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EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
citrulline ureidase, citrulline hydrolase, citrullinase,
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L-citrulline N5-carbamoyldehydrolase
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citrulline hydrolase
Euphorbia sp.
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citrulline hydrolase
Phytomonas davidi
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citrulline ureidase
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CTU
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L-citrulline + H2O = L-ornithine + CO2 + NH3
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L-citrulline N5-carbamoyldihydrolase
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citrulline + H2O
ornithine + CO2 + NH3
L-citrulline + H2O
L-ornithine + CO2 + NH3
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-
-
?
citrulline + H2O
ornithine + CO2 + NH3
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-
-
-
?
citrulline + H2O
ornithine + CO2 + NH3
Euphorbia sp.
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-
-
-
?
citrulline + H2O
ornithine + CO2 + NH3
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-
-
-
?
citrulline + H2O
ornithine + CO2 + NH3
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-
-
-
?
citrulline + H2O
ornithine + CO2 + NH3
Phytomonas davidi
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-
-
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?
citrulline + H2O
ornithine + CO2 + NH3
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-
-
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?
citrulline + H2O
ornithine + CO2 + NH3
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-
-
-
?
L-citrulline + H2O
?
Euphorbia sp.
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first intermediate in urea cycle, involved in arginine biosynthesis
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L-citrulline + H2O
?
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enzyme is specific for citrulline, no hydrolysis of arginine, argininosuccinate, or other guanidino compounds
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L-citrulline + H2O
?
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first intermediate in urea cycle, involved in arginine biosynthesis
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L-citrulline + H2O
?
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first intermediate in urea cycle, involved in arginine biosynthesis
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-
L-citrulline + H2O
?
Phytomonas davidi
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first intermediate in urea cycle, involved in arginine biosynthesis
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-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
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-
L-citrulline + H2O
?
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-
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L-citrulline + H2O
?
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first intermediate in urea cycle, involved in arginine biosynthesis
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-
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L-citrulline + H2O
L-ornithine + CO2 + NH3
-
-
-
?
L-citrulline + H2O
?
Euphorbia sp.
-
first intermediate in urea cycle, involved in arginine biosynthesis
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-
-
L-citrulline + H2O
?
-
enzyme is specific for citrulline, no hydrolysis of arginine, argininosuccinate, or other guanidino compounds
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-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
Phytomonas davidi
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first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
-
-
-
L-citrulline + H2O
?
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-
-
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L-citrulline + H2O
?
-
first intermediate in urea cycle, involved in arginine biosynthesis
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-
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HgCl2
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1 mM, inhibition reversed by 2-mercaptoethanol
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1.06
citrulline
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-
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40 - 60
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stable up to 40°C for 10 min, retains 87% activity after treatment at 50°C, activity completely lost at 60°C
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protozoan, strain Z
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brenda
Euphorbia sp.
pinea, characias, hyssopifolia
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brenda
strain Schu S4, gene ctu or FTT0435
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brenda
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brenda
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brenda
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UniProt
brenda
human
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brenda
cassava
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brenda
no activity in Francisella tularensis ssp. holarctica
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brenda
Phytomonas davidi
trypanosomatide, parasite in euphorbs and asclepiads and other plants
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brenda
tomato
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brenda
protozoan; thermophila, pyryformis
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brenda
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brenda
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brenda
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brenda
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physiological function
citrulline ureidase is highly expressed in Francisella tularensis subsp. tularensis Schu S4 when compared to Francisella novicida U112, suggesting that it may contribute to the relative high virulence of Francisella tularensis subsp. tularensis Schu S4
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Q5NHL7_FRATT
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
286
0
32430
TrEMBL
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31000
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3 * 31000, 3 identical subunits, SDS-PAGE
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trimer
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3 * 31000, 3 identical subunits, SDS-PAGE
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additional information
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generation of a nonpolar deletion DELTActu mutant. Deletion of the ctu gene results in loss of CTU activity, which is restored by transcomplementing the ctu gene. Loss of CTU does not affect acellular growth, but attenuates intramacrophage survival. Mice infected intranasally with the DELTActu mutant show significantly reduced bacterial burden in the lungs, liver, and spleen compared to wild-type Schu S4-infected mice.
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40 - 60
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stable up to 40°C for 10 min, retains 87% activity after treatment at 50°C, activity completely lost at 60°C
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-10°C stable for several days
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recombinant His-tagged enzyme
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expression in Escherichia coli. The soluble and active recombinant enzyme is expressed in the periplasmic space with the vector pET-22b
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medicine
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clinical biochemistry, therapeutic measurement of citrulline
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Camargo Plessmann, E.; Silva, S.; Roitmann, I.; De Souza, W.; Jankevicius, J.V.; Dollet, M.
Enzymes of ornithine-arginine metabolism in trypanosomatids of the genus Phytomonas
J. Protozool.
34
439-441
1987
Euphorbia sp., Manihot esculenta, Phytomonas davidi, Solanum lycopersicum
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brenda
Eichler, W.
L-Citrulline
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
8
412-418
1985
Homo sapiens, Tetrahymena sp.
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brenda
Park, B.S.; Hirotani, A.; Nakano, Y.; Kitaoka, S.
Subcellular distribution and some properties of citrullinase in Euglena gracilis Z
Agric. Biol. Chem.
49
2205-2206
1985
Euglena gracilis, Tetrahymena sp.
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brenda
Park, B.S.; Hirotani, A.; Nakano, Y.; Kitaoka, S.
The physiological role and catabolism of arginine in Euglena gracilis
Agric. Biol. Chem.
47
2561-2567
1983
Euglena gracilis
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brenda
Hill, D.L.; Chambers, P.
The biosynthesis of proline by Tetrahymena pyriformis
Biochim. Biophys. Acta
148
435-447
1967
Tetrahymena sp.
brenda
Eichler, W.
Regulation of growth and polyamine biosynthesis of the ciliated protozoan Tetrahymena thermophila. Effects of L-arginine metabolites and polyamines
Biol. Chem. Hoppe-Seyler
371
273-282
1990
Tetrahymena sp.
brenda
Mahawar, M.; Kirimanjeswara, G.S.; Metzger, D.W.; Bakshi, C.S.
Contribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesis
J. Bacteriol.
191
4798-4806
2009
Francisella tularensis
brenda
Zhu, T.; Fang, S.; Wang, W.; Wang, K.; Cui, Z.; Wang, C.
The expression, purification and activity analysis of Francisella tularensis citrulline ureidase in Escherichia coli
J. Appl. Biomed.
13
189-194
2015
Francisella tularensis subsp. tularensis (Q5NHL7)
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brenda
Timofeev, V.; Bakhteeva, I.; Pavlov, V.; Mokrievich, A.
Citrulline ureidase gene diversity in the genus Francisella
Mol. Gen. Mikrobiol. Virusol.
30
173-180
2015
no activity in Francisella tularensis ssp. holarctica
brenda
Sarva, S.T.; Waldo, R.H.; Belland, R.J.; Klose, K.E.
Comparative Transcriptional Analyses of Francisella tularensis and Francisella novicida
PLoS ONE
11
e0158631
2016
Francisella tularensis subsp. novicida, Francisella tularensis subsp. novicida U112, Francisella tularensis subsp. tularensis (Q5NHL7)
brenda
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Transporter Classification Database (TCDB):
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