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Information on EC 3.5.2.15 - cyanuric acid amidohydrolase

for references in articles please use BRENDA:EC3.5.2.15
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IUBMB Comments
The enzyme catalyses the ring cleavage of cyanuric acid, an intermediate in the degradation of s-triazide herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is highly specific for cyanuric acid. The product was initially thought to be bioret, but was later shown to be 1-carboxybioret.
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The enzyme appears in viruses and cellular organisms
Synonyms
amidase, cyanurate, AtzD, CAH, cyanurate amidase, cyanuric acid hydrolase, s-triazine ring-cleavage enzyme, TrzD, trzD gene product, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
cyanuric acid + H2O = 1-carboxybiuret
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involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria
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