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Information on EC - cyanuric acid amidohydrolase

for references in articles please use BRENDA:EC3.5.2.15
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IUBMB Comments
Along with EC (allophanate hydrolase) and EC (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. This is a key enzyme in the pathway, catalysing the ring cleavage of cyanuric acid. The enzyme is specific for cyanuric acid as substrate as neither the structurally related compounds ammeline (2,4-diamino-6-hydroxy-s-triazine) and ammelide (2-amino-4,6-dihydroxy-s-triazine) nor a number of pyrimidine compounds, such as uracil and cytosine, can act as substrates .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
amidase, cyanurate, AtzD, cyanurate amidase, s-triazine ring-cleavage enzyme, TrzD, trzD gene product, more
cyanuric acid + H2O = biuret + CO2
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involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria
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