Disease on EC 3.5.3.15 - protein-arginine deiminase
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Acute Kidney Injury
ATP induces PAD4 in renal proximal tubule cells via P2X7 receptor activation to exacerbate ischemic AKI.
Acute Kidney Injury
Divergent roles for kidney proximal tubule and granulocyte PAD4 in ischemic AKI.
Acute Kidney Injury
Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury.
Adenocarcinoma
DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.
Adenocarcinoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Adenocarcinoma
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
Adenocarcinoma of Lung
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Adenocarcinoma, Papillary
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Alopecia
Autosomal-Dominant Mutation in PADI3 Responsible for up to 25% of Central Centrifugal Cicatricial Alopecia Cases.
Alopecia
Comprehensive analysis of protein expression levels and phosphorylation levels in host skin in response to tick (Haemaphysalis longicornis) bite.
Alopecia
Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles.
Alveolar Bone Loss
Induction of immune response and prevention of alveolar bone loss with recombinant Porphyromonas gingivalis peptidylarginine deiminase.
Alzheimer Disease
Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.
Alzheimer Disease
Arginine Metabolising Enzymes as Therapeutic Tools for Alzheimer's Disease: Peptidyl Arginine Deiminase Catalyses Fibrillogenesis of beta-amyloid Peptides.
Alzheimer Disease
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Alzheimer Disease
Peptidyl arginine deiminase 4 and its potential role in Alzheimer's disease.
Anemia, Sickle Cell
Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso-occlusive crisis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Significance of serum peptidylarginine deiminase type 4 in ANCA-associated vasculitis.
Aortic Aneurysm, Abdominal
Inhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice.
Appendicitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Arthritis
Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.
Arthritis
Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
Arthritis
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.
Arthritis
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis.
Arthritis
Genetics of arthritis severity: A genome-wide and species-wide dissection in HS mice.
Arthritis
Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: comment on the article by Shelef et al.
Arthritis
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis.
Arthritis
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) Gene Polymorphisms and Polyarticular Juvenile Idiopathic Arthritis.
Arthritis
Peptidyl arginine deiminase inhibition suppresses arthritis via decreased protein citrullination in joints and serum with the downregulation of interlukin-6.
Arthritis
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.
Arthritis
Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
Arthritis
Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis.
Arthritis
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Arthritis
Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.
Arthritis
Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin.
Arthritis
Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD).
Arthritis
Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis.
Arthritis
Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans.
Arthritis
The relationship of the immune response mediator genes polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis.
Arthritis
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Arthritis, Experimental
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Arthritis, Experimental
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats.
Arthritis, Experimental
N-{alpha}-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis.
Arthritis, Experimental
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.
Arthritis, Experimental
The regulation of macrophage polarization by hypoxia-PADI4 coordination in Rheumatoid arthritis.
Arthritis, Juvenile
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) Gene Polymorphisms and Polyarticular Juvenile Idiopathic Arthritis.
Arthritis, Juvenile
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
Arthritis, Juvenile
The relationship of the immune response mediator genes polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population.
Arthritis, Rheumatoid
A functional haplotype and expression of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Chinese.
Arthritis, Rheumatoid
A Functional Haplotype of PADI4 Gene in Rheumatoid Arthritis: Positive Correlation in a French Population.
Arthritis, Rheumatoid
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans.
Arthritis, Rheumatoid
A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population.
Arthritis, Rheumatoid
Active site cysteine is protonated in the PAD4 Michaelis complex: evidence from Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.
Arthritis, Rheumatoid
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis.
Arthritis, Rheumatoid
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system.
Arthritis, Rheumatoid
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate.
Arthritis, Rheumatoid
Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis.
Arthritis, Rheumatoid
Antibodies against transglutaminases, peptidylarginine deiminase and citrulline in rheumatoid arthritis - new pathways to epitope spreading.
Arthritis, Rheumatoid
Antibodies targeting protein-arginine deiminase 4 (PAD4) demonstrate diagnostic value in rheumatoid arthritis.
Arthritis, Rheumatoid
Association between PADI4 and rheumatoid arthritis: a replication study.
Arthritis, Rheumatoid
Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort.
Arthritis, Rheumatoid
Association between peptidyl arginine deiminase 4 (PADI4)-104C/T polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population.
Arthritis, Rheumatoid
Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran.
Arthritis, Rheumatoid
Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis.
Arthritis, Rheumatoid
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population.
Arthritis, Rheumatoid
Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis.
Arthritis, Rheumatoid
Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans.
Arthritis, Rheumatoid
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
Arthritis, Rheumatoid
Association of baseline peptidylarginine deiminase 4 autoantibodies with favorable response to treatment escalation in rheumatoid arthritis.
Arthritis, Rheumatoid
Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.
Arthritis, Rheumatoid
Association of MiRNA-146a, MiRNA-499, IRAK1 and PADI4 Polymorphisms with Rheumatoid Arthritis in Egyptian Population.
Arthritis, Rheumatoid
Association of PADI4 and rheumatoid arthritis: a successful multidisciplinary approach.
Arthritis, Rheumatoid
Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population.
Arthritis, Rheumatoid
Associations Between PADI4 Gene Polymorphisms and Rheumatoid Arthritis: An Updated Meta-analysis.
Arthritis, Rheumatoid
Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine.
Arthritis, Rheumatoid
Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis.
Arthritis, Rheumatoid
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
Arthritis, Rheumatoid
Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
Citrullination by peptidylarginine deiminase in rheumatoid arthritis.
Arthritis, Rheumatoid
Citrullination in the periodontium-a possible link between periodontitis and rheumatoid arthritis.
Arthritis, Rheumatoid
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
Arthritis, Rheumatoid
Citrullination of fibronectin in rheumatoid arthritis synovial tissue.
Arthritis, Rheumatoid
Citrulline Not a Major Determinant in the Recognition of Peptidylarginine Deiminase 2 and 4 by Autoantibodies in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides.
Arthritis, Rheumatoid
Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features.
Arthritis, Rheumatoid
Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes.
Arthritis, Rheumatoid
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.
Arthritis, Rheumatoid
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
Arthritis, Rheumatoid
Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.
Arthritis, Rheumatoid
Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology.
Arthritis, Rheumatoid
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen.
Arthritis, Rheumatoid
Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study.
Arthritis, Rheumatoid
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Arthritis, Rheumatoid
Erratum to: PADI4 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
Arthritis, Rheumatoid
Estrogen-enhanced peptidylarginine deiminase type IV gene (PADI4) expression in MCF-7 cells is mediated by estrogen receptor-alpha-promoted transfactors activator protein-1, nuclear factor-Y, and Sp1.
Arthritis, Rheumatoid
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Arthritis, Rheumatoid
Evaluation of allele frequencies in the PADI4 gene and anti-cyclic citrullinated peptide antibodies of patients with rheumatoid arthritis in a Japanese population.
Arthritis, Rheumatoid
Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis.
Arthritis, Rheumatoid
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Arthritis, Rheumatoid
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats.
Arthritis, Rheumatoid
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Arthritis, Rheumatoid
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.
Arthritis, Rheumatoid
Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies.
Arthritis, Rheumatoid
Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes.
Arthritis, Rheumatoid
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay.
Arthritis, Rheumatoid
Genetic background of anticyclic citrullinated Peptide autoantibody production in hungarian patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Great Therapeutic Potential of Peptidylarginine Deiminase 4 (PAD4) Inhibitors: Treatment of Rheumatoid Arthritis, Epigenetic Tools, Regulation of Pluripotency in Stem Cells, and More.
Arthritis, Rheumatoid
Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Arthritis, Rheumatoid
Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population.
Arthritis, Rheumatoid
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
Arthritis, Rheumatoid
Heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to tuberculosis in Koreans.
Arthritis, Rheumatoid
High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach.
Arthritis, Rheumatoid
High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4.
Arthritis, Rheumatoid
Hypoxia?induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast?like synoviocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.
Arthritis, Rheumatoid
Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers.
Arthritis, Rheumatoid
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.
Arthritis, Rheumatoid
Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases.
Arthritis, Rheumatoid
Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis.
Arthritis, Rheumatoid
Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.
Arthritis, Rheumatoid
Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients.
Arthritis, Rheumatoid
Lack of association between PADI4 polymorphisms and rheumatoid arthritis in the Tunisian population.
Arthritis, Rheumatoid
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis.
Arthritis, Rheumatoid
Matrix-assisted laser desorption ionization-time of flight mass spectrometry identification of peptide citrullination site using Br signature.
Arthritis, Rheumatoid
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Arthritis, Rheumatoid
Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population.
Arthritis, Rheumatoid
Meta-analysis: diagnostic accuracy of antibody against peptidylarginine deiminase 4 by ELISA for rheumatoid arthritis.
Arthritis, Rheumatoid
Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV.
Arthritis, Rheumatoid
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
Arthritis, Rheumatoid
NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.
Arthritis, Rheumatoid
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.
Arthritis, Rheumatoid
PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis.
Arthritis, Rheumatoid
PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico.
Arthritis, Rheumatoid
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) Gene Polymorphisms and Polyarticular Juvenile Idiopathic Arthritis.
Arthritis, Rheumatoid
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients.
Arthritis, Rheumatoid
PADI4 Gene Polymorphism is not Associated with Ankylosing Spondylitis in Chinese Han Population.
Arthritis, Rheumatoid
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population.
Arthritis, Rheumatoid
PADI4 haplotypes in association with RA Mexican patients, a new prospect for antigen modulation.
Arthritis, Rheumatoid
PADI4 polymorphisms and related haplotype in rheumatoid arthritis patients.
Arthritis, Rheumatoid
PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.
Arthritis, Rheumatoid
PADI4 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
Arthritis, Rheumatoid
PADI4 polymorphisms and the functional haplotype are associated with increased rheumatoid arthritis susceptibility: A replication study in a Southern Mexican population.
Arthritis, Rheumatoid
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population.
Arthritis, Rheumatoid
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Arthritis, Rheumatoid
Peptidyl arginine deiminase autoimmunity and the development of ACPA in rheumatoid arthritis. The "hapten carrier" model.
Arthritis, Rheumatoid
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.
Arthritis, Rheumatoid
Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.
Arthritis, Rheumatoid
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis.
Arthritis, Rheumatoid
Peptidyl-arginine deiminase: an additional marker of rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations.
Arthritis, Rheumatoid
Peptidylarginine deiminase 4 and citrullination in health and disease.
Arthritis, Rheumatoid
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and ?-enolase: implications for autoimmunity in rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase type 2 and 4 generate distinct patterns of rheumatoid arthritis autoantigens during perforin-induced cell damage.
Arthritis, Rheumatoid
Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Arthritis, Rheumatoid
Peptidylarginine deiminase type 4, anticitrullinated peptide antibodies, and rheumatoid arthritis.
Arthritis, Rheumatoid
Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.
Arthritis, Rheumatoid
Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome.
Arthritis, Rheumatoid
Periodontal Treatment Decreases Levels of Antibodies to Porphyromonas Gingivalis and Citrulline in Patients With Rheumatoid Arthritis and Periodontitis.
Arthritis, Rheumatoid
Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.
Arthritis, Rheumatoid
Polymorphisms and functional haplotype in PADI4: Further evidence for contribution on rheumatoid arthritis susceptibility and anti-cyclic citrullinated peptide antibodies in a western Mexican population.
Arthritis, Rheumatoid
Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.
Arthritis, Rheumatoid
Predominance of IgG1 and IgG3 subclasses of autoantibodies to peptidylarginine deiminase 4 in rheumatoid arthritis.
Arthritis, Rheumatoid
Prevalence of functional haplotypes of the peptidylarginine deiminase citrullinating enzyme gene in patients with rheumatoid arthritis: no influence of the presence of anti-citrullinated peptide antibodies.
Arthritis, Rheumatoid
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4.
Arthritis, Rheumatoid
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Arthritis, Rheumatoid
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.
Arthritis, Rheumatoid
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
Arthritis, Rheumatoid
Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans.
Arthritis, Rheumatoid
Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3.
Arthritis, Rheumatoid
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
Arthritis, Rheumatoid
Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.
Arthritis, Rheumatoid
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Arthritis, Rheumatoid
Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis - a systematic review and meta-analysis.
Arthritis, Rheumatoid
Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity.
Arthritis, Rheumatoid
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents.
Arthritis, Rheumatoid
Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Arthritis, Rheumatoid
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Arthritis, Rheumatoid
The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.
Arthritis, Rheumatoid
The development of N-?-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-?-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Arthritis, Rheumatoid
The expression of mRNA for peptidylarginine deiminase type 2 and type 4 in bone marrow CD34+ cells in rheumatoid arthritis.
Arthritis, Rheumatoid
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells.
Arthritis, Rheumatoid
The inhibition of antithrombin by peptidylarginine deiminase 4 may contribute to pathogenesis of rheumatoid arthritis.
Arthritis, Rheumatoid
The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin.
Arthritis, Rheumatoid
The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population.
Arthritis, Rheumatoid
The regulation of macrophage polarization by hypoxia-PADI4 coordination in Rheumatoid arthritis.
Arthritis, Rheumatoid
The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Theoretical insights into the protonation states of active site cysteine and citrullination mechanism of Porphyromonas gingivalis peptidylarginine deiminase.
Arthritis, Rheumatoid
There's no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis.
Arthritis, Rheumatoid
Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Zinc is the modulator of the calcium-dependent activation of post-translationally acting thiol-enzymes in autoimmune diseases.
Arthritis, Rheumatoid
[Association between the synovial expression of cyclic citrullinated peptide and susceptibility variants of HLA-DRB1 shared epitope alleles and PADI 4 gene single nucleotide polymorphisms in patients with rheumatoid arthritis].
Arthritis, Rheumatoid
[Association of HLA-DR4, PAD4, and STAT4 expression in the peripheral blood with disease activity in patients with rheumatoid arthritis]
Arthritis, Rheumatoid
[Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan].
Arthritis, Rheumatoid
[Association of the PADI4 gene polymorphism and HLA-DRB1 shared epitope alleles with rheumatoid arthritis]
Arthritis, Rheumatoid
[Susceptibility genes in rheumatoid arthritis: peptidylarginine deiminase (PADI) type 4]
Arthritis, Rheumatoid
[The significance of serum peptidylarginine deiminase 4 in rheumatoid arthritis.]
Astrocytoma
Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.
Atherosclerosis
Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.
Atherosclerosis
Neutrophils Cast NETs in Atherosclerosis: Employing Peptidylarginine Deiminase as a Therapeutic Target.
Atherosclerosis
Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
Atherosclerosis
The role of neutrophils in the pathogenesis of systemic lupus erythematosus.
Autoimmune Diseases
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
Autoimmune Diseases
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
Autoimmune Diseases
Cleavage Region Thyrotropin Receptor Antibodies Influence Thyroid Cell Survival In Vivo.
Autoimmune Diseases
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.
Autoimmune Diseases
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
Autoimmune Diseases
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Autoimmune Diseases
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Autoimmune Diseases
Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.
Autoimmune Diseases
Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.
Autoimmune Diseases
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Autoimmune Diseases
Vimentin citrullination probed by a novel monoclonal antibody serves as a specific indicator for reactive astrocytes in neurodegeneration.
Brain Edema
Neutrophil Extracellular Traps may be a Potential Target for Treating Early Brain Injury in Subarachnoid Hemorrhage.
Breast Neoplasms
BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.
Breast Neoplasms
Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis.
Breast Neoplasms
Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.
Breast Neoplasms
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Breast Neoplasms
Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Breast Neoplasms
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Breast Neoplasms
Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.
Breast Neoplasms
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
Breast Neoplasms
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Breast Neoplasms
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Breast Neoplasms
Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3?/p53 activation.
Breast Neoplasms
Peptidylarginine Deiminase IV Regulates Breast Cancer Stem Cells via a Novel Tumor Cell-Autonomous Suppressor Role.
Breast Neoplasms
Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.
Carcinogenesis
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Carcinogenesis
Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib.
Carcinogenesis
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Carcinogenesis
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Carcinogenesis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Carcinogenesis
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Carcinogenesis
Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
Carcinogenesis
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
Carcinogenesis
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Carcinogenesis
PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer.
Carcinogenesis
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
Carcinogenesis
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Carcinogenesis
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Carcinogenesis
Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.
Carcinogenesis
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Carcinoma
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Carcinoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Carcinoma
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
Carcinoma
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Carcinoma, Ductal
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Carcinoma, Ductal
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Carcinoma, Hepatocellular
Decreased PADI4 mRNA Association with Global Hypomethylation in Hepatocellular Carcinoma During HBV Exposure.
Carcinoma, Hepatocellular
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Carcinoma, Hepatocellular
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Carcinoma, Hepatocellular
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Carcinoma, Hepatocellular
Peptidylarginine deiminase IV promotes the development of chemoresistance through inducing autophagy in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Carcinoma, Squamous Cell
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Cardiovascular Diseases
Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease.
Carotid Stenosis
Peptidylarginine Deiminase 4 as a Possible Biomarker of Plaque Instability in Carotid Artery Stenosis.
Central Nervous System Diseases
Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.
Cholecystitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Cholera
Stimulation of bovine brain phospholipase C activity by myelin basic protein requires arginyl residues in peptide linkage.
Chondroma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Chronic Periodontitis
Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides.
Chronic Periodontitis
[Role of Porphyromonas gingivalis in rheumatoid arthritis and inflammatory spondyloarthropathies].
Colitis
SUPPRESSION OF COLITIS IN MICE BY CL-AMIDINE: A NOVEL PEPTIDYLARGININE DEIMINASE (PAD) INHIBITOR.
Colitis, Ulcerative
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Colitis, Ulcerative
Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population.
Colitis, Ulcerative
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Colitis, Ulcerative
The development of N-?-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-?-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Colonic Neoplasms
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Colonic Neoplasms
PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer.
Colonic Neoplasms
PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
Colonic Neoplasms
Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.
Colonic Neoplasms
The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
Colorectal Neoplasms
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Colorectal Neoplasms
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Colorectal Neoplasms
The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer.
Crohn Disease
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Cystadenocarcinoma, Mucinous
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Cysts
SUMOylation and deimination of proteins: two epigenetic modifications involved in Giardia encystation.
Demyelinating Diseases
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Demyelinating Diseases
Peptidylarginine deiminase: a candidate factor in demyelinating disease.
Diabetes Mellitus
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Diabetes Mellitus, Type 1
Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.
Diabetes Mellitus, Type 1
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Diabetes Mellitus, Type 1
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Encephalomyelitis
Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice.
Encephalomyelitis, Autoimmune, Experimental
Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice.
Endometrial Hyperplasia
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Endometrial Neoplasms
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Endometrial Neoplasms
PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.
Endometrial Neoplasms
Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target.
Endotoxemia
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.
Epstein-Barr Virus Infections
Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.
Esophageal Neoplasms
Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer.
Esophageal Squamous Cell Carcinoma
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Investigating the pathogenic role of PADI4 in oesophageal cancer.
Esophageal Squamous Cell Carcinoma
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Felty Syndrome
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Gastritis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Gingivitis
Evaluation of galectin-3, peptidylarginine deiminase-4 and tumor necrosis factor-? levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study.
Gingivitis
Impact of chronic gingivitis management on the cytokine and anti-PPAD expressions in juvenile systemic lupus erythematosus: A six-month follow-up.
Glaucoma
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
Glaucoma
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis.
Glaucoma, Open-Angle
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
Glioblastoma
Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Glomerulonephritis
Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.
Graves Disease
Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases.
Heart Diseases
Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease.
Hemangioma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Hemangioma, Cavernous
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Hepatitis, Chronic
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis.
Hydatidiform Mole
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Hyperalgesia
Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation.
Hyperparathyroidism, Secondary
Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Hypersensitivity
Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
Hypertension
Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.
Infections
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.
Infections
Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance?
Infections
Mycoplasma and host interaction: In vitro gene expression modulation in Mycoplasma synoviae and infected chicken chondrocytes.
Infections
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Infections
Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.
Infections
Porphyromonas gingivalis and its LPS differentially regulate the expression of peptidyl arginine deiminases in human chondrocytes.
Infections
Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells.
Infections
Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of Francisella tularemia.
Infections
Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity.
Infections
The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans.
Inflammatory Bowel Diseases
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Invasive Pulmonary Aspergillosis
Neutrophil extracellular traps impair fungal clearance in a mouse model of invasive pulmonary aspergillosis.
Kidney Neoplasms
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Leiomyoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Leukemia
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Leukemia
Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.
Leukemia
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells.
Liver Cirrhosis
Peptidyl arginine deiminase inhibitor effect on hepatic fibrogenesis in a CCl4 pre-clinical model of liver fibrosis.
Liver Cirrhosis
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis.
Liver Neoplasms
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Low Tension Glaucoma
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
Lung Diseases
Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases.
Lung Diseases, Interstitial
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis.
Lung Diseases, Interstitial
Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.
Lung Injury
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.
Lung Neoplasms
Differential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung Cancer in Wistar Rats and their Implications.
Lung Neoplasms
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Lupus Erythematosus, Systemic
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Lupus Erythematosus, Systemic
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps.
Lupus Erythematosus, Systemic
Fine specificity of anti-citrullinated peptide antibodies discloses a heterogeneous antibody population in rheumatoid arthritis.
Lupus Erythematosus, Systemic
Impact of chronic gingivitis management on the cytokine and anti-PPAD expressions in juvenile systemic lupus erythematosus: A six-month follow-up.
Lupus Erythematosus, Systemic
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Lupus Erythematosus, Systemic
Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome.
Lupus Erythematosus, Systemic
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Lupus Erythematosus, Systemic
Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis.
Lupus Erythematosus, Systemic
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Lupus Nephritis
Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice.
Lupus Nephritis
Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.
Lymphatic Metastasis
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Multiple Myeloma
A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma.
Multiple Sclerosis
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
Multiple Sclerosis
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay.
Multiple Sclerosis
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Multiple Sclerosis
Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood.
Multiple Sclerosis
Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis.
Multiple Sclerosis
Novel Inhibitors of Protein Arginine Deiminase with Potential Activity in Multiple Sclerosis Animal Model.
Multiple Sclerosis
Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.
Multiple Sclerosis
Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis.
Multiple Sclerosis
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Multiple Sclerosis
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
Multiple Sclerosis
Vitamin D3 and estradiol alter PAD2 expression and activity levels in C6 glioma cells.
Myocardial Infarction
Gaps in public knowledge of peripheral arterial disease: the first national PAD public awareness survey.
Myocardial Infarction
Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.
Nasopharyngeal Carcinoma
PADI4, negatively regulated by miR-335-5p, participates in regulating the proliferation, migration, invasion and radiosensitivity of nasopharyngeal carcinoma cells.
Neoplasm Metastasis
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma.
Neoplasm Metastasis
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Neoplasm Metastasis
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Neoplasm Metastasis
Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis.
Neoplasm Metastasis
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Neoplasm Metastasis
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Neoplasm Metastasis
NF-?B and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis.
Neoplasm Metastasis
PADI1 contributes to EMT in PAAD by activating the ERK1/2-p38 signaling pathway.
Neoplasm Metastasis
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
Neoplasm Metastasis
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
Neoplasm Metastasis
The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer.
Neoplasm Metastasis
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Neoplasms
Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity.
Neoplasms
Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.
Neoplasms
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
Neoplasms
Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
Neoplasms
Colorectal cancer detection by biomarker quantification in noninvasively collected colorectal mucus: preliminary comparison of 24 protein biomarkers.
Neoplasms
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Neoplasms
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Neoplasms
DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.
Neoplasms
Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib.
Neoplasms
Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.
Neoplasms
Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis.
Neoplasms
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.
Neoplasms
Evaluation of galectin-3, peptidylarginine deiminase-4 and tumor necrosis factor-? levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study.
Neoplasms
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Neoplasms
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Neoplasms
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Neoplasms
Hypoxia-induced production of peptidylarginine deiminases and citrullinated proteins in malignant glioma cells.
Neoplasms
Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Neoplasms
Immunologic detection of markers of keratinocyte differentiation. Its use in neoplastic and preneoplastic lesions of skin.
Neoplasms
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Neoplasms
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Neoplasms
LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
Neoplasms
Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue.
Neoplasms
NF-?B and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis.
Neoplasms
Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.
Neoplasms
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Neoplasms
PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.
Neoplasms
PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer.
Neoplasms
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-? expression levels.
Neoplasms
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
Neoplasms
PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression.
Neoplasms
Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer.
Neoplasms
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Neoplasms
Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
Neoplasms
Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis.
Neoplasms
Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.
Neoplasms
Peptidylarginine Deiminase IV Regulates Breast Cancer Stem Cells via a Novel Tumor Cell-Autonomous Suppressor Role.
Neoplasms
Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.
Neoplasms
Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice.
Neoplasms
Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.
Neoplasms
Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target.
Neoplasms
Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase.
Neoplasms
Regulation of Protein Citrullination through p53/PADI4 Network in DNA Damage Response.
Neoplasms
Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Neoplasms
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents.
Neoplasms
Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer.
Neoplasms
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Neoplasms
The development of N-?-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-?-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Neoplasms
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Neoplasms
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Neoplasms
[Effect of PADI4 on the Expression of Inflammatory Cytokines During NB4 Cells Differentiation].
Neoplasms, Germ Cell and Embryonal
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Neoplasms, Squamous Cell
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Neurilemmoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Neurodegenerative Diseases
Age-related reduction in retinal deimination levels in the F344BN rat.
Neurodegenerative Diseases
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay.
Neurodegenerative Diseases
Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases.
Neurofibroma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Osteoarthritis
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
Osteoarthritis
Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.
Osteoarthritis
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Osteoarthritis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Osteoarthritis
Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis.
Osteoarthritis
Tumour necrosis factor alpha promotes secretion of 14-3-3? by inducing necroptosis in macrophages.
Osteomalacia
Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Osteosarcoma
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Osteosarcoma
PADI4 modulates the invasion and migration of osteosarcoma cells by down-regulation of epithelial-mesenchymal transition.
Ovarian Neoplasms
Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib.
Ovarian Neoplasms
The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
Pancreatic Neoplasms
DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.
Pancreatic Neoplasms
Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.
Pancreatitis
Different Types of Periampullary Duodenal Diverticula Are Associated with Occurrence and Recurrence of Bile Duct Stones: A Case-Control Study from a Chinese Center.
Pancreatitis
Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis.
Periodontal Diseases
Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase-2 levels in periodontal health and disease.
Periodontal Diseases
Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis.
Periodontal Diseases
Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis.
Periodontal Diseases
Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis - a systematic review and meta-analysis.
Periodontal Diseases
The role of anti-cyclic citrullinated peptide antibody in periodontal disease.
Periodontitis
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system.
Periodontitis
Citrullination in the periodontium-a possible link between periodontitis and rheumatoid arthritis.
Periodontitis
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
Periodontitis
Evaluation of galectin-3, peptidylarginine deiminase-4 and tumor necrosis factor-? levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study.
Periodontitis
Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis.
Periodontitis
Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis.
Periodontitis
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
Periodontitis
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase.
Peripheral Arterial Disease
Effect of Peptidylarginine Deiminase 4 on Endothelial Progenitor Cell Function in Peripheral Arterial Disease.
Pneumonia
Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep.
Pneumonia
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Prion Diseases
Peptidylarginine deiminase and protein citrullination in prion diseases: Strong evidence of neurodegeneration.
protein-arginine deiminase deficiency
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.
protein-arginine deiminase deficiency
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Proteinuria
Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice.
Psoriasis
Unraveling the genetics of complex diseases: Susceptibility genes for rheumatoid arthritis and psoriasis.
Pulmonary Disease, Chronic Obstructive
Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis.
Pulmonary Disease, Chronic Obstructive
Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities.
Pulmonary Fibrosis
PAD4 Deficiency Improves Bleomycin-induced Neutrophil Extracellular Traps and Fibrosis in Mouse Lung.
Pyelonephritis
TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.
Rheumatic Diseases
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
Rheumatic Diseases
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.
Rheumatic Diseases
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Rheumatic Diseases
Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis.
Rheumatic Diseases
[The significance of serum peptidylarginine deiminase 4 in rheumatoid arthritis.]
Rheumatic Fever
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase.
Sarcoma
Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis.
Sepsis
Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Rabbit Model of Endotoxic Shock.
Sepsis
Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.
Sepsis
Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae-Induced Pneumonia-Derived Sepsis.
Shock, Septic
Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury.
Shock, Septic
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.
Shock, Septic
Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients.
Shock, Septic
Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice.
Skin Neoplasms
Immunohistochemical demonstration of peptidylarginine deiminase in human sweat glands.
Spondylitis, Ankylosing
Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-? on the proliferation and osteogenic differentiation of human mesenchymal stem cells.
Spondylitis, Ankylosing
PADI4 Gene Polymorphism is not Associated with Ankylosing Spondylitis in Chinese Han Population.
Stomach Neoplasms
A Novel Citrullinated Modification of Histone 3 and Its Regulatory Mechanisms Related to IPO-38 Antibody-Labeled Protein.
Stomach Neoplasms
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Stroke
Gaps in public knowledge of peripheral arterial disease: the first national PAD public awareness survey.
Stroke
[Effect of neutrophil extracellular traps on ischemic stroke and intervention of traditional Chinese medicine].
Synovitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Teratoma
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Thrombosis
Effect of Peptidylarginine Deiminase 4 on Endothelial Progenitor Cell Function in Peripheral Arterial Disease.
Thrombosis
Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.
Thrombosis
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
Thrombosis
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Thrombosis
Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury.
Thrombosis
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review.
Thyroid Cancer, Papillary
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors.
Thyroiditis
Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases.
Tuberculosis
Heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to tuberculosis in Koreans.
Tuberculosis
Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance?
Urinary Bladder Neoplasms
Peptidyl Arginine Deiminase, Type II (PADI2) Is Involved in Urothelial Bladder Cancer.
Uterine Cervicitis
Increased PADI4 expression in blood and tissues of patients with malignant tumors.
Vascular Diseases
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Vasculitis
Significance of serum peptidylarginine deiminase type 4 in ANCA-associated vasculitis.
Venous Thrombosis
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
Venous Thrombosis
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Vitamin D Deficiency
Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Wound Infection
Long-term follow-up of superior gluteal artery perforator flap closure of large myelomeningoceles.
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