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Information on EC 3.5.1.23 - ceramidase
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3.5.1.23 ceramidaseSpecify your search results
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- 3.5.1.23
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adipor1
- sphingolipids
- obesity
-
adipokine
- agonist
- sphingomyelinase
- sphingomyelin
- lysosomal
- farber
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obese
- leptin
- adipocytes
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amp-activated
- sphingosine-1-phosphate
- peroxisome
- cardiovascular
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proliferator-activated
- triglyceride
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globular
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insulin-sensitizing
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high-fat
- tnf
- smases
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adipocytokine
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adipocyte-derived
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monophosphate-activated
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anti-atherogenic
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t-cadherin
- steatosis
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adiposity
- glucosylceramide
- glycosphingolipids
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obesity-related
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antidiabetic
- 1-phosphate
-
seven-transmembrane
- gaucher
- dihydrosphingosine
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p-ampk
- palmitoyltransferase
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homa-ir
-
sphingoid
- hoarseness
-
ceramide-induced
- sphinganine
-
ceramide-mediated
- dihydroceramide
-
myoclonic
-
adipocyte-secreted
- analysis
- pharmacology
- drug development
- medicine
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hypoadiponectinemia
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
adipor2, adiponectin receptor, ceramidase, acid ceramidase, asah1, neutral ceramidase, acdase, ncdase, acer2, acer3, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acylsphingosine deacylase
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glycosphingolipid ceramide deacylase
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N-acylsphingosine amidohydrolase
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PHP32
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Putative 32 KDA heart protein
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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SYSTEMATIC NAME
IUBMB Comments
N-acylsphingosine amidohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
37289-06-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
C18-ceramide + H2O
stearate + sphingosine
preferred substrate, fluorescent C18 ceramide in detergent micelles
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?
additional information
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ADIPOR2 may have a preference for C18 ceramide substrate, but can also hydrolyse shorter (C6 ceramide) and longer (C24 ceramide) substrates, but to a lesser extent. Low overall ceramidase catalytic activity of ADIPOR2. Substrate binding structure, overview. The substrate amide carbonyl contacts the R278TM5 and Y328TM6 side chains, which are typical carbonyl-polarizing and oxyanion-stabilizing residues in zinc-dependent hydrolases
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
adiponectin
activates the ceramidase activity of adiponectin receptor ADIPOR2 about 20fold. Adiponectin is a hormone, secreted mainly from adipocytes, that stimulates glucose utilization and fatty-acid oxidation
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Acquired Immunodeficiency Syndrome
Current status and perspectives in ceramide-targeting molecular medicine.
Adenocarcinoma
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Adenocarcinoma
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.
Adenocarcinoma
Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma.
Adenocarcinoma
Globular adiponectin inhibits leptin-stimulated esophageal adenocarcinoma cell proliferation via adiponectin receptor 2-mediated suppression of UHRF1.
Adenocarcinoma of Lung
Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.
Adenocarcinoma of Lung
Sphingosine-1-Phosphate Contributes to TLR9-Induced TNF-? Release in Lung Tumor Cells.
Adenoma
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Adenoma
Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas.
Adenoma
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Adenoma
Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: Adiponectin regulates steroidogenesis.
Adenomatous Polyps
Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer.
Adrenal Cortex Neoplasms
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Albuminuria
Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse.
Alopecia
Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells.
Alzheimer Disease
Altered Brain Adiponectin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Current status and perspectives in ceramide-targeting molecular medicine.
Alzheimer Disease
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.
Alzheimer Disease
Small molecule of adiponectin receptor agonist-AdipoRon-for Alzheimer disease: abridged secondary publication.
Alzheimer Disease
[Effect of moxibustion at "Shenque" (CV8) and "Zusanli" (ST36) on expression of adiponectin and adiponectin receptor in Alzheimer's disease rats].
Arthritis
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Arthritis
Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis.
Arthritis
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Arthritis, Experimental
Blockade of adiponectin receptor 1 signaling inhibits synovial inflammation and alleviates joint damage in collagen-induced arthritis.
Arthritis, Juvenile
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Arthritis, Rheumatoid
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappaB pathway.
Arthritis, Rheumatoid
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Arthritis, Rheumatoid
Association of adiponectin and adiponectin receptor gene polymorphisms with rheumatoid arthritis in a Chinese population.
Arthritis, Rheumatoid
High Adiponectin and Adiponectin Receptor 1 Expression in Synovial Fluids and Synovial Tissues of Patients with Rheumatoid Arthritis.
Arthritis, Rheumatoid
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Atherosclerosis
Adipocyte Hypoxia-Inducible Factor 2? Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.
Atherosclerosis
Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.
Atherosclerosis
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction.
Atherosclerosis
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.
Atherosclerosis
miR-449a induces EndMT, promotes the development of atherosclerosis by targeting the interaction between AdipoR2 and E-cadherin in Lipid Rafts.
Atherosclerosis
Reduced adiponectin receptor signalling accelerates atherosclerosis and may worsen the outcome in type 2 diabetes mellitus - another one of those missing links?
Atherosclerosis
The effects of oleanolic acid on atherosclerosis in different animal models.
Bacterial Infections
Current status and perspectives in ceramide-targeting molecular medicine.
Bone Diseases, Metabolic
Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPAR? coactivator-1? and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia.
Brain Contusion
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Injuries
Designer Adiponectin Receptor Agonist Stabilizes Metabolic Function and Prevents Brain Injury Caused by HIV Protease Inhibitors.
Brain Injuries
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Injuries, Traumatic
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Ischemia
Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice Through Adiponectin Receptor 1-Mediated Phosphorylation of GSK-3?
Breast Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Breast Neoplasms
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Breast Neoplasms
Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.
Breast Neoplasms
Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity.
Breast Neoplasms
Adiponectin receptor signaling on dendritic cells blunts antitumor immunity.
Breast Neoplasms
ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis.
Breast Neoplasms
Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ER?.
Breast Neoplasms
C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.
Breast Neoplasms
Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor.
Breast Neoplasms
Correction to: Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor.
Breast Neoplasms
Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells.
Breast Neoplasms
Development of second generation peptides modulating cellular adiponectin receptor responses.
Breast Neoplasms
Effects of Two Types of Calorie Restriction on Methylation Levels of Adiponectin Receptor 1 (AdipoR1) and Leptin Receptor Overlapping Transcript (Leprot) in a MMTV-TGF-? Breast Cancer Mouse Model.
Breast Neoplasms
Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells.
Breast Neoplasms
Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms.
Breast Neoplasms
Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.
Breast Neoplasms
Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features.
Breast Neoplasms
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
Breast Neoplasms
Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer.
Breast Neoplasms
Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis.
Breast Neoplasms
Histotype-specific analysis of acid ceramidase expression in ovarian cancer.
Breast Neoplasms
Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype.
Breast Neoplasms
Influence of insulin resistance on adiponectin receptor expression in breast cancer.
Breast Neoplasms
Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies.
Breast Neoplasms
Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies.
Breast Neoplasms
miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer.
Breast Neoplasms
No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk.
Breast Neoplasms
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Breast Neoplasms
Silencing lnc-ASAH2B-2 Inhibits Breast Cancer Cell Growth via the mTOR Pathway.
Breast Neoplasms
Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
Breast Neoplasms
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Breast Neoplasms
Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk.
Bronchiolitis
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma.
Carcinogenesis
Adiponectin Receptor Expression Predicts Favorable Prognosis in Cases of Hepatocellular Carcinoma.
Carcinogenesis
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Carcinogenesis
Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment.
Carcinogenesis
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Carcinogenesis
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
Carcinogenesis
LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis.
Carcinogenesis
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Carcinogenesis
Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis.
Carcinoma
Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression.
Carcinoma
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Carcinoma
Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Carcinoma
Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies.
Carcinoma
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma.
Carcinoma
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Carcinoma
microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma.
Carcinoma
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Carcinoma, Ductal
Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.
Carcinoma, Ductal
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Carcinoma, Endometrioid
Expression levels of adiponectin receptors are decreased in human endometrial adenocarcinoma tissues.
Carcinoma, Hepatocellular
Adiponectin Receptor Expression Predicts Favorable Prognosis in Cases of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Adiponectin receptor R1 is upregulated by valproic acid but not by topiramate in human hepatoma cell line, HepG2.
Carcinoma, Hepatocellular
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Carcinoma, Hepatocellular
An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways.
Carcinoma, Hepatocellular
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Carcinoma, Hepatocellular
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B.
Carcinoma, Hepatocellular
Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo.
Carcinoma, Intraductal, Noninfiltrating
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Carcinoma, Intraductal, Noninfiltrating
Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.
Carcinoma, Non-Small-Cell Lung
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma.
Carcinoma, Ovarian Epithelial
Acid Ceramidase (AC)-A Key Enzyme of Sphingolipid Metabolism-Correlates With Better Prognosis in Epithelial Ovarian Cancer.
Carcinoma, Ovarian Epithelial
Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors.
Carcinoma, Renal Cell
Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate.
Carcinoma, Squamous Cell
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Cardiomegaly
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.
Cardiomegaly
Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
Cardiomyopathies
HILIC-MS-based metabolomics reveal that Astragalus polysaccharide alleviates doxorubicin-induced cardiomyopathy by regulating sphingolipid and glycerophospholipid homeostasis.
Cardiomyopathy, Hypertrophic
Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin.
Cardiovascular Diseases
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
Cardiovascular Diseases
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.
Cardiovascular Diseases
Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.
Cardiovascular Diseases
In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene.
Cardiovascular Diseases
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.
Cardiovascular Diseases
[Research progress in regulation of adiponectin receptors expression].
Carotid Artery Diseases
Intensive Statin Therapy Compromises the Adiponectin-AdipoR Pathway in the Human Monocyte-Macrophage Lineage.
ceramidase deficiency
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
ceramidase deficiency
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.
ceramidase deficiency
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
ceramidase deficiency
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
ceramidase deficiency
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
ceramidase deficiency
Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.
ceramidase deficiency
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
ceramidase deficiency
Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
ceramidase deficiency
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
ceramidase deficiency
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
ceramidase deficiency
Bone marrow transplantation for infantile ceramidase deficiency (Farber disease).
ceramidase deficiency
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.
ceramidase deficiency
Clinical diagnosis of a new case of ceramidase deficiency (Farber's disease).
ceramidase deficiency
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
ceramidase deficiency
Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
ceramidase deficiency
Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.
ceramidase deficiency
Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.
ceramidase deficiency
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
ceramidase deficiency
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
ceramidase deficiency
Farber disease: an ultrastructural study. Report of a case and review of the literature.
ceramidase deficiency
Farber disease: clinical presentation, pathogenesis and a new approach to treatment.
ceramidase deficiency
Farber's disease in two siblings, sural nerve and subcutaneous biopsies by light and electron microscopy.
ceramidase deficiency
Farber's lipogranulomatosis: ceramidase deficiency and prolonged survival in three relatives.
ceramidase deficiency
Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration.
ceramidase deficiency
Hematopoietic stem cell transplant does not prevent neurological deterioration in infants with Farber disease: Case report and literature review.
ceramidase deficiency
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.
ceramidase deficiency
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease.
ceramidase deficiency
Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice.
ceramidase deficiency
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies.
ceramidase deficiency
Molecular analysis of acid ceramidase deficiency in patients with Farber disease.
ceramidase deficiency
Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene.
ceramidase deficiency
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
ceramidase deficiency
Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue.
ceramidase deficiency
Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells.
ceramidase deficiency
Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells.
ceramidase deficiency
Novel V97G ASAH1 mutation found in Farber disease patients: Unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system.
ceramidase deficiency
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
ceramidase deficiency
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
ceramidase deficiency
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease.
ceramidase deficiency
Systemic ceramide accumulation leads to severe and varied pathological consequences.
ceramidase deficiency
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.
ceramidase deficiency
Tissue accumulation of sulfatide and GM3 ganglioside in a patient with variant Farber disease.
ceramidase deficiency
Transcriptional changes revealed genes and pathways involved in the deficient testis caused by the inhibition of alkaline ceramidase (Dacer) in Drosophila melanogaster.
ceramidase deficiency
[Farber disease [Farber lipogranulomatosis], acid ceramidase deficiency]
Cerebellar Ataxia
Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Cerebellar Ataxia
Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Cerebral Hemorrhage
Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice.
Cerebral Infarction
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction.
Cerebrovascular Disorders
Administration of rCTRP9 Attenuates Neuronal Apoptosis Through AdipoR1/PI3K/Akt Signaling Pathway after ICH in Mice.
Cervical Intraepithelial Neoplasia
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Chemical and Drug Induced Liver Injury
Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.
Chondrosarcoma
Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells.
Colitis
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Colitis
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.
Colitis
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Colitis, Ulcerative
Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.
Colitis, Ulcerative
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Colitis-Associated Neoplasms
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Colonic Neoplasms
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Colonic Neoplasms
Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation.
Colonic Neoplasms
Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells.
Colonic Neoplasms
AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity.
Colonic Neoplasms
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
Colonic Neoplasms
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line.
Colonic Neoplasms
Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue.
Colonic Neoplasms
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening.
Colonic Neoplasms
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Colonic Neoplasms
[Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis].
Colorectal Neoplasms
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.
Colorectal Neoplasms
Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway.
Colorectal Neoplasms
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Colorectal Neoplasms
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Colorectal Neoplasms
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
Colorectal Neoplasms
Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer.
Colorectal Neoplasms
Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
Colorectal Neoplasms
Association of ADIPOQ and ADIPOR variants with risk of colorectal cancer: A meta-analysis.
Colorectal Neoplasms
Association of IGFBP-6 Expression with Metabolic Syndrome and Adiponectin and IGF-IR Receptor Levels in Colorectal Cancer.
Colorectal Neoplasms
Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Colorectal Neoplasms
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Colorectal Neoplasms
Interactions between genetic variants in the adiponectin, adiponectin receptor 1 and environmental factors on the risk of colorectal cancer.
Colorectal Neoplasms
Reduced expression of the AdipoR1 gene is correlated with venous invasion in colorectal cancer.
Colorectal Neoplasms
Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
Congenital Abnormalities
[A case report of childhood Farber's disease and literature review].
Coronary Artery Disease
Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes.
Coronary Artery Disease
Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?
Coronary Artery Disease
Arterial stiffness is associated with increased monocyte expression of adiponectin receptor mRNA and protein in patients with coronary artery disease.
Coronary Artery Disease
Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes.
Coronary Artery Disease
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.
Coronary Artery Disease
Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow-Induced Dilation in the Human Microvasculature.
Cystadenoma
[Study of the genes correlated with cyst calcification in patients with cystic echinococcosis].
Cystic Fibrosis
Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.
Cystic Fibrosis
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.
Cystic Fibrosis
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Cystic Fibrosis
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
Cystic Fibrosis
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
Cystic Fibrosis
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Dermatitis
Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067.
Dermatitis, Atopic
Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase.
Dermatitis, Atopic
Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.
Dermatitis, Atopic
Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis.
Dermatitis, Atopic
Citric acid inhibits a bacterial ceramidase and alleviates atopic dermatitis in an animal model.
Dermatitis, Atopic
Current status and perspectives in ceramide-targeting molecular medicine.
Dermatitis, Atopic
Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus.
Dermatitis, Atopic
Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis.
Dermatitis, Atopic
Oral supplementation of Lithospermum erythrorhizon prevents the development of atopic dermatitis with reducing ceramide degradation in the epidermis of NC/Nga mice.
Dermatitis, Atopic
Purification and characterization of a novel ceramidase from Pseudomonas aeruginosa.
Dermatitis, Atopic
Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the ?-Subunit of Acid Ceramidase.
Diabetes Complications
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Diabetes Insipidus
Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.
Diabetes Insipidus, Nephrogenic
Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.
Diabetes Mellitus
?-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
Diabetes Mellitus
Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese.
Diabetes Mellitus
Current status and perspectives in ceramide-targeting molecular medicine.
Diabetes Mellitus
Impact of 1,25(OH) 2 D 3 on TG content in liver of rats with type 2 diabetes.
Diabetes Mellitus
Reduced adiponectin receptor signalling accelerates atherosclerosis and may worsen the outcome in type 2 diabetes mellitus - another one of those missing links?
Diabetes Mellitus
Regulation of Adiponectin Receptor 2 Expression via PPAR-alpha in NIT-1 Cells.
Diabetes Mellitus
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
Diabetes Mellitus
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
Diabetes Mellitus, Type 2
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Diabetes Mellitus, Type 2
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Diabetes Mellitus, Type 2
Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.
Diabetes Mellitus, Type 2
Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.
Diabetes Mellitus, Type 2
Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes.
Diabetes Mellitus, Type 2
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Diabetes Mellitus, Type 2
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Diabetes Mellitus, Type 2
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Diabetes Mellitus, Type 2
Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.
Diabetes Mellitus, Type 2
Association of the +33371 A/G polymorphism in adiponectin receptor 2 gene with Type 2 diabetes in the Chinese population.
Diabetes Mellitus, Type 2
Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese.
Diabetes Mellitus, Type 2
Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes.
Diabetes Mellitus, Type 2
Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Diabetes Mellitus, Type 2
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Diabetes Mellitus, Type 2
Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian Population.
Diabetes Mellitus, Type 2
Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.
Diabetes Mellitus, Type 2
Impact of 1,25(OH) 2 D 3 on TG content in liver of rats with type 2 diabetes.
Diabetes Mellitus, Type 2
In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene.
Diabetes Mellitus, Type 2
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Diabetes Mellitus, Type 2
Neutral Ceramidase Secreted Via Exosome Protects Against Palmitate-Induced Apoptosis in INS-1 Cells.
Diabetes Mellitus, Type 2
Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPAR? coactivator-1? and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia.
Diabetes Mellitus, Type 2
Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.
Diabetes Mellitus, Type 2
Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.
Diabetes Mellitus, Type 2
Reduced adiponectin receptor signalling accelerates atherosclerosis and may worsen the outcome in type 2 diabetes mellitus - another one of those missing links?
Diabetes Mellitus, Type 2
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
Diabetes Mellitus, Type 2
The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
Diabetes Mellitus, Type 2
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Utilization of electronic health records for the assessment of adiponectin receptor autoantibodies during the progression of cardio-metabolic comorbidities.
Diabetes Mellitus, Type 2
Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis.
Diabetes, Gestational
Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines.
Diabetic Cardiomyopathies
Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy.
Diabetic Nephropathies
Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy.
Diabetic Nephropathies
Erratum to: Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy.
Diabetic Nephropathies
Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease.
Diabetic Nephropathies
Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy.
Diabetic Nephropathies
The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
Drug Resistant Epilepsy
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Dyslipidemias
Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Dyslipidemias
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
Dystonia
ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Eclampsia
Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy.
Endometrial Neoplasms
Adiponectin mediates antiproliferative and apoptotic responses in endometrial carcinoma by the AdipoRs/AMPK pathway.
Endometrial Neoplasms
Clinicopathological roles of adiponectin and leptin receptors in endometrial carcinoma.
Endometrial Neoplasms
Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans.
Endometrial Neoplasms
Genetic polymorphisms in obesity-related genes and endometrial cancer risk.
Endometrial Neoplasms
[Effects of metformin and adiponectin on endometrial cancer cells growth].
Endometriosis
Expression of adiponectin, leptin, and their receptors in ovarian endometrioma.
Endometriosis
in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression.
Endotoxemia
Identification and Characterization of a Novel Adiponectin Receptor Agonist AdipoAI and its Anti-Inflammatory Effects in vitro and in vivo.
Ependymoma
Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation.
Epilepsies, Myoclonic
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Epilepsy
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy.
Epilepsy
Whole-exome sequencing broadens the phenotypic spectrum of rare pediatric epilepsy: a retrospective study.
Fabry Disease
Synthesis of novel internal standards for the quantitative determination of plasma ceramide trihexoside in Fabry disease by tandem mass spectrometry.
Farber Lipogranulomatosis
A fluorescence-based high-performance liquid chromatographic assay to determine acid ceramidase activity.
Farber Lipogranulomatosis
A high-performance liquid chromatographic assay for acid ceramidase activity in cultured fibroblasts from patients with Farber's disease and from controls.
Farber Lipogranulomatosis
A novel mutation in an atypical presentation of the rare infantile Farber disease.
Farber Lipogranulomatosis
A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease.
Farber Lipogranulomatosis
A simple method for screening for Farber disease on cultured skin fibroblasts.
Farber Lipogranulomatosis
A132: farber disease explains subset of juvenile idiopathic arthritis.
Farber Lipogranulomatosis
Abnormalities of lysosomes in human diploid fibroblasts from patients with Farber's disease.
Farber Lipogranulomatosis
Accumulation of Ordered Ceramide-Cholesterol Domains in Farber Disease Fibroblasts.
Farber Lipogranulomatosis
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Farber Lipogranulomatosis
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.
Farber Lipogranulomatosis
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
Farber Lipogranulomatosis
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Farber Lipogranulomatosis
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
Farber Lipogranulomatosis
Acid ceramidase is a novel factor required for early embryo survival.
Farber Lipogranulomatosis
Allogeneic hematopoietic cell transplantation in Farber disease.
Farber Lipogranulomatosis
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Farber Lipogranulomatosis
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Farber Lipogranulomatosis
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
Farber Lipogranulomatosis
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Farber Lipogranulomatosis
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Farber Lipogranulomatosis
Atypical presentation of infantile-onset farber disease with novel ASAH1 mutations.
Farber Lipogranulomatosis
Autologous Transplantation of Lentivector/Acid Ceramidase-Transduced Hematopoietic Cells in Nonhuman Primates.
Farber Lipogranulomatosis
Bone marrow transplantation for infantile ceramidase deficiency (Farber disease).
Farber Lipogranulomatosis
C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease.
Farber Lipogranulomatosis
Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase.
Farber Lipogranulomatosis
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.
Farber Lipogranulomatosis
Clinical diagnosis of a new case of ceramidase deficiency (Farber's disease).
Farber Lipogranulomatosis
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Farber Lipogranulomatosis
Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.
Farber Lipogranulomatosis
Diagnosis of lipogranulomatosis (Farber disease) by use of cultured fibroblasts.
Farber Lipogranulomatosis
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.
Farber Lipogranulomatosis
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
Farber Lipogranulomatosis
Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.
Farber Lipogranulomatosis
Farber disease: an ultrastructural study. Report of a case and review of the literature.
Farber Lipogranulomatosis
Farber disease: clinical presentation, pathogenesis and a new approach to treatment.
Farber Lipogranulomatosis
Farber lipogranulomatosis type 1 - Late presentation and early death in a Croatian boy with a novel homozygous ASAH1 mutation.
Farber Lipogranulomatosis
Farber lipogranulomatosis: clinical and molecular genetic analysis reveals a novel mutation in an Indian family.
Farber Lipogranulomatosis
Farber's disease in two siblings, sural nerve and subcutaneous biopsies by light and electron microscopy.
Farber Lipogranulomatosis
Farber's lipogranulomatosis: ceramidase deficiency and prolonged survival in three relatives.
Farber Lipogranulomatosis
Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1.
Farber Lipogranulomatosis
Hematopoietic stem cell transplant does not prevent neurological deterioration in infants with Farber disease: Case report and literature review.
Farber Lipogranulomatosis
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.
Farber Lipogranulomatosis
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
Farber Lipogranulomatosis
In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease.
Farber Lipogranulomatosis
Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
Farber Lipogranulomatosis
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.
Farber Lipogranulomatosis
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease.
Farber Lipogranulomatosis
Leukocyte and plasma N-laurylsphingosine deacylase (ceramidase) in Farber disease.
Farber Lipogranulomatosis
Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts.
Farber Lipogranulomatosis
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies.
Farber Lipogranulomatosis
Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation.
Farber Lipogranulomatosis
Molecular analysis of acid ceramidase deficiency in patients with Farber disease.
Farber Lipogranulomatosis
Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene.
Farber Lipogranulomatosis
Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.
Farber Lipogranulomatosis
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
Farber Lipogranulomatosis
Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue.
Farber Lipogranulomatosis
Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells.
Farber Lipogranulomatosis
Novel manifestations of Farber disease mimicking neuronopathic Gaucher disease.
Farber Lipogranulomatosis
Novel V97G ASAH1 mutation found in Farber disease patients: Unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system.
Farber Lipogranulomatosis
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.
Farber Lipogranulomatosis
Overexpression and mass spectrometry analysis of mature human acid ceramidase.
Farber Lipogranulomatosis
Pathological manifestations of Farber disease in a new mouse model.
Farber Lipogranulomatosis
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Farber Lipogranulomatosis
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Farber Lipogranulomatosis
Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells.
Farber Lipogranulomatosis
Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.
Farber Lipogranulomatosis
Spinal muscular atrophy associated with progressive myoclonic epilepsy.
Farber Lipogranulomatosis
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Farber Lipogranulomatosis
Stress-induced apoptosis is not mediated by endolysosomal ceramide.
Farber Lipogranulomatosis
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease.
Farber Lipogranulomatosis
Surgical treatment of hand disorders in Farber's disease: a case report.
Farber Lipogranulomatosis
Systemic ceramide accumulation leads to severe and varied pathological consequences.
Farber Lipogranulomatosis
The in situ degradation of ceramide, a potential lipid mediator, is not completely impaired in Farber disease.
Farber Lipogranulomatosis
The synthetic pathway for glucosylsphingosine in cultured fibroblasts.
Farber Lipogranulomatosis
Tissue accumulation of sulfatide and GM3 ganglioside in a patient with variant Farber disease.
Farber Lipogranulomatosis
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1.
Farber Lipogranulomatosis
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
Farber Lipogranulomatosis
[Farber disease [Farber lipogranulomatosis], acid ceramidase deficiency]
Fatty Liver
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
Fatty Liver
Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathway.
Fatty Liver
Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis.
Fatty Liver
Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.
Fatty Liver
Downregulation of Adiponectin/AdipoR2 is Associated with Steatohepatitis in Obese Mice.
Fatty Liver
Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
Fatty Liver
Identification of protective components that prevent the exacerbation of goose fatty liver: Characterization, expression and regulation of adiponectin receptors.
Fatty Liver
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Fatty Liver
[The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver]
Fatty Liver, Alcoholic
Role of SIRT1-FoxO1 Signaling in Dietary Saturated Fat-Dependent Up-Regulation of Liver Adiponectin Receptor 2 in Ethanol-Administered Mice.
Fatty Liver, Alcoholic
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Follicular Cyst
Alterations in key metabolic sensors involved in bovine cystic ovarian disease.
Gastrointestinal Stromal Tumors
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Gaucher Disease
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Gaucher Disease
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Genetic Diseases, Inborn
Acid ceramidase is a novel factor required for early embryo survival.
Genetic Diseases, Inborn
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease.
Glaucoma
Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma.
Glioblastoma
AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
Glioblastoma
Development of second generation peptides modulating cellular adiponectin receptor responses.
Glioblastoma
Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.
Glioma
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells.
Glioma
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.
Glucose Intolerance
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Glucose Intolerance
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Glucose Intolerance
Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.
Glucose Intolerance
Fish oil consumption prevents glucose intolerance and hypercorticosteronemy in footshock-stressed rats.
Glucose Intolerance
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Glucose Intolerance
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Granuloma
An autopsy case of Farber's lipogranulomatosis in a Japanese boy with gastrointestinal involvement.
Head and Neck Neoplasms
Targeting acid ceramidase sensitises head and neck cancer to cisplatin.
Heart Failure
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.
Heart Failure
MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure.
Hematologic Neoplasms
Ceramidases in Hematological Malignancies: Senseless Or Neglected Target?
Hepatitis
Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice.
Hepatitis
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Hepatitis C
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Herpes Simplex
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Herpes Zoster
Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas.
Hyperglycemia
Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action.
Hyperglycemia
Black Soybean Leaf Extract Suppresses Hyperglycemia and Hepatic Steatosis by Enhancing Adiponectin Receptor Signaling and AMPK Activation.
Hyperglycemia
Endothelial acid ceramidase in exosome-mediated release of NLRP3 inflammasome products during hyperglycemia: Evidence from endothelium-specific deletion of Asah1 gene.
Hyperglycemia
High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations.
Hyperglycemia
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Hyperglycemia
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Hyperglycemia
Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs.
Hyperinsulinism
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Hyperinsulinism
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Hyperinsulinism
Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
Hypertension
Novel effect of adenosine 5'-monophosphate on ameliorating hypertension and the metabolism of lipids and glucose in stroke-prone spontaneously hypertensive rats.
Hyperthyroidism
AdipoR1 and AdipoR2 gene expression are regulated by thyroid hormones in adipose tissue.
Hypertriglyceridemia
Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.
Infections
CORRELATION OF HELICOBACTER PYLORI INFECTION WITH DEVELOPMENT OF CARDIOVASCULAR RISK IN PATIENTS WITH CORONARY HEART DISEASE IN ASSOCIATION WITH TYPE 2 DIABETES MELLITUS.
Infections
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.
Infections
Identification and biochemical characterization of Laodelphax striatellus neutral ceramidase.
Infections
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.
Infections
Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-toxin.
Infections
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Infections
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
Infections
Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection.
Infections
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Inflammatory Bowel Diseases
Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease.
Inflammatory Bowel Diseases
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Insulin Resistance
A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome.
Insulin Resistance
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
Insulin Resistance
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Insulin Resistance
A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population.
Insulin Resistance
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Insulin Resistance
Abundance of adiponectin system and G-protein coupled receptor GPR109A mRNA in adipose tissue and liver of F2 offspring cows of Charolais × German Holstein crosses that differ in body fat accumulation.
Insulin Resistance
Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells.
Insulin Resistance
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
Insulin Resistance
Adiponectin and adiponectin receptors in obesity-linked insulin resistance.
Insulin Resistance
Adiponectin and its receptors are expressed in the chicken testis: influence of sexual maturation on testicular ADIPOR1 and ADIPOR2 mRNA abundance.
Insulin Resistance
Adiponectin is secreted by theca layer cells isolated from chicken ovarian follicles.
Insulin Resistance
Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.
Insulin Resistance
Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans.
Insulin Resistance
Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist.
Insulin Resistance
Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action.
Insulin Resistance
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Insulin Resistance
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Insulin Resistance
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Insulin Resistance
Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice.
Insulin Resistance
Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.
Insulin Resistance
Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone.
Insulin Resistance
AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells.
Insulin Resistance
AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice.
Insulin Resistance
AdR1-TG/TALLYHO mice have improved lipid accumulation and insulin sensitivity.
Insulin Resistance
Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men.
Insulin Resistance
ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES.
Insulin Resistance
Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.
Insulin Resistance
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Insulin Resistance
Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
Insulin Resistance
Association of ADIPOR2 with liver function tests in type 2 diabetic subjects.
Insulin Resistance
Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population.
Insulin Resistance
Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome.
Insulin Resistance
Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study.
Insulin Resistance
beta-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-alpha expression in adipocytes.
Insulin Resistance
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.
Insulin Resistance
Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.
Insulin Resistance
Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth hormone (GH)-treated children with Prader-Willi syndrome and in non-GH-treated obese children.
Insulin Resistance
Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Insulin Resistance
Dietary Conjugated Linoleic Acid Lowered Tumor Necrosis Factor-alpha Content and Altered Expression of Genes Related to Lipid Metabolism and Insulin Sensitivity in the Skeletal Muscle of Zucker Rats.
Insulin Resistance
Dietary supplement of conjugated linoleic acids or polyunsaturated fatty acids suppressed the mobilization of body fat reserves in dairy cows at early lactation through different pathways.
Insulin Resistance
Effects of adrenal hormones on the expression of adiponectin and adiponectin receptors in adipose tissue, muscle and liver.
Insulin Resistance
Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.
Insulin Resistance
Exercise Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1.
Insulin Resistance
Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.
Insulin Resistance
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Insulin Resistance
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
Insulin Resistance
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
Insulin Resistance
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.
Insulin Resistance
Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways.
Insulin Resistance
Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.
Insulin Resistance
Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
Insulin Resistance
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Insulin Resistance
Influence of insulin resistance on adiponectin receptor expression in breast cancer.
Insulin Resistance
Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy.
Insulin Resistance
Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.
Insulin Resistance
Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain.
Insulin Resistance
Overexpression of the Adiponectin Receptor AdipoR1 in Rat Skeletal Muscle Amplifies Local Insulin Sensitivity.
Insulin Resistance
PEG-BHD1028 Peptide Regulates Insulin Resistance and Fatty Acid ?-Oxidation, and Mitochondrial Biogenesis by Binding to Two Heterogeneous Binding Sites of Adiponectin Receptors, AdipoR1 and AdipoR2.
Insulin Resistance
PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL.
Insulin Resistance
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
Insulin Resistance
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.
Insulin Resistance
Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.
Insulin Resistance
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.
Insulin Resistance
Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.
Insulin Resistance
Porcine adiponectin receptor 1 transgene resists high-fat/sucrose diet-induced weight gain, hepatosteatosis and insulin resistance in mice.
Insulin Resistance
Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.
Insulin Resistance
Responsiveness to peripherally administered melanocortins in lean and obese mice.
Insulin Resistance
RNA-binding protein PTB and microRNA-221 coregulate AdipoR1 translation and adiponectin signaling.
Insulin Resistance
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
Insulin Resistance
Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-alpha-treated cardiomyocytes in association with improved glucose uptake.
Insulin Resistance
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.
Insulin Resistance
The -8503 G/A polymorphism of the adiponectin receptor 1 gene is associated with insulin sensitivity dependent on adiposity.
Insulin Resistance
The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats.
Insulin Resistance
The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
Insulin Resistance
The insulin sensitizing effects of PPAR-? agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats.
Insulin Resistance
The relationship between -8503G/A polymorphism of adiponectin receptor 1 and insulin sensitivity in the Japanese population.
Insulin Resistance
Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?
Insulin Resistance
[Effects of lotus leaf on inflammatory factors and liver AdipoR2 expressions in rats with NAFLD induced by high fat diet and high glucose].
Insulin Resistance
[Relationship between adiponectin receptor 1 gene -3881T/C variant and glucose metabolism in the Chinese]
Intellectual Disability
Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans.
Iron Overload
Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells.
Ischemic Stroke
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction.
Ischemic Stroke
Association between microRNA binding site polymorphisms in immunoinflammatory genes and recurrence risk of ischemic stroke.
Ischemic Stroke
Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.
Ischemic Stroke
Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke.
Kidney Failure, Chronic
Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease.
Kidney Neoplasms
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Lentivirus Infections
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Leukemia
IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Leukemia
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Adiponectin signals through Adiponectin Receptor 1 to reverse imatinib resistance in K562 human chronic myeloid leukemia cells.
Leukemia, Myeloid, Acute
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-?B-dependent P-glycoprotein upregulation.
Leukemia, Myeloid, Acute
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia - Impact on enzyme activity and response to cytotoxics.
Leukemia, Myeloid, Acute
The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia.
Leukodystrophy, Globoid Cell
Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target.
Leukodystrophy, Globoid Cell
Lipid-Conjugated Rigidochromic Probe Discloses Membrane Alteration in Model Cells of Krabbe Disease.
Leukoencephalopathies
ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Leukoencephalopathies
Deficiency of alkaline ceramidase 3 with infancy-onset progressive leukoencephalopathy: a second case report.
Lipid Metabolism Disorders
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Lipodystrophy
Polymorphisms in adiponectin receptor genes are associated with lipodystrophy-related phenotypes in HIV-infected patients receiving antiretroviral therapy.
Liver Cirrhosis
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
Liver Cirrhosis
Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats.
Liver Diseases
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
Liver Diseases
Association of ADIPOR2 with liver function tests in type 2 diabetic subjects.
Liver Diseases
Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.
Liver Diseases
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Liver Diseases
[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease].
Liver Diseases
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Liver Diseases
[The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver]
Liver Neoplasms
Adiponectin receptor R1 is upregulated by valproic acid but not by topiramate in human hepatoma cell line, HepG2.
Lung Diseases
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Lung Injury
Chronic Intermittent Hypoxia in Premature Infants: The Link Between Low Fat Stores, Adiponectin Receptor Signaling and Lung Injury.
Lung Injury
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.
Lung Neoplasms
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Lung Neoplasms
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Lung Neoplasms
Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis.
Lung Neoplasms
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Lung Neoplasms
Single nucleotide polymorphisms in VTI1A gene contribute to the susceptibility of Chinese population to non-small cell lung cancer.
Lung Neoplasms
Transcriptome analysis reveals gender-specific differences in overall metabolic response of male and female patients in lung adenocarcinoma.
Lymphatic Metastasis
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Lymphatic Metastasis
Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Lysosomal Storage Diseases
Bone marrow transplantation for infantile ceramidase deficiency (Farber disease).
Lysosomal Storage Diseases
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
Macular Degeneration
Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population.
Malnutrition
Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.
Malnutrition
Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep.
Malnutrition
Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?
Measles
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Melanoma
A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics.
Melanoma
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells.
Melanoma
Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin.
Melanoma
Acid ceramidase expression modulates the sensitivity of a375 melanoma cells to dacarbazine.
Melanoma
Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION.
Melanoma
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.
Melanoma
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.
Melanoma
Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells.
Melanoma
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
Melanoma
Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.
Melanoma, Experimental
Enzymatic synthesis of omega-amino-ceramide: preparation of a sensitive fluorescent substrate for ceramidase.
Metabolic Diseases
Adiponectin receptor 1 C-terminus interacts with PDZ-domain proteins such as syntrophins.
Metabolic Diseases
Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes.
Metabolic Diseases
Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach.
Metabolic Syndrome
A Variant Upstream of the CDH13 Adiponectin Receptor Gene and Metabolic Syndrome in Swedes.
Metabolic Syndrome
Adiponectin concentration in plasma is associated with muscle fiber size in healthy middle-aged men.
Metabolic Syndrome
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
Metabolic Syndrome
Circadian expression of adiponectin and its receptors in human adipose tissue.
Metabolic Syndrome
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
Metabolic Syndrome
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
Metabolic Syndrome
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.
Metabolic Syndrome
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
Metabolic Syndrome
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
Metabolic Syndrome
[Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis].
Motor Neuron Disease
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Motor Neuron Disease
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Motor Neuron Disease
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Multiple Myeloma
[Adiponectin Receptor Agonist AdipoRon Inhibits the Proliferation of Myeloma Cells via the AMPK/Autophagy Pathway].
Muscle Weakness
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Muscle Weakness
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Muscular Atrophy
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Muscular Atrophy
Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy.
Muscular Atrophy, Spinal
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Muscular Atrophy, Spinal
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
Muscular Atrophy, Spinal
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
Muscular Atrophy, Spinal
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Muscular Atrophy, Spinal
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Muscular Atrophy, Spinal
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy.
Muscular Atrophy, Spinal
Eyelid myoclonic status epilepticus: A rare phenotype in spinal muscular atrophy with progressive myoclonic epilepsy associated with ASAH1 gene mutation.
Muscular Atrophy, Spinal
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Muscular Atrophy, Spinal
Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.
Muscular Atrophy, Spinal
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Muscular Atrophy, Spinal
Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations in ASAH1.
Muscular Atrophy, Spinal
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Muscular Atrophy, Spinal
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1.
Muscular Atrophy, Spinal
Whole-transcriptome sequencing in blood provides a diagnosis of spinal muscular atrophy with progressive myoclonic epilepsy.
Muscular Atrophy, Spinal
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
Myocardial Infarction
Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart.
Myocardial Infarction
Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese.
Myocardial Ischemia
Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats.
Myocarditis
Adiponectin replacement therapy attenuates myocardial damage in leptin-deficient mice with viral myocarditis.
Myocarditis
Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis.
Myoclonic Epilepsies, Progressive
A novel case report of spinal muscular atrophy with progressive myoclonic epilepsy from Iran.
Myoclonic Epilepsies, Progressive
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Myoclonic Epilepsies, Progressive
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
Myoclonic Epilepsies, Progressive
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
Myoclonic Epilepsies, Progressive
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Myoclonic Epilepsies, Progressive
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Myoclonic Epilepsies, Progressive
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Myoclonic Epilepsies, Progressive
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy.
Myoclonic Epilepsies, Progressive
Eyelid myoclonic status epilepticus: A rare phenotype in spinal muscular atrophy with progressive myoclonic epilepsy associated with ASAH1 gene mutation.
Myoclonic Epilepsies, Progressive
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Myoclonic Epilepsies, Progressive
Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.
Myoclonic Epilepsies, Progressive
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Myoclonic Epilepsies, Progressive
Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations in ASAH1.
Myoclonic Epilepsies, Progressive
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Myoclonic Epilepsies, Progressive
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1.
Myoclonic Epilepsies, Progressive
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
Neoplasm Metastasis
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Neoplasm Metastasis
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Neoplasm Metastasis
LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis.
Neoplasm Metastasis
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
Neoplasm Metastasis
Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer.
Neoplasm Metastasis
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Neoplasm Metastasis
[Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer].
Neoplasms
A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy.
Neoplasms
Acid Ceramidase (AC)-A Key Enzyme of Sphingolipid Metabolism-Correlates With Better Prognosis in Epithelial Ovarian Cancer.
Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Neoplasms
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Neoplasms
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
Neoplasms
Acid ceramidase expression modulates the sensitivity of a375 melanoma cells to dacarbazine.
Neoplasms
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Neoplasms
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Neoplasms
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Neoplasms
Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling.
Neoplasms
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
Neoplasms
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B.
Neoplasms
Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.
Neoplasms
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.
Neoplasms
Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies.
Neoplasms
Adiponectin inhibits tumor necrosis factor-?-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.
Neoplasms
Adiponectin receptor 1 (ADIPOR1) rs1342387 polymorphism and risk of cancer: a meta-analysis.
Neoplasms
Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain.
Neoplasms
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Neoplasms
Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression.
Neoplasms
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Neoplasms
Adiponectin Receptor Expression Predicts Favorable Prognosis in Cases of Hepatocellular Carcinoma.
Neoplasms
Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors.
Neoplasms
Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.
Neoplasms
AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments.
Neoplasms
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
Neoplasms
Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.
Neoplasms
Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.
Neoplasms
Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.
Neoplasms
Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.
Neoplasms
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Neoplasms
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Neoplasms
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Neoplasms
Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.
Neoplasms
Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.
Neoplasms
Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Neoplasms
Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma.
Neoplasms
Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Neoplasms
Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.
Neoplasms
beta-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-alpha expression in adipocytes.
Neoplasms
Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen.
Neoplasms
Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.
Neoplasms
Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver.
Neoplasms
Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins.
Neoplasms
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells.
Neoplasms
Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells.
Neoplasms
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment.
Neoplasms
Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies.
Neoplasms
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation.
Neoplasms
Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells.
Neoplasms
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.
Neoplasms
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.
Neoplasms
Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production.
Neoplasms
Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma.
Neoplasms
Expression of adiponectin and its receptors is altered in epithelial ovarian tumors and ascites-derived ovarian cancer cell lines.
Neoplasms
Expression of adiponectin and leptin receptors in adrenal incidentaloma patients with subclinical hormone secretion.
Neoplasms
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Neoplasms
Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms.
Neoplasms
Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features.
Neoplasms
Genetic analysis of ADIPOQ variants and gastric cancer risk: a hospital-based case-control study in China.
Neoplasms
Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis.
Neoplasms
Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.
Neoplasms
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B.
Neoplasms
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Neoplasms
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells.
Neoplasms
Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.
Neoplasms
Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney.
Neoplasms
Measurement of ceramide and sphingolipid metabolism in tumors: potential modulation of chemotherapy.
Neoplasms
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
Neoplasms
microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma.
Neoplasms
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
Neoplasms
Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.
Neoplasms
No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk.
Neoplasms
Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer.
Neoplasms
Novel off-target effect of tamoxifen - Inhibition of acid ceramidase activity in cancer cells.
Neoplasms
Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.
Neoplasms
Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.
Neoplasms
Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study.
Neoplasms
Perinatal ciclosporin A exposure elicits sex-related cardiac dysfunction and inflammation in the rat progeny.
Neoplasms
Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo.
Neoplasms
Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.
Neoplasms
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Neoplasms
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Neoplasms
Rapid screening of specific changes in mRNA in thyroid carcinomas by sequence specific-differential display: decreased expression of acid ceramidase mRNA in malignant and benign thyroid tumors.
Neoplasms
Reduced expression of the AdipoR1 gene is correlated with venous invasion in colorectal cancer.
Neoplasms
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Neoplasms
Renoprotective effect of a combination of garlic and telmisartan against ischemia/reperfusion-induced kidney injury in obese rats.
Neoplasms
Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN.
Neoplasms
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Neoplasms
Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer.
Neoplasms
Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247).
Neoplasms
Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
Neoplasms
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases.
Neoplasms
Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis.
Neoplasms
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Neoplasms
Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
Neoplasms
Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy.
Neoplasms
The Functional Effects of Acid Ceramidase Overexpression in Prostate Cancer Progression and Resistance to Chemotherapy.
Neoplasms
The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro.
Neoplasms
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Neoplasms
Three ADIPOR1 Polymorphisms and Cancer Risk: A Meta-Analysis of Case-Control Studies.
Neoplasms
Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies.
Neoplasms
Transcriptome analysis reveals gender-specific differences in overall metabolic response of male and female patients in lung adenocarcinoma.
Neoplasms
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.
Neoplasms
[14C]ceramide synthesis by sphingolipid ceramide N-deacylase: new assay for ceramidase activity detection.
Neoplasms
[Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer].
Neoplasms
[Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis].
Nephrotic Syndrome
Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion.
Nephrotic Syndrome
Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli.
Nervous System Malformations
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
Neuroblastoma
Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices.
Neuroinflammatory Diseases
Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice.
Neurologic Manifestations
ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Neurologic Manifestations
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Neuroma
Regular Swimming Exercise Attenuated Neuroma Pain in Rats: Involvement of Leptin and Adiponectin.
Niemann-Pick Disease, Type C
Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.
Niemann-Pick Disease, Type C
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Niemann-Pick Disease, Type C
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Niemann-Pick Diseases
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Niemann-Pick Diseases
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Niemann-Pick Diseases
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.
Non-alcoholic Fatty Liver Disease
Correction: Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.
Non-alcoholic Fatty Liver Disease
Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
Non-alcoholic Fatty Liver Disease
Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells.
Non-alcoholic Fatty Liver Disease
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Non-alcoholic Fatty Liver Disease
Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Non-alcoholic Fatty Liver Disease
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.
Non-alcoholic Fatty Liver Disease
The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats.
Non-alcoholic Fatty Liver Disease
[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease].
Non-alcoholic Fatty Liver Disease
[Effects of lotus leaf on inflammatory factors and liver AdipoR2 expressions in rats with NAFLD induced by high fat diet and high glucose].
Obesity
A potential determinant role of adiponectin and receptors for the early embryo development in PCOS patients with obesity hinted by quantitative profiling.
Obesity
Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.
Obesity
Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity.
Obesity
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Obesity
Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots.
Obesity
ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children.
Obesity
ADIPOQ, ADIPOR1, and ADIPOR2 Polymorphisms in Relation to Serum Adiponectin Levels and BMI in Black and White Women.
Obesity
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
Obesity
Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
Obesity
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.
Obesity
Danthron ameliorates obesity and MAFLD through activating the interplay between PPAR?/RXR? heterodimer and adiponectin receptor 2.
Obesity
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study.
Obesity
Effects of Obesity on Adiponectin System Skin Expression in Dogs: A Comparative Study.
Obesity
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.
Obesity
Expression of Adiponectin and its Receptors in the Porcine Hypothalamus During the Oestrous Cycle.
Obesity
Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms.
Obesity
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Obesity
Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans.
Obesity
Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
Obesity
In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene.
Obesity
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.
Obesity
Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation.
Obesity
No conclusive evidence for association of polymorphisms in the adiponectin receptor 1 gene, AdipoR1, with common obesity.
Obesity
Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state.
Obesity
Pattern of Expression of Adiponectin Receptors in Human Liver and its Relation to Nonalcoholic Steatohepatitis.
Obesity
Protracted Upregulation of Leptin and IGF1 is Associated with Activation of PI3K/Akt and JAK2 Pathway in Mouse Intestine after Ionizing Radiation Exposure.
Obesity
Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.
Obesity
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Obesity
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Obesity
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
Obesity
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Obesity
The adiponectin receptor agonist AdipoRon normalizes glucose metabolism and prevents obesity but not growth retardation induced by glucocorticoids in young mice.
Obesity
The insulin sensitizing effects of PPAR-? agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats.
Obesity, Abdominal
Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma.
Obesity, Abdominal
Circadian expression of adiponectin and its receptors in human adipose tissue.
Obesity, Maternal
Effects of maternal obesity on maternal and fetal plasma concentrations of adiponectin and expression of adiponectin and its receptor genes in cotyledonary and adipose tissues at mid- and late-gestation in sheep.
Obesity, Maternal
Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta.
Osteoarthritis
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappaB pathway.
Osteoarthritis
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Osteoarthritis
Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy.
Osteolysis
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Ovarian Neoplasms
Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells.
Ovarian Neoplasms
Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors.
Ovarian Neoplasms
Expression of adiponectin and its receptors is altered in epithelial ovarian tumors and ascites-derived ovarian cancer cell lines.
Ovarian Neoplasms
Histotype-specific analysis of acid ceramidase expression in ovarian cancer.
Overweight
Adiponectin concentration in plasma is associated with muscle fiber size in healthy middle-aged men.
Overweight
Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes.
Overweight
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Pancreatic Neoplasms
Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1? signaling.
Pancreatic Neoplasms
Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.
Pancreatic Neoplasms
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells.
Pancreatic Neoplasms
Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.
Pancreatic Neoplasms
Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.
Papillomavirus Infections
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Parkinson Disease
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Periodontal Diseases
Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro.
Periodontitis
Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro.
Pheochromocytoma
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Pneumonia
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
Polycystic Ovary Syndrome
A potential determinant role of adiponectin and receptors for the early embryo development in PCOS patients with obesity hinted by quantitative profiling.
Polycystic Ovary Syndrome
Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial.
Polycystic Ovary Syndrome
Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome.
Prader-Willi Syndrome
Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth hormone (GH)-treated children with Prader-Willi syndrome and in non-GH-treated obese children.
Pre-Eclampsia
Expressions of adiponectin receptors in placenta and their correlation with preeclampsia.
Pre-Eclampsia
Increased placental mitochondrial fusion in gestational diabetes mellitus: an adaptive mechanism to optimize feto-placental metabolic homeostasis?
Prostatic Hyperplasia
Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia.
Prostatic Neoplasms
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Prostatic Neoplasms
Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling.
Prostatic Neoplasms
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Prostatic Neoplasms
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
Prostatic Neoplasms
Adiponectin receptor activation inhibits prostate cancer xenograft growth.
Prostatic Neoplasms
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
Prostatic Neoplasms
Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.
Prostatic Neoplasms
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
Prostatic Neoplasms
Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.
Prostatic Neoplasms
Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2.
Prostatic Neoplasms
Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.
Prostatic Neoplasms
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
Prostatic Neoplasms
MiR-323 Inhibits Prostate Cancer Vascularization Through Adiponectin Receptor.
Prostatic Neoplasms
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer.
Prostatic Neoplasms
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Prostatic Neoplasms
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
Prostatic Neoplasms
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.
Prostatic Neoplasms
The Functional Effects of Acid Ceramidase Overexpression in Prostate Cancer Progression and Resistance to Chemotherapy.
Pseudomonas Infections
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.
Psoriasis
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Pulmonary Disease, Chronic Obstructive
Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Gene expression profile of human lung in a relatively early stage of COPD with emphysema.
Rectal Neoplasms
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.
Rectal Neoplasms
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer.
Reperfusion Injury
Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice Through Adiponectin Receptor 1-Mediated Phosphorylation of GSK-3?
Retinal Degeneration
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse.
Retinal Degeneration
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Retinal Degeneration
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.
Rhinitis, Allergic
The expression of adiponectin receptor is altered in mild and moderate/severe persistent allergic nasal mucosa.
Scleroderma, Systemic
An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis.
Seizures
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Seizures
Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
Small Cell Lung Carcinoma
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Sphingolipidoses
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Sphingolipidoses
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Squamous Cell Carcinoma of Head and Neck
Fas ligand gene transfer effectively induces apoptosis in head and neck cancer cells.
Squamous Cell Carcinoma of Head and Neck
Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy.
Starvation
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
Status Epilepticus
Eyelid myoclonic status epilepticus: A rare phenotype in spinal muscular atrophy with progressive myoclonic epilepsy associated with ASAH1 gene mutation.
Stomach Neoplasms
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Stomach Neoplasms
Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment.
Stomach Neoplasms
Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer.
Stomach Neoplasms
Genetic analysis of ADIPOQ variants and gastric cancer risk: a hospital-based case-control study in China.
Stomach Neoplasms
Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer.
Stomach Neoplasms
RNA Sequencing of Early-Stage Gastric Adenocarcinoma Reveals Multiple Activated Pathways and Novel Long Non-Coding RNAs in Patient Tissue Samples.
Stomach Ulcer
AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice.
Stroke
Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.
Synucleinopathies
Acid ceramidase inhibition ameliorates ?-synuclein accumulation upon loss of GBA1 function.
Thrombosis
Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation.
Thyroid Neoplasms
Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma.
Thyroid Neoplasms
Rapid screening of specific changes in mRNA in thyroid carcinomas by sequence specific-differential display: decreased expression of acid ceramidase mRNA in malignant and benign thyroid tumors.
Tuberculosis
Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis.
Tuberculosis
Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
The role of adipocytokines and their receptors in bladder cancer: expression of adiponectin or leptin is an independent prognosticator.
Uterine Cervical Neoplasms
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Vascular Diseases
Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease.
Vasculitis
Intragraft vasculitis and gene expression analysis: Association with acute rejection and prediction of mortality in long-term heart transplantation.
Virus Diseases
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Vision Disorders
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.
Whooping Cough
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
Whooping Cough
Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetic analysis
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
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UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
ADIPORs display distant homology with alkaline ceramidases, comparison of structures of ADIPOR1 and ADIPOR2
metabolism
adiponectin receptors (ADIPORs) are integral membrane proteins that control glucose and lipid metabolism by mediating, at least in part, a cellular ceramidase activity that catalyses the hydrolysis of ceramide to produce sphingosine and a free fatty acid. ADIPOR2 possesses intrinsic basal ceramidase activity that is enhanced by adiponectin
additional information
possible mechanism for the hydrolytic activity of ADIPOR2 using computational approaches. In molecular dynamics simulations, the side chains of residues coordinating the zinc rearrange quickly to promote the nucleophilic attack of a zinc-bound hydroxide ion onto the ceramide amide carbonyl. Enzyme structure analysis, overbiew. An uninterrupted cavity goes through the entire receptor from the domain exposed to the upper lipid bilayer to the domain exposed to the cytoplasm. A tunnel enters the top half of the receptor between TM5 and TM6 and links the upper lipid bilayer to the FFA binding pocket. Some electron density is present in this domain indicating that this large opening might play a key role in modulating the entrance or exit of molecules to or from the receptor. On the intracellular side of ADIPOR2, the cavity splits into two tunnels immediately below the zinc binding domain, one of which is largely exposed to the cytoplasm
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
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additional information
the crystal structures of the two receptor subtypes, ADIPOR1 and ADIPOR2, show a similar overall seven-transmembranedomain architecture with large unoccupied cavities and a zinc binding site within the seven transmembrane domain
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant ADIPOR2 complexed with a free fatty acid molecule, X-ray diffraction structure determination and analysis
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vasiliauskaite-Brooks, I.; Sounier, R.; Rochaix, P.; Bellot, G.; Fortier, M.; Hoh, F.; De Colibus, L.; Bechara, C.; Saied, E.M.; Arenz, C.; Leyrat, C.; Granier, S.
Structural insights into adiponectin receptors suggest ceramidase activity
Nature
544
120-123
2017
Homo sapiens (Q86V24)
brenda
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Release 2023.1 (January 2023)
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