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Information on EC 3.5.1.38 - glutamin-(asparagin-)ase

for references in articles please use BRENDA:EC3.5.1.38

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IUBMB Comments

The enzyme from the bacterium Achromobacter hydrolyses L-asparagine at 0.8 of the rate of L-glutamine; the D-isomers are also hydrolysed, but more slowly. cf. EC 3.5.1.2, glutaminase and EC 3.5.1.1, asparaginase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
glutaminase-asparaginase, asparaginase a, periplasmic glutaminase/asparaginase, glutamin-(asparagin-)ase, glutaminase/asparaginase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
L-asparagine is hydrolysed at 0.8 of the rate of L-glutamine, the D-isomers are also hydrolysed, but more slowly
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PATHWAY SOURCE
PATHWAYS
MetaCyc
ammonia assimilation cycle III, glutaminyl-tRNAgln biosynthesis via transamidation, L-asparagine biosynthesis III (tRNA-dependent), L-asparagine degradation I, L-asparagine degradation III (mammalian), L-citrulline biosynthesis, L-glutamate biosynthesis I, L-glutamine degradation I, superpathway of L-aspartate and L-asparagine biosynthesis