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cytokine IL-17
increased expression of vanin-1
-
cytokine Th1
increased expression of vanin-1
-
cytokine IL-17
increased expression vanin-3
-
cytokine Th1
increased expression vanin-3
-
additional information
19fold upregultion of gene expression of vanin-1 psoriasis, vanin-1 expression in atopic dermatits little increased
-
additional information
19fold upregultion of gene expression of vanin-1 psoriasis, vanin-1 expression in atopic dermatits little increased
-
additional information
Q9NY84
19fold upregultion of gene expression of vanin-1 psoriasis, vanin-1 expression in atopic dermatits little increased
-
additional information
-
19fold upregultion of gene expression of vanin-1 psoriasis, vanin-1 expression in atopic dermatits little increased
-
additional information
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-1 in reconstructed human epidermis
-
additional information
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-1 in reconstructed human epidermis
-
additional information
Q9NY84
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-1 in reconstructed human epidermis
-
additional information
-
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-1 in reconstructed human epidermis
-
additional information
2.3fold overexpression of vanin-3 in psioriais
-
additional information
2.3fold overexpression of vanin-3 in psioriais
-
additional information
Q9NY84
2.3fold overexpression of vanin-3 in psioriais
-
additional information
-
2.3fold overexpression of vanin-3 in psioriais
-
additional information
induced expression of vanin-2 in psoriasis and atopic dermatitis
-
additional information
induced expression of vanin-2 in psoriasis and atopic dermatitis
-
additional information
Q9NY84
induced expression of vanin-2 in psoriasis and atopic dermatitis
-
additional information
-
induced expression of vanin-2 in psoriasis and atopic dermatitis
-
additional information
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-3 in reconstructed human epidermis
-
additional information
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-3 in reconstructed human epidermis
-
additional information
Q9NY84
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-3 in reconstructed human epidermis
-
additional information
-
mixture of TNF-alpha, IL-1alpha and IL-6 results in increased expression of vanin-3 in reconstructed human epidermis
-
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Acute Kidney Injury
A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study.
Acute Kidney Injury
Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury.
Albuminuria
Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.
Albuminuria
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Arthritis, Rheumatoid
A sandwich ELISA for detection of soluble GPI-80, a glycosylphosphatidyl-inositol (GPI)-anchored protein on human leukocytes involved in regulation of neutrophil adherence and migration--its release from activated neutrophils and presence in synovial fluid of rheumatoid arthritis patients.
Asthma
Experimental asthma in guinea pigs revisited.
Asthma
Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response.
Carcinogenesis
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Carcinogenesis
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Carcinoma
Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.
Carcinoma
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
Carcinoma
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.
Carcinoma, Renal Cell
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
Carcinoma, Renal Cell
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.
Cardiovascular Diseases
Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases.
Cardiovascular Diseases
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Colitis
Early detection of renal injury using urinary vanin-1 in rats with experimental colitis.
Colitis
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colitis
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Colitis
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
Colitis-Associated Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colitis-Associated Neoplasms
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Colonic Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colorectal Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Cystinosis
Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.
Cystinosis
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Dermatitis, Atopic
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Diabetes Mellitus, Type 1
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
Diabetes Mellitus, Type 2
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Diabetic Nephropathies
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Eczema
Molecular Diagnostics of Psoriasis, Atopic Dermatitis, Allergic Contact Dermatitis and Irritant Contact Dermatitis.
Granuloma
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
HIV Infections
Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.
Hydronephrosis
Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis.
Hypertension
Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.
Hypertension
The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.
Hypertension
Vanin-1 T26I polymorphism, hypertension and cardiovascular events in two large urban-based prospective studies in Swedes.
Ichthyosis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Infections
Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Infections
Dissecting Flavivirus Biology in Salivary Gland Cultures from Fed and Unfed Ixodes scapularis (Black-Legged Tick).
Infections
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Infections
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Infections
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Infections
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Infections
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Inflammatory Bowel Diseases
A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo.
Influenza, Human
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Insulin Resistance
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Kidney Diseases
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Leukemia
Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells.
Leukemia, Myeloid, Acute
Vanin 1 (VNN1) levels predict poor outcome in acute myeloid leukemia.
Liver Diseases
Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids.
Lupus Erythematosus, Systemic
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus.
Lymphohistiocytosis, Hemophagocytic
Are all mutant SNARES equal?
Malaria
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Malaria
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Malaria
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Malaria, Cerebral
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Metabolic Diseases
Bioluminescent Probe for Detection of Starvation-Induced Pantetheinase Upregulation.
Metabolic Diseases
MiR-122 targets the vanin 1 gene to regulate its expression in chickens.
Metabolic Diseases
Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue.
Metabolic Diseases
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Neoplasms
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Neoplasms
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients.
Neoplasms
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
Neoplasms
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
Neoplasms
Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Neoplasms
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.
Neoplasms
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
Neoplasms
Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice.
Neoplasms
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Nephritis
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus.
Non-alcoholic Fatty Liver Disease
Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids.
Obesity
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Pancreatic Neoplasms
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
pantetheine hydrolase deficiency
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
pantetheine hydrolase deficiency
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
pantetheine hydrolase deficiency
Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue.
pantetheine hydrolase deficiency
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
pantetheine hydrolase deficiency
Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia.
Parasitemia
Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J.
Pneumonia
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Psoriasis
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Psoriasis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Psoriasis
Molecular Diagnostics of Psoriasis, Atopic Dermatitis, Allergic Contact Dermatitis and Irritant Contact Dermatitis.
Purpura, Thrombocytopenic, Idiopathic
Value of vanin-1 assessment in adult patients with primary immune thrombocytopenia.
Pyelonephritis
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Q Fever
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Renal Insufficiency, Chronic
Commentary: Urinary vanin-1 and chronic kidney disease in hypertensive patients.
Renal Insufficiency, Chronic
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Renal Insufficiency, Chronic
Urinary vanin-1 associated with chronic kidney disease in hypertensive patients: A pilot study.
Reperfusion Injury
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Sarcoma
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Scleroderma, Systemic
Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.
Sepsis
Plasma Vanin-1 as a Novel Biomarker of Sepsis for Trauma Patients: A Prospective Multicenter Cohort Study.
Shock, Septic
MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1.
Starvation
Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo.
Thymoma
Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage.
Tuberculosis, Pulmonary
Kayne, Pagel and O'shaughnessy's Pulmonary Tuberculosis.
Urinary Tract Infections
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
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Nitto, T.; Inoue, T.; Node, K.
Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils
Gene
426
57-64
2008
Homo sapiens (O95497), Homo sapiens (O95498), Homo sapiens (Q9NY84), Homo sapiens
brenda
Jansen, P.A.; Kamsteeg, M.; Rodijk-Olthuis, D.; van Vlijmen-Willems, I.M.; de Jongh, G.J.; Bergers, M.; Tjabringa, G.S.; Zeeuwen, P.L.; Schalkwijk, J.
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines
J. Invest. Dermatol.
129
2167-2174
2009
Homo sapiens (O95497), Homo sapiens (O95498), Homo sapiens (Q9NY84), Homo sapiens
brenda
Ruan, B.H.; Cole, D.C.; Wu, P.; Quazi, A.; Page, K.; Wright, J.F.; Huang, N.; Stock, J.R.; Nocka, K.; Aulabaugh, A.; Krykbaev, R.; Fitz, L.J.; Wolfman, N.M.; Fleming, M.L.
A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
Anal. Biochem.
399
284-292
2010
Homo sapiens, Mus musculus
brenda
Kaskow, B.J.; Michael Proffit, J.; Blangero, J.; Moses, E.K.; Abraham, L.J.
Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases
Biochem. Biophys. Res. Commun.
417
653-658
2012
Homo sapiens, Mus musculus
brenda
Zhang, B.; Lo, C.; Shen, L.; Sood, R.; Jones, C.; Cusmano-Ozog, K.; Park-Snyder, S.; Wong, W.; Jeng, M.; Cowan, T.; Engleman, E.G.; Zehnder, J.L.
The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP
Blood
117
4569-4579
2011
Homo sapiens
brenda
Hosohata, K.; Ando, H.; Fujiwara, Y.; Fujimura, A.
Vanin-1: a potential biomarker for nephrotoxicant-induced renal injury
Toxicology
290
82-88
2011
Homo sapiens, Rattus norvegicus
brenda
Boersma, Y.L.; Newman, J.; Adams, T.E.; Cowieson, N.; Krippner, G.; Bozaoglu, K.; Peat, T.S.
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation
Acta Crystallogr. Sect. D
70
3320-3329
2014
Homo sapiens (O95497), Homo sapiens
brenda
Wang, Y.J.; Tayo, B.O.; Bandyopadhyay, A.; Wang, H.; Feng, T.; Franceschini, N.; Tang, H.; Gao, J.; Sung, Y.J.; Sung, Y.J.; Elston, R.C.; Williams, S.M.; Cooper, R.S.; Mu, T.W.; Zhu, X.
The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function
PLoS Genet.
10
e1004641
2014
Homo sapiens (O95497)
brenda
Rommelaere, S.; Millet, V.; Rihet, P.; Atwell, S.; Helfer, E.; Chasson, L.; Beaumont, C.; Chimini, G.; Sambo, M.d.o. .R.; Viallat, A.; Penha-Goncalves, C.; Galland, F.; Naquet, P.
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria
Am. J. Pathol.
185
3039-3052
2015
Homo sapiens (O95497), Homo sapiens, Mus musculus (Q9Z0K8), Mus musculus, Mus musculus C57BL/6 (Q9Z0K8)
brenda
Yamashita, N.; Yashiro, M.; Ogawa, H.; Namba, H.; Nosaka, N.; Fujii, Y.; Morishima, T.; Tsukahara, H.; Yamada, M.
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells
Biochem. Biophys. Res. Commun.
489
466-471
2017
Homo sapiens (O95497), Homo sapiens
brenda
Bartucci, R.; Salvati, A.; Olinga, P.; Boersma, Y.L.
Vanin 1 its physiological function and role in diseases
Int. J. Mol. Sci.
20
3891
2019
Homo sapiens (O95497)
brenda