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Information on EC 3.5.1.6 - beta-ureidopropionase
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3.5.1.6 beta-ureidopropionaseIUBMB Comments
The animal enzyme also acts on beta-ureidoisobutyrate.
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Word Map
- 3.5.1.6
- pyrimidine
- uracil
- dihydropyrimidinase
- thymine
- dihydrouracil
- kluyveri
- nitrilase
-
amidohydrolases
-
beta-aminoisobutyric
- beta-ureidoisobutyrate
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
beta-ureidopropionase, beta-alanine synthase, betaas, 3-ureidopropionase, betaupase, beta-up, n-carbamoyl-beta-alanine amidohydrolase, bup-1, betaup, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
beta-alanine synthase
beta-UP
beta-ureidopropionate decarbamylase
betaAS
N-carbamoyl-beta-alanine amidohydrolase
N-carbamyl-beta-alanine decarbamylase
beta-alanine synthase
Clostridium uracilicum M5-2
-
-
-
beta-ureidopropionate decarbamylase
Clostridium uracilicum M5-2
-
-
-
N-carbamoyl-beta-alanine amidohydrolase
-
-
-
-
N-carbamyl-beta-alanine decarbamylase
Clostridium uracilicum M5-2
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-ureidopropanoate + H2O = beta-alanine + CO2 + NH3
-
-
-
-
3-ureidopropanoate + H2O = beta-alanine + CO2 + NH3
detailed reaction mechanism, catalytic mechanism
3-ureidopropanoate + H2O = beta-alanine + CO2 + NH3
the animal enzyme also acts on beta-ureidoisobutyrate
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of linear amides
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
N-carbamoyl-beta-alanine amidohydrolase
The animal enzyme also acts on beta-ureidoisobutyrate.
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CAS REGISTRY NUMBER
COMMENTARY
9027-27-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-methyl-3-ureidopropionic acid + H2O
3-amino-2-methylpropanoic acid + NH3 + CO2
82% activity in comparison to 3-ureidopropionic acid
-
-
?
3-methyl-3-ureidopropionic acid + H2O
beta-homoalanine + CO2 + NH3
-
-
-
-
?
4-amino-4-oxobutyric acid + H2O
?
3% activity in comparison to 3-ureidopropionic acid
-
-
?
N-carbamoyl-5-aminopentanoate + H2O
5-aminopentanoate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-alpha-amino-beta-alanine + H2O
2,3-diaminopropanoate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-alpha-methyl-beta-alanine + H2O
3-amino-2-methylpropanoic acid + CO2 + NH3
-
-
-
-
?
N-carbamoyl-alpha-phenyl-beta-alanine + H2O
3-amino-2-phenylpropanoic acid + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyric acid + H2O
beta-aminoisobutyric acid + NH3 + CO2
-
-
-
-
?
N-carbamoyl-beta-homoalanine + H2O
beta-homoalanine + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-2-aminovaleric acid + H2O
2-aminopentanoate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-alanine + H2O
DL-alanine + CO2 + NH3
-
poor substrate, relative enzyme activity 4%
-
-
?
N-carbamoyl-homoisoserine + H2O
homoisoserine + CO2 + NH3
-
-
-
-
?
N-carbamyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
2-amino-3-ureidopropionic acid + H2O
3-aminoalanine + CO2 + NH3
-
-
-
-
?
2-amino-3-ureidopropionic acid + H2O
3-aminoalanine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
2-methyl-3-ureidopropionic acid + H2O
alpha-methyl-beta-alanine + CO2 + NH3
-
-
-
-
?
2-methyl-3-ureidopropionic acid + H2O
alpha-methyl-beta-alanine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
-
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
final enzyme of the catabolic pathway of pyrimidine bases, substrate derives from thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
betaAS is the final enzyme of the reductive pyrimidine catabolic pathway, which is responsible for the breakdown of the pyrimidine bases uracil and thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
catalytic mechanism, substrate-binding residues
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
-
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
completes the catabolism of the pyrimidine bases uracil and thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
final enzyme of the catabolic pathway of pyrimidine bases, substrate derives from thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
only one enantiomer of the racemic substrate is hydrolyzed
-
-
?
2-phenyl-3-ureidopropionic acid + H2O
3-amino-2-phenylpropanoic acid + CO2 + NH3
-
-
-
-
?
2-phenyl-3-ureidopropionic acid + H2O
3-amino-2-phenylpropanoic acid + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
2-ureidoethane phosphonic acid + H2O
ciliatine + CO2 + NH3
-
-
-
-
?
2-ureidoethane phosphonic acid + H2O
ciliatine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
3-ureidopropanoate + H2O
beta-alanine + CO2 + NH3
3-ureidopropanoate i.e. N-carbamoyl-beta-alanine
-
-
?
N-carbamoyl-beta-alanine + H2O
?
Clostridium uracilicum
-
-
-
-
?
N-carbamoyl-beta-alanine + H2O
?
Clostridium uracilicum M5-2
-
-
-
-
?
N-carbamoyl-beta-alanine + H2O
?
-
-
-
-
?
N-carbamoyl-beta-alanine + H2O
?
-
-
172056, 172057, 172058, 172059, 172060, 172061, 172062, 172063, 172064, 172065, 172066, 172068, 172069
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
final enzyme of the catabolic pathway of pyrimidine bases, substrate derives from uracil
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
Blastobacter sp.
-
N-carbamoyl-D-amino acid hydrolyzing activity
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
Clostridium uracilicum
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
Clostridium uracilicum M5-2
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
N-carbamoyl-D-amino acid hydrolyzing activity
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
N-carbamoyl-D-amino acid hydrolyzing activity
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
betaAS is the final enzyme of the reductive pyrimidine catabolic pathway, which is responsible for the breakdown of the pyrimidine bases uracil and thymine
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
catalytic mechanism, substrate-binding residues
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
Pigeon
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
completes the catabolism of the pyrimidine bases uracil and thymine
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
L enantiomer specific hydrolysis
-
-
ir
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
-
final enzyme of the catabolic pathway of pyrimidine bases, substrate derives from uracil
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
Blastobacter sp.
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
Pigeon
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
-
?
N-carbamoyl-L-alanine + H2O
L-alanine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
N-carbamoyl-L-methionine + H2O
L-methionine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
N-carbamoyl-L-phenylalanine + H2O
L-phenylalanine + CO2 + NH3
-
-
-
-
?
N-carbamoyl-L-phenylalanine + H2O
L-phenylalanine + CO2 + NH3
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
N-carbamoylglycine + H2O
glycine + CO2 + NH3
-
poor substrate, relative enzyme activity 1%
-
-
?
additional information
?
-
-
the enzyme is involved in the pyrimidine catabolism
-
-
?
additional information
?
-
-
betaAS catalyzes the terminal reaction of the reductive pyrimidine catabolic pathway
-
-
?
additional information
?
-
detailed enzyme/active site structure, a subunit consists of two domains: a larger catalytic domain with a dizinc metal center representing the active site, and a smaller domain mediating the majority of the intersubunit contacts, conformational changes occur during each catalytic cycle
-
-
?
additional information
?
-
-
detailed enzyme/active site structure, a subunit consists of two domains: a larger catalytic domain with a dizinc metal center representing the active site, and a smaller domain mediating the majority of the intersubunit contacts, conformational changes occur during each catalytic cycle
-
-
?
additional information
?
-
-
enzyme shows cooperativity for the substrate and allosteric regulation
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
final enzyme of the catabolic pathway of pyrimidine bases, substrate derives from thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
betaAS is the final enzyme of the reductive pyrimidine catabolic pathway, which is responsible for the breakdown of the pyrimidine bases uracil and thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
completes the catabolism of the pyrimidine bases uracil and thymine
-
-
?
2-methyl-N-carbamoyl-beta-alanine + H2O
2-methyl-beta-alanine + CO2 + NH3
-
final enzyme of the catabolic pathway of pyrimidine bases, substrate derives from thymine
-
-
?
N-carbamoyl-beta-alanine + H2O
?
Clostridium uracilicum
-
-
-
-
?
N-carbamoyl-beta-alanine + H2O
?
Clostridium uracilicum M5-2
-
-
-
-
?