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Information on EC 3.5.1.23 - ceramidase and Organism(s) Mus musculus and UniProt Accession Q8R4X1

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.23 ceramidase
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This record set is specific for:
Mus musculus
UNIPROT: Q8R4X1 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
adipor2, adiponectin receptor, ceramidase, acid ceramidase, asah1, neutral ceramidase, acdase, ncdase, acer2, acer3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkaline ceramidase
-
alkaline ceramidase 1
ACER1
ceramidase
-
maCER1
mouse alkaline ceramidase
ACER
-
-
acid ceramidase
acylsphingosine deacylase
-
-
-
-
alkaline ceramidase
-
-
alkaline ceramidase 2
ACER2
alkaline ceramidase 3
ACER3
CDase
ceramidase
glycosphingolipid ceramide deacylase
-
-
-
-
N-acylsphingosine amidohydrolase
-
-
-
-
N-acylsphingosine amidohydrolase 2
-
N-acylsphingosine deacylase
nCDase
neutral CDase
-
-
neutral ceramidase
PHP32
-
-
-
-
Putative 32 KDA heart protein
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a ceramide + H2O = a carboxylate + sphingosine
show the reaction diagram
neutral CDase contains a zinc ion in the active site that functions as a catalytic center, and the hydrolysis of the N-acyl linkage in ceramide proceeds through a mechanism that is similar to that described for zinc-dependent carboxypeptidase, reaction mechanism, overview
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
hydrolysis of peptide bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
N-acylsphingosine amidohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37289-06-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ceramide + H2O
sphingosine + fatty acid
show the reaction diagram
-
-
-
?
D-erythro-C12-NBD-ceramide + H2O
D-erythro-sphingosine + 4-nitrobenzo-2-oxa-1,3-diazoyl-dodecanoic acid
show the reaction diagram
maCER1 has a highly restricted substrate specificity, maCER1 has a major ceramidase activity and only a very minor reverse activity
-
-
r
11-[[9-(diethylamino)-5-oxo-5H-benzo[a]phenoxazin-2-yl]oxy]-N-[(2S,3R,4E)-1,3-dihydroxy-7-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hept-4-en-2-yl]undecanamide + H2O
?
show the reaction diagram
-
-
-
ir
4-nitrobenzo-2-oxa-1,3-diazole-C12-ceramide + H2O
4-nitrobenzo-2-oxa-1,3-diazole-dodecanoic acid + ceramide
show the reaction diagram
-
-
-
-
?
4-nitrobenzo-2-oxa-1,3-diazole-N-dodecanoylsphingosine + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitrobenzo-2-oxa-1,3-diazole-N-hexanoylsphingosine + H2O
?
show the reaction diagram
-
-
-
-
?
C12-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + H2O
?
show the reaction diagram
-
-
-
-
?
C16-14C-ceramide + H2O
?
show the reaction diagram
-
-
-
-
?
C5-ceramide + H2O
valerate + sphingosine
show the reaction diagram
-
-
-
?
ceramide + H2O
sphingosine + fatty acid
show the reaction diagram
D-erythro-C12-NBD-ceramide + H2O
D-erythro-sphingosine + 4-nitrobenzo-2-oxa-1,3-diazoyl-dodecanoic acid
show the reaction diagram
-
substrate in activity assay
-
-
?
D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O
12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine
show the reaction diagram
-
-
-
-
r
N-acyl-sphingosine + H2O
a carboxylate + sphingosine
show the reaction diagram
N-acylsphingosine + H2O
carboxylate + sphingosine
show the reaction diagram
the carboxylate is a fatty acid
-
-
?
N-laurylsphingosine + H2O
laureate + sphingosine
show the reaction diagram
-
-
-
-
?
N-oleoyl-D-erythro-ceramide + H2O
oleate + D-erythro-sphingosine
show the reaction diagram
N-palmitoyl-D-erythro-sphingosine + H2O
D-erythro-sphingosine + palmitic acid
show the reaction diagram
-
-
-
-
?
N-palmitoylphytosphingosine + H2O
?
show the reaction diagram
-
-
-
-
?
N-palmitoylsphinganine + H2O
palmitic acid + sphinganine
show the reaction diagram
-
-
-
-
?
N-palmitoylsphingosine + H2O
palmitic acid + sphingosine
show the reaction diagram
-
-
-
-
?
N-stearoylphytosphingosine + H2O
?
show the reaction diagram
-
-
-
-
?
N-stearoylsphinganine + H2O
stearic acid + sphinganine
show the reaction diagram
-
-
-
-
?
N-stearoylsphingosine + H2O
stearic acid + sphingosine
show the reaction diagram
-
-
-
-
?
N-[(2S,3R,4E)-7-[[9-(diethylamino)-5-oxo-5H-benzo[a]phenoxazin-3-yl]oxy]-1,3-dihydroxyhept-4-en-2-yl]-11-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]undecanamide + H2O
?
show the reaction diagram
fluorescently labelled ceramide analogue, 5.8% hydrolýsis
-
-
ir
octanoyl-D-erythro-sphingosine + H2O
?
show the reaction diagram
-
substrate activity assay
-
-
?
palmitoyl-D-[erythro-9,10]sphingosine + H2O
palmitate + D-erythro-sphingosine
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ceramide + H2O
sphingosine + fatty acid
show the reaction diagram
-
-
-
?
ceramide + H2O
sphingosine + fatty acid
show the reaction diagram
N-acyl-sphingosine + H2O
a carboxylate + sphingosine
show the reaction diagram
-
the Asah2-encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the cellular levels of bioactive sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, in the intestinal tract
-
-
?
N-acylsphingosine + H2O
carboxylate + sphingosine
show the reaction diagram
the carboxylate is a fatty acid
-
-
?
N-oleoyl-D-erythro-ceramide + H2O
oleate + D-erythro-sphingosine
show the reaction diagram
-
common substrate in erythrocytes
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
slightly activates in a dose-dependent manner
Mg2+
-
-
Zn2+
neutral CDase contains a zinc ion in the active site that functions as a catalytic center
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
1 mM, 60% inhibition, inhibits in a dose-dependent manner
Mn2+
1 mM, 10% inhibition, inhibits in a dose-dependent manner
sphingosine
product inhibition in a dose-dependent manner, IC50: 0.08 mM
Zn2+
1 mM, 60% inhibition, inhibits in a dose-dependent manner
(1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol
-
-
(1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol
-
-
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol
-
i.e. D-e-MAPP, an alkaline ceramidase inhibitor, that potently and specifically inhibits ACER activity
1-hexylcarbamoyl-5-fluorouracil
i.e. carmofur
1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
-
1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
-
2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide
-
6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide}
in vivo plasma pharmacokinetic profile in mice, overview
6-bromo-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide
-
Cu2+
-
-
D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol
-
inhibitor of alkaline ceramidase
gemcitabine
-
-
Hg2+
-
-
N-oleoylethanolamine
N-oleylethanolamine
-
-
NCDase siRNA
-
-
-
sphinganine
-
-
sphingenine
-
-
urea-hexanoyl-ceramide
-
-
Zn2+
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Detergents
-
required for activity, e.g. NP-40, sodium cholate, Triton X-100, or Tween-20
sodium cholate
-
-
sodium taurodeoxycholate
-
-
Triton X-100
-
-
additional information
-
doxorubicin induces enzyme expression
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0223
C12-4-nitrobenzo-2-oxa-1,3-diazole-ceramide
-
-
0.0724
C16-14C-ceramide
-
-
-
0.1818
N-[(2S,3R,4E)-7-[[9-(diethylamino)-5-oxo-5H-benzo[a]phenoxazin-3-yl]oxy]-1,3-dihydroxyhept-4-en-2-yl]-11-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]undecanamide
pH 4.5, 37°C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.08
sphingosine
Mus musculus
product inhibition in a dose-dependent manner, IC50: 0.08 mM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000000053
-
homozygous F508del mice, lung
0.000000055
-
wild-type mice, lung
0.000000056
-
heterozygous F508del mice, lung
0.000002
0.0000028
-
homozygous F508del mice, spleen
0.0000035
-
wild-type mice, lung
0.00000375
-
heterozygous F508del mice, lung
0.00000416
-
homozygous F508del mice, lung
0.00001
-
homozygous F508del mice, mucosal homogenates
0.0000127
-
heterozygous F508del mice, mucosal homogenates
0.0000137
-
heterozygous F508del mice, mucosal homogenates
0.0000145
-
homozygous F508del mice, mucosal homogenates
0.0000155
-
wild-type mice, mucosal homogenates
0.0000163
-
wild-type mice, mucosal homogenates
0.0000167
-
wild-type mice, mucosal homogenates
0.0000187
-
wild-type mice, kidney
0.0000188
-
heterozygous F508del mice, mucosal homogenates
0.0000192
-
homozygous F508del mice, mucosal homogenates
0.0000193
-
homozygous F508del mice, kidney
0.00002
-
homozygous F508del mice, mucosal homogenates
0.0000208
0.0000215
-
wild-type mice, liver
0.0000227
-
heterozygous F508del mice, mucosal homogenates
0.000023
-
wild-type mice, mucosal homogenates
0.0000238
-
homozygous F508del mice, liver
0.0000255
-
heterozygous F508del mice, liver
0.0000272
-
heterozygous F508del mice, mucosal homogenates
0.0000273
-
wild-type mice, mucosal homogenates
0.0000292
-
homozygous F508del mice, mucosal homogenates
0.0000308
-
heterozygous F508del mice, mucosal homogenates
0.0000417
-
wild-type mice, mucosal homogenates
0.000048
-
wild-type mice, mucosal homogenates
0.0000542
-
homozygous F508del mice, mucosal homogenates
0.0000625
-
heterozygous F508del mice, mucosal homogenates
0.0001
-
heterozygous F508del mice, mucosal homogenates
14.45
-
-
additional information
-
determination of sphingolipid levels by mass spectrometry
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
9
-
activity assay, for alkaline ceramidase activity
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 7.5
maCER1 has a slight activity in the range
6.5 - 10.5
maCER1 has a negligible activity at pH lower than 6.5 or higher than 10.5
9.5 - 10
maCER1 has a slight activity in the range
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
fibroblast cell line
Manually annotated by BRENDA team
mouse embryonic fibroblast
Manually annotated by BRENDA team
-
acid ceramidase protein is observed in unfertilized eggs
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
maCER1 is localized to the endoplasmic reticulum and contains a Golgi to ER retrieval signal sequence
Manually annotated by BRENDA team
additional information
-
subcellular localization, overview
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
physiological function
additional information
enzyme structure-function relationship, overview. The enzyme contains a signal/anchor sequence and a mucin box
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACER1_MOUSE
273
7
32082
Swiss-Prot
other Location (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
135000
-
determined by SDS-PAGE and Western blot analysis, the multiple band pattern between about 95 and 135 kDa may be due to the complexity of modifications, such as O-glycosylation and N-glycosylation
94000
-
x * 94000, SDS-PAGE
95000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 94000, SDS-PAGE
heterodimer
alpha and beta subunit
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
-
70% loss of activity after 1 h at 60°C
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, 2 months, no loss of activity
-
37°C, 24 h, no loss of acitivity
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
151182fold
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
maCER1 gene, overexpression in HeLa cells, expression in yeast cells and in COS-1 cells, sequencing
DNA and amino acid determination, phylogenetic tree, genetic structure, the promoter region of mouse brain neutral CDase contains transcriptional response elements for GATA-2, C/EBP, and HNF3beta
expression of C-terminally myc-tagged enzyme in CHOP cells in endoplasmic reticulum and Golgi apparatus, as well as in plasma membranes
-
gene Asah2, DNA and amino acid sequence determination and analysis, expression in ES cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
acid ceramidase protein and mRNA are decreased during egg aging
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
because of its central role in the ceramide metabolism, the enzyme may offer a novel molecular target in disorders with dysfunctional ceramide-mediated signaling
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tani, M.; Okino, N.; Mitsutake, S.; Tanigawa, T.; Izu, H.; Ito, M.
Purification and characterization of a neutral ceramidase from mouse liver
J. Biol. Chem.
275
3462-3468
2000
Mus musculus
Manually annotated by BRENDA team
Mao, C.; Xu, R.; Szulc, Z.M.; Bielawski, J.; Becker, K.P.; Bielawska, A.; Galadari, S.H.; Hu, W.; Obeid, L.M.
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase. An enzyme that preferentially regulates metabolism of very long chain ceramides
J. Biol. Chem.
278
31184-31191
2003
Mus musculus (Q8R4X1), Mus musculus
Manually annotated by BRENDA team
Jensen, J.M.; Forl, M.; Winoto-Morbach, S.; Seite, S.; Schunck, M.; Proksch, E.; Schutze, S.
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging
Exp. Dermatol.
14
609-618
2005
Mus musculus
Manually annotated by BRENDA team
Tani, M.; Igarashi, Y.; Ito, M.
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu
J. Biol. Chem.
280
36592-36600
2005
Mus musculus
Manually annotated by BRENDA team
Zeidan, Y.H.; Pettus, B.J.; Elojeimy, S.; Taha, T.; Obeid, L.M.; Kawamori, T.; Norris, J.S.; Hannun, Y.A.
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production
J. Biol. Chem.
281
24695-24703
2006
Mus musculus
Manually annotated by BRENDA team
Kono, M.; Dreier, J.L.; Ellis, J.M.; Allende, M.L.; Kalkofen, D.N.; Sanders, K.M.; Bielawski, J.; Bielawska, A.; Hannun, Y.A.; Proia, R.L.
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids
J. Biol. Chem.
281
7324-7331
2006
Mus musculus
Manually annotated by BRENDA team
Eliyahu, E.; Park, J.H.; Shtraizent, N.; He, X.; Schuchman, E.H.
Acid ceramidase is a novel factor required for early embryo survival
FASEB J.
21
1403-1409
2007
Mus musculus
Manually annotated by BRENDA team
Ohlsson, L.; Hjelte, L.; Huehn, M.; Scholte, B.J.; Wilke, M.; Flodstroem-Tullberg, M.; Nilsson, A.
Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice
J. Pediatr. Gastroenterol. Nutr.
47
547-554
2008
Mus musculus
Manually annotated by BRENDA team
Mao, C.; Obeid, L.M.
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Biochim. Biophys. Acta
1781
424-434
2008
Homo sapiens, Homo sapiens (Q5QJU3), Homo sapiens (Q8TDN7), Homo sapiens (Q9NR71), Homo sapiens (Q9NUN7), Mus musculus (Q8R4X1), Mus musculus (Q8VD53), Mus musculus (Q9D099), Mus musculus (Q9JHE3), Mus musculus (Q9WV54), Mus musculus
Manually annotated by BRENDA team
Wu, B.X.; Zeidan, Y.H.; Hannun, Y.A.
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation
Biochim. Biophys. Acta
1791
730-739
2009
Mus musculus
Manually annotated by BRENDA team
Houben, E.; Hachem, J.P.; De Paepe, K.; Rogiers, V.
Epidermal ceramidase activity regulates epidermal desquamation via stratum corneum acidification
Skin Pharmacol. Physiol.
21
111-118
2008
Mus musculus
Manually annotated by BRENDA team
Xu, R.; Sun, W.; Jin, J.; Obeid, L.M.; Mao, C.
Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes
FASEB J.
24
2507-2515
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Novgorodov, S.A.; Wu, B.X.; Gudz, T.I.; Bielawski, J.; Ovchinnikova, T.V.; Hannun, Y.A.; Obeid, L.M.
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA
J. Biol. Chem.
286
25352-25362
2011
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Park, J.; Yoon, S.
Ceramide, a crucial functional lipid, and its metabolic regulation by acid ceramidase
Food Sci. Biotechnol.
19
859-864
2010
Homo sapiens, Mus musculus
-
Manually annotated by BRENDA team
Pizzirani, D.; Bach, A.; Realini, N.; Armirotti, A.; Mengatto, L.; Bauer, I.; Girotto, S.; Pagliuca, C.; De Vivo, M.; Summa, M.; Ribeiro, A.; Piomelli, D.
Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase
Angew. Chem. Int. Ed. Engl.
54
485-489
2015
Homo sapiens (Q13510), Mus musculus (Q9WV54)
Manually annotated by BRENDA team
Ito, M.; Okino, N.; Tani, M.
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase
Biochim. Biophys. Acta
1841
682-691
2014
Dictyostelium discoideum, Mycobacterium tuberculosis, Oryza sativa, Pseudomonas aeruginosa, Tribolium castaneum, Dermatophilus congolensis, Triticum aestivum (A9YFM2), Aspergillus oryzae (Q5B5D5), Danio rerio (Q5W7F1), Rattus norvegicus (Q91XT9), Mus musculus (Q9JHE3), Homo sapiens (Q9NR71), Drosophila melanogaster (Q9VA70), Laodelphax striatellus (R4N4U2)
Manually annotated by BRENDA team
Bhabak, K.P.; Hauser, A.; Redmer, S.; Banhart, S.; Heuer, D.; Arenz, C.
Development of a novel FRET probe for the real-time determination of ceramidase activity
ChemBioChem
14
1049-1052
2013
Homo sapiens (Q9NR71), Mus musculus (Q9WV54)
Manually annotated by BRENDA team
Coant, N.; Hannun, Y.A.
Neutral ceramidase advances in mechanisms, cell regulation, and roles in cancer
Adv. Biol. Regul.
71
141-146
2019
Nilaparvata lugens, Amorphophallus muelleri (A0A2D1WBF2), Rattus norvegicus (Q91XT9), Mus musculus (Q9JHE3), Homo sapiens (Q9NR71)
Manually annotated by BRENDA team
Ferraz, M.J.; Marques, A.R.; Appelman, M.D.; Verhoek, M.; Strijland, A.; Mirzaian, M.; Scheij, S.; Ouairy, C.M.; Lahav, D.; Wisse, P.; Overkleeft, H.S.; Boot, R.G.; Aerts, J.M.
Lysosomal glycosphingolipid catabolism by acid ceramidase formation of glycosphingoid bases during deficiency of glycosidases
FEBS Lett.
590
716-725
2016
Homo sapiens (Q13510), Homo sapiens, Mus musculus (Q9WV54)
Manually annotated by BRENDA team