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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
agmatinase, agmatine ureohydrolase, agmat, agm-1, agmatinase-like protein, alr2310, agmatine amidinohydrolase, mj0309, proclavaminic acid amidino hydrolase,
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agmatine ureohydrolase
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N130D variant of arginase type I
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Proclavaminic acid amidino hydrolase
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amidine hydrolysis
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agmatine amidinohydrolase
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agmatine + H2O
putrescine + urea
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agmatine + H2O
putrescine + urea
agmatine + H2O
putrescine + urea
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agmatine + H2O
putrescine + urea
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the N130D mutant of arginase type I is able to cleave not only arginine but also agmatine (1-amino-4-guanidinobutane)
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agmatine + H2O
putrescine + urea
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Mn2+
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totally dependent on Mn2+ for catalytic activity
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putrescine
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linear competitive inhibitor
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Adenocarcinoma of Lung
Agmatinase promotes the lung adenocarcinoma tumorigenesis by activating the NO-MAPKs-PI3K/Akt pathway.
Asthma
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
Carcinogenesis
Agmatinase promotes the lung adenocarcinoma tumorigenesis by activating the NO-MAPKs-PI3K/Akt pathway.
Carcinoma
Human agmatinase is diminished in the clear cell type of renal cell carcinoma.
Carcinoma, Renal Cell
Human agmatinase is diminished in the clear cell type of renal cell carcinoma.
Hepatitis
Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus.
Hepatitis B
Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus.
Malaria
Structural metal dependency of the arginase from the human malaria parasite Plasmodium falciparum.
Mania
Evaluation of plasma agmatine level and its metabolic pathway in patients with bipolar disorder during manic episode and remission period.
Neoplasms
Agmatinase promotes the lung adenocarcinoma tumorigenesis by activating the NO-MAPKs-PI3K/Akt pathway.
Neoplasms
Human agmatinase is diminished in the clear cell type of renal cell carcinoma.
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UniProt
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agmatinase protein is detected in a subset of hippocampal interneurons. The protein is localized to perikarya, neurites and putative nerve endings contacting hippocampal pyramidal neurons and dentate gyrus granule cells. The number and the numerical density of agmatinase-immunopositive cell bodies are strongly elevated in depressive patients
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agmatinase in normal kidneys is restricted to tubulus epithelial cells, while in tumors activity is low and heterogeneous
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agmatinase in normal kidneys is restricted to tubulus epithelial cells, while in tumors activity is low and heterogeneous
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agmatinase is predominantly detected in distinct populations of neurons, especially cortical interneurons. Principal neurons in limbic regions like the habenula and in the cerebellum robustly express agmatinase protein
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SPEB_HUMAN
352
0
37660
Swiss-Prot
Mitochondrion (Reliability: 3 )
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hanging-drop vapour-diffusion method, agmatinase (residues Ala36-Val352) overexpressed as a fusion with both N- and C-terminal purification tags in Escherichia coli and crystallized in the presence of Mn2+ and 1,6-diaminohexane at 297 K using polyethylene glycol 4000 as a precipitant. X-ray diffraction data are collected at 100 K to 2.49 A from a flash-frozen crystal. The crystals are tetragonal, belonging to space group P4(2), with unit-cell parameters a = b = 114.54 A, c =125.65A, alpha = beta = gamma = 90°. Three monomers are likely to be present in the asymmetric unit, giving a crystal volume per protein weight of 3.66A
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DEAE-cellulose column chromatography
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expressed in Escherichia coli strain JM109
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residues Ala36-Val352 overexpressed as a fusion with both N- and C-terminal purification tags in Escherichia coli
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agmatinase expression is up-regulated in hippocampal interneurons of patients with mood disorders
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Kim, K.H.; Ahn, H.J.; Kim, D.J.; Lee, H.H.; Ha, J.Y.; Kim, H.K.; Yoon, H.J.; Suh, S.W.
Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase
Acta Crystallogr. Sect. F
61
889-891
2005
Homo sapiens
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Dallmann, K.; Junker, H.; Balabanov, S.; Zimmermann, U.; Giebel, J.; Walther, R.
Human agmatinase is diminished in the clear cell type of renal cell carcinoma
Int. J. Cancer
108
342-347
2004
Homo sapiens
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Alarcon, R.; Orellana, M.S.; Neira, B.; Uribe, E.; Garcia, J.R.; Carvajal, N.
Mutational analysis of substrate recognition by human arginase type I -agmatinase activity of the N130D variant
FEBS J.
273
5625-5631
2006
Homo sapiens
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Haenisch, B.; von Kuegelgen, I.; Boenisch, H.; Goethert, M.; Sauerbruch, T.; Schepke, M.; Marklein, G.; Hoefling, K.; Schroeder, D.; Molderings, G.J.
Regulatory mechanisms underlying agmatine homeostasis in humans
Am. J. Physiol. Gastrointest. Liver Physiol.
295
G1104-G1110
2008
Homo sapiens (Q9BSE5), Homo sapiens
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Bernstein, H.G.; Derst, C.; Stich, C.; Pruess, H.; Peters, D.; Krauss, M.; Bogerts, B.; Veh, R.W.; Laube, G.
The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain?
Amino Acids
40
453-465
2010
Homo sapiens, Rattus norvegicus
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Bernstein, H.G.; Stich, C.; Jaeger, K.; Dobrowolny, H.; Wick, M.; Steiner, J.; Veh, R.; Bogerts, B.; Laube, G.
Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders
Neuropharmacology
62
237-246
2012
Homo sapiens
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