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Enzyme Nomenclature
Information on EC 3.5.1.20 - citrullinase
for references in articles please use BRENDA:EC3.5.1.20
Word Map on EC 3.5.1.20
- 3.5.1.20
- tularensis
- francisella
-
polyamine
-
protozoan
-
deiminase
-
geographic
- putrescine
-
avirulent
- holarctica
- thermophila
-
ciliated
-
subspecies
- tetrahymena
- l-arginine
- l-ornithine
-
biovars
- tularemia
-
octase
-
pasteurella
- novicida
-
ornithine-oxo-acid
- medicine
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
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EC NUMBER 
COMMENTARY 
3.5.1.20
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RECOMMENDED NAME
GeneOntology No.
citrullinase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-citrulline + H2O = L-ornithine + CO2 + NH3
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
L-citrulline N5-carbamoyldihydrolase
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CAS REGISTRY NUMBER
COMMENTARY
59088-17-4
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-citrulline + H2O
?
Euphorbia sp.
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first intermediate in urea cycle, involved in arginine biosynthesis
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-
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L-citrulline + H2O
?
-
enzyme is specific for citrulline, no hydrolysis of arginine, argininosuccinate, or other guanidino compounds
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-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
Phytomonas davidi
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first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-citrulline + H2O
?
Euphorbia sp.
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
enzyme is specific for citrulline, no hydrolysis of arginine, argininosuccinate, or other guanidino compounds
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
Phytomonas davidi
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40 - 60
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stable up to 40°C for 10 min, retains 87% activity after treatment at 50°C, activity completely lost at 60°C
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40 - 60
-
stable up to 40°C for 10 min, retains 87% activity after treatment at 50°C, activity completely lost at 60°C
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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generation of a nonpolar deletion DELTActu mutant. Deletion of the ctu gene results in loss of CTU activity, which is restored by transcomplementing the ctu gene. Loss of CTU does not affect acellular growth, but attenuates intramacrophage survival. Mice infected intranasally with the DELTActu mutant show significantly reduced bacterial burden in the lungs, liver, and spleen compared to wild-type Schu S4-infected mice.
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 3.5.1.20)
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