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Information on EC 3.5.2.2 - dihydropyrimidinase and Organism(s) Mus musculus and UniProt Accession Q9EQF5

for references in articles please use BRENDA:EC3.5.2.2
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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase
IUBMB Comments
Also acts on dihydrothymine and hydantoin.
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This record set is specific for:
Mus musculus
UNIPROT: Q9EQF5
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
dhp, dihydropyrimidine dehydrogenase, dihydropyrimidinase, hydantoinase, d-hydantoinase, dhp-1, dhpase, dihydropyrimidine amidohydrolase, dhp-2, padhpase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-hydantoinase
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-
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DHP
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-
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Dihydropyrimidinase
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-
-
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hydantoin peptidase
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-
-
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hydantoinase
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-
-
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hydropyrimidine hydrase
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-
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pyrimidine hydrase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide hydrolysis
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-
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-
SYSTEMATIC NAME
IUBMB Comments
5,6-dihydropyrimidine amidohydrolase
Also acts on dihydrothymine and hydantoin.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-74-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5,6-dihydrouracil + H2O
3-ureidopropionate
show the reaction diagram
-
-
-
-
?
DL-5-phenylhydantoin + H2O
N-carbamoyl-D-phenylglycine
show the reaction diagram
-
-
-
-
?
hydantoin + H2O
N-carbamoyl glycine
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5,6-dihydrouracil + H2O
3-ureidopropionate
show the reaction diagram
-
-
-
-
?
hydantoin + H2O
N-carbamoyl glycine
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DPYS_MOUSE
519
0
56725
Swiss-Prot
other Location (Reliability: 4)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Traut, T.W.; Loechel, S.
Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay
Biochemistry
23
2533-2539
1984
Bos taurus, Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Escherichia coli, Euglena gracilis, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Dudley, K.H.; Buttler, T.C.; Bius, D.L.
The role of dihydropyrimidinase in the metabolism of some hydantoin and succinimide drugs
Drug Metab. Dispos.
2
103-112
1974
Bos taurus, Canis lupus familiaris, Cavia porcellus, Felis catus, Mus musculus, Oryctolagus cuniculus, Platyrrhini, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Rawls, J.M.
Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism
Genetics
172
1665-1674
2006
Caenorhabditis elegans (Q18677), Caenorhabditis elegans (Q21773), Drosophila melanogaster (Q2XST3), Drosophila melanogaster (Q8IPQ2), Drosophila melanogaster, Dictyostelium discoideum (Q55DL0), Mus musculus (Q9EQF5), Arabidopsis thaliana (Q9FMP3), Pseudomonas aeruginosa (Q9I676), Lachancea kluyveri (Q9P903), Drosophila melanogaster EP(3)3238 (Q2XST3), Drosophila melanogaster EP(3)3238 (Q8IPQ2)
Manually annotated by BRENDA team