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Information on EC 3.5.1.92 - pantetheine hydrolase

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IUBMB Comments
The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant .
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The enzyme appears in viruses and cellular organisms
Synonyms
GPI-80, PAGEL, pantetheinase, pantetheinase-associated gene expressed in leukocytes, pantetheinases, pantetheine hydrolase, vanin, vanin 1, vanin gene family, vanin-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol
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PATHWAY SOURCE
PATHWAYS
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