BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
formylmethionine deformylase,
morePlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-formyl-L-methionine deformylase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-formyl-L-methionine + H2O = formate + L-methionine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
hydrolysis of peptide bond
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-formyl-L-methionine amidohydrolase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-formyl-alanine + H2O
formate + alanine
-
at 2-7% of the activity with N-formyl-methionine, depending on tissue
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
N-formyl-leucine + H2O
formate + leucine
-
at 0.8-12% of the activity with N-formyl-methionine, depending on tissue
-
-
?
additional information
?
-
N-formyl-L-methionine + H2O
formate + L-methionine
-
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
-
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
-
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
-
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
-
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
-
-
-
?
additional information
?
-
-
no activity with N-formyl-L-methionyl-L-Ala
-
-
?
additional information
?
-
-
the enzyme might indirectly be involved in protein biosynthesis
-
-
?
additional information
?
-
-
the enzyme may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
?
-
additional information
?
-
-
the enzyme might indirectly be involved in protein biosynthesis
-
-
?
additional information
?
-
-
the enzyme may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Co2+
-
0.1 mM, 7-10fold stimulation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,10-phenanthroline
-
2 mM, 90-100% inhibition
dithiothreitol
-
2 mM, 90-100% inhibition
EDTA
-
2 mM, 65-80% inhibition
phenylmethanesulfonyl fluoride
-
2 mM, 10% inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3.3 - 12.5
N-formyl-methionine
3.3
N-formyl-methionine
-
enzyme from spleen
3.8
N-formyl-methionine
-
-
5
N-formyl-methionine
-
enzyme from brain, heart or muscle
6.5
N-formyl-methionine
-
enzyme from kidney
12.5
N-formyl-methionine
-
enzyme from liver
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7.4
-
-
additional information
-
activity in 0.1 M Tris buffer is 10fold lower than in 0.1 M phosphate buffer, pH 8.5
additional information
-
27% more active with phosphate than with Tris-Cl- buffer
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6.5 - 9.5
-
pH 6.5: about 75% of maximal activity, pH 9.5: about 50% of maximal activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
A0A6I3VDG8_STREE
136
0
15369
TrEMBL
-
A0A064C274_STREE
136
0
15305
TrEMBL
-
A0A4N5NCY0_STREE
136
0
15362
TrEMBL
-
A0A4N2HNH0_STREE
136
0
15349
TrEMBL
-
A0A4G5Q0Y0_STREE
94
1
10518
TrEMBL
-
A0A4U9ZSU3_STRGN
136
1
15482
TrEMBL
-
F9US20_LACPL
Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
136
0
15047
TrEMBL
-
F2QCC7_STROU
Streptococcus oralis (strain Uo5)
136
1
15400
TrEMBL
-
A0A0T7YLR0_STREE
136
1
15413
TrEMBL
-
A0A654U7H9_MYCTX
53
0
5970
TrEMBL
-
A0A4U9XRR7_STRMT
136
0
15422
TrEMBL
-
A0A0E8T281_STREE
136
0
15358
TrEMBL
-
A0A822QBI9_9STRE
136
0
15436
TrEMBL
-
A0A0T7ZN62_STREE
136
0
15430
TrEMBL
-
F0HVS6_LACDL
143
0
15423
TrEMBL
-
A0A0T8EF89_STREE
136
0
15380
TrEMBL
-
A0A4M3JJV8_STREE
136
0
15420
TrEMBL
-
A0A4J2FKX7_STREE
136
0
15372
TrEMBL
-
A0A0T8UAW6_9STRE
136
0
15331
TrEMBL
-
I6L8M1_STREE
136
0
15372
TrEMBL
-
A0A0T7K1S3_STREE
136
0
15371
TrEMBL
-
A0A4V0EQF1_STROR
136
1
15390
TrEMBL
-
A0A0E7TCL9_STREE
136
0
15381
TrEMBL
-
A0A4G3V854_STREE
103
1
11462
TrEMBL
-
A0A0U0KJR1_STREE
136
0
15338
TrEMBL
-
A0A4V0ETK9_STRGN
136
1
15461
TrEMBL
-
A0A4J2FPH3_STREE
136
0
15367
TrEMBL
-
Q8GDQ9_HELMO
166
0
18505
TrEMBL
-
A0A0H2ZM43_STRP2
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
136
0
15372
TrEMBL
-
A0A654XNB4_STREE
136
1
15281
TrEMBL
-
Q5FMW0_LACAC
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
137
0
15487
TrEMBL
-
A0A0T7ILF0_9STRE
136
0
15400
TrEMBL
-
A0A0U0E416_STREE
136
0
15341
TrEMBL
-
A0A0Y3L8S6_STREE
136
0
15381
TrEMBL
-
Q8DP22_STRR6
136
0
15372
TrEMBL
-
A0A0T8BV07_STREE
136
0
15464
TrEMBL
-
A8AZ14_STRGC
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
136
1
15495
TrEMBL
-
A0A0U0ANN2_STREE
136
1
15404
TrEMBL
-
A0A0H2UR41_STRPN
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
136
0
15372
TrEMBL
-
A0A8B4IL56_STRGN
136
1
15465
TrEMBL
-
A0A655F669_MYCTX
154
0
16551
TrEMBL
-
A0A0T8SNA2_STREE
136
0
15339
TrEMBL
-
A0A0T8VUY1_STREE
136
0
15394
TrEMBL
-
A0A655FKU1_MYCTX
102
0
11031
TrEMBL
-
D3HA84_STRM6
Streptococcus mitis (strain B6)
136
0
15426
TrEMBL
-
A0A4V0BWG7_9STRE
136
0
15384
TrEMBL
-
DEF_ECOLI
Escherichia coli (strain K12)
169
0
19328
Swiss-Prot
other Location (Reliability: 4)
Q8I372_PLAF7
241
1
28394
TrEMBL
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ackerman, S.K.; Douglas, S.D.
N-Formyl-L-methionine deformylase activity in human leucocytes and platelets
Biochem. J.
182
885-887
1979
Homo sapiens
brenda
Grisolia, S.; Reglero.A.; Rivas, J.
N-Formyl-methionine deformylase of animal tissues
Biochem. Biophys. Res. Commun.
77
237-244
1977
Bos taurus, Gallus gallus, Rattus norvegicus, Sus scrofa
brenda
Aronson, J.N.; Lugay, J.C.
N-Formylmethionine deformylase from Euglena gracilis
Biochem. Biophys. Res. Commun.
34
311-314
1969
Euglena gracilis
brenda
Select items on the left to see more content.
html completed
3.5.1.31 formylmethionine deformylase
top
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
