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Information on EC 3.5.1.4 - amidase and Organism(s) Rattus norvegicus and UniProt Accession Q5KTC7
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3.5.1.4 amidaseSpecify your search results
Word Map
- 3.5.1.4
-
deamination
- 1-aminocyclopropane-1-carboxylate
- peptidoglycan
- cytidine
- inosine
- esterase
- nitrile
-
siderophore
-
growth-promoting
- rhodococcus
-
hydratase
-
endocannabinoids
- cannabinoids
- iaa
- penicillin
-
hypermutation
- autolysins
-
endophytic
-
indole-3-acetic
-
rhizosphere
- rhizobacteria
- apobec3s
- deoxycytidine
-
editor
-
activation-induced
- porphobilinogen
- palmitoylethanolamide
-
a-to-i
- glucosamine-6-phosphate
- erythropolis
- porphyria
- 2-arachidonoylglycerol
- endolysins
- monoacylglycerol
- ehna
-
rna-specific
-
biofertilizer
-
dihydrolase
- uroporphyrinogens
-
polypeptide-like
- muropeptides
- deoxycytidylate
-
bacteriolytic
- 5-fluorocytosine
- dcmp
-
2\'-deoxycoformycin
-
diphosphohydrolase
- synthesis
- deoxycoformycin
-
pngase
-
ecto-5\'-nucleotidase
- drug development
- biotechnology
- environmental protection
- medicine
- industry
- pharmacology
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
amidase, deaminase, acylase, acetamidase, amide hydrolase, acid transferase, n-acylethanolamine acid amidase, n-acylethanolamine-hydrolyzing acid amidase, atfaah, acylamidase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acid transferase
-
-
-
-
acylamidase
-
-
-
-
acylase
-
-
-
-
amide hydrolase
-
-
-
-
amide transferase
-
-
-
-
amidohydrolase
-
-
-
-
deaminase
-
-
-
-
ester transferase
-
-
-
-
N-acetylaminohydrolase
-
-
-
-
Wide spectrum amidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic acid amide
transfer of amide group
transfer of acyl group
hydrolysis of carboxylic acid amide
-
-
-
-
transfer of amide group
-
-
-
-
transfer of acyl group
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acylamide amidohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY
9012-56-0
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
anandamide + H2O
arachidonic acid + ethanolamine
substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide
-
-
?
arachidonoyl-ethanolamine + H2O
arachidonic acid + ethanolamine
-
hydrolysis of anandamide
-
-
?
N-(4-hydroxy-2-methylphenyl)arachidonylamide + H2O
4-amino-3-cresol + arachidonic acid
-
i.e. VDM11, 15-20% of the activity with anandamide
-
-
?
N-(4-hydroxyphenyl)arachidonylamide + H2O
4-aminophenol + arachidonic acid
-
i.e. AM404
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine
-
-
?
additional information
?
-
hardly hydrolyzes 2-arachidonoylglycerol
-
-
?
additional information
?
-
hardly hydrolyzes 2-arachidonoylglycerol
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(+/-)-(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
-
-
(+/-)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid 5-phenylpentyl ester
-
potent inhibitor, rapidly cleaved in plasma
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[2-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[2-(trifluoromethyl)phenyl]heptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[3-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[3-(trifluoromethyl)phenyl]heptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[4-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[4-(trifluoromethyl)phenyl]heptan-1-one
-
-
1-nor-arachidonoyl-3-(2'3-dihydroxypropyl) urea
-
i.e. O-1502, complete inhibition at 0.1 mM
2,3-dihydroxypropyl (11Z)-icos-11-enoate
-
i.e. O-4066, IC50: 0.010, complete inhibition is possible
2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate
-
i.e. O-3907, IC50: 0.0057, complete inhibition is possible
2,3-dihydroxypropyl (4Z,7Z,10Z,13Z)-17-ethylcycloheptadeca-4,7,10,13-tetraene-1-carboxylate
-
i.e. O-1428, 28% inhibition at 0.1 mM
2,3-dihydroxypropyl (5Z)-icos-5-enoate
-
i.e. 3908, IC50: 0.011, 84% inhibition is possible
2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate
-
i.e. O-3973, IC50: 0.0024, 95% inhibition is possible
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
-
i.e. O-3832, IC50: 0.0076, complete inhibition is possible
2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate
-
i.e. O-4081, IC50: 0.0051, 90% inhibition is possible
2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate
-
i.e. O-3872, IC50: 0.014, complete inhibition is possible
2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate
-
i.e. 3846, IC50: 0.023, complete inhibition is possible
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models of persistent (formalin test) and neuropathic (Chung model) pain
2-[methyl(4-phenylbutyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanol
-
-
3-(4-anilinophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-benzylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-phenoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-phenoxyphenyl)-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
-
-
3-biphenyl-4-yl-1-[5-[6-(1H-tetrazol-1-yl)pyridin-2-yl]-1,3-oxazol-2-yl]propan-1-one
-
-
3-[4-(benzyloxy)cyclohexa-1,5-dien-1-yl]-1-[1,3]oxazolo[4,5-b]pyridin-2-ylpropan-1-one
-
-
3-[4-(benzyloxy)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[4-(phenoxymethyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[4-(phenoxymethyl)phenyl]-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
-
-
3-[4-(phenoxymethyl)phenyl]-1-[5-[6-(1H-tetrazol-5-yl)pyridin-2-yl]-1,3-oxazol-2-yl]propan-1-one
-
-
3-[4-(phenylthio)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[4-[hydroxy(phenyl)methyl]cyclohexa-1,5-dien-1-yl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[4-[hydroxy(phenyl)methyl]phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[methyl(3-phenylpropyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
4-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
4-[methyl(2-phenylethyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)butan-1-one
-
-
5-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(morpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(piperidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(thiomorpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carbonitrile
-
-
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-3-carboxylic acid
-
-
6-(2-[3-[4-(piperidin-4-yloxy)phenyl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carbonitrile
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(3-[4'-[(4-aminopiperazin-1-yl)methyl]biphenyl-4-yl]propyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-[3-(4-[[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy]phenyl)propyl]-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
7-(2,3-dichlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-phenyl-1-[5-[6-(1H-tetrazol-5-yl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-[2-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[3-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[3-(tert-butylamino)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[4-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[4-(tert-butylamino)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
alpha-methyl-1-arachidonoylglycerol
-
IC50: 0.033 mM, complete inhibition at 0.1 mM
ethyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
Ibuprofen
-
both enantiomers, more potent inhibitors at pH 5.3 than at pH 8.4
methyl 2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxylate
-
-
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
methyl 4-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
methyl 5-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(morpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(piperidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(thiomorpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-3-carboxylate
-
-
methyl 6-(2-[3-[4-(piperidin-4-yloxy)phenyl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-(3-[4'-[(dimethylamino)methyl]biphenyl-4-yl]propyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-[3-(4-[[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy]phenyl)propyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
N,N-dimethyl-2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxamide
-
-
N,N-dimethyl-2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
N-(4-hydroxy-2-methylphenyl)arachidonylamide
-
i.e. VDM11, an anandamide uptake inhibitor, IC50 is 0.0026 mM, inhibitory potency depends upon the concentration of bovine serum albumin
N-(4-hydroxyphenyl)arachidonylamide
-
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM
N-methyl-2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
oleoyltrifluoromethylketone
-
more potent inhibitor at pH 5.3 than at pH 8.4
phenylmethyl sulfonyl fluoride
-
more potent inhibitor at pH 8.4 than at pH 5.3
tert-butyl [3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]phenyl]carbamate
-
-
tert-butyl [4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]phenyl]carbamate
-
-
(5Z,8Z,11Z,14Z)-eicosantetraenoic acid 3-thienyl methyl ester
-
i.e. CAY-10402
(5Z,8Z,11Z,14Z)-eicosantetraenoic acid 3-thienyl methyl ester
-
i.e. CAY-10402, IC50: 0.010 mM, 37% inhibition at 0.1 mM
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
-
i.e. URB597, specific, complete inhibition at 0.001 mM
additional information
-
inactivation of FAAH might affect the levels of 2-arachidonoylglycerol and, hence, the activity of CB1 receptors
-
additional information
-
N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors, synthesis and structure-activity and structure-property relationships, overview. The beta-lactone ring is responsible for inhibition and and low compound stability. The compounds inhibit NAAA with a rapid, noncompetitive, and reversible mechanism, consistent with the acylation of the catalytic Cys131
-
additional information
-
N-(2-oxo-3-oxetanyl)amide inhibitor synthesis and evaluation, overview. No inhibition by N-pentadecylcyclohexanecarboxamide
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000004
1-(5-iodo-1,3-oxazol-2-yl)-3-[4-(phenoxymethyl)phenyl]propan-1-one
-
-
0.000016
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[2-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
0.000004
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[2-(trifluoromethyl)phenyl]heptan-1-one
-
-
0.00001
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[3-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
0.000001
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[3-(trifluoromethyl)phenyl]heptan-1-one
-
-
0.000075
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[4-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
0.000004
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[4-(trifluoromethyl)phenyl]heptan-1-one
-
-
0.000025
1-([4'-[3-(1,3-oxazol-2-yl)propyl]biphenyl-4-yl]methyl)piperidine
-
-
0.000003
2-(3-biphenyl-4-ylpropanoyl)-N,N-dimethyl-1,3-oxazole-5-carboxamide
-
-
0.000008
2-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.001
2-[(4-phenylbutyl)sulfinyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
0.02
2-[(4-phenylbutyl)sulfonyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
0.000004
2-[(4-phenylbutyl)thio]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
0.000041
2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxylic acid
-
-
0.0021
2-[3-(benzyloxy)phenoxy]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
0.0000005
2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carbonitrile
-
-
0.0000045
2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
0.000022
2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxylic acid
-
-
0.0053
2-[4-(benzyloxy)phenoxy]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
0.002
2-[methyl(4-phenylbutyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanol
-
-
0.00000075
3-(2-naphthyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.00009
3-(3-phenylpropoxy)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000002
3-(4-anilinophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.0000032
3-(4-benzylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.0000034
3-(4-phenoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000002
3-(4-phenoxyphenyl)-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
-
-
0.00000075
3-biphenyl-4-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.0000011
3-biphenyl-4-yl-1-(5-pyridin-3-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.0000023
3-biphenyl-4-yl-1-(5-pyridin-4-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000003
3-biphenyl-4-yl-1-[5-(methylthio)-1,3-oxazol-2-yl]propan-1-one
-
-
0.000008
3-biphenyl-4-yl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]propan-1-one
-
-
0.0000007
3-biphenyl-4-yl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
-
-
0.000025
3-biphenyl-4-yl-1-[5-[6-(1H-tetrazol-1-yl)pyridin-2-yl]-1,3-oxazol-2-yl]propan-1-one
-
-
0.000035
3-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000025
3-[3-(benzyloxy)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.00000038
3-[4-(benzyloxy)cyclohexa-1,5-dien-1-yl]-1-[1,3]oxazolo[4,5-b]pyridin-2-ylpropan-1-one
-
-
0.0000013
3-[4-(benzyloxy)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000001
3-[4-(phenoxymethyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.0000008
3-[4-(phenoxymethyl)phenyl]-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
-
-
0.000021
3-[4-(phenoxymethyl)phenyl]-1-[5-[6-(1H-tetrazol-5-yl)pyridin-2-yl]-1,3-oxazol-2-yl]propan-1-one
-
-
0.0000022
3-[4-(phenylthio)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000001
3-[4-[hydroxy(phenyl)methyl]cyclohexa-1,5-dien-1-yl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000001
3-[4-[hydroxy(phenyl)methyl]phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.0002
3-[methyl(3-phenylpropyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
0.000063
4-(2-phenylethoxy)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)butan-1-one
-
-
0.0005
4-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.00005
4-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.0035
4-[methyl(2-phenylethyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)butan-1-one
-
-
0.0025
5-(benzylsulfinyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
-
-
0.0015
5-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000044
5-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.0002
5-[benzyl(methyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
-
-
0.00015
6-(2-[3-[4'-(morpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
0.000033
6-(2-[3-[4'-(piperidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
0.00013
6-(2-[3-[4'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
0.000028
6-(2-[3-[4'-(thiomorpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
0.0000003
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carbonitrile
-
-
0.000006
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
0.0000046
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-3-carboxylic acid
-
-
0.011
6-(2-[3-[4-(piperidin-4-yloxy)phenyl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
0.0002
6-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.01
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]nicotinic acid
-
-
0.02
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
0.0011
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.0000013
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
0.000014
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]nicotinic acid
-
-
0.0000029
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carbonitrile
-
-
0.0000012
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
0.000022
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.004
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
0.01
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.0012
6-[2-(3-[4'-[(4-aminopiperazin-1-yl)methyl]biphenyl-4-yl]propyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.0000029
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carbonitrile
-
-
0.00002
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.000033
6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]nicotinic acid
-
-
0.000065
6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.00012
6-[2-[3-(4-[[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy]phenyl)propyl]-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
0.00004
6-[methyl(phenyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
0.000005
7-(2,3-dichlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000009
7-(2,3-dichlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000013
7-(2-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000019
7-(2-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000008
7-(2-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000017
7-(2-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000058
7-(2-methoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000003
7-(2-methylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000017
7-(2-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.00003
7-(3-aminophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000007
7-(3-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000009
7-(3-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000032
7-(3-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000022
7-(3-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000025
7-(3-methoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000033
7-(3-methylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.00000048
7-(3-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.000003
7-(4-aminophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.00002
7-(4-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.000027
7-(4-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000036
7-(4-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000032
7-(4-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000062
7-(4-methoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000028
7-(4-methylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000031
7-(4-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000065
7-(4-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000035
7-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000026
7-naphthalen-1-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000011
7-naphthalen-2-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000047
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.00004
7-phenyl-1-[5-[6-(1H-tetrazol-5-yl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
0.00028
7-pyridin-2-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0003
7-pyridin-3-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.00015
7-pyridin-4-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
0.0000033
7-[2-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000042
7-[3-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000024
7-[3-(tert-butylamino)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000025
7-[4-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.0000056
7-[4-(tert-butylamino)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
0.000003
ethyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.0000015
methyl 2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazole-5-carboxylate
-
-
0.0000017
methyl 2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxylate
-
-
0.0000016
methyl 2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxylate
-
-
0.000034
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
0.000037
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
0.000001
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzoate
-
-
0.00003
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
0.0000013
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
0.0000019
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzoate
-
-
0.0000015
methyl 4-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.000025
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
0.000019
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
0.0000015
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzoate
-
-
0.0000006
methyl 5-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.000031
methyl 6-(2-[3-[4'-(morpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
0.000009
methyl 6-(2-[3-[4'-(piperidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
0.000018
methyl 6-(2-[3-[4'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
0.000005
methyl 6-(2-[3-[4'-(thiomorpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
0.000002
methyl 6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
0.0000035
methyl 6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-3-carboxylate
-
-
0.0045
methyl 6-(2-[3-[4-(piperidin-4-yloxy)phenyl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
0.009
methyl 6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.0011
methyl 6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
0.0000012
methyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.0000022
methyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
0.007
methyl 6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.05
methyl 6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
0.000029
methyl 6-[2-(3-[4'-[(dimethylamino)methyl]biphenyl-4-yl]propyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.000008
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.0000035
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
0.000013
methyl 6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.000054
methyl 6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
0.000032
methyl 6-[2-[3-(4-[[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy]phenyl)propyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
0.0000054
N,N-dimethyl-2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxamide
-
-
0.0000067
N,N-dimethyl-2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
0.000011
N-methyl-2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxamide
-
-
0.0000036
N-methyl-2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
0.000012
tert-butyl [3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]phenyl]carbamate
-
-
0.000023
tert-butyl [4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]phenyl]carbamate
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.09
(+/-)-(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
-
0.098
(+/-)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.012
(+/-)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.051
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.0075
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
Rattus norvegicus
-
-
0.019
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
-
0.0049
(2R,3R)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.1
(2R,3S)-2-methyl-4-oxo-3-oxetanylcarbamic acid benzyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.08
(2R,3S)-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.000127
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid 5-phenylpentyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.001
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid benzyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.00022
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.00019
(2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.01
(5Z,8Z,11Z,14Z)-eicosantetraenoic acid 3-thienyl methyl ester
Rattus norvegicus
-
i.e. CAY-10402, IC50: 0.010 mM, 37% inhibition at 0.1 mM
0.0005
(R)-(2-oxo-3-oxetanyl)carbamic acid tert-butyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.0492
(R)-1-methyl-3-(2-oxo-3-oxetanyl)urea
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.0007
(R)-2-oxo-3-oxetanylcarbamic acid benzyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.1
(R,S)-2-oxocyclobutylcarbamic acid benzyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.00058
(S)-(2-oxo-3-oxetanyl)carbamic acid tert-butyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.015
(S)-1-methyl-3-(2-oxo-3-oxetanyl)urea
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.00296
(S)-2-oxo-3-oxetanylcarbamic acid benzyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.091
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.01
2,3-dihydroxypropyl (11Z)-icos-11-enoate
Rattus norvegicus
-
i.e. O-4066, IC50: 0.010 mM, complete inhibition is possible
0.0057
2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate
Rattus norvegicus
-
i.e. O-3907, IC50: 0.0057 mM, complete inhibition is possible
0.011
2,3-dihydroxypropyl (5Z)-icos-5-enoate
Rattus norvegicus
-
i.e. O-3908, IC50: 0.011 mM, 84% inhibition is possible
0.0024
2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate
Rattus norvegicus
-
i.e. O-3973, IC50: 0.0024, 95% inhibition is possible
0.0076
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
Rattus norvegicus
-
i.e. O-3832, IC50: 0.0076 mM, complete inhibition is possible
0.0051
2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate
Rattus norvegicus
-
i.e. O-4081, IC50: 0.0051 mM, 90% inhibition is possible
0.014
2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate
Rattus norvegicus
-
i.e. O-3872, IC50: 0.014, complete inhibition is possible
0.023
2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate
Rattus norvegicus
-
i.e. 3846, IC50: 0.023, complete inhibition is possible
0.021
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.000002
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
-
-
0.033
alpha-methyl-1-arachidonoylglycerol
Rattus norvegicus
-
IC50: 0.033 mM, complete inhibition at 0.1 mM
0.0049
arachidonoyl glycine
Rattus norvegicus
-
IC50: 0.0049 mM, complete inhibition at 0.1 mM
0.1
cyclobutylcarbamic acid benzyl ester
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.0026
N-(4-hydroxy-2-methylphenyl)arachidonylamide
Rattus norvegicus
-
i.e. VDM11, an anandamide uptake inhibitor, IC50 is 0.0026 mM, inhibitory potency depends upon the concentration of bovine serum albumin
0.0021
N-(4-hydroxyphenyl)arachidonylamide
Rattus norvegicus
-
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM
0.000115
N-[(3S)-2-oxooxetan-3-yl]biphenyl-4-carboxamide
Rattus norvegicus
-
pH 5.0, 37°C, recombinant enzyme
0.0053
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
basophilic leukemia cell. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C249A
-
inhibition of the mutant by ibuprofen is similar than that of wild type
S152A
-
inhibition of the mutant by ibuprofen is similar than that of wild type
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
FAAH inhibition shows potential utility for the clinical treatment of persistent and neuropathic pain
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holt, S.; Nilsson, J.; Omeir, R.; Tiger, G.; Fowler, C.J.
Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen
Br. J. Pharmacol.
133
513-520
2001
Rattus norvegicus
Vandevoorde, S.; Saha, B.; Mahadevan, A.; Razdan, R.K.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase
Biochem. Biophys. Res. Commun.
337
104-109
2005
Rattus norvegicus
Ghafouri, N.; Tiger, G.; Razdan, R.K.; Mahadevan, A.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol
Br. J. Pharmacol.
143
774-784
2004
Rattus norvegicus
Vandevoorde, S.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate
Br. J. Pharmacol.
145
885-893
2005
Rattus norvegicus
Cisneros, J.A.; Vandevoorde, S.; Ortega-Gutierrez, S.; Paris, C.; Fowler, C.J.; Lopez-Rodriguez, M.L.
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis - comparison with effects upon fatty acid amide hydrolase
J. Med. Chem.
50
5012-5023
2007
Rattus norvegicus
Sit, S.Y.; Conway, C.; Bertekap, R.; Xie, K.; Bourin, C.; Burris, K.; Deng, H.
Novel inhibitors of fatty acid amide hydrolase
Bioorg. Med. Chem. Lett.
17
3287-3291
2007
Homo sapiens, Rattus norvegicus
Tsuboi, K.; Takezaki, N.; Ueda, N.
The N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Chem. Biodivers.
4
1914-1925
2007
Homo sapiens (O00519), Homo sapiens (Q02083), Homo sapiens, Mus musculus (O08914), Mus musculus (Q9D7V9), Mus musculus, Rattus norvegicus (P97612), Rattus norvegicus (Q5KTC7), Sus scrofa (Q9TUI8)
Lodola, A.; Mor, M.; Rivara, S.; Christov, C.; Tarzia, G.; Piomelli, D.; Mulholland, A.J.
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
Chem. Commun. (Camb. )
2
214-216
2008
Rattus norvegicus
Kaczocha, M.; Hermann, A.; Glaser, S.T.; Bojesen, I.N.; Deutsch, D.G.
Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase
J. Biol. Chem.
281
9066-9075
2006
Rattus norvegicus
Hardouin, C.; Kelso, M.J.; Romero, F.A.; Rayl, T.J.; Leung, D.; Hwang, I.; Cravatt, B.F.; Boger, D.L.
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase
J. Med. Chem.
50
3359-3368
2007
Homo sapiens, Rattus norvegicus
Kimball, F.S.; Romero, F.A.; Ezzili, C.; Garfunkle, J.; Rayl, T.J.; Hochstatter, D.G.; Hwang, I.; Boger, D.L.
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase
J. Med. Chem.
51
937-947
2008
Homo sapiens, Rattus norvegicus
Di Marzo, V.; Maccarrone, M.
FAAH and anandamide: is 2-AG really the odd one out?
Trends Pharmacol. Sci.
29
229-233
2008
Rattus norvegicus
Duranti, A.; Tontini, A.; Antonietti, F.; Vacondio, F.; Fioni, A.; Silva, C.; Lodola, A.; Rivara, S.; Solorzano, C.; Piomelli, D.; Tarzia, G.; Mor, M.
N-(2-Oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships
J. Med. Chem.
55
4824-4836
2012
Rattus norvegicus
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