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Disease on EC 3.5.3.1 - arginase

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DISEASE
TITLE OF PUBLICATION
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Aberrant Crypt Foci
Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice.
Acidosis
Long lasting protective effects of early l-arginine treatment on endothelium in an in vitro study.
Acute Kidney Injury
Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.
Acute Lung Injury
Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
Adenocarcinoma
Arginase activity and nucleic acid content in mamary adenocarcinoma and normal homologous tissue of C3H mice.
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
Arginase isoforms in human colorectal cancer.
Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies.
Arginase-1 is frequently positive in hepatoid adenocarcinomas.
Arginase-1: a highly specific marker separating pancreatic adenocarcinoma from hepatocellular carcinoma.
CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma.
Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells.
Clinical significance of arginase in colorectal cancer.
DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization.
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
Effects of adrenocorticotropic hormone (ACTH), cortisone, and arginase on growth of transplanted mammary adenocarcinoma in C3H mice.
Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.
Hepatocyte differentiation markers in adenocarcinoma of the prostate: hepatocyte paraffin 1 but not arginase-1 is specifically expressed in a subset of prostatic adenocarcinoma.
HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region.
Immunohistochemical study of arginase in cancer of the stomach.
Inhibitory effects of arginase on mammary adenocarcinoma transplants in strain "A" mice.
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver.
Adenocarcinoma of Lung
Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma.
Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models.
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
Adenocarcinoma, Papillary
Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.
Adenomyoma
Immunohistochemical results and case report of an incidental finding of uterine polypoid adenomyoma after long-time therapy for metrorrhagia.
Adrenoleukodystrophy
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
Airway Obstruction
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD).
Albuminuria
Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.
Alopecia
[Clinical and biochemical alterations in rats treated with high doses of vitamin A]
Alphavirus Infections
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.
Alzheimer Disease
Alzheimer's disease as a chronic maladaptive polyamine stress response.
Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice.
Bioinformatics methods in drug repurposing for Alzheimer's disease.
L-Norvaline, a new therapeutic agent against Alzheimer's disease.
Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-? Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis.
The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.
Amebiasis
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
amino-acid n-acetyltransferase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Amyloidosis
Arginase 1 Insufficiency Precipitates Amyloid-? Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis.
Amyotrophic Lateral Sclerosis
Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis.
Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis.
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase.
[Study of cerebrospinal fluid arginase activity in the diagnosis of amyotrophic lateral sclerosis]
Anaplasmosis
Enzymes of oxidant defence system of leucocytes and erythrocytes in bovine anaplasmosis.
Anemia
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
Anemia, Hemolytic
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
Anemia, Hypochromic
Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation.
Anemia, Pernicious
The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major.
Anemia, Sickle Cell
Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.
Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.
Cysteine-iron promotes arginase activity by driving the Fenton reaction.
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway.
Hemolysis-associated pulmonary hypertension in thalassemia.
In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.
Influence of ?S-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease.
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy.
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
Anemia, Sideroblastic
A case of sideroblastic anaemia associated with marked elevation of erythrocytic arginase activity.
Angina Pectoris
Early diagnosis of myocardial infarction by arginase activity determination.
Aortic Aneurysm, Abdominal
Transforming growth factor ? neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta.
arginase deficiency
"Cerebral Palsy" in a Patient With Arginase Deficiency.
A long-term survival case of arginase deficiency with severe multicystic white matter and compound mutations.
A new case of arginase deficiency in a Spanish male.
A new French-Canadian family affected by hyperargininaemia.
A new metabolic disorder in human cationic amino acid transporter-2 that mimics arginase 1 deficiency in newborn screening.
A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family.
A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation.
A simple quantitative micromethod of arginase assay in blood spots dried on filter paper.
A simple screening test for arginase deficiency (hyperargininemia).
A simple spot-test for the detection of erythrocyte arginase deficiency.
A successful trial of enzyme replacement therapy in a case of argininemia.
AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse.
Adult-onset arginase deficiency.
Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency.
Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.
Anesthesia in a patient with arginase deficiency: implications and management.
Anesthetic management of a patient with arginase deficiency undergoing liver transplantation.
Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report.
Arginase deficiency and phenylketonuria.
Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function.
Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver.
Arginase deficiency in multiple tissues in argininemia.
Arginase deficiency in two brothers.
Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme.
Arginase Deficiency Presenting as Acute Encephalopathy.
Arginase deficiency presenting as cerebral palsy.
Arginase deficiency presenting with cerebral oedema and failure to thrive.
Arginase deficiency presenting with convulsions.
Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema.
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Arginase deficiency.
Arginase I deficiency: Severe infantile presentation with hyperammonemia: More common than reported?
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.
Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury.
Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia.
Arginase-1 deficiency.
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
Arginase-2 mediates renal ischemia-reperfusion injury.
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
Arginine to ornithine ratio as a diagnostic marker in patients with positive newborn screening for hyperargininemia.
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Biomarkers identified in inborn errors for lysine, arginine, and ornithine.
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.
Case series of Arginase 1 deficiency: Expanding the spectrum in hyperargininemia.
Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism.
Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency.
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency.
Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates.
Creatine metabolism and the urea cycle.
Creatine metabolism in patients with urea cycle disorders.
Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy.
Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
Excretion of guanidino-derivates in urine of hyperargininemic patients.
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper.
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.
Genetic approach to prenatal diagnosis in urea cycle defects.
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Hyperargininemia due to liver arginase deficiency.
Hyperargininemia with arginase deficiency.
Hyperargininemia, epilepsy and the metabolism of guanidino compounds.
Hyperargininemia.
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations.
Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI.
Impaired neurotransmitter amine metabolism in arginase deficiency.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.
Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism.
Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings]
Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts.
Isotropic growth of spores and salt tolerance in Aspergillus nidulans
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
Liver fibrosis in arginase deficiency.
Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
Loss of function mutations in conserved regions of the human arginase I gene.
Metabolic Serendipities of Expanded Newborn Screening.
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.
Molecular genetic study of human arginase deficiency.
Mouse model for human arginase deficiency.
Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice.
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
Newborn screening for hyperargininemia due to arginase 1 deficiency.
Novel ARG1 variants identified in a patient with arginase 1 deficiency.
Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2.
Orotic acid excretion and arginine metabolism.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity.
Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis.
Prenatal diagnosis for arginase deficiency: a case study.
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency.
Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency.
Pteridines and mono-amines: relevance to neurological damage.
Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency.
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
Review of Multi-Modal Imaging in Urea Cycle Disorders: The Old, the New, the Borrowed, and the Blue.
Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan.
Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector.
Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency.
Strategies to rescue the consequences of inducible arginase-1 deficiency in mice.
The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.
The human arginases and arginase deficiency.
The nutritional management of urea cycle disorders.
Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet.
Unsuccessful trial of gene replacement in arginase deficiency.
Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders.
Urinary pyrimidine excretion in arginase deficiency.
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
[Arginase deficiency]
[Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.]
[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]
[Late diagnosis of congenital argininemia during administration of sodium valproate]
[Proposal for a diet treatment in arginase deficiency]
[Seven patients of argininemia with spastic tetraplegia as the first and major symptom and prenatal diagnosis of two fetuses with high risk].
[The dibasic amino acid metabolic disorders]
argininosuccinate lyase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
argininosuccinate synthase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country.
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan.
Argininosuccinic Aciduria
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
ARGININOSUCCINIC ACIDURIA. ARGININOSUCCINASE AND ARGINASE IN HUMAN BLOOD CELLS.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Creatine metabolism in patients with urea cycle disorders.
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
Arrhythmias, Cardiac
Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart.
Arthritis
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis.
Endothelial dysfunction in rat adjuvant-induced arthritis: Up-regulation of the vascular arginase pathway.
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
Modulatory effect of eugenol on arginase, nucleotidase, and adenosine deaminase activities of platelets in a carrageenan-induced arthritis rat model: A possible anti-arthritic mechanism of eugenol.
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.
The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages.
Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.
Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis.
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
Arthritis, Gouty
[Effect of Electroacupuncture on Synovial M 1/M 2 Macrophage Polarization in Rats with Acute Gouty Arthritis].
Arthritis, Reactive
[SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES].
Arthritis, Rheumatoid
Arginase levels are increased in patients with rheumatoid arthritis.
Changes in the pattern of cytokine production from peripheral blood mononuclear cells in patients with rheumatoid arthritis treated with infliximab and their relation to plasma arginase activity.
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis.
TNF? induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNF? antibodies.
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
Asthma
2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I.
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
Airway arginase expression and N?-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains.
Alterations of the arginine metabolome in asthma.
Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model.
Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection.
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.
Arginase and arginine dysregulation in asthma.
Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness.
Arginase and pulmonary diseases.
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.
Arginase: marker, effector, or candidate gene for asthma?
Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.
Arginine and asthma.
Arginine homeostasis in allergic asthma.
Arginine metabolic control of airway inflammation.
Arginine metabolic endotypes related to asthma severity.
Arginine Therapy for Lung Diseases.
Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.
Asthma in sickle cell disease.
Asthma management: reinventing the wheel in sickle cell disease.
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.
Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma.
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.
cNOS-iNOS paradigm and arginase in asthma.
Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.
Decreased arginine bioavailability and increased serum arginase activity in asthma.
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization.
Effects of inhaled L-arginine administration in a murine model of acute asthma.
Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
Enhancer-mediated control of macrophage-specific arginase I expression.
Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients.
Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma.
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts.
High Serum Arginase I Levels in Asthma: its Correlation with High-Sensitivity C-Reactive Protein.
Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma.
Impact of substrate protonation and tautomerization States on interactions with the active site of arginase I.
Increased arginase activity contributes to airway remodelling in chronic allergic asthma.
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.
Increased expression of arginase I and II in allergic nasal mucosa.
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
Increased Ornithine-Derived Polyamines cause Airways Hyperresponsiveness in a Mouse Model of Asthma.
Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages.
Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I.
l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.
L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction.
Mapping Arginase Expression with 18F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary ?-Amino Acids.
Mechanisms of occupational asthma: Not all allergens are equal.
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
Modeling gas phase nitric oxide release in lung epithelial cells.
Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide?
Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4.
New Strategies for the Treatment of Pulmonary Hypertension in Sickle Cell Disease : The Rationale for Arginine Therapy.
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation.
Nitric oxide in asthma physiopathology.
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo.
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
Pollutant particles induce arginase II in human bronchial epithelial cells.
Probing the specificity determinants of amino acid recognition by arginase.
Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis.
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
Relationship among manganese, arginase, and nitric oxide in childhood asthma.
Relationship between arginase genes polymorphisms and preschool wheezing phenotypes.
Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.
Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.
Role of arginase in asthma: potential clinical applications.
Roles of arginase variants, atopy, and ozone in childhood asthma.
Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children.
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
Small-molecule arginase inhibitors.
Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
TGF-{beta}2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells.
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
The effects of WW2/WW3 domains of Smurf2 molecule on TGF-? signaling and arginase I gene expression.
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
The role of polymorphic variants of arginase genes (ARG1, ARG2) involved in beta-2-agonist metabolism in the development and course of asthma.
The therapeutic potential of drugs targeting the arginase pathway in asthma.
Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.
[Arginine metabolism in bronchial asthma]
[Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure]
[Sputum arginase activity in bronchial asthma]
Atherosclerosis
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.
Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets.
Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis.
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Arginase as a target for treatment of myocardial ischemia-reperfusion injury.
Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32-Dependent Manner.
Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica.
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis.
Arginase II: Atherogenesis Beyond Enzyme Activity.
Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase.
Arginase type I as a marker of coronary heart disease in hemodialysis patients.
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and L-arginine metabolism in mice.
Endothelial arginase II and atherosclerosis.
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
Endothelial arginase: a new target in atherosclerosis.
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques.
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
Identification of macrophage arginase I as a new candidate gene of atherosclerosis resistance.
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit.
Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling.
LXR{alpha} Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8.
Macrophage plasticity in experimental atherosclerosis.
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism.
Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.
p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs.
Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity.
Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II.
Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers.
Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Probing the specificity determinants of amino acid recognition by arginase.
Regulation of arginase pathway in response to wall shear stress.
Role of arginase in vessel wall remodeling.
Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice.
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction.
Transcriptional regulation of endothelial arginase 2 by histone deacetylase 2.
Transcriptional regulation of macrophage arginase 1 expression and its role in atherosclerosis.
[Arginase, nitrates, and nitrites in the blood plasma and erythrocytes in hypertension and after therapy with lisinopril and simvastatin].
Atrioventricular Block
Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation: Implications for the Antiarrhythmic Effect of Statins.
Autoimmune Diseases
Amino acid metabolism as drug target in autoimmune diseases.
Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.
Increased circulating myeloid-derived suppressor cells correlated negatively with Th17 cells in patients with rheumatoid arthritis.
Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo.
Azoospermia
[Importance of arginine content and arginase activity in fertility]
Azotemia
Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
Bacterial Infections
Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection.
Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection.
Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator.
Reduction of salivary arginine catabolic activity through periodontal therapy.
Smoking increases salivary arginase activity in patients with dental implants.
beta-Thalassemia
The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major.
Blister
Arginase activity and polyamine biosynthesis in psoriasis.
Brain Diseases
Arginase Deficiency Presenting as Acute Encephalopathy.
Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema.
Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues.
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
Molecular pathways differentiate hepatitis C virus (HCV) recurrence from acute cellular rejection in HCV liver recipients.
[Activity of serum arginase in liver cirrhosis. Its special study in the hemorrhagic syndrome and cirrhogenic encephalopathies]
[Arginase and experimental hyperammoniemia. II. Action of arginase on experimental portacaval encephalopathy in the dog.]
Brain Diseases, Metabolic
Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations.
Brain Edema
Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Brain Injuries
Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Potential role of fibronectin in microglia/macrophage activation following cryoinjury in the rat brain: An immunohistochemical study.
Brain Injuries, Traumatic
Arginase overexpression in neurons and its effect on traumatic brain injury.
Brain Ischemia
Protective Role of Arginase II in Cerebral Ischemia and Excitotoxicity.
Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice.
Brain Neoplasms
Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies.
Roles of nitric oxide and polyamines in brain tumor growth.
The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer.
[Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals]
Breast Neoplasms
A nanobiosensor for the detection of arginase activity.
Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines.
Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics.
Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy.
Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells.
Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor.
Arginase in patients with breast cancer.
Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade.
Arginase, a new marker of mammary carcinoma.
Breast cancer derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment.
Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells.
Effect of rosuvastatin on arginase enzyme activity and polyamine production in experimental breast cancer.
Elevated serum arginase activity levels in patients with breast cancer.
Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients.
Indicators of L-arginine metabolism in saliva: A focus on breast cancer.
Key genes and pathways in tumor-educated dendritic cells by bioinformatical analysis.
L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo.
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
PEGylated recombinant human arginase as a drug for breast cancer.
Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide.
Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.
Proteomic identification of mitochondrial targets of arginase in human breast cancer.
Simvastatin downregulates HER2 via upregulation of PEA3 to induce cell death in HER2-positive breast cancer cells.
The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer.
uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.
[The supernatant of 4T1 breast cancer cell culture increases arginase 1 content in ANA-1 macrophages].
[Usefulness of postoperative assay of arginase activity in blood serum of women after breast cancer resection]
Bronchopulmonary Dysplasia
An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes.
Arginase and ?-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia.
Arginase I gene single-nucleotide polymorphism is associated with decreased risk of pulmonary hypertension in bronchopulmonary dysplasia.
Arginase Inhibition Prevents Bleomycin-Induced Pulmonary Hypertension, Vascular Remodeling and Collagen Deposition in Neonatal Rat Lungs.
Arginine Therapy for Lung Diseases.
Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia.
Burkitt Lymphoma
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
carbamoyl-phosphate synthase (ammonia) deficiency
Autosomal recessive inheritance of human mitochondrial carbamyl phosphate synthetase deficiency.
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan.
Carbamoyl-Phosphate Synthase I Deficiency Disease
Autosomal recessive inheritance of human mitochondrial carbamyl phosphate synthetase deficiency.
Carcinogenesis
6-Gingerol as an arginase inhibitor prevents urethane-induced lung carcinogenesis by reprogramming tumor supporting M2 macrophages to M1 phenotype.
Arginase activity and nitrogen content in epidermal carcinogenesis in mice.
Arginase and glucose-6-phosphate dehydrogenase activities in spontaneous mammary carcinogenesis.
Determination of arginase activity in tissue homogenates; application to epidermal carcinogenesis in mice.
Human cytomegalovirus may promote tumour progression by upregulating arginase-2.
Increased Arginase1 expression in tumor microenvironment promotes mammary carcinogenesis via multiple mechanisms.
Mapping Arginase Expression with 18F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary ?-Amino Acids.
Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice.
Significance of arginase and ornithine in malignant tumors of the human skin.
The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer.
The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats.
Carcinoma
A preliminary report on the histological and histocytochemical changes in mammary carcinoma in mice after intraperitoneal injections of arginase.
Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas.
Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells.
Arginase activity in carcinoma of the gallbladder: a pilot study.
Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma.
Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India.
Arginase and ornithine, as markers in human non-small cell lung carcinoma.
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
Arginase, a new marker of mammary carcinoma.
Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma.
Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma.
Arginase-1: A novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology.
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.
Arginine uptake and arginase activity in Ehrlich ascites carcinoma cells.
Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1.
Bioengineered human arginase I with enhanced activity and stability controls hepatocellular and pancreatic carcinoma xenografts.
BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas.
Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver.
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
Effect of an alkylating agent on liver arginase in normal and Ehrlich carcinoma bearing mice.
Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma.
Effects of intraperitoneally injected arginase on growth of mammary carcinoma implants in the mouse.
Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma.
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response.
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Functions of tumor-associated macrophages and macrophages residing in remote anatomical niches in Ehrlich carcinoma bearing mice.
Hepatic arginase activity in mice bearing Ehrlich ascites carcinoma.
HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region.
Humoral autoimmune responses to the squamous cell carcinoma antigen protein family in psoriasis.
In vitro repolarized tumor macrophages inhibit gastric tumor growth.
Increased number of arginase 1-positive cells in the stroma of carcinomas compared to precursor lesions and nonneoplastic tissues.
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma.
Liposomal CpG-ODN: An in vitro and in vivo study on macrophage subtypes responses, biodistribution and subsequent therapeutic efficacy in mice models of cancers.
Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis.
Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase.
Possible implications of arginase and diamine oxidase in prostatic carcinoma.
Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide.
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Some aspects of the role of arginine and arginase in mouse carcinoma 63.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Studies on liver arginase in mice with Ehrlich carcinoma.
Study of activities of arginase, hexosaminidase, and leucine aminopeptidase in prostate fluid.
The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1.
The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver.
The immunoregulatory mechanisms of carcinoma for its survival and development.
The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma.
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors.
[Action of arginine and arginase on the Guerin carcinoma.]
[Significance of arginase-1, glypican-3, hepatocyte paraffin antigen 1 and alpha-fetoprotein in diagnosis and differential diagnosis of liver tumors].
Carcinoma, Ehrlich Tumor
Oxidative stress, polarization of macrophages and tumour angiogenesis: Efficacy of caffeic acid.
Carcinoma, Endometrioid
Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review.
Carcinoma, Hepatocellular
A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma.
A phase 1 study of recombinant human arginase 1 (PEG-BCT- 100) in combination with capecitabine and oxaliplatin in advanced hepatocellular carcinoma patients.
A phase II clinical study on the efficacy and predictive biomarker of pegylated recombinant arginase on hepatocellular carcinoma.
A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative.
Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas.
An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.
Anti-tumor Efficacy of a Recombinant Human Arginase in Human Hepatocellular Carcinoma.
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Arginase isoenzymes in human cirrhotic liver.
Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma.
Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma.
Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma.
Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation.
Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens.
Arginase-1: a highly specific marker separating pancreatic adenocarcinoma from hepatocellular carcinoma.
Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1.
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase.
Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells.
BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas.
Changes in arginase isoenzymes pattern in human hepatocellular carcinoma.
Clinicopathological and prognostic implications of arginase expression in hepatocellular carcinoma.
Cloning of rat liver arginase cDNA and elucidation of regulation of arginase gene expression in H4 rat hepatoma cells.
Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma.
Control of expression of the gene for the arginine transporter Cat-1 in rat liver cells by glucocorticoids and insulin.
Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver.
Establishment of a clonal strain of hepatoma cells derived from Morris hepatoma 8999.
Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.
Functional and molecular analysis of liver arginase promoter sequences from man and Macaca fascicularis.
Growth inhibitory and arginase activities in liver and hepatoma extracts.
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts.
Hepatobiliary pathology.
HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region.
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models.
Inhibitory effect of arginine restriction on hepatoma growth.
Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC).
Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion.
Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma.
Prognostic Implications of Arginase and Cytokeratin 19 Expression in Hepatocellular Carcinoma After Curative Hepatectomy: Correlation With Recurrence-Free Survival.
Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy.
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.
Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest.
Regulation of glucocorticoids of arginase and argininosuccinate synthetase in cultured rat hepatoma cells.
Regulation of urea cycle enzymes in transplantable hepatomas and in the livers of tumor-bearing rats and humans.
Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma.
Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment.
The delayed glucocorticoid-responsive and hepatoma cell-selective enhancer of the rat arginase gene is located around intron 7.
The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1.
The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver.
Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors.
Well differentiated arginase-1 negative hepatocellular carcinoma.
[Arginase inhibitor nor-NOHA induces apoptosis and inhibits invasion and migration of HepG2 cells].
[Effects of lithium carbonate nanosized particles on nitric oxide production and arginase activity in tumor and peritoneal macrophages in hepatocellular carcinoma 29].
[Role of arginase-1 expression in distinguishing hepatocellular carcinoma from non-hepatocellular tumors].
[Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma]
[Significance of arginase-1, glypican-3, hepatocyte paraffin antigen 1 and alpha-fetoprotein in diagnosis and differential diagnosis of liver tumors].
[Study on the clinical significance and correlation of arginase-1 and inducible nitric oxide synthase expression in hepatocellular carcinoma].
Carcinoma, Lewis Lung
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma.
Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis.
Carcinoma, Non-Small-Cell Lung
Arginase and ornithine, as markers in human non-small cell lung carcinoma.
IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer.
Carcinoma, Renal Cell
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma.
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.
Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma.
Carcinoma, Squamous Cell
Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India.
Humoral autoimmune responses to the squamous cell carcinoma antigen protein family in psoriasis.
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Cardiomegaly
Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat.
Cardiomyopathies
Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice.
Cardiomyopathy, Dilated
Common Variants in the ARG1 Gene Contribute to the Risk of Dilated Cardiomyopathy in the Han Chinese Population.
Cardiovascular Diseases
2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I.
Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study.
Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway.
Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.
Angiotensin II-induced Vascular Endothelial Dysfunction through RhoA/Rho Kinase/p38 Mitogen-Activated Protein Kinase/Arginase Pathway.
Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets.
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis.
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica.
Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile.
Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase.
Arginase-1 Variants and the Risk of Familial Coronary Artery Disease in Subjects Originating from Pakistan.
Cyperaceae Species Are Potential Sources of Natural Mammalian Arginase Inhibitors with Positive Effects on Vascular Function.
Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
Effects of lipoprotein-associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients.
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome.
Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders.
Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
Human cytomegalovirus induces upregulation of arginase II: possible implications for vasculopathies.
Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases.
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
Korean red ginseng water extract restores impaired endothelial function by inhibiting arginase activity in aged mice.
Mature Twin Neonates Exhibit Oxidative Stress via Nitric Oxide Synthase Dysfunctionality: A Prognostic Stress Marker in the Red Blood Cells and Umbilical Cord Vessels.
Mechanisms of obesity-induced metabolic and vascular dysfunctions.
Metabolite profiling of arginase inhibitor activity guided fraction of Ficus religiosa leaves by LC-HRMS.
Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats.
Oxidative stress, l-arginine-nitric oxide and arginase pathways in platelets from adolescents with anorexia nervosa.
Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity.
Regulation of arginase pathway in response to wall shear stress.
Small-molecule arginase inhibitors.
Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
The role of arginase in the microcirculation in cardiovascular disease.
The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction.
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans.
Cataract
Urea cycle enzymes in retina, ciliary body-iris, lens and senile cataracts.
Central Nervous System Diseases
Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
Cerebral Palsy
A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
Arginase Deficiency Presenting as Acute Encephalopathy.
Arginase deficiency presenting as cerebral palsy.
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
Cerebrovascular Disorders
Insights into the Structural Requirements of 2(S)-Amino-6-Boronohexanoic Acid Derivatives as Arginase I Inhibitors: 3D-QSAR, Docking, and Interaction Fingerprint Studies.
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
Chagas Disease
Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection.
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice.
Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages.
Peripheral blood monocytes show morphological pattern of activation and decreased nitric oxide production during acute Chagas' disease in rats.
[Macrophages and arginase induction as a mechanism for parasite escape]
Chemical and Drug Induced Liver Injury
A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase I, and 4-Hydroxyphenyl-Pyruvate Dioxygenase.
[Effect of Arnica montana tincture on some hydrolytic enzyme activities of rat liver in experimental toxic hepatitis]
Cholangiocarcinoma
Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas.
Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms.
BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas.
Budd Chiari Syndrome and Intrahepatic Cholangiocarcinoma, An Unusual Combination: Case Report and Review of the Literature.
Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver.
Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.
The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1.
Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors.
Cholecystitis
Arginase activity in carcinoma of the gallbladder: a pilot study.
Cholecystitis, Acute
[Changes of serum arginase in patients with acute cholecystitis and pancreatitis]
[Serum and liver arginase activity in acute cholecystitis]
Cholestasis
Alterations in selected serum biochemical constituents in equids after induced hepatic disease.
Effect of L: -arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis.
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Supplementation with L-arginine affects its metabolizing pathways in rat liver subjected to bile duct ligation.
[Changes in arginase activity in various types of experimental cholestasis]
Chronic Periodontitis
Effectiveness of scaling and root planing versus modified Widman flap on nitric oxide synthase and arginase activity in patients with chronic periodontitis.
Periodontal therapy reduces arginase activity in saliva of patients with chronic periodontitis.
Salivary arginase in patients with adult periodontitis.
Citrullinemia
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country.
Creatine metabolism in patients with urea cycle disorders.
Diagnosis and monitoring of inborn errors of metabolism using urease-pretreatment of urine, isotope dilution, and gas chromatography-mass spectrometry.
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan.
Coinfection
Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite.
Colitis
Arginase activity in alternatively activated macrophages protects PI3Kp110? deficient mice from dextran sodium sulfate induced intestinal inflammation.
Arginase impedes the resolution of colitis by altering the microbiome and metabolome.
Cinobufacini Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization.
Dietary Nondigestible Polysaccharides Ameliorate Colitis by Improving Gut Microbiota and CD4+ Differentiation, as Well as Facilitating M2 Macrophage Polarization.
Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice.
Inhibition of arginase ameliorates experimental ulcerative colitis in mice.
Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.
Myeloid-Derived Suppressor Cell-Derived Arginase-1 Oppositely Modulates IL-17A and IL-17F Through the ESR/STAT3 Pathway During Colitis in Mice.
Protective role of arginase in a mouse model of colitis.
Colitis, Ulcerative
Inhibition of arginase ameliorates experimental ulcerative colitis in mice.
Small-molecule arginase inhibitors.
Colonic Neoplasms
Activation of autophagy following [HuArgI (Co)-PEG5000]-induced arginine deprivation mediates cell death in colon cancer cells.
Arginase activity is inhibited by L-NAME, both in vitro and in vivo.
Arginine metabolism in benign and malignant disease of breast and colon: evidence for possible inhibition of tumor-infiltrating macrophages.
Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway.
Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of the human and murine iNOS gene.
Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells.
The Redox State of the Glutathione/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells.
Colorectal Neoplasms
Arginase as a useful factor for the diagnosis of colorectal cancer liver metastases.
Arginase isoforms in human colorectal cancer.
Clinical significance of arginase in colorectal cancer.
Diagnostic performance of arginase activity in colorectal cancer.
Differences of alkaline phosphatase and arginase activities in human colorectal carcinoma cell lines.
HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region.
Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion.
l-Arginine as a factor increasing arginase significance in diagnosis of primary and metastatic colorectal cancer.
Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines.
Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.
Overexpression of Arginase-1 is an indicator of poor prognosis in patients with colorectal cancer.
Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma.
Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma.
[Arginase a marker of cancerogenesis. II. Monitoring of patients after resection of colorectal liver metastases]
[Arginase as a marker of cancerogenesis. I. Monitoring patients after resection of colorectal cancer]
[Arginase as a marker of cancerogenesis. III. Comparison of arginase activity with CEA and Ca 19-9 in liver metastases of colorectal cancer]
[Proteome study of colorectal cancer genesis and hepatic metastasis]
Coma
Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency.
Communicable Diseases
Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.
Congenital Hypothyroidism
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
Conjunctivitis
[Clinical and biochemical alterations in rats treated with high doses of vitamin A]
Coronary Artery Disease
Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus.
Arginase-1 Variants and the Risk of Familial Coronary Artery Disease in Subjects Originating from Pakistan.
Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus.
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
[The role of myeloperoxidase, paraoxonase and nitric oxide system in blood and pericardial fluid in patients with IHD who underwent direct myocardial revascularization.]
Coronary Disease
Arginase type I as a marker of coronary heart disease in hemodialysis patients.
Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure.
COVID-19
Altered amino acid profile in patients with SARS-CoV-2 infection.
Arginase 1 (Arg1) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy.
Deciphering the state of immune silence in fatal COVID-19 patients.
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity.
Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells.
Transcriptome and Functions of Granulocytic Myeloid-Derived Suppressor Cells Determine their Association with Disease Severity of COVID-19.
Cross Infection
Early Expansion of Circulating Granulocytic Myeloid-derived Suppressor Cells Predicts Development of Nosocomial Infections in Septic Patients.
Crush Syndrome
[Enzymatic activity in the organism in experimental crush syndrome of the limbs. III. Arginase in kidney and liver, glutaminase in kidney.]
Cystic Fibrosis
Arginase and pulmonary diseases.
Arginine Therapy for Lung Diseases.
Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis.
Increased arginase activity in cystic fibrosis airways.
L-ornithine derived polyamines in cystic fibrosis airways.
Lung arginase expression and activity is increased in cystic fibrosis mouse models.
Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.
ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel.
Oscillatory shear stress-induced arginase activity may explain reduced exhaled nitric oxide levels after vest chest physiotherapy in cystic fibrosis.
Cysticercosis
Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection.
Cysts
Sarcocystis fusiformis: some protein metabolic enzymes in various fractions of sarcocysts of buffalo (Bubalus bubalis).
Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice.
Dacryocystitis
Arginase 1 is involved in lacrimal hyposecretion in male NOD mice, a model of Sjögren's syndrome, regardless of dacryoadenitis status.
Dehydration
Adaptations of amphibian arginase. I. Response to dehydration.
Effect of drought on polyamine metabolism, yield, protein content and in vitro protein digestibility in tepary (Phaseolus acutifolius) and common (Phaseolus vulgaris) bean seeds
Dementia
Alzheimer's disease as a chronic maladaptive polyamine stress response.
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Demyelinating Diseases
Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action.
Myeloid cell plasticity in the evolution of central nervous system autoimmunity.
Dengue
Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study.
Dermatitis, Atopic
Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis.
Dermatitis, Contact
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
Diabetes Complications
Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model.
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Diabetes Mellitus
Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes.
Arginase activity and magnesium levels in blood of children with diabetes mellitus.
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus.
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy.
Arginase inhibition improves microvascular endothelial function in patients with type 2 diabetes mellitus.
Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients.
Association of serum arginase I with oxidative stress in a healthy population.
Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus.
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Increased levels of circulating arginase I in overweight compared to normal weight adolescents.
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase.
Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction.
The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes.
The Emerging Role of Arginase in Endothelial Dysfunction in Diabetes.
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
Diabetes Mellitus, Experimental
Effect of thyroidectomy & alloxan diabetes on rat brain arginase.
[The activity of arginase in salivary glands of rats with alloxan diabetes]
[The effect of agmatine on L-arginine metabolism in erythrocytes under streptozotocin-induced diabetes in rats].
Diabetes Mellitus, Type 1
Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans.
Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice.
Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes.
l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice.
Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
Diabetes Mellitus, Type 2
Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction.
Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus.
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy.
Arginase inhibition improves microvascular endothelial function in patients with type 2 diabetes mellitus.
Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients.
Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus.
Heparin inhibits pro-inflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress.
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Insulin reduces plasma arginase activity in type 2 diabetic patients.
L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes.
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase.
Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species.
The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes.
Diabetes, Gestational
Increased endothelial inflammation, sTie-2 and arginase activity in umbilical cords obtained from gestational diabetic mothers.
Diabetic Cardiomyopathies
Upregulation of arginase activity contributes to intracellular ROS production induced by high glucose in H9c2 cells.
Diabetic Foot
The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1.
Diabetic Nephropathies
Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism.
Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy.
Arginase-2 mediates diabetic renal injury.
Xiao-Shen-Formula, a Traditional Chinese Medicine, Improves Glomerular Hyper-Filtration in Diabetic Nephropathy via Inhibiting Arginase Activation and Heparanase Expression.
Diabetic Retinopathy
Arginase as a mediator of diabetic retinopathy.
Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.
The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.
Digestive System Diseases
Use of plasma arginase and gamma-glutamyl transpeptidase as specific indicators of heptocellular or hepatobiliary disease in the dog.
Disseminated Intravascular Coagulation
Transgenic mice overexpressing arginase 1 in monocytic cell lineage are affected by lympho-myeloproliferative disorders and disseminated intravascular coagulation.
Dystonia
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Encephalitis
The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia.
Encephalomyelitis
Arginase and autoimmune inflammation in the central nervous system.
Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.
Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.
Metabolic determinants of the immune modulatory function of neural stem cells.
Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Arginase and autoimmune inflammation in the central nervous system.
Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.
Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.
Metabolic determinants of the immune modulatory function of neural stem cells.
Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
Endometrial Neoplasms
Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy.
Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells.
Endotoxemia
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.
Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia.
Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia.
Eosinophilia
Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma.
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite.
Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus.
Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis.
Epilepsy
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model.
Manganese and epilepsy: brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats.
Erectile Dysfunction
2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I.
Arginase II Deletion Increases Corpora Cavernosa Relaxation in Diabetic Mice.
Arginase-boronic acid complex highlights a physiological role in erectile function.
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
Chronic Oral Administration of the Arginase Inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) Improves Erectile Function in Aged Rats.
Classical and slow-binding inhibitors of human type II arginase.
Expression, purification, and characterization of human type II arginase.
Human arginase II: crystal structure and physiological role in male and female sexual arousal.
Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction.
Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil.
Moringa oleifera leaf and seed inclusive diets influenced the restoration of biochemicals associated with erectile dysfunction in the penile tissue of STZ-induced diabetic male rats treated with/without Acarbose drug.
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.
New approaches to the design and discovery of therapies to prevent erectile dysfunction.
Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase.
p38 Mitogen-Activated Protein Kinase (MAPK) Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora Cavernosa from Angiotensin-II-Treated Mice.
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
Phenolic analysis and erectogenic function of African Walnut (Tetracarpidium conophorum) seeds: The impact of the seed shell on biological activity.
Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats' Penile Tissues.
Probing the specificity determinants of amino acid recognition by arginase.
Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction.
Serum Arginase II level can be a novel indicator for erectile dysfunction in patients with vasculogenic erectile dysfunction: a comparative study.
Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction.
Essential Hypertension
Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension.
Fallopian Tube Neoplasms
Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course.
Fatty Liver
Arginase 1: a potential marker of a common pattern of liver steatosis in HCV and NAFLD children.
Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis.
Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase.
Macrophage p38? promotes nutritional steatohepatitis through M1 polarization.
Fetal Growth Retardation
Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction.
Fibromyalgia
Arginase, NOS activities, and clinical features in fibromyalgia patients.
Fibrosarcoma
Properties of arginase from SV40-induced hamster fibrosarcomas and hamster liver tissues.
Foot Ulcer
The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1.
Gallbladder Neoplasms
Arginase activity in carcinoma of the gallbladder: a pilot study.
Gastritis
Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.
Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients.
Helicobacter pylori induces macrophage apoptosis by activation of arginase II.
Gastroenteritis
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
Gastrointestinal Neoplasms
Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13.
Genetic Diseases, Inborn
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
Liver transplantation prevents progressive neurological impairment in argininemia.
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency.
Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia.
Three novel mutations of ARG1 identified in Chinese patients with argininemia detected by newborn screening.
Giardiasis
Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection.
Gingivitis
Arginine-Nitric Oxide-Polyamine Metabolism in Periodontal Disease.
Glaucoma
Congenital glaucoma associated with an arginase deficit: a case report.
Glioblastoma
Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function.
Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells.
Low expressions of ASS1 and OTC in glioblastoma suggest the potential clinical use of recombinant human arginase (rhArg).
MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.
Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma.
uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.
Glioma
A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment.
Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function.
Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.
Granulocyte Macrophage-Colony Stimulation Factor Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-?
Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma.
[Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals]
Glomerulonephritis
Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells.
Arginase in glomerulonephritis.
Arginase is a major pathway of L-arginine metabolism in nephritic glomeruli.
Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase.
Role of Metabolites of Nitric Oxide and Arginase in the Pathogenesis of Glomerulonephritis.
Glucose Intolerance
Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients.
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting.
Graft vs Host Disease
Extracorporeal photochemotherapy induces arginase 1 in patients with graft versus host disease.
Granuloma
Arginase-1 expression in granulomas of tuberculosis patients.
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model.
Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair.
High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccines.
IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages.
IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness.
Immunohistological features of visceral leishmaniasis in BALB/c mice.
Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration.
Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.
M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis.
Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.
Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages.
Paracoccidioidomycosis: characterization of subpopulations of macrophages and cytokines in human mucosal lesions.
Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice.
The IL-13/IL-4R? axis is involved in tuberculosis-associated pathology.
TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response.
Graves Disease
Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.
guanidinoacetate n-methyltransferase deficiency
Creatine metabolism in patients with urea cycle disorders.
Gyrate Atrophy
Induction of arginase II mRNA by nitric oxide using in vitro model of gyrate atrophy of choroid and retina.
Heart Arrest
Increased arginase levels contribute to impaired perfusion after cardiopulmonary resuscitation.
Heart Defects, Congenital
Derangement of Arginine and Related Amino Acids in Children Undergoing Surgery for Congenital Heart Disease With Cardiopulmonary Bypass.
Heart Diseases
Chronic Co-Administration of Sepiapterin and l-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.
Heart Failure
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice.
Early diagnosis of myocardial infarction by arginase activity determination.
Increased arginase levels in heart failure represent a therapeutic target to rescue microvascular perfusion.
Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation.
HELLP Syndrome
Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity.
Hemangiosarcoma
Immunomodulatory effect of bisphosphonate risedronate sodium on CD163+ arginase 1+ M2 macrophages: the development of a possible supportive therapy for angiosarcoma.
Hematologic Diseases
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
Hemoglobinopathies
Cysteine-iron promotes arginase activity by driving the Fenton reaction.
Hepatic Encephalopathy
Liver arginase activity in patients with liver cirrhosis and in patients in endogenous hepatic coma.
[Hepatic arginase activity in patients in hepatic coma.]
Hepatitis
Arginase, a new marker of mammary carcinoma.
Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis.
DETERMINATION OF ARGINASE ACTIVITY IN BLOOD IN EPIDEMIC HEPATITIS.
Identification of a canine adenovirus (infectious canine hepatitis virus) inhibitor in dog liver extracts as arginase.
Tumor-induced CD11b(+) Gr-1(+) myeloid-derived suppressor cells exacerbate immune-mediated hepatitis in mice in a CD40-dependent manner.
[Serum arginase activities in acute hepatitis. 3]
[Significance of determining arginase activity in epidemic hepatitis]
Hepatitis B
Increased levels of arginase in patients with acute hepatitis B suppress antiviral T cells.
Hepatitis C
Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis.
Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-? Production by Altering Cellular Metabolism via Arginase-1.
LncRNA HOTAIRM1 promotes MDSC expansion and suppressive functions through the HOXA1-miR124 axis during HCV infection.
Hepatitis C, Chronic
HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3-miR124 Axis.
Hepatitis, Autoimmune
Anti-CYP2D6 antibodies detected by quantitative radioligand assay and relation to antibodies to liver-specific arginase in patients with autoimmune hepatitis.
Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis.
Enzyme immunoassay for autoantibodies to human liver-type arginase and its clinical application.
Hepatitis, Chronic
Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis.
[Usefulness of determining serum arginase in acute and chronic hepatitis]
Hepatoblastoma
Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2.
Herpes Simplex
Amniotic Membrane Induces Peroxisome Proliferator-Activated Receptor-? Positive Alternatively Activated Macrophages.
CCAAT/enhancer-binding protein beta (C/EBP beta) binds and activates while hepatocyte nuclear factor-4 (HNF-4) does not bind but represses the liver-type arginase promoter.
Contribution of macrophage arginase in the intrinsic restriction of herpes simplex virus replication in permissive macrophage cultures induced by gamma-interferon containing products of activated spleen cells.
The significance of the arginine and arginase of tears in experimentally-induced herpes simplex corneae.
[Polyvinylpyrrolidone iodine and arginase: effect on corneal regeneration and its antiviral effect]
HIV Infections
Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection.
Correction: Arginase Activity in the Blood of Patients with Visceral Leishmaniasis and HIV Infection.
Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.
Hodgkin Disease
The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin Lymphoma.
Hyperalgesia
Predictive and Preventive Potential of Preoperative Gut Microbiota in Chronic Postoperative Pain in Breast Cancer Survivors.
Treatment with nerve grafts and aFGF attenuates allodynia caused by cervical root transection injuries.
Hyperargininemia
"Cerebral Palsy" in a Patient With Arginase Deficiency.
A case report of neurological complications owing to lately diagnosed hyperargininemia emphasizing the role of national neonatal screening policies in the kingdom of Bahrain.
A long-term survival case of arginase deficiency with severe multicystic white matter and compound mutations.
A new case of arginase deficiency in a Spanish male.
A new French-Canadian family affected by hyperargininaemia.
A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family.
A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation.
A simple quantitative micromethod of arginase assay in blood spots dried on filter paper.
A simple screening test for arginase deficiency (hyperargininemia).
A simple spot-test for the detection of erythrocyte arginase deficiency.
A successful trial of enzyme replacement therapy in a case of argininemia.
AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse.
Absence of erythrocyte arginase protein in Japanese patients with hyperargininemia.
Adult-onset arginase deficiency.
Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.
Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes.
Anesthesia in a patient with arginase deficiency: implications and management.
Anesthetic management of a patient with arginase deficiency undergoing liver transplantation.
Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report.
Arginase activity in human fibroblast cultures.
Arginase and free amino acids in hyperargininemia: leukocyte arginine as a diagnostic parameter for heterozygotes.
Arginase deficiency and phenylketonuria.
Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function.
Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver.
Arginase deficiency in multiple tissues in argininemia.
Arginase deficiency in two brothers.
Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme.
Arginase Deficiency Presenting as Acute Encephalopathy.
Arginase deficiency presenting as cerebral palsy.
Arginase deficiency presenting with cerebral oedema and failure to thrive.
Arginase deficiency presenting with convulsions.
Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema.
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Arginase deficiency.
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
Arginase-2 mediates renal ischemia-reperfusion injury.
Arginine to ornithine ratio as a diagnostic marker in patients with positive newborn screening for hyperargininemia.
Argininemia presenting with progressive spastic diplegia.
Argininemia: a treatable genetic cause of progressive spastic diplegia simulating cerebral palsy: case reports and literature review.
Argocytes containing enzyme nanoparticles reduce toxic concentrations of arginine in the blood.
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Biomarkers identified in inborn errors for lysine, arginine, and ornithine.
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
Brain Na+,K(+)-ATPase inhibition induced by arginine administration is prevented by vitamins E and C.
Case series of Arginase 1 deficiency: Expanding the spectrum in hyperargininemia.
Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism.
Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency.
Clinical features and neurologic progression of hyperargininemia.
Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency.
Cloning and characterization of the mouse and rat type II arginase genes.
Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates.
Creatine metabolism and the urea cycle.
Creatine metabolism in patients with urea cycle disorders.
Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy.
Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity.
Differential expression of the two human arginase genes in hyperargininemia. Enzymatic, pathologic, and molecular analysis.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
Epilepsia Partialis Continua and Generalized Nonconvulsive Status Epilepticus during the Course of Argininemia: A Report on Two Cases.
Excretion of guanidino-derivates in urine of hyperargininemic patients.
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper.
Functional consequences of the G235R mutation in liver arginase leading to hyperargininemia.
Genetic approach to prenatal diagnosis in urea cycle defects.
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
Human hyperargininemia: a mutation not expressed in skin fibroblasts?
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Hyperargininemia due to liver arginase deficiency.
Hyperargininemia with arginase deficiency.
Hyperargininemia, epilepsy and the metabolism of guanidino compounds.
Hyperargininemia.
Hyperargininemia: a family with a novel mutation in an unexpected site.
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations.
Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia.
Identification of mutations (D128G, H141L) in the liver arginase gene of patients with hyperargininemia.
Immunologic studies of arginase in tissues of normal human adult and arginase-deficient patients.
Impaired neurotransmitter amine metabolism in arginase deficiency.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.
Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism.
Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings]
Intravenous loading with arginine-hydrochloride and ornithine-aspartate in siblings of two families, presenting a familial neurological syndrome associated with cystinuria.
Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts.
Isotropic growth of spores and salt tolerance in Aspergillus nidulans
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
Liver fibrosis in arginase deficiency.
Liver transplantation prevents progressive neurological impairment in argininemia.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
Loss of function mutations in conserved regions of the human arginase I gene.
Measurement of arginine transport in human erythrocytes using their intrinsic arginase activity: implications for the treatment of familial hyperargininemia.
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.
Molecular basis of argininemia. Identification of two discrete frame-shift deletions in the liver-type arginase gene.
Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase.
Molecular basis of phenotypic variation in patients with argininemia.
Molecular cloning and nucleotide sequence of cDNA for human liver arginase.
Molecular genetic study of human arginase deficiency.
Mouse model for human arginase deficiency.
Mutations and common variants in the human arginase 1 (ARG1) gene: Impact on patients, diagnostics, and protein structure considerations.
Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice.
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition.
Neurological Deterioration in Three Siblings: Exploring the Spectrum of Argininemia.
Newborn screening for hyperargininemia due to arginase 1 deficiency.
Novel Complex Re-Arrangement of ARG1 commonly shared by unrelated patients with Hyperargininemia.
Novel Homozygous Missense Mutation in the ARG1 Gene in a Large Sudanese Family.
Orotic acid excretion and arginine metabolism.
Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity.
Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis.
Prenatal diagnosis for arginase deficiency: a case study.
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency.
Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency.
Pteridines and mono-amines: relevance to neurological damage.
Purification, modification, physico-chemical and pharmacokinetic characterization of arginase, an enzyme of potential use in therapy.
Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia.
Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency.
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
Review of Multi-Modal Imaging in Urea Cycle Disorders: The Old, the New, the Borrowed, and the Blue.
SCHEMA Designed Variants of Human Arginase I & II Reveal Sequence Elements Important to Stability and Catalysis.
Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector.
Spastic gait, intellectual disability and seizures due to a rare mutation causing hyperargininemia.
Strategies to rescue the consequences of inducible arginase-1 deficiency in mice.
The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.
The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.
The human arginases and arginase deficiency.
The nutritional management of urea cycle disorders.
Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.
Three novel mutations of ARG1 identified in Chinese patients with argininemia detected by newborn screening.
Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet.
Unsuccessful trial of gene replacement in arginase deficiency.
Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders.
Urinary pyrimidine excretion in arginase deficiency.
Use of enzyme-loaded erythrocytes in in-vitro correction of arginase-deficient erythrocytes in familial hyperargininemia.
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
[Advances in clinical and molecular genetics studies on argininemia].
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
[Arginase deficiency]
[Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.]
[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]
[Late diagnosis of congenital argininemia during administration of sodium valproate]
[Proposal for a diet treatment in arginase deficiency]
[Seven patients of argininemia with spastic tetraplegia as the first and major symptom and prenatal diagnosis of two fetuses with high risk].
[The dibasic amino acid metabolic disorders]
Hypercholesterolemia
An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia.
Chitosan treatment abrogates hypercholesterolemia-induced erythrocyte's arginase activation.
Effect of Two Ginger Varieties on Arginase Activity in Hypercholesterolemic Rats.
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Inhibition of platelet aggregation by putrescine, spermidine, and spermine in hypercholesterolemic rabbits.
Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction: Role of Endothelial Nitric Oxide Synthase and Arginase II.
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.
Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase.
Hyperglycemia
Arginase activity and magnesium levels in blood of children with diabetes mellitus.
Insulin reduces plasma arginase activity in type 2 diabetic patients.
Obesity-induced vascular inflammation involves elevated arginase activity.
Panax notoginseng Saponins Regulate Macrophage Polarization under Hyperglycemic Condition via NF-?B Signaling Pathway.
Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia.
Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation.
Hyperhomocysteinemia
Nitric oxide bioavailability dysfunction involves in atherosclerosis.
Hyperinsulinism
Arginase inhibition alleviates hypertension in the metabolic syndrome.
Insulin reduces plasma arginase activity in type 2 diabetic patients.
Hyperlipidemias
Hyperlipidemic versus healthy pancreases: a proteomic analysis using an animal model.
Hyperlysinemias
Periodic hyperammonemia, hyperlysinemia, and homocitrullinuria associated with decreased argininosuccinate synthetase and arginase activities.
Hypersensitivity
Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model.
Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese workers.
Cyclooxygenase-2 blockade inhibits accumulation and function of myeloid-derived suppressor cells and restores T cell response after traumatic stress.
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
Effect of starvation and refeeding on biochemical and immunological status of Balb/c mice: an experimental model of malnutrition.
Human eosinophil granulocytes do not express the enzyme arginase.
Hypertension
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension.
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile.
Arginase inhibition alleviates hypertension associated with diabetes: Effect on endothelial dependent relaxation and NO production.
Arginase inhibition alleviates hypertension in the metabolic syndrome.
Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats.
Arginase inhibition protects against hypoxia?induced pulmonary arterial hypertension.
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension.
Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia.
Arginase promotes endothelial dysfunction and hypertension in obese rats.
Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats.
Arginase: a critical regulator of nitric oxide synthesis and vascular function.
Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension.
Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats.
Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
Endothelial dysfunction in hypertension: the role of arginase.
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Experimental studies of OH° radical/pressure dependence of arginase activity using a molecular chromatography approach.
Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice.
Extracts from Almond (Terminalia catappa) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A-stressed rats.
How could aortic arginase activity enhancement be involved in DOCA-salt hypertension?
HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS.
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Increased arginase activity in aorta of mineralocorticoid-salt hypertensive rats.
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension.
Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling.
L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis.
Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats.
Naringin protects against Bisphenol-A induced oculopathy as implication of cataract in hypertensive rat model.
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.
Oxidative Species Increase Arginase Activity in Endothelial Cells through RhoA/Rho Kinase Pathway.
Peculiarities of a novel bioenzymatic reactor using carbon nanotubes as enzyme activity enhancers: application to arginase.
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
Pulmonary Arterial Hypertension in Rats Due to Age-related Arginase Activation in Intermittent Hypoxia.
Regulation of nitric oxide production in health and disease.
Role of arginase in vessel wall remodeling.
Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice.
Time course of vascular arginase expression and activity in spontaneously hypertensive rats.
Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat.
Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia.
Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles.
Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock.
Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase.
[Arginase, nitrates, and nitrites in the blood plasma and erythrocytes in hypertension and after therapy with lisinopril and simvastatin].
[Disorders of endothelium-dependent vascular reactions and of the arginase and NO-synthase pathways of L-arginine metabolism in arterial hypertension]
[Effect of irbesartan, an antagonist of AT-1 receptors for angiotensin II, on L-arginine metabolism in arterial hypertension]
[Inhibitors of arginase in the L-arginine metabolic pathway as a new class of antihypertensive drugs: effect of carbamide on lipid oxidative metabolism and on vessel tonus during arterial hypertension]
[Inhibitors of arginase pathway in L-arginine metabolism as a new class of antihypertensive drugs: action of urea on oxidative and nonoxidative metabolism of L-arginine and vascular tone in chronic hypertension]
Hypertension, Pulmonary
An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes.
Arginase and pulmonary diseases.
Arginase I gene single-nucleotide polymorphism is associated with decreased risk of pulmonary hypertension in bronchopulmonary dysplasia.
Arginase Inhibition Prevents Bleomycin-Induced Pulmonary Hypertension, Vascular Remodeling and Collagen Deposition in Neonatal Rat Lungs.
Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.
Arginase Inhibition Reverses Monocrotaline-Induced Pulmonary Hypertension.
Arginase release following liver reperfusion. Evidence of hemodynamic action of arginase infusions.
Arginine Therapy for Lung Diseases.
Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways.
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
HIF2?-arginase axis is essential for the development of pulmonary hypertension.
Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPK?1 signaling.
Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.
HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS.
In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension.
Intravascular hemolysis and the pathophysiology of sickle cell disease.
L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells.
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.
Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia.
Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling.
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.
Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia.
Hyperthyroidism
Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats.
l-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats.
Regulation of pathways of ornithine metabolism. Effects of thyroid hormone and diabetes on the activity of enzymes at the "ornithine crossroads' in rat liver.
[Inhibition with ethionine and puromycin of the increase of hepatic arginase and urea excretion in hyperthyroid rats]
Hypertriglyceridemia
Arginase inhibition alleviates hypertension in the metabolic syndrome.
Hypertrophy, Right Ventricular
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
Hypoxia-Ischemia, Brain
Changes in arginase isoforms in a murine model of neonatal brain hypoxia-ischemia.
The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia.
Idiopathic Pulmonary Fibrosis
Arginase and pulmonary diseases.
Functional role and species-specific contribution of arginases in pulmonary fibrosis.
Immune System Diseases
Small-molecule arginase inhibitors.
Infarction, Middle Cerebral Artery
Effectiveness of arginase inhibitors against experimentally induced stroke.
Infections
A nanobiosensor for the detection of arginase activity.
A non-classical type of alveolar macrophage response to Trichinella spiralis infection.
A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue.
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.
Aberrant host defense against Leishmania major in the absence of SLPI.
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.
Alternative strategy for visceral leishmaniosis control: HisAK70-Salmonella Choleraesuis-pulsed dendritic cells.
Alternatively activated and immunoregulatory monocytes in human filarial infections.
An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis.
An overview of the immune response and Arginase I on CHIKV immunopathogenesis.
Anti-MHV3 state induced by IFN gamma in macrophages is not related to arginine metabolism.
Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection.
Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.
Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection.
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.
Arginase I induction during Leishmania major infection mediates the development of disease.
Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.
Arginase induction represses gall development during clubroot infection in Arabidopsis.
Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.
Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection.
Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection.
Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection.
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
Arginine and immunity.
Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase.
Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome.
Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection.
Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism.
Characterisation of arginase paralogues in salmonids and their modulation by immune stimulation/ infection.
Characterisation of the ex vivo virulence of Leishmania infantum isolates from Phlebotomus perniciosus from an outbreak of human leishmaniosis in Madrid, Spain.
Correction: MAP Kinase Phosphatase-2 Plays a Key Role in the Control of Infection with Toxoplasma gondii by Modulating iNOS and Arginase-1 Activities in Mice.
Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite.
Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages.
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection .
Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma.
Decidual macrophage M1 polarization contributes to adverse pregnancy induced by Toxoplasma gondii PRU strain infection.
Diagnosis of Fasciola hepatica infection in beef calves by plasma enzyme analysis.
Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection.
Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection.
Differential liver protein expression during schistosomiasis.
Differential macrophage polarisation during parasitic infections in common carp (Cyprinus carpio L.).
Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis.
Differential regulation of root arginine catabolism and polyamine metabolism in clubroot-susceptible and partially resistant Arabidopsis genotypes.
Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity.
DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4?+?T cells in response to SIV infections.
Does placental MDSC-mediated modulation of arginine levels help protect the foetus from auxotrophic pathogens?
Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background.
Effect of arginase inhibition on pulmonary L-arginine metabolism in murine pseudomonas pneumonia.
Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages.
Effect of the Mammalian Arginase Inhibitor 2(S)-Amino-6-Boronohexanoic Acid on Bacillus anthracis Arginase.
Effects of alpha-adrenergic agonists on Toxoplasma gondii replication in human umbilical vein endothelial cells.
Enhancer-mediated control of macrophage-specific arginase I expression.
Evaluation of arginase activity, nitric oxide and oxidative stress status in sheep with contagious agalactia.
Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis.
First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones.
Galectin-3 and Galectin-9 May Differently Regulate the Expressions of Microglial M1/M2 Markers and T Helper 1/Th2 Cytokines in the Brains of Genetically Susceptible C57BL/6 and Resistant BALB/c Mice Following Peroral Infection With Toxoplasma gondii.
Galectins, Eosinophiles, and Macrophages May Contribute to Schistosoma japonicum Egg-Induced Immunopathology in a Mouse Model.
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.
Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice.
Glycoproteins from sugarcane plants regulate cell polarity of Ustilago scitaminea teliospores.
Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8(+) T cell responses during acute Friend retrovirus infection.
HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3-miR124 Axis.
Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta).
High dissemination and hepatotoxicity in rats infected with Candida albicans after stress exposure: potential sensitization to liver damage.
Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities: Secondary Analysis of a Randomized Clinical Trial.
Human eosinophil granulocytes do not express the enzyme arginase.
HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS.
IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction.
Immunohistological features of visceral leishmaniasis in BALB/c mice.
Immunonutrition.
Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of the human and murine iNOS gene.
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice.
In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice.
Increased disease severity of parasite-infected TLR2-/- mice is correlated with decreased central nervous system inflammation and reduced numbers of cells with alternatively activated macrophage phenotypes in a murine model of neurocysticercosis.
Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages.
Induction of arginases I and II in cornea during herpes simplex virus infection.
Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis.
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection.
Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates.
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection.
Kinetoplastid Membrane Protein-11 as a Vaccine Candidate and a Virulence Factor in Leishmania.
Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages.
L-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis.
l-Citrulline Metabolism in Mice Augments CD4
Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism.
Leishmania amazonensis Promastigotes or Extracellular Vesicles Modulate B-1 Cell Activation and Differentiation.
Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection.
Lung arginase expression and activity is increased in cystic fibrosis mouse models.
Lysophosphatidylcholine exacerbates Leishmania major-dendritic cell infection through interleukin-10 and a burst in arginase1 and indoleamine 2,3-dioxygenase activities.
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite.
Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection.
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana.
MAP Kinase Phosphatase-2 Plays a Key Role in the Control of Infection with Toxoplasma gondii by Modulating iNOS and Arginase-1 Activities in Mice.
Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism.
Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection with L. amazonensis.
MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBP? regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection.
Mitigating an undesirable immune response of inherent susceptibility to cutaneous leishmaniosis in a mouse model: the role of the pathoantigenic HISA70 DNA vaccine.
Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator.
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors.
Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect.
Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells.
Multitracer stable isotope quantification of arginase and nitric oxide synthase activity in a mouse model of pseudomonas lung infection.
MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae.
Myeloid-Derived Suppressor Cells Infiltrate the Heart in Acute Trypanosoma cruzi Infection.
Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice.
Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients.
Neutrophils, Crucial, or Harmful Immune Cells Involved in Coronavirus Infection: A Bioinformatics Study.
Nitric oxide production is downregulated during respiratory syncytial virus persistence by constitutive expression of arginase 1.
Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea.
Parasite-Derived Arginase Influences Secondary Anti-Leishmania Immunity by Regulating Programmed Cell Death-1-Mediated CD4+ T Cell Exhaustion.
Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection.
Protective role of arginase in a mouse model of colitis.
Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection.
RANK Ligand Helps Immunity to Leishmania major by Skewing M2-Like Into M1 Macrophages.
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype.
Rat models to investigate host macrophage defense against Trypanosoma cruzi.
Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.
Recombinant IL-4/13A and IL-4/13B induce arginase activity and down-regulate nitric oxide response of primary goldfish (Carassius auratus L.) macrophages.
Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine.
Role of l-arginine and CD11b+Gr-1+ cells in immunosuppression induced by Heligmosomoides polygyrus bakeri.
Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis.
RON Receptor Tyrosine Kinase, a Negative Regulator of Inflammation, Is Decreased during Simian Immunodeficiency Virus-Associated Central Nervous System Disease.
Serum gamma glutamyl transpeptidase activity in cattle with induced fascioliasis.
Signaling pathways that regulate Trypanosoma cruzi infection and immune response.
Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo.
Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients.
Susceptibility of bone marrow derived macrophages to influenza virus infection is dependent on macrophage phenotype.
Susceptibility to Yersinia pseudotuberculosis infection is linked to the pattern of macrophage activation.
The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection.
The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury.
The first description of complete invertebrate arginine metabolism pathways implies dose-dependent pathogen regulation in Apostichopus japonicus.
The increase in mannose receptor recycling favors arginase induction and Trypanosoma cruzi survival in macrophages.
The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages.
The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo.
Thymic stromal lymphopoietin and apocynin alter the expression of airway remodeling factors in human rhinovirus-infected cells.
Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis.
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages.
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.
Transcriptome of American oysters, Crassostrea virginica, in response to bacterial challenge: insights into potential mechanisms of disease resistance.
Treatment of Amaranthus cruentus with chemical and biological inducers of resistance has contrasting effects on fitness and protection against compatible Gram positive and Gram negative bacterial pathogens.
Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.
Type 2 Innate Immunity in Helminth Infection Is Induced Redundantly and Acts Autonomously following CD11c+ Cell Depletion.
Vagal-?7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection.
Virulence mechanisms of coccidioides.
[Expression and Activity of Arginase from Monocytic-type Myeloid-derived Suppressor Cells in Rats Infected with Echinococcus granulosus].
[Macrophages and arginase induction as a mechanism for parasite escape]
[Metabolic aspects of hepatic tissue in infection of the mouse from EDP virus. II. Transaminase and arginase activity.]
Infertility
Alterations in Arginase-NO-synthase System of Spermatozoa in Human Subjects with Different Fertility Potential.
Seminal arginase activity in infertility.
Inflammatory Bowel Diseases
Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease.
Nitric oxide in inflammatory bowel disease.
Small-molecule arginase inhibitors.
Influenza, Human
Vagal-?7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection.
Insulin Resistance
ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans.
Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation.
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis.
Arginase inhibition alleviates hypertension in the metabolic syndrome.
Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats.
Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide.
CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues.
Intellectual Disability
A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation.
A successful trial of enzyme replacement therapy in a case of argininemia.
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
Intestinal Obstruction
Arginine Supplementation Induces Arginase Activity and Inhibits TNF-? Synthesis in Mice Spleen Macrophages After Intestinal Obstruction.
Iron Deficiencies
Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer.
Iron Overload
Pulmonary hypertension in thalassemia.
Irritable Bowel Syndrome
Arginase, NOS activities, and clinical features in fibromyalgia patients.
Ischemic Stroke
Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke.
Effect of stroke on arginase expression and localization in the rat brain.
Effectiveness of arginase inhibitors against experimentally induced stroke.
Intravascular hemolysis and the pathophysiology of sickle cell disease.
The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity.
Keratitis
Induction of arginases I and II in cornea during herpes simplex virus infection.
Keratoconus
Arginase activity, urea, and hydroxyproline concentration are reduced in keratoconus keratocytes.
[Increased NF-?B and iNOS Expression in Keratoconus Keratocytes - Hints for an Inflammatory Component?]
Kidney Diseases
[Arginase activity of the kidney in some experimental kidney diseases.]
Kidney Failure, Chronic
Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
Effect of experimental chronic renal failure upon the production of urea, as measured by the liver arginase activity in rats.
Erythrocyte nitric oxide metabolism in patients with chronic renal failure.
Impact of transplantation on neutrophil extracellular trap formation in patients with end-stage renal disease: A single-center, prospective cohort study.
[Progression of chronic renal failure in remnant rats: role of arginase inhibition]
Kyphosis
Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy.
Leg Ulcer
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer.
CORRIGENDUM: A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer.
Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers.
Intravascular hemolysis and the pathophysiology of sickle cell disease.
Leiomyoma
Immunohistochemical study of arginase in cancer of the stomach.
Leiomyosarcoma
Immunohistochemical study of arginase in cancer of the stomach.
Leishmaniasis
Age-related alteration of arginase activity impacts on severity of leishmaniasis.
Arginase and its mechanisms in Leishmania persistence.
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.
Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets.
Arginase I induction during Leishmania major infection mediates the development of disease.
Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.
Arginase in leishmania.
Biochemical and biophysical properties of a highly active recombinant arginase from Leishmania (Leishmania) amazonensis and subcellular localization of native enzyme.
Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Crystal structures of Leishmania mexicana arginase complexed with ?,?-disubstituted boronic amino-acid inhibitors.
Dietary polyphenols rutin, taxifolin and quercetin related compounds target Leishmania amazonensis arginase.
Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis.
Inhibition of Leishmania amazonensis arginase by fucogalactan isolated from Agrocybe aegerita mushroom.
Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection.
L-arginine deprivation impairs Leishmania major-specific T-cell responses.
l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis.
Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism.
Molecular characterization of recombinant arginase of Leishmania donovani.
Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase.
Residue-Specific Message Encoding in CD40-Ligand.
Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis.
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Th1/Th2-regulated arginase availability modulates Leishmania infection.
The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages.
The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase.
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.
Leishmaniasis, Cutaneous
An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis.
Arginase activity of Leishmania isolated from patients with cutaneous leishmaniasis.
Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis.
Comparing acute and chronic human cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica focusing on arginase activity.
Differential expression of TLRs 2, 4, 9, iNOS and TNF-? and arginase activity in peripheral blood monocytes from glucantime unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis caused by Leishmania tropica.
Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis.
Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.
Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1.
Leishmaniasis, Diffuse Cutaneous
Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis.
Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis.
Leishmaniasis, Visceral
Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia.
Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection.
Correction: Arginase Activity in the Blood of Patients with Visceral Leishmaniasis and HIV Infection.
Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis.
Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis.
IL-10 and TGF-? Induced Arginase Expression Contributes to Deficient Nitric Oxide Response in Human Visceral Leishmaniasis.
Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances.
Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression.
Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients.
Leprosy
In situ expression of M2 macrophage subpopulation in leprosy skin lesions.
Lymphocyte arginase activity in leprosy--a preliminary report.
Leukemia
Arginase purified from endophytic Pseudomonas aeruginosa IH2: Induce apoptosis through both cell cycle arrest and MMP loss in human leukemic HL-60 cells.
Arginase-mediated "field" defects in AML.
Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase.
Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia.
Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine.
Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase.
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Leukemia, Erythroblastic, Acute
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
Leukemia, Lymphocytic, Chronic, B-Cell
Arginase activity alterations in peripheral blood lymphocytes in the human chronic lymphocytic leukemia.
Purification of arginases from human-leukemic lymphocytes and granulocytes: study of their physicochemical and kinetic properties.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Purification of arginases from human-leukemic lymphocytes and granulocytes: study of their physicochemical and kinetic properties.
Leukemia, Myeloid
Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway.
Modification by serum of differentiation of cultured human myeloid leukemia cells in response to 12-O-tetradecanoylphorbol-13-acetate.
Leukemia, Myeloid, Acute
Arginase-mediated "field" defects in AML.
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts.
Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells.
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.
Leukemia, Myelomonocytic, Chronic
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Leukemia, T-Cell
Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia.
Leukocytosis
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
Leukodystrophy, Globoid Cell
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
Leukodystrophy, Metachromatic
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
Leukostasis
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Arginase as a mediator of diabetic retinopathy.
Liver Abscess, Amebic
Characteristics of inflammatory reactions during development of liver abscess in hamsters inoculated with Entamoeba nuttalli.
Liver Cirrhosis
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Arginase isoenzymes in human cirrhotic liver.
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Induction of arginase II in livers of bile duct-ligated rats.
Liver arginase activity in patients with liver cirrhosis and in patients in endogenous hepatic coma.
Liver fibrosis in arginase deficiency.
miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells.
Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment.
[Activity of serum arginase in liver cirrhosis. Its special study in the hemorrhagic syndrome and cirrhogenic encephalopathies]
[Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma]
[Study of ureogenesis in liver cirrhosis by determination of ornithine carbamoyl- transferase and arginase activity in hepatic biopsy specimens]
Liver Diseases
A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases.
Arginase, a new marker of mammary carcinoma.
Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis.
Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity.
Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity.
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
Occurrence of cytotoxic autoantibody in rabbits by immunization with heterologous liver arginase: a possible implication in the mechanism of the autoimmune liver diseases.
Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.
Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment.
The effect of thioacetamide on urea cycle enzymes of rat liver.
[Arginase activity in cardiopulmonary diseases. Value of its study in statistic liver diseases]
[Arginase and carbamyl phosphate synthase activities in chronic liver diseases]
[Enzyme determination by radiochemical methods: serum arginase and its clinical use in liver diseases]
[EXPLORATION OF ARGINASE ACTIVITY IN THE COURSE OF LIVER DISEASES, TUMORS AND INCLUSIVE.]
[Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma]
Liver Failure
Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia.
The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase.
Liver Failure, Acute
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Liver Neoplasms
Interactions between interleukin-6 and myeloid-derived suppressor cells drive the chemoresistant phenotype of hepatocellular cancer.
Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC).
The significance of arginase-1 expression in the diagnosis of liver cancer: A protocol for a systematic review.
[Inhibitory effect of ellipticine (dimethyl-5,11-(6H) pyrido (4,3-b) carbazole on the induction of liver cancer by BT6 (N,N-dimethyl-p-(benzothiazolylazo) analine) and its effect on the levels of cytochrome P450 and arginase activity]
Lung Diseases
Arginase and pulmonary diseases.
Arginine Therapy for Lung Diseases.
Asthma in sickle cell disease.
Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation.
Increased arginase activity in cystic fibrosis airways.
Increased expression of arginase I and II in allergic nasal mucosa.
Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages.
L-ornithine derived polyamines in cystic fibrosis airways.
Lung arginase expression and activity is increased in cystic fibrosis mouse models.
Method development and validation for rat serum fingerprinting with CE-MS: application to ventilator-induced-lung-injury study.
[Study of arginase activity in alveolar macrophages from patients with lung cancer]
Lung Injury
Arginase Inhibition Prevents Bleomycin-Induced Pulmonary Hypertension, Vascular Remodeling and Collagen Deposition in Neonatal Rat Lungs.
Induction of arginase isoforms in the lung during hyperoxia.
Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia.
Nitric Oxide Synthase Activity Correlates with OGG1 in Ozone-Induced Lung Injury Animal Models.
The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats.
Lung Neoplasms
A potential role for nitric oxide pathway in tuberculous pleural effusion.
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Arginase Pathway Markers of Immune-Microenvironment in Thymic Epithelial Tumors and Small Cell Lung Cancer.
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.
CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production.
Contactin 1 modulates pegylated arginase resistance in small cell lung cancer through induction of epithelial-mesenchymal transition.
Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma.
IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer.
Key genes and pathways in tumor-educated dendritic cells by bioinformatical analysis.
LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer.
Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release.
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.
The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer.
Thymosin ?1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1.
TRAF6 Regulates the Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Tumor-Bearing Host.
Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I.
[Study of arginase activity in alveolar macrophages from patients with lung cancer]
Lupus Erythematosus, Systemic
Arginase levels are increased in patients with rheumatoid arthritis.
Lymphoma
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
Differential effects of low-dose fludarabine or 5-fluorouracil on the tumor growth and myeloid derived immunosuppression status of tumor-bearing mice.
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
Tissue enzyme changes in parabiotic rats with subcutaneous lymphoma or fibrosarcoma.
Lymphoma, B-Cell, Marginal Zone
Myeloid-Derived Suppressor Cells and ??T17 Cells Contribute to the Development of Gastric MALT Lymphoma in H. felis-Infected Mice.
Lymphoma, Non-Hodgkin
CD14(+) HLA-DR low/(-) monocytes as indicator of disease aggressiveness in B-cell non-Hodgkin lymphoma.
Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cells.
Lymphopenia
SARS-CoV-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage.
Malaria
Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria.
Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.
Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria.
Host-parasite interactions revealed by Plasmodium falciparum metabolomics.
Increased pulmonary pressures and myocardial wall stress in children with severe malaria.
Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity.
Structural metal dependency of the arginase from the human malaria parasite Plasmodium falciparum.
Malaria, Cerebral
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection .
Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.
The activity of Plasmodium falciparum arginase is mediated by a novel inter-monomer salt-bridge between Glu295-Arg404.
Malnutrition
Protein energy malnutrition increases arginase activity in monocytes and macrophages.
Studies of renal urea cycle enzymes. I. Renal concentrating ability and urea cycle enzymes in the rat during protein deprivation.
Marek Disease
Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance.
Melanoma
Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1.
An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.
Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling.
Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors.
Differential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma.
Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy.
Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach.
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts.
Liposomal CpG-ODN: An in vitro and in vivo study on macrophage subtypes responses, biodistribution and subsequent therapeutic efficacy in mice models of cancers.
Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma.
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.
Recombinant Human Arginase Inhibits the In vitro and In vivo Proliferation of Human Melanoma by Inducing Cell Cycle Arrest and Apoptosis.
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
Role of poly(?-caprolactone) lipid-core nanocapsules on melanoma-neutrophil crosstalk.
Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator.
The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.
Melanoma, Experimental
Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.
Melanosis
Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition.
Melioidosis
The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease.
Memory Disorders
Effect of diet supplemented with P. ostreatus and L. subnudus on memory index and key enzymes linked with Alzheimer's disease in streptozotocin-induced diabetes rats.
Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats.
Mesothelioma
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts.
Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models.
Mesothelioma, Malignant
Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts.
Metabolic Diseases
A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension.
[Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.]
[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]
Metabolic Syndrome
Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study.
Arginase inhibition alleviates hypertension in the metabolic syndrome.
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome.
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.
Transcriptional changes in blood after aerobic interval training in patients with the metabolic syndrome.
Metabolism, Inborn Errors
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Microcephaly
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases.
Multiple Myeloma
Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes.
Multiple Sclerosis
Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.
Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis.
Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
The importance of nitric oxide and arginase in the pathogenesis of acute neuroinflammation: are those contra players with the same direction?
Multiple Sclerosis, Relapsing-Remitting
The importance of nitric oxide and arginase in the pathogenesis of acute neuroinflammation: are those contra players with the same direction?
Muscle Spasticity
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
Metabolite alterations in the genetically spastic mouse.
Muscular Diseases
Classical and slow-binding inhibitors of human type II arginase.
Expression, purification, and characterization of human type II arginase.
Muscular Dystrophies
Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy.
Myelodysplastic Syndromes
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
Myocardial Infarction
Arginase 1 is upregulated at admission in patients with ST-elevation myocardial infarction.
Arginase as a target for treatment of myocardial ischemia-reperfusion injury.
Arginase inhibition mediates cardioprotection during ischaemia-reperfusion.
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.
Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population.
Early diagnosis of myocardial infarction by arginase activity determination.
Occurrence of arginase in human blood serum in patients with myocardial infarction.
Serum levels of arginase I are associated with left ventricular function after myocardial infarction.
[Clinical value of arginase activity determination in human blood serum: diagnosis of myocardial infarction]
[Usefulness of serum arginase activity determination in the diagnosis of acute myocardial infarct]
Myocardial Ischemia
Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity.
Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
Myocarditis
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice.
Nasal Polyps
Comparison of arginase isoform expression in patients with different subtypes of chronic rhinosinusitis.
Neoplasm Metastasis
Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics.
Arginase as a useful factor for the diagnosis of colorectal cancer liver metastases.
Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade.
Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-Mediated Inflammatory Cell Infiltration.
l-Arginine as a factor increasing arginase significance in diagnosis of primary and metastatic colorectal cancer.
Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines.
Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept.
Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma.
Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma.
The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer.
TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases.
[Arginase a marker of cancerogenesis. II. Monitoring of patients after resection of colorectal liver metastases]
[Arginase as a marker of cancerogenesis. I. Monitoring patients after resection of colorectal cancer]
[Arginase as a marker of cancerogenesis. III. Comparison of arginase activity with CEA and Ca 19-9 in liver metastases of colorectal cancer]
[Proteome study of colorectal cancer genesis and hepatic metastasis]
[Usefulness of postoperative assay of arginase activity in blood serum of women after breast cancer resection]
Neoplasms
1,25?Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b.
6-Gingerol as an arginase inhibitor prevents urethane-induced lung carcinogenesis by reprogramming tumor supporting M2 macrophages to M1 phenotype.
?-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke.
A bioengineered arginine-depleting enzyme as a long-lasting therapeutic agent against cancer.
A case of primary carcinosarcoma of the liver with combined hepatocellular carcinoma and cholangiocarcinoma.
A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137).
A high-corn-oil diet strongly stimulates mammary carcinogenesis, while a high-extra-virgin-olive-oil diet has a weak effect, through changes in metabolism, immune system function and proliferation/apoptosis pathways.
A nanobiosensor for the detection of arginase activity.
A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor.
A Study of Arginase Expression in Chronic Non-healing Wounds.
A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative.
Activated macrophages kill tumour cells by releasing arginase.
Activation of PPAR? in myeloid cells promotes lung cancer progression and metastasis.
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.
Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response.
Age-associated differences in macrophage response in a vaginal wound healing rat model.
Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas.
Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth.
Alterations in morphology, arginase, and beta-glucuronidase within a clone of mouse tumor cells in vitro.
Altered ornithine metabolism in tumor-bearing mice.
Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1.
Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy.
An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.
An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway.
An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis.
Analysis of Macrophage Activation Markers in an Experimental Model of Cutaneous Leishmaniasis Treated with Photodynamic Therapy Mediated by 5-Aminolevulinic Acid.
Anti-Jagged immunotherapy inhibits MDSCs and overcomes tumor-induced tolerance.
Anti-tumor Efficacy of a Recombinant Human Arginase in Human Hepatocellular Carcinoma.
Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy.
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.
ARG1 mRNA Level Is a Promising Prognostic Marker in Head and Neck Squamous Cell Carcinomas.
Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors.
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Arginase activity determination. A marker of large bowel mucosa proliferation.
Arginase activity in carcinoma of the gallbladder: a pilot study.
Arginase activity in nickel sulfide-induced rat tumors.
Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor.
Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma.
Arginase activity is inhibited by L-NAME, both in vitro and in vivo.
Arginase and ornithine, as markers in human non-small cell lung carcinoma.
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.
Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis.
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.
Arginase in human urogenital tumors.
Arginase in patients with breast cancer.
Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade.
Arginase pathway in human endothelial cells in pathophysiological conditions.
Arginase Pathway Markers of Immune-Microenvironment in Thymic Epithelial Tumors and Small Cell Lung Cancer.
Arginase plays an important role in ammonia detoxification of yellow catfish Pelteobagrus fulvidraco.
Arginase promotes immune evasion of Echinococcus granulosus in mice.
Arginase purified from endophytic Pseudomonas aeruginosa IH2: Induce apoptosis through both cell cycle arrest and MMP loss in human leukemic HL-60 cells.
Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities.
Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth.
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma.
Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma.
Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation.
Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppressor cell-mediated inhibition of T-cell proliferation.
Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens.
Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope.
Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.
Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling.
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.
Arginase: A Multifaceted Enzyme Important in Health and Disease.
Arginine and immunity.
Arginine and nutrition in renal disease.
Arginine deprivation and tumour cell death: arginase and its inhibition.
Arginine deprivation in cancer therapy.
Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment.
Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy.
Arginine metabolism in benign and malignant disease of breast and colon: evidence for possible inhibition of tumor-infiltrating macrophages.
Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors.
Arginine metabolism: a potential target in pancreatic cancer therapy.
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.
Arginine Supplementation Induces Arginase Activity and Inhibits TNF-? Synthesis in Mice Spleen Macrophages After Intestinal Obstruction.
ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin?C via Wnt/??catenin pathway.
Atorvastatin attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats postmyocardial infarction.
ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment.
Autologous reconstitution of human cancer and immune system in vivo.
Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion.
Axitinib, a selective inhibitor of vascular endothelial growth factor receptor, exerts an anticancer effect in melanoma through promoting antitumor immunity.
Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice.
Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype.
Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup.
Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1.
Blockade of CCL2 enhances immunotherapeutic effect of anti-PD1 in lung cancer.
Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells.
Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase.
Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells.
Bone marrow macrophage M2 polarization and adipose-derived stem cells osteogenic differentiation synergistically promote rehabilitation of bone damage.
Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers.
Boronic acid-based arginase inhibitors in cancer immunotherapy.
Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms.
Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro.
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms.
Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia.
Cancer-promoting mechanisms of tumor-associated neutrophils.
Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to ? Amyloid via Protein Kinase C.
CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production.
CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer.
Cellular and Molecular Pathways Leading to External Root Resorption.
Characterization of a Wilms' tumor model.
Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells.
Characterization of macrophage phenotype, redox, and purinergic response upon chronic treatment with methionine and methionine sulfoxide in mice.
Characterization of vascular complications in experimental model of fructose-induced metabolic syndrome.
Chemical modification by polyethylene glycol of the anti-tumor enzyme arginine deiminase from Mycoplasma arginini.
Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.
Circulating myeloid-derived suppressor cells in patients with pancreatic cancer.
Cladribine modifies functional properties of microglia.
Clear cell hepatocellular carcinoma diagnosed by bile duct brushing cytology.
Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets.
Clinical significance of arginase in colorectal cancer.
Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma.
Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-Mediated Inflammatory Cell Infiltration.
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.
Constitutive intracellular production of iNOS and NO in human melanoma: possible role in regulation of growth and resistance to apoptosis.
Continuous Inhalation Exposure to Fungal Allergen Particulates Induces Lung Inflammation While Reducing Innate Immune Molecule Expression in the Brainstem.
Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC.
Correction: Possible Role of Arginase-1 in Concomitant Tumor Immunity.
Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients.
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.
Critical illness induces alternative activation of M2 macrophages in adipose tissue.
Critical role for arginase 2 in obesity-associated pancreatic cancer.
Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages.
Crystal Structures of Complexes with Cobalt-Reconstituted Human Arginase I.
Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer.
Decoy Receptor 3 Enhances Tumor Progression via Induction of Tumor-Associated Macrophages.
Denatonium and Naringenin Promote SCA-9 Tumor Growth and Angiogenesis: Participation of Arginase.
Deprivation of arginine by recombinant human arginase in prostate cancer cells.
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry.
Diagnostic performance of arginase activity in colorectal cancer.
Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver.
Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity.
Differences Between Patients with and without Atherosclerosis in Expression Levels of Inflammatory Mediators in the Adipose Tissue Around the Coronary Artery.
Differences of alkaline phosphatase and arginase activities in human colorectal carcinoma cell lines.
Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines.
Differential activation of peritoneal cells by subcutaneous treatment of rats with cryptococcal antigens.
Differential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma.
Differential effects of low-dose fludarabine or 5-fluorouracil on the tumor growth and myeloid derived immunosuppression status of tumor-bearing mice.
Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis.
Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide.
Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK.
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
Disruption of arginase II alters prostate tumor formation in TRAMP mice.
Distinct in vivo CD8 and CD4 T cell responses against normal and malignant tissues.
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.
Docosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor Cells.
Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis.
Dual biological effects of the cytokines interleukin-10 and interferon-?.
Ectopic hepatocellular carcinoma mimicking a retroperitoneal tumor: A case report.
EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer.
Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma.
Effect of hydrocortisone on arginase activity in ICRC mouse mammary tumours in vitro.
Effect of Hyperbaric Oxygen Therapy on Polarization Phenotype of Rat Microglia After Traumatic Brain Injury.
Effect of occupational exposure to aflatoxins on some liver tumor markers in textile workers.
Effect of rosuvastatin on arginase enzyme activity and polyamine production in experimental breast cancer.
Effector mechanisms of human monocyte-mediated tumor cytotoxicity in vitro: biochemical, functional, and serological characterization of cytotoxins produced by peripheral blood monocytes isolated by counterflow elutriation.
Effects of Environmental pH on Macrophage Polarization and Osteoimmunomodulation.
Effects of female sex steroids on concanavalin A-mediated agglutination of hepatocytes from nonregenerating and regenerating rat liver and hepatic tumor marker enzymes.
Effects of mitochondrial dysfunction on the immunological properties of microglia.
Effects of Nanosized Lithium Carbonate Particles on the Functional Activity of Macrophages During Development of Hepatocarcinoma 29.
Efficacy of expressions of Arg-1, Hep Par-1, and CK19 in the diagnosis of the primary hepatocellular carcinoma subtypes and exclusion of the metastases.
Electroacupuncture Pretreatment Alleviates Cerebral Ischemic Injury Through ?7 Nicotinic Acetylcholine Receptor-Mediated Phenotypic Conversion of Microglia.
Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function.
Elevated serum arginase activity levels in patients with breast cancer.
Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma.
Engineered immune cells as highly sensitive cancer diagnostics.
Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared to their peripheral counterparts.
Enzyme activities in prostatic carcinoma related to Gleason grades.
Eplerenone reduced lesion size in early but not advanced atherosclerosis in apolipoprotein E-deficient mice.
Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination.
Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer.
Ex vivo simulation of leukocyte function: Stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs.
Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer.
Exposure of polyethylene particles induces interferon-? expression in a natural killer T lymphocyte and dendritic cell coculture system in vitro: A preliminary study.
Expression of arginase by mouse myeloid leukemic cell differentiation in vitro induced with tumor necrosis factor.
Expression of arginase I in myeloid cells limits control of residual disease after radiation therapy of tumors in mice.
Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.
Expression of immunomodulating genes in prostate cancer and benign prostatic tissue.
Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients.
Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
Expression, purification, and biochemical properties of arginase from Bacillus subtilis 168.
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells.
Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response.
Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy.
Fetal-type gastrointestinal adenocarcinoma: a morphologically distinct entity with unfavourable prognosis.
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Frequent adaptive immune responses against arginase-1.
Functional heterogeneity among peritoneal macrophages. III. No evidence for the role of arginase in the inhibition of tumor cell growth by supernatants from macrophages or macrophage subpopulation cultures.
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGF?1-induced macrophages.
Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice.
Granulocyte functions are independent of arginine availability.
Gypenoside Attenuates ? Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling.
Hepatic Stellate Cells Enhance Liver Cancer Progression by Inducing Myeloid-Derived Suppressor Cells through Interleukin-6 Signaling.
Hepatocellular carcinoma with neuroendocrine differentiation: a case report.
Hepatoid Teratoma, Hepatoid Yolk Sac Tumor, and Hepatocellular Carcinoma: A Morphologic and Immunohistochemical Study of 30 Cases.
HIF-1? regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment.
High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites.
High-Throughput Fluorescence-Based Activity Assay for Arginase-1.
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model.
Human cytomegalovirus may promote tumour progression by upregulating arginase-2.
Human eosinophil granulocytes do not express the enzyme arginase.
Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models.
Human splenic myeloid derived suppressor cells: Phenotypic and clustering analysis.
Hypolipidemic drug clofibrate induces hepatic dedifferentiation.
HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS.
Identification and characterization of B220+/B220- subpopulations in murine Gr1+CD11b+ cells during tumorigenesis.
Identifying Factors of Microparticles Modified with Arginine Derivatives That Induce Phenotypic Shifts in Macrophages.
IL-4R? aptamer-liposome-CpG oligodeoxynucleotides suppress tumour growth by targeting the tumour microenvironment.
Ileocolonic Healing After Extended Small Bowel Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing and Postoperative Outcome.
Immunocompetence of macrophages in rats exposed to Candida albicans infection and stress.
Immunohistochemical study of arginase in cancer of the stomach.
Immunosuppressive effects and mechanisms of three myeloid-derived suppressor cells subsets including monocytic-myeloid-derived suppressor cells, granulocytic-myeloid-derived suppressor cells, and immature-myeloid-derived suppressor cells.
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer.
Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course.
Immunotherapy: Beyond Anti-PD-1 and Anti-PD-L1 Therapies.
Impact of Marine-Based Biomaterials on the Immunoregulatory Properties of Bone Marrow-Derived Mesenchymal Stem Cells: Potential Use of Fish Collagen in Bone Tissue Engineering.
Impact of substrate protonation and tautomerization States on interactions with the active site of arginase I.
Impacts of replacement of dietary fish oil by vegetable oils on growth performance, anti-oxidative capacity, and inflammatory response in large yellow croaker Larimichthys crocea.
In situ hybridisation for albumin RNA in paediatric liver cancers compared with common immunohistochemical markers.
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells.
Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma.
Increased Arginase1 expression in tumor microenvironment promotes mammary carcinogenesis via multiple mechanisms.
Increased levels of circulating arginase I in overweight compared to normal weight adolescents.
Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis.
Induction of arginase II in human Caco-2 tumor cells by cyclic AMP.
Inflammatory and biocompatibility evaluation of antimicrobial peptide GL13K immobilized onto titanium by silanization.
Influence of hormonal status on arginase activity in mammary tissue and tumour.
Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes.
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment.
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma.
Inhibition of curcumin on myeloid-derived suppressor cells is requisite for controlling lung cancer.
Inhibition of KCa3.1 Channels Suppresses Atrial Fibrillation via the Attenuation of Macrophage Pro-inflammatory Polarization in a Canine Model With Prolonged Rapid Atrial Pacing.
Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment.
Inhibitory effect of arginine restriction on hepatoma growth.
Inhibitory effect of mycoplasma-released arginase. Activity in mixed-lymphocyte and tumour cell cultures.
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury.
Interferon-gamma-induced nitric oxide inhibits the proliferation of murine renal cell carcinoma cells.
Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis.
Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury.
Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response.
Intracellular sources of ornithine for polyamine synthesis in endothelial cells.
Investigating the Synergistic Effects of Combined Modified Alginates on Macrophage Phenotype.
Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells.
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
Key genes and pathways in tumor-educated dendritic cells by bioinformatical analysis.
L-arginine availability regulates T-lymphocyte cell-cycle progression.
l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells.
Lack of effect of high potency arginase on tumor growth.
Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a d-galactose-induced accelerated aging mouse model.
Lactobacillus rhamnosus GG promotes M1 polarization in murine bone marrow-derived macrophages by activating TLR2/MyD88/MAPK signaling pathway.
Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype.
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.
Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature.
Liver metastatic basaloid squamous cell carcinoma with negative expression of pancytokeratin: a case report and literature review.
Luteolin transforms the polarity of bone marrow-derived macrophages to regulate the cytokine storm.
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.
Macrophage arginine metabolism and the inhibition or stimulation of cancer.
Macrophage Depletion Improves Chronic Rejection in Rats With Allograft Heart Transplantation.
Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis.
Macrophage-Derived IL1? and TNF? Regulate Arginine Metabolism in Neuroblastoma.
Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth.
Macrophages - a perspective target for antineoplastic immunotherapy.
Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells.
Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy.
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
Mesenchymal stem cells induce the ramification of microglia via the small RhoGTPases Cdc42 and Rac1.
Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages.
Metabolic pathways of L-arginine and therapeutic consequences in tumors.
Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives.
Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo.
Microenvironmental arginine depletion by macrophages in vivo.
MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression.
MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.
Mitochondrial arginase-2 is a cell?autonomous regulator of CD8+ T cell function and antitumor efficacy.
Molecular basis and current strategies of therapeutic arginine depletion for cancer.
Molecular genetics of ornithine decarboxylase in human tumor cells.
Mouse bone marrow-derived mesenchymal stem cells induce macrophage M2 polarization through the nuclear factor-?B and signal transducer and activator of transcription 3 pathways.
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Myeloid Cell-Derived Arginase in Cancer Immune Response.
Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy.
Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice.
Myeloid-Derived Suppressor Cells Specifically Suppress IFN-? Production and Antitumor Cytotoxic Activity of V?2 T Cells.
Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity.
Neuroblastoma formation requires unconventional CD4 T cells and Arginase-1-dependent myeloid cells.
Neurotoxicity of soluble macrophage products in vitro--influence of dexamethasone.
Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release.
Newly available antibodies with practical applications in surgical pathology.
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms.
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells.
Nitric oxide, apoptosis and macrophage polarization during tumor progression.
NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization.
Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases.
Obesity-induced vascular inflammation involves elevated arginase activity.
Occurrence of isoenzymes of arginase in mouse lung tumour.
Opposing roles for complement component c5a in tumor progression and the tumor microenvironment.
Ovarian cancer stem cells induce the M2 polarization of macrophages through the PPAR? and NF-?B pathways.
Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element.
Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines.
Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells.
Oxidative stress, polarization of macrophages and tumour angiogenesis: Efficacy of caffeic acid.
Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase.
Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.
Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC).
Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells.
PGC-1?-Mediated Mitochondrial Biogenesis is Involved in Cannabinoid Receptor 2 Agonist AM1241-Induced Microglial Phenotype Amelioration.
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function.
Physalis angulata Calyces Modulate Macrophage Polarization and Alleviate Chemically Induced Intestinal Inflammation in Mice.
Physicochemical properties of liposomal modifiers that shift macrophage phenotype.
Plasma arginase concentration measured by an enzyme-linked immunosorbent assay (ELISA) in normal adult population.
Possible implications of arginase and diamine oxidase in prostatic carcinoma.
Possible role of arginase-1 in concomitant tumor immunity.
Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept.
Preconditioning Human Adipose-Derived Stromal Cells on Decellularized Adipose Tissue Scaffolds Within a Perfusion Bioreactor Modulates Cell Phenotype and Promotes a Pro-regenerative Host Response.
Primary Hepatoid Carcinoma of the Pancreas: A Clinicopathological Study of 3 Cases With Review of Additional 31 Cases in the Literature.
Probiotics protect mice from CoCrMo particles-induced osteolysis.
Prognostic Implications of Arginase and Cytokeratin 19 Expression in Hepatocellular Carcinoma After Curative Hepatectomy: Correlation With Recurrence-Free Survival.
Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection.
Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice.
Promotion of Primary Murine Breast Cancer Growth and Metastasis by Adipose-Derived Stem Cells Is Reduced in the Presence of Autologous Fat Graft.
Properties of partially purified arginase from mouse lung tumour.
Properties of arginase immobilized in a fibrin clot.
Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an m1 phenotype in retinal microglia.
Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats.
Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide.
Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.
Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma.
Pten null prostate epithelium promotes localized MDSC expansion and immune suppression during tumor initiation and progression.
Purification and immobilization of L-arginase from thermotolerant Penicillium chrysogenum KJ185377.1; with unique kinetic properties as thermostable anticancer enzyme.
Purification, modification, physico-chemical and pharmacokinetic characterization of arginase, an enzyme of potential use in therapy.
Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment.
Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multifiliis.
Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells.
Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy.
Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cells.
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.
Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest.
Recombinant human arginase toxicity in mice is reduced by citrulline supplementation.
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells.
Regulation of macrophage arginase expression and tumor growth by the ron receptor tyrosine kinase.
Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma.
Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.
Research of novel anticancer agents targeting arginase inhibition.
Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance.
Resolution mediator chemerin15 reprograms the wound microenvironment to promote repair and reduce scarring.
Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4.
rIFN-gamma-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition.
Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.
Role of non-neuronal cholinergic system in breast cancer progression.
Role of OGR1 in myeloid-derived cells in prostate cancer.
Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors.
Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities.
Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation.
SCHEMA Designed Variants of Human Arginase I & II Reveal Sequence Elements Important to Stability and Catalysis.
Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.
Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma.
Significance of arginase and ornithine in malignant tumors of the human skin.
Silicone Implants Immobilized with Interleukin-4 Promote the M2 Polarization of Macrophages and Inhibit the Formation of Fibrous Capsules.
Silymarin suppressed lung cancer growth in mice via inhibiting myeloid-derived suppressor cells.
Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation.
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Small-molecule arginase inhibitors.
Soluble factors differ in platelets derived from separate niches: a pilot study comparing the secretome of peripheral blood and bone marrow platelets.
Some new approaches to potential test systems for drugs against prostatic cancer.
Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors.
Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation.
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses.
Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy.
Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
Suppression of T-cell functions by human granulocyte arginase.
Suppression of T-cell responses by tumor metabolites.
Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis.
Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.
Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo.
T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.
T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma.
Targeting arginine metabolism pathway to treat arginine-dependent cancers.
Targeting macrophages in the tumour environment to enhance the efficacy of ?OX40 therapy.
Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice.
Tart Cherry Reduces Inflammation in Adipose Tissue of Zucker Fatty Rats and Cultured 3T3-L1 Adipocytes.
Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models.
Temporal profile of M1 and M2 responses in the hippocampus following early 24h of neurotrauma.
Tetrahydroxystilbene glycoside antagonizes ?-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression.
The Applicability of a Human Immunohistochemical Panel to Mouse Models of Hepatocellular Neoplasia.
THE EFFECT OF ARGINASE ON THE RETARDATION OF TUMOUR GROWTH.
The effect of chemically modified alginates on macrophage phenotype and biomolecule transport.
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
The effects of arginase on neoplasm. I. The role of arginase in the immunosuppressive effects of extract from gastric cancer.
The effects of WW2/WW3 domains of Smurf2 molecule on TGF-? signaling and arginase I gene expression.
The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer.
The histological distribution of arginase activity in solid mouse tumor transplants and a comparison with ascites tumors and normal tissues.
The immunoregulatory mechanisms of carcinoma for its survival and development.
The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients.
The inhibition of arginase by proline in cell-free extracts of mouse mammary tumour.
The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer.
The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines.
The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats.
The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer.
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma.
The Redox State of the Glutathione/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells.
The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma.
The role of SHIP1 in macrophage programming and activation.
The significance of arginase I administration on the survival of mice bearing NS-1 myeloma cells.
The significance of arginase-1 expression in the diagnosis of liver cancer: A protocol for a systematic review.
Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors.
TNF-?-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma.
TNF-alpha contributes to endothelial dysfunction by upregulating arginase in ischemia/reperfusion injury.
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Toxoplasma ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages.
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers.
Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity.
TREATMENT of cancer with arginase.
Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity.
Tumor-Associated Macrophages: Therapeutic Targets for Skin Cancer.
Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development.
Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I.
Tumour effect on arginine/ornithine metabolic relationship in hypertrophic mouse kidney.
Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.
Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats.
Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review.
VitA or VitD ameliorates bronchopulmonary dysplasia by regulating the balance between M1 and M2 macrophages.
Vitamin D improves sunburns by increasing autophagy in M2 macrophages.
Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties.
Well differentiated arginase-1 negative hepatocellular carcinoma.
Wnt-3a alleviates neuroinflammation after ischemic stroke by modulating the responses of microglia/macrophages and astrocytes.
[Adipose-derived stem cells promote the polarization from M1 macrophages to M2 macrophages].
[Arginase a marker of cancerogenesis. II. Monitoring of patients after resection of colorectal liver metastases]
[Arginase activity in blood serum of patients with acute and chronic pancreatitis]
[Arginase as a marker of cancerogenesis. I. Monitoring patients after resection of colorectal cancer]
[Arginase as a marker of cancerogenesis. III. Comparison of arginase activity with CEA and Ca 19-9 in liver metastases of colorectal cancer]
[Blood arginase in cancer patients.]
[Brain arginase isoenzyme activity during the growth of neurinomas]
[Changes in arginase activity during neurinoma growth]
[Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals]
[Correlation between autophagy and polarization of macrophages in atherosclerosis plaque in arteriosclerosis obliterans amputees].
[Detection and analysis of phenotypes of tumor-associated macrophages in mouse model of spontaneous breast cancer].
[Effect of acupoint thread-embedding on macrophage polarization of epididymis adipose tissue in obese mice].
[Effect of decellularized adipose tissue combined with vacuum sealing drainage on wound inflammation in pigs].
[Effect of polysaccharides from cancer urine and tissues on liver catalase and arginase.]
[Effect of vitamin A in significant doses on incorporation of (14C) retinol, acceptor capacity of tRNA and activity of certain enzymes in tissues and plasma membranes of cells in the presence of Guerin's carcinoma]
[Effects of butylphthalide on microglia activation in frontal lobe of rats after chronic sleep deprivation].
[Effects of lithium carbonate nanosized particles on nitric oxide production and arginase activity in tumor and peritoneal macrophages in hepatocellular carcinoma 29].
[Effects of metformin on the polarization and Notch 1 expression of RAW264.7 macrophages].
[Enzymes in benign and malignant tumors of the liver; arginase and histidase.]
[EXPLORATION OF ARGINASE ACTIVITY IN THE COURSE OF LIVER DISEASES, TUMORS AND INCLUSIVE.]
[Immune function of myeloid-derived suppressor cells and its mechanism in obstructive sleep apnea syndrome].
[Interferon regulatory factor 5 (IRF5) regulates the differentiation of bone marrow-derived macrophages in mice].
[Progress in functions and mechanisms of immunosuppressive neutrophil subsets: An update].
[Proteome study of colorectal cancer genesis and hepatic metastasis]
[Regulatory effect of bone marrow mesenchymal stem cells on polarization of macrophages].
[Role of arginase-1 expression in distinguishing hepatocellular carcinoma from non-hepatocellular tumors].
[Role of arginine and arginase in tumors]
[Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma]
[Study of arginase activity of mixed saliva in cancer].
[Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation].
Neoplasms, Basal Cell
Significance of arginase and ornithine in malignant tumors of the human skin.
Neoplasms, Nerve Tissue
[Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals]
Neoplasms, Squamous Cell
Significance of arginase and ornithine in malignant tumors of the human skin.
Nephritis
L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis.
Neurilemmoma
[Brain arginase isoenzyme activity during the growth of neurinomas]
[Changes in arginase activity during neurinoma growth]
[Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals]
Neuroblastoma
IL-10 and ARG-1 concentrations in bone marrow and peripheral blood of metastatic neuroblastoma patients do not associate with clinical outcome.
Macrophage-Derived IL1? and TNF? Regulate Arginine Metabolism in Neuroblastoma.
Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity.
Neuroblastoma arginine addiction subverts the anticancer immune response.
Neurodegenerative Diseases
Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective.
Neuroinflammatory Diseases
Arginase 1+ microglia reduce A? plaque deposition during IL-1?-dependent neuroinflammation.
Arginase 2 Deficiency Promotes Neuroinflammation and Pain Behaviors Following Nerve Injury in Mice.
Central Nervous System Barriers Impact Distribution and Expression of iNOS and Arginase-1 in Infiltrating Macrophages During Neuroinflammation.
Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis.
Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.
Modifying effect of intravenous laser therapy on the protein expression of arginase and epidermal growth factor receptor in type 2 diabetic patients.
The importance of nitric oxide and arginase in the pathogenesis of acute neuroinflammation: are those contra players with the same direction?
Non-alcoholic Fatty Liver Disease
Arginase 1: a potential marker of a common pattern of liver steatosis in HCV and NAFLD children.
Arginine/citrulline cycle changes in diet-induced rat model of non-alcoholic fatty liver disease.
Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase.
Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation.
Obesity
ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans.
Aging Modulates the Influence of Arginase on Endothelial Dysfunction in Obesity.
Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity.
Arginase inhibition ameliorates adipose tissue inflammation in mice with diet-induced obesity.
Arginase inhibition ameliorates hepatic metabolic abnormalities in obese mice.
Arginase inhibition restores endothelial function in diet-induced obesity.
Critical role for arginase 2 in obesity-associated pancreatic cancer.
Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and L-arginine metabolism in mice.
Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung.
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Increased levels of circulating arginase I in overweight compared to normal weight adolescents.
Mechanisms of obesity-induced metabolic and vascular dysfunctions.
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.
Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity.
Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice.
Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice.
Serum fetuin-A and arginase-1 in human obesity model: Is there any interaction between inflammatory status and arginine metabolism?
The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients.
The Ron Receptor Tyrosine Kinase Regulates Macrophage Heterogeneity and Plays a Protective Role in Diet-Induced Obesity, Atherosclerosis, and Hepatosteatosis.
Obesity, Morbid
ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans.
Microvascular Endothelial Dysfunction in Patients with Obesity.
Oligospermia
THE PECULIARITIES OF ARGINASE PATHWAY OF L-ARGININE IN SPERMATOZOA IN MEN WITH DIFFERENT FORMS OF PATHOSPERMIA.
Optic Nerve Injuries
Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma.
Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury.
Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2.
Optic Neuritis
Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis.
ornithine aminotransferase deficiency
Biomarkers identified in inborn errors for lysine, arginine, and ornithine.
ornithine carbamoyltransferase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan.
[The dibasic amino acid metabolic disorders]
Ornithine Carbamoyltransferase Deficiency Disease
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
Genetic approach to prenatal diagnosis in urea cycle defects.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan.
Physical, cognitive, and social status of patients with urea cycle disorders in Japan.
Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan.
[The dibasic amino acid metabolic disorders]
Osteoarthritis
Arginase levels are increased in patients with rheumatoid arthritis.
Critical role for arginase II in osteoarthritis pathogenesis.
Osteomyelitis
Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice.
Osteosarcoma
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction.
Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II.
Ovarian Neoplasms
Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent.
Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA.
Influence of CA125, platelet count and neutrophil to lymphocyte ratio on the immune system of ovarian cancer patients.
Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression.
Overweight
Increased levels of circulating arginase I in overweight compared to normal weight adolescents.
Pancreatic Neoplasms
Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer.
Circulating myeloid-derived suppressor cells in patients with pancreatic cancer.
Critical role for arginase 2 in obesity-associated pancreatic cancer.
Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity.
Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms: ?A Potential Diagnostic Pitfall.
Growth inhibitory effect of L-canavanine against MIA PaCa-2 pancreatic cancer cells is not due to conversion to its toxic metabolite canaline.
Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release.
uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.
[Arginase activity in blood serum of patients with acute and chronic pancreatitis]
[Usefulness of preoperative assay of arginase in pancreatic cancer patients]
Pancreatitis
Inhibition of arginase activity ameliorates L-arginine-induced acute pancreatitis in rats.
[Changes of serum arginase in patients with acute cholecystitis and pancreatitis]
[Rat liver arginase activity in acute experimental pancreatitis]
Pancreatitis, Chronic
[Arginase activity in blood serum of patients with acute and chronic pancreatitis]
pantoate-beta-alanine ligase (amp-forming) deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
Papilloma
Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas.
Induction of arginase in rabbit epithelium by the Shope rabbit papilloma virus.
On the arginase of the Shope papillomas.
Studies of the mechanism of action of the Shope rabbit papilloma virus. I. Concerning the nature of the induction of arginase in the infected cells.
Unsuccessful trial of gene replacement in arginase deficiency.
[Purification and properties of L-arginase of papillomas induced with the rabbit papilloma virus]
Paraparesis, Spastic
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
Paraplegia
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Parasitemia
Rat models to investigate host macrophage defense against Trypanosoma cruzi.
S. mansoni-T. cruzi co-infection modulates arginase-1/iNOS expression, liver and heart disease in mice.
Parasitic Diseases
Arginase Activity in Eisenia andrei Coelomocytes: Function in the Earthworm Innate Response.
Arginase in parasitic infections: macrophage activation, immunosuppression, and intracellular signals.
Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.
Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors.
Pemphigus
Arginase 1+ IL-10+ polymorphonuclear myeloid-derived suppressor cells are elevated in patients with active pemphigus and correlate with an increased Th2/Th1 response.
Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.
Periodontal Diseases
Salivary arginase in patients with adult periodontitis.
Periodontitis
Arginine-Nitric Oxide-Polyamine Metabolism in Periodontal Disease.
Salivary arginase in patients with adult periodontitis.
Peripheral Nervous System Diseases
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Peritonitis
Corrigendum to "Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6" [Cell. Immunol. 349 (2020) 104047].
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Decrease in lung nitric oxide production after peritonitis in mice with sickle cell disease.
Decreased exhaled nitric oxide as a marker of postinsult immune paralysis.
Persistent Infection
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.
Crystallization and preliminary crystallographic studies of Helicobacter pylori arginase.
Nitric oxide production is downregulated during respiratory syncytial virus persistence by constitutive expression of arginase 1.
Suppression of T-cell functions by human granulocyte arginase.
phenylalanine 4-monooxygenase deficiency
Biopterins in arginase, dihydropteridine reductase and phenylalanine hydroxylase deficiency.
Phenylketonurias
Arginase deficiency and phenylketonuria.
Biopterins in arginase, dihydropteridine reductase and phenylalanine hydroxylase deficiency.
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
Pleural Effusion
A potential role for nitric oxide pathway in tuberculous pleural effusion.
Pneumococcal Infections
Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection.
Pneumonia
A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
A potential role for nitric oxide pathway in tuberculous pleural effusion.
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.
Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation.
Effect of arginase inhibition on pulmonary L-arginine metabolism in murine pseudomonas pneumonia.
Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.
Human eosinophil granulocytes do not express the enzyme arginase.
In utero environmental tobacco smoke exposure alters gene expression in lungs of adult BALB/c mice.
Lung arginase expression and activity is increased in cystic fibrosis mouse models.
MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice.
Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia.
Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4.
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.
The Inhibition of Caspase-1- Does Not Revert Particulate Matter (PM)-Induced Lung Immunesuppression in Mice.
Vagal-?7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection.
Pneumoperitoneum
Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats.
Erratum to: The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats.
The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats.
Pre-Eclampsia
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Arginase controls soluble vascular endothelial growth factor receptor 1 (sFlt1) to maintain pregnancy homeostasis.
Different profiles of circulating arginase 2 in subtypes of preeclampsia pregnant women.
Effects of arginase genetic polymorphisms on nitric oxide formation in healthy pregnancy and in preeclampsia.
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Influence of the AT(2) receptor on the L-arginine-nitric oxide pathway and effects of (-)-epicatechin on HUVECs from women with preeclampsia.
Inhibition of pregnancy-associated granulocytic myeloid-derived suppressor cell expansion and arginase-1 production in preeclampsia.
L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species.
Plasma nitric oxide, endothelin-1, arginase and superoxide dismutase in pre-eclamptic women.
Red blood cells from patients with pre-eclampsia induce endothelial dysfunction.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in etiology.
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pegylated arginase I: a potential therapeutic approach in T-ALL.
Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment.
Priapism
Intravascular hemolysis and the pathophysiology of sickle cell disease.
Prolidase Deficiency
Increased manganese content and reduced arginase activity in erythrocytes of a patient with prolidase deficiency (iminodipeptiduria).
Prostatic Diseases
Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer.
Possible implications of arginase and diamine oxidase in prostatic carcinoma.
Prostatic Hyperplasia
Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma.
Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer.
Possible implications of arginase and diamine oxidase in prostatic carcinoma.
Prostatic Neoplasms
Altered Cd8+ T lymphocyte Response Triggered by Arginase 1: Implication for Fatigue Intensification during Localized Radiation Therapy in Prostate Cancer Patients.
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer.
Apoptosis-inducing high (.)NO concentrations are not sustained either in nascent or in developed cancers.
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer.
Arginase purified from endophytic Pseudomonas aeruginosa IH2: Induce apoptosis through both cell cycle arrest and MMP loss in human leukemic HL-60 cells.
Deprivation of arginine by recombinant human arginase in prostate cancer cells.
Diagnostic performance of serum arginase activity in prostatic cancer.
Disruption of arginase II alters prostate tumor formation in TRAMP mice.
Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer.
Expression of arginase II in prostate cancer.
Expression of immunomodulating genes in prostate cancer and benign prostatic tissue.
High expression of indoleamine 2,3-dioxygenase gene in prostate cancer.
Some new approaches to potential test systems for drugs against prostatic cancer.
Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity.
Protein-Energy Malnutrition
Biochemical changes in saliva of malnourished children.
Protein energy malnutrition increases arginase activity in monocytes and macrophages.
Proteinuria
Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats.
Protozoan Infections
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
Pseudomonas Infections
Lung arginase expression and activity is increased in cystic fibrosis mouse models.
Psoriasis
Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation.
Arginase activity and polyamine biosynthesis in psoriasis.
Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Possible significance of elevated arginase activity in psoriasis scales.
Pulmonary Arterial Hypertension
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Arginase inhibition protects against hypoxia?induced pulmonary arterial hypertension.
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension.
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
Pulmonary Arterial Hypertension in Rats Due to Age-related Arginase Activation in Intermittent Hypoxia.
Pulmonary Disease, Chronic Obstructive
Arginase and pulmonary diseases.
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
Arginine Therapy for Lung Diseases.
Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD).
Elevated levels of arginase activity are related to inflammation in patients with COPD exacerbation.
Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer.
Increased platelet and erythrocyte arginase activity in chronic obstructive pulmonary disease associated with tobacco or wood smoke exposure.
Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease.
Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation.
Role of nitric oxide synthase/arginase balance in bronchial reactivity in patients with chronic obstructive pulmonary disease.
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
Pulmonary Embolism
Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism.
Leukocyte expression of heme oxygenase-1 [hmox1] varies inversely with severity of tricuspid regurgitation in acute pulmonary embolism.
Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism.
Pulmonary Fibrosis
Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
Functional role and species-specific contribution of arginases in pulmonary fibrosis.
Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway.
Quadriplegia
A successful trial of enzyme replacement therapy in a case of argininemia.
Prenatal diagnosis for arginase deficiency: a case study.
Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.
Reflex, Abnormal
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
Renal Insufficiency
Arginase inhibition slows the progression of renal failure in rats with renal ablation.
Renal Insufficiency, Chronic
Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease.
Intravascular hemolysis and the pathophysiology of sickle cell disease.
Reperfusion Injury
Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress.
Arginase as a target for treatment of myocardial ischemia-reperfusion injury.
Arginase-2 mediates renal ischemia-reperfusion injury.
Arginase-2 protects myocardial ischemia-reperfusion injury via NF-?B/TNF-? pathway.
Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injury.
Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus.
Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury.
In situ and real-time imaging of superoxide anion and peroxynitrite elucidating arginase 1 nitration aggravating hepatic ischemia-reperfusion injury.
Mechanisms of vasculopathy in sickle cell disease and thalassemia.
Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice.
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
Respiratory Hypersensitivity
Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo.
The therapeutic potential of drugs targeting the arginase pathway in asthma.
Respiratory Insufficiency
[Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure]
Retinal Degeneration
Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis.
Retinopathy of Prematurity
Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity.
Rhinitis, Allergic
Increased expression of arginase I and II in allergic nasal mucosa.
Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis.
Serum nitrite/nitrate and arginase levels in patients with allergic rhinitis.
The effect of montelukast sodium on serum arginase levels in patients with seasonal allergic rhinitis.
Rhinitis, Allergic, Seasonal
The effect of montelukast sodium on serum arginase levels in patients with seasonal allergic rhinitis.
Root Resorption
Cellular and Molecular Pathways Leading to External Root Resorption.
Salmonella Infections
Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection.
Pathological physiology of salmonellosis. V. Serum arginase and glutamic-oxaloacetic transaminase in children with typhoid fever.
Sarcoidosis
M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis.
Sarcoma
Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies.
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy.
Microenvironmental arginine depletion by macrophages in vivo.
Sarcoma 180
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Schistosomiasis
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.
Assessment of serum arginase activity in intestinal and hepatic schistosomiasis.
Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis.
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model.
Incomplete deletion of IL-4R? by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.
Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis.
Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages.
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.
Schistosomiasis mansoni
Arginase activity in peripheral blood of patients with intestinal schistosomiasis, Wonji, Central Ethiopia.
Scrapie
Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis.
Seizures
A successful trial of enzyme replacement therapy in a case of argininemia.
Arginase deficiency presenting with convulsions.
Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency.
Effects of febrile and afebrile seizures on oxidant state in children.
Functional significance of the activities of glutaminase and ornithine-?-aminotransferase in rat brain.
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
Manganese and epilepsy: brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats.
Prenatal diagnosis for arginase deficiency: a case study.
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures.
Sepsis
Arginine and immunity.
Differential expression of arginase and iNOS in the lung in sepsis.
Hepatic glutamine metabolism in the septic rat.
Immunotherapy-on-Chip Against an Experimental Sepsis Model.
Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils.
Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites.
Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients.
Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant Staphylococcus aureus.
Regulation of T cell receptor CD3zeta chain expression by L-arginine.
Silicosis
Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation.
Skin Abnormalities
[Clinical and biochemical alterations in rats treated with high doses of vitamin A]
Sleep Apnea, Obstructive
Arginase activity and nitric oxide levels in patients with obstructive sleep apnea syndrome.
Small Cell Lung Carcinoma
Arginase Pathway Markers of Immune-Microenvironment in Thymic Epithelial Tumors and Small Cell Lung Cancer.
Contactin 1 modulates pegylated arginase resistance in small cell lung cancer through induction of epithelial-mesenchymal transition.
Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.
Spinal Cord Diseases
Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis.
Spinal Cord Injuries
Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration.
Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury.
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
Spinal Cord Vascular Diseases
Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state.
Squamous Cell Carcinoma of Head and Neck
Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India.
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India.
The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma.
ST Elevation Myocardial Infarction
Arginase 1 is upregulated at admission in patients with ST-elevation myocardial infarction.
The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance.
Staphylococcal Infections
Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites.
Starvation
An arginase-based system for selection of transfected CHO cells without the use of toxic chemicals.
Arginase activity is a useful marker of nitrogen limitation during alcoholic fermentations.
Axenic Leishmania amazonensis promastigotes sense both the external and internal arginine pool distinctly regulating the two transporter-coding genes.
Capillary electrophoresis reveals polyamine metabolism modulation in Leishmania (Leishmania) amazonensis wild type and arginase knockout mutants under arginine starvation.
Catabolic synergism: a cooperation between the availability of substrate and the need for nitrogen in the regulation of arginine catabolism in Saccharomyces cerevisiae.
Distribution of amino acids and amino-acid enzymes in whole kidney and renal cortex. Effect of 24-h starvation.
Effects of cortisol or starvation on the activities of four enzymes in small intestine and liver of the rat during development.
induction and derepression of arginase and ornithine transaminase in different strains of Saccharomyces cerevisiae.
Intramitochondrial localization of arginase appearing in chicken liver upon starvation.
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
Molecular charcteristics of chicken kidney arginase.
Oxidative stress and some biochemical parameters during starvation and refeeding in Astacus leptodactylus (Esch., 1823).
Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.
The effect of adrenalectomy and starvation on arginase and ornithine-transcarbamylase activities in the liver of rats during development.
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.
Status Epilepticus
Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia.
Stomach Neoplasms
Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells.
Content of glucocorticoid receptor and arginase in gastric cancer and normal gastric mucosal tissues.
Effect of arginase on splenic killer cell activity in patients with gastric cancer.
Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer.
Immunohistochemical study of arginase in cancer of the stomach.
Regulation of arginase production by glucocorticoid in three human gastric cancer cell lines.
Serum arginase level in patients with gastric cancer.
The effects of arginase on neoplasm. I. The role of arginase in the immunosuppressive effects of extract from gastric cancer.
Stomach Ulcer
Immunohistochemical study of arginase in cancer of the stomach.
Strabismus
Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report.
Stroke
Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke.
Arginase I release from activated neutrophils induces peripheral immunosuppression in a murine model of stroke.
CD4 T cell deficiency attenuates ischemic stroke, inhibits oxidative stress, and enhances Akt/mTOR survival signaling pathways in mice.
Effect of stroke on arginase expression and localization in the rat brain.
Effectiveness of arginase inhibitors against experimentally induced stroke.
Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
Pair housing reverses post-stroke depressive behavior in mice.
[New insights into arginase. Part II. Role in physiology and pathology]
Subarachnoid Hemorrhage
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
Tauopathies
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
Teratoma
Embryonic Stem Cells Promoting Macrophage Survival and Function are Crucial for Teratoma Development.
Thrombosis
Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis.
Arginase blockade lessens endothelial dysfunction after thrombosis.
Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis.
L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis.
Mature coconut water exhibits antidiabetic and antithrombotic potential via L-arginine-nitric oxide pathway in alloxan induced diabetic rats.
Thrombin induces endothelial arginase through AP-1 activation.
Tics
Melanoma-initiating cells exploit M2 macrophage TGF? and arginase pathway for survival and proliferation.
Toxemia
[The effect of antiprotein plasma on humoral resistance in children with severe burns]
Toxoplasmosis
Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection.
Tremor
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.
Triple Negative Breast Neoplasms
Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells.
Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells.
Trypanosomiasis, African
Serum arginase, a biomarker of treatment efficacy in human African trypanosomiasis.
Tuberculosis
A potential role for nitric oxide pathway in tuberculous pleural effusion.
Adaptation of M. tuberculosis to impaired host immunity in HIV-infected patients.
Arginase-1 expression in granulomas of tuberculosis patients.
Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.
Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.
Small-molecule arginase inhibitors.
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Tumor Virus Infections
Change in the structure of Shope papilloma virus-induced arginase associated with mutation of the virus.
Induction of arginase activity with the Shope papilloma virus in tissue culture cells from an argininemic patient.
Studies on the arginase activity of Shope papilloma: possible presence of isozymes.
USE OF THE SHOPE PAPILLOMA VIRUS-INDUCED ARGINASE AS A BIOCHEMICAL MARKER IN VITRO.
Typhoid Fever
Pathological physiology of salmonellosis. V. Serum arginase and glutamic-oxaloacetic transaminase in children with typhoid fever.
Urea Cycle Disorders, Inborn
A Case of Hyperargininaemia Presenting at Unusually Low Age.
A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation.
AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse.
Anesthetic management of a patient with arginase deficiency undergoing liver transplantation.
Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report.
Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme.
Arginase Deficiency Presenting as Acute Encephalopathy.
Arginase deficiency.
Arginase I mRNA therapy - a novel approach to rescue arginase 1 enzyme deficiency.
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury.
Argininemia: a treatable genetic cause of progressive spastic diplegia simulating cerebral palsy: case reports and literature review.
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Creatine metabolism in patients with urea cycle disorders.
Guanidino compound levels in blood, cerebrospinal fluid, and post-mortem brain material of patients with argininemia.
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
Mutations and common variants in the human arginase 1 (ARG1) gene: Impact on patients, diagnostics, and protein structure considerations.
Neurological Deterioration in Three Siblings: Exploring the Spectrum of Argininemia.
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
Uremia
Arginase activity of human erythrocyte ghosts in uremia.
Liver arginase activity as related to blood urea in acute uremia of new-born rats.
[Effect of flavonoids on aspects of nitrogen metabolism in experimental uremia]
[Hepatic and renal arginase in uremia; experimental study in uremia produced by ligation of the ureters in guinea pig.]
Ureteral Obstruction
Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis.
Urinary Bladder Neoplasms
Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells.
Urinary Bladder, Neurogenic
Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury.
Uterine Cervical Neoplasms
Immunosuppression in cervical cancer with special reference to arginase activity.
Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells.
Uveitis
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats.
Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis.
Uveitis, Anterior
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Varicocele
Major protein alterations in spermatozoa from infertile men with unilateral varicocele.
Varicose Ulcer
Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers.
Vascular Diseases
A Novel Arginase Inhibitor Derived from Scutellavia indica Restored Endothelial Function in ApoE-Null Mice Fed a High-Cholesterol Diet.
Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia.
Arginase Inhibitor 2,3,5,4'-Tetrahydroxystilbene-2-O-?-D-Glucoside Activates Endothelial Nitric Oxide Synthase and Improves Vascular Function.
Arginase: a critical regulator of nitric oxide synthesis and vascular function.
Endothelial arginase II and atherosclerosis.
Endothelial arginase II responds to pharmacological inhibition by elevation in protein level.
HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS.
Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I.
Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling.
Korean red ginseng water extract restores impaired endothelial function by inhibiting arginase activity in aged mice.
Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells.
Role of arginase in vessel wall remodeling.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
The Redox State of the Glutathione/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells.
Time course of vascular arginase expression and activity in spontaneously hypertensive rats.
Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice.
Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase.
Vascular System Injuries
Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.
Vasospasm, Intracranial
Melatonin Ameliorates Cerebral Vasospasm After Experimental Subarachnoidal Haemorrhage Correcting Imbalance of Nitric Oxide Levels in Rats.
Venous Insufficiency
Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers.
Virus Diseases
Contribution of macrophage arginase in the intrinsic restriction of herpes simplex virus replication in permissive macrophage cultures induced by gamma-interferon containing products of activated spleen cells.
Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis.
Nitric oxide production is downregulated during respiratory syncytial virus persistence by constitutive expression of arginase 1.
Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis.
[SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES].
Vitamin A Deficiency
Influence of vitamin A on formation and excretion of end products of nitrogen catabolism in chicks.
Vitamin B 12 Deficiency
Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B12 Deficiency.
Whooping Cough
Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis.
xaa-pro dipeptidase deficiency
Increased manganese content and reduced arginase activity in erythrocytes of a patient with prolidase deficiency (iminodipeptiduria).
Xanthomatosis, Cerebrotendinous
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]