the synovial expression of cyclic citrullinated peptide and susceptibility variants of HLA-DRB1 shared epitope alleles and PADI 4 gene single nucleotide polymorphisms in patients with rheumatoid arthritis].
[Association of HLA-DR4, PAD4, and STAT4 expression in the peripheral blood with disease activity in patients with rheumatoid arthritis]
[Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan].
[Association of the PADI4 gene polymorphism and HLA-DRB1 shared epitope alleles with rheumatoid arthritis]
[Genetics and genomics in rheumatoid arthritis (RA): An update].
[Susceptibility genes in rheumatoid arthritis: peptidylarginine deiminase (PADI) type 4]
[The significance of serum peptidylarginine deiminase 4 in rheumatoid arthritis.]
Astrocytoma
Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.
Atherosclerosis
Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.
Neutrophils Cast NETs in Atherosclerosis: Employing Peptidylarginine Deiminase as a Therapeutic Target.
Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
The role of neutrophils in the pathogenesis of systemic lupus erythematosus.
Autoimmune Diseases
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
Cleavage Region Thyrotropin Receptor Antibodies Influence Thyroid Cell Survival In Vivo.
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.
Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.
Protein citrullination as a source of cancer neoantigens.
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Vimentin citrullination probed by a novel monoclonal antibody serves as a specific indicator for reactive astrocytes in neurodegeneration.
Brain Edema
Neutrophil Extracellular Traps may be a Potential Target for Treating Early Brain Injury in Subarachnoid Hemorrhage.
Breast Neoplasms
BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis.
Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3?/p53 activation.
Peptidylarginine Deiminase IV Regulates Breast Cancer Stem Cells via a Novel Tumor Cell-Autonomous Suppressor Role.
Protein citrullination as a source of cancer neoantigens.
Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.
Carcinogenesis
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib.
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Histone citrullination: a new target for tumors.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Investigating citrullinated proteins in tumour cell lines.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer.
PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
PADI4 and tumourigenesis.
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Carcinoma
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Investigating the pathogenic role of PADI4 in oesophageal cancer.
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Role of peptidylarginine deiminase type 4 in gastric cancer.
Carcinoma, Ductal
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Carcinoma, Hepatocellular
Decreased PADI4 mRNA Association with Global Hypomethylation in Hepatocellular Carcinoma During HBV Exposure.
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Peptidylarginine deiminase IV promotes the development of chemoresistance through inducing autophagy in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Carcinoma, Squamous Cell
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Cardiovascular Diseases
Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease.
Carotid Stenosis
Peptidylarginine Deiminase 4 as a Possible Biomarker of Plaque Instability in Carotid Artery Stenosis.
Central Nervous System Diseases
Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.
Cholecystitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Cholera
Stimulation of bovine brain phospholipase C activity by myelin basic protein requires arginyl residues in peptide linkage.
Chondroma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Chronic Periodontitis
Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides.
Periodontal Pathogens in the Etiology of Pancreatic Cancer.
[Role of Porphyromonas gingivalis in rheumatoid arthritis and inflammatory spondyloarthropathies].
Colitis
SUPPRESSION OF COLITIS IN MICE BY CL-AMIDINE: A NOVEL PEPTIDYLARGININE DEIMINASE (PAD) INHIBITOR.
Colitis, Ulcerative
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population.
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
The development of N-?-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-?-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Colonic Neoplasms
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer.
PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.
The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
Colorectal Neoplasms
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer.
COVID-19
Putative Roles for Peptidylarginine Deiminases in COVID-19.
Crohn Disease
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Genomic modulators of gene expression in human neutrophils.
Cystadenocarcinoma
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Cystadenocarcinoma, Mucinous
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Cystadenoma
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Cysts
SUMOylation and deimination of proteins: two epigenetic modifications involved in Giardia encystation.
Demyelinating Diseases
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Peptidylarginine deiminase: a candidate factor in demyelinating disease.
Diabetes Mellitus
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Diabetes Mellitus, Type 1
Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Dysgerminoma
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Encephalomyelitis
Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice.
Encephalomyelitis, Autoimmune, Experimental
Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice.
Endodermal Sinus Tumor
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Endometrial Hyperplasia
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Endometrial Neoplasms
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.
Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target.
Endotoxemia
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.
Epstein-Barr Virus Infections
Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.
Esophageal Neoplasms
Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer.
Esophageal Squamous Cell Carcinoma
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Investigating the pathogenic role of PADI4 in oesophageal cancer.
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Felty Syndrome
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Gallstones
Neutrophil Extracellular Traps Initiate Gallstone Formation.
Gastritis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Gingivitis
Evaluation of galectin-3, peptidylarginine deiminase-4 and tumor necrosis factor-? levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study.
Impact of chronic gingivitis management on the cytokine and anti-PPAD expressions in juvenile systemic lupus erythematosus: A six-month follow-up.
Glaucoma
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis.
Glaucoma, Open-Angle
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
Glioblastoma
Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Glomerulonephritis
Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.
Granulosa Cell Tumor
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Graves Disease
Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases.
Heart Diseases
Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease.
NETosis as a Pathogenic Factor for Heart Failure.
Hemangioma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Hemangioma, Cavernous
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Hepatitis, Chronic
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis.
Hydatidiform Mole
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Hyperalgesia
Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation.
Hyperparathyroidism, Secondary
Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Hypersensitivity
Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
Hypertension
Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.
Infections
Anti-phospholipid Antibodies and Smoking: An Overview.
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.
Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance?
Mycoplasma and host interaction: In vitro gene expression modulation in Mycoplasma synoviae and infected chicken chondrocytes.
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.
Porphyromonas gingivalis and its LPS differentially regulate the expression of peptidyl arginine deiminases in human chondrocytes.
Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells.
Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of Francisella tularemia.
Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity.
The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans.
Inflammatory Bowel Diseases
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Invasive Pulmonary Aspergillosis
Neutrophil extracellular traps impair fungal clearance in a mouse model of invasive pulmonary aspergillosis.
Kidney Neoplasms
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Leiomyoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Leprosy
Genomic modulators of gene expression in human neutrophils.
Leukemia
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells.
Lipoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Liver Cirrhosis
Peptidyl arginine deiminase inhibitor effect on hepatic fibrogenesis in a CCl4 pre-clinical model of liver fibrosis.
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis.
Liver Neoplasms
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Low Tension Glaucoma
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
Lung Diseases
Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases.
Lung Diseases, Interstitial
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis.
Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.
Lung Injury
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.
Lung Neoplasms
Differential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung Cancer in Wistar Rats and their Implications.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
PADI4?mediated epithelial?mesenchymal transition in lung cancer cells.
Lupus Erythematosus, Systemic
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Fine specificity of anti-citrullinated peptide antibodies discloses a heterogeneous antibody population in rheumatoid arthritis.
Impact of chronic gingivitis management on the cytokine and anti-PPAD expressions in juvenile systemic lupus erythematosus: A six-month follow-up.
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome.
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis.
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Lupus Nephritis
Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice.
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Lymphatic Metastasis
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Multiple Myeloma
A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma.
Multiple Sclerosis
A two-stage case-control association study of PADI2 with schizophrenia.
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay.
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood.
Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis.
Novel Inhibitors of Protein Arginine Deiminase with Potential Activity in Multiple Sclerosis Animal Model.
PADI4 gene in multiple sclerosis: a family-based association study.
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Peptidylarginine deiminase 4 and citrullination in health and disease.
Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis.
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Vitamin D3 and estradiol alter PAD2 expression and activity levels in C6 glioma cells.
Myocardial Infarction
Gaps in public knowledge of peripheral arterial disease: the first national PAD public awareness survey.
Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.
Myoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Nasopharyngeal Carcinoma
PADI4, negatively regulated by miR-335-5p, participates in regulating the proliferation, migration, invasion and radiosensitivity of nasopharyngeal carcinoma cells.
Neoplasm Metastasis
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
NF-?B and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis.
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
PADI4?mediated epithelial?mesenchymal transition in lung cancer cells.
Possible role of Porphyromonas gingivalis in orodigestive cancers.
The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer.
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Neoplasms
Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity.
Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
Colorectal cancer detection by biomarker quantification in noninvasively collected colorectal mucus: preliminary comparison of 24 protein biomarkers.
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.
Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib.
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis.
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.
Evaluation of galectin-3, peptidylarginine deiminase-4 and tumor necrosis factor-? levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study.
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors.
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Hypoxia-induced production of peptidylarginine deiminases and citrullinated proteins in malignant glioma cells.
Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Immunologic detection of markers of keratinocyte differentiation. Its use in neoplastic and preneoplastic lesions of skin.
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Investigating citrullinated proteins in tumour cell lines.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Investigating the pathogenic role of PADI4 in oesophageal cancer.
LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue.
NF-?B and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis.
Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.
PAD2 overexpression in transgenic mice promotes spontaneous skin neoplasia.
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.
PADI2-mediated citrullination promotes prostate cancer progression.
PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer.
PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
PADI4 and tumourigenesis.
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer.
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis.
Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.
Peptidylarginine Deiminase IV Regulates Breast Cancer Stem Cells via a Novel Tumor Cell-Autonomous Suppressor Role.
Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.
Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice.
Possible role of Porphyromonas gingivalis in orodigestive cancers.
Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.
Protein arginine deiminase 4: a target for an epigenetic cancer therapy.
Protein citrullination as a source of cancer neoantigens.
Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target.
Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase.
Regulation of Protein Citrullination through p53/PADI4 Network in DNA Damage Response.
Rheumatoid arthritis susceptibility genes: An overview.
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Role of peptidylarginine deiminase type 4 in gastric cancer.
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents.
Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer.
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
The development of N-?-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-?-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
[Effect of PADI4 on the Expression of Inflammatory Cytokines During NB4 Cells Differentiation].
Neoplasms, Germ Cell and Embryonal
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Neoplasms, Squamous Cell
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Nephritis
Lupus and proliferative nephritis are PAD4 independent in murine models.
Neurilemmoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Neurodegenerative Diseases
Age-related reduction in retinal deimination levels in the F344BN rat.
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay.
Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases.
Neurofibroma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Osteoarthritis
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
PADI2 is significantly associated with rheumatoid arthritis.
Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis.
The expression of PADI4 in synovium of rheumatoid arthritis.
Tumour necrosis factor alpha promotes secretion of 14-3-3? by inducing necroptosis in macrophages.
Osteomalacia
Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Osteosarcoma
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
Ovarian Neoplasms
Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib.
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Pancreatic Neoplasms
DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.
Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.
Pancreatitis
Different Types of Periampullary Duodenal Diverticula Are Associated with Occurrence and Recurrence of Bile Duct Stones: A Case-Control Study from a Chinese Center.
Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis.
Periodontal Diseases
Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase-2 levels in periodontal health and disease.
Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis.
Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis.
Rheumatoid arthritis and periodontal disease.
Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis - a systematic review and meta-analysis.
The role of anti-cyclic citrullinated peptide antibody in periodontal disease.
Periodontitis
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system.
Anti-phospholipid Antibodies and Smoking: An Overview.
Citrullination in the periodontium-a possible link between periodontitis and rheumatoid arthritis.
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
Effects by periodontitis on pristane-induced arthritis in rats.
Evaluation of galectin-3, peptidylarginine deiminase-4 and tumor necrosis factor-? levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study.
Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis.
Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis.
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase.
Rheumatoid arthritis and periodontal disease.
Peripheral Arterial Disease
Effect of Peptidylarginine Deiminase 4 on Endothelial Progenitor Cell Function in Peripheral Arterial Disease.
Pneumonia
Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep.
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Prion Diseases
Peptidylarginine deiminase and protein citrullination in prion diseases: Strong evidence of neurodegeneration.
protein-arginine deiminase deficiency
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Proteinuria
Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice.
Psoriasis
Unraveling the genetics of complex diseases: Susceptibility genes for rheumatoid arthritis and psoriasis.
Pulmonary Disease, Chronic Obstructive
Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis.
Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities.
Pulmonary Fibrosis
PAD4 Deficiency Improves Bleomycin-induced Neutrophil Extracellular Traps and Fibrosis in Mouse Lung.
Pyelonephritis
TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.
Rheumatic Diseases
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis.
[The significance of serum peptidylarginine deiminase 4 in rheumatoid arthritis.]
Rheumatic Fever
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase.
Sarcoma
Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis.
Sepsis
Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Rabbit Model of Endotoxic Shock.
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis.
Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.
Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae-Induced Pneumonia-Derived Sepsis.
Shock, Septic
Citrullinated histone H3: a novel target for the treatment of sepsis.
Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury.
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.
Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients.
Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice.
Skin Neoplasms
Immunohistochemical demonstration of peptidylarginine deiminase in human sweat glands.
Spondylitis, Ankylosing
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
PADI4 Gene Polymorphism is not Associated with Ankylosing Spondylitis in Chinese Han Population.
The expression of PADI4 in synovium of rheumatoid arthritis.
Stomach Neoplasms
A Novel Citrullinated Modification of Histone 3 and Its Regulatory Mechanisms Related to IPO-38 Antibody-Labeled Protein.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Role of peptidylarginine deiminase type 4 in gastric cancer.
Stroke
Gaps in public knowledge of peripheral arterial disease: the first national PAD public awareness survey.
[Effect of neutrophil extracellular traps on ischemic stroke and intervention of traditional Chinese medicine].
Synovitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Teratoma
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Thecoma
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Thrombosis
Effect of Peptidylarginine Deiminase 4 on Endothelial Progenitor Cell Function in Peripheral Arterial Disease.
Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.
Neutrophil accumulation and NET release contribute to thrombosis in HIT.
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury.
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review.
Thrombosis: tangled up in NETs.
Thyroid Cancer, Papillary
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Thyroiditis
Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases.
Tuberculosis
Heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to tuberculosis in Koreans.
Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance?
Urinary Bladder Neoplasms
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Uterine Cervicitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Vascular Diseases
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Vasculitis
Significance of serum peptidylarginine deiminase type 4 in ANCA-associated vasculitis.
Venous Thrombosis
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Vitamin D Deficiency
Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Wound Infection
Long-term follow-up of superior gluteal artery perforator flap closure of large myelomeningoceles.