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IUBMB CommentsThe reaction is the first stage in the conversion of 5-hydroxyisourate into S-allantoin. This reaction will also occur spontaneously but more slowly.
The taxonomic range for the selected organisms is: Bacillus subtilis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
transthyretin, transthyretin-like protein, hydroxyisourate hydrolase, hiuhase, 5-hydroxyisourate hydrolase, transthyretin-related protein, hiu hydrolase, hiuase, sbttr, ectrp,
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5-hydroxyisourate hydrolase
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transthyretin-related protein
TRP
5-hydroxyisourate hydrolase
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5-hydroxyisourate amidohydrolase
The reaction is the first stage in the conversion of 5-hydroxyisourate into S-allantoin. This reaction will also occur spontaneously but more slowly.
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5-hydroxyisourate + H2O
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
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Uniprot
brenda
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homotetramer
size exclusion chromatography
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glutathione-agarose 4B in column mode
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expressed in Escherichia coli strani BL21
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Jung, D.K.; Lee, Y.; Park, S.G.; Park, B.C.; Kim, G.H.; Rhee, S.
Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family
Proc. Natl. Acad. Sci. USA
103
9790-9795
2006
Bacillus subtilis (O32142), Bacillus subtilis
brenda
3.5.2.17 hydroxyisourate hydrolase
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