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IUBMB CommentsSome other taurine conjugates are hydrolysed, but not glycine conjugates of bile acids.
The enzyme appears in viruses and cellular organisms
Synonyms
CTH, hydrolase, chenodeoxychoyltaurine,
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hydrolase, chenodeoxychoyltaurine
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CTH
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chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine
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hydrolysis of linear amides
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chenodeoxycholoyltaurine amidohydrolase
Some other taurine conjugates are hydrolysed, but not glycine conjugates of bile acids.
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tauro (3alpha,5beta,7beta,12alpha)-3,7,12-trihydroxycholan-24-oic amide + H2O
taurine + (3alpha,5beta,7beta,12alpha)-3,7,12-trihydroxycholan-24-oic acid
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0.5% of activity compared to taurochenodeoxycholic acid
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tauro-beta-muricholic acid + H2O
taurine + beta-muricholic acid
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62% of activity compared to taurochenodeoxycholic acid
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taurochenodeoxycholic acid + H2O
chenodeoxycholate + taurine
taurocholic acid + H2O
taurine + cholic acid
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2.8% of activity compared to taurochenodeoxycholic acid
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taurodeoxycholic acid + H2O
taurine + deoxycholic acid
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31% of activity compared to taurochenodeoxycholic acid
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taurohyocholic acid + H2O
taurine + hyocholic acid
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24% of activity compared to taurochenodeoxycholic acid
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taurohyodeoxycholic acid + H2O
taurine + hyodeoxycholic acid
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36% of activity compared to taurochenodeoxycholic acid
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tauroursodeoxycholic acid + H2O
taurine + ursodeoxycholic acid
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56% of activity compared to taurochenodeoxycholic acid
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additional information
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taurochenodeoxycholic acid + H2O
chenodeoxycholate + taurine
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best substrate
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taurochenodeoxycholic acid + H2O
chenodeoxycholate + taurine
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best substrate
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additional information
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substrate specificity
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additional information
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hydrolyzes taurine-conjugated bile acids, glycine-conjugated bile acids are no substrates
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additional information
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no activity with glycocholic acid, glyco-7beta-cholic acid, glycodeoxycholic acid, glycochenodeoxycholic acid, glyco-beta-muricholic acid, glycoursodeoxycholic acid, glycohyocholic acid, glycohyodeoxycholic acid
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additional information
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specificity for not only the amino acid moiety but also the steroidal moiety
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additional information
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substrate specificity
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additional information
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hydrolyzes taurine-conjugated bile acids, glycine-conjugated bile acids are no substrates
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additional information
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no activity with glycocholic acid, glyco-7beta-cholic acid, glycodeoxycholic acid, glycochenodeoxycholic acid, glyco-beta-muricholic acid, glycoursodeoxycholic acid, glycohyocholic acid, glycohyodeoxycholic acid
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additional information
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specificity for not only the amino acid moiety but also the steroidal moiety
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dithiodipyridine
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0.1 mM: 15.9% inhibition, 1 mM: 50.2% inhibition, 10 mM: complete inhibition
N-ethylmaleimide
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0.1 mM: 3.5% inhibition, 1 mM: 27.4% inhibition, 10 mM: 90.8% inhibition
p-hydroxymercuribenzoate
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0.00001 mM: 4% inhibition, 0.0001 mM: 60% inhibition, 0.001 mM: complete inhibition
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dithiothreitol
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0.1-1 mM: slight activation, 10 mM: high activation
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additional information
additional information
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kinetic properties
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0.11
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substrate: tauro-7beta-cholic acid
0.69
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substrate: taurocholic acid
13.68
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substrate: tauroursodeoxycholic acid
15.15
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substrate: tauro-beta-muricholic acid
24.45
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substrate: taurochenodeoxycholic acid
5.86
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substrate: taurohyocholic acid
7.56
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substrate: taurodeoxycholic acid
8.74
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substrate: taurohyodeoxycholic acid
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5.6 - 6.4
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broad pH-optimum
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isolated from human feces
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brenda
isolated from human feces
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brenda
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CBH_BIFLN
317
0
35155
Swiss-Prot
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36000
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4 * 36000, SDS-PAGE
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tetramer
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4 * 36000, SDS-PAGE
tetramer
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4 * 36000, SDS-PAGE
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-20°C, stable for 1 month without any loss of activity
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Kawamoto, K.; Horibe, I.; Uchida, K.
Purification and characterization of a new hydrolase for conjugated bile acids, chenodeoxycholyltaurine hydrolase, from Bacteroides vulgatus
J. Biochem.
106
1049-1053
1989
Phocaeicola vulgatus, Phocaeicola vulgatus VI-31
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3.5.1.74 chenodeoxycholoyltaurine hydrolase
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