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Information on EC 3.5.1.77 - N-carbamoyl-D-amino-acid hydrolase

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IUBMB Comments
This enzyme, along with EC 3.5.1.87 (N-carbamoyl-L-amino-acid hydrolase), EC 5.1.99.5 (hydantoin racemase) and hydantoinase, forms part of the reaction cascade known as the "hydantoinase process", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids . It has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or on the N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases.
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The enzyme appears in viruses and cellular organisms
Synonyms
carbamoylase, dcase, d-carbamoylase, n-carbamyl-d-amino acid amidohydrolase, n-carbamoyl-d-amino acid amidohydrolase, d-ncaase, dcase-m3, n-carbamoyl d-amino acid amidohydrolase, achyuc, n-carbamoyl-d-amino-acid amidohydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an N-carbamoyl-D-amino acid + H2O = a D-amino acid + NH3 + CO2
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