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Disease on EC 3.5.1.19 - nicotinamidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Bacteremia
Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections.
Cysts
The NAD+ Responsive Transcription Factor ERM-BP Functions Downstream of Cellular Aggregation and Is an Early Regulator of Development and Heat Shock Response in Entamoeba.
Infections
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host.
Defining plasmids required by Borrelia burgdorferi for colonization of tick vector Ixodes scapularis (Acari: Ixodidae).
Leishmaniasis
In silico pharmacophore modeling and simulation studies for searching potent antileishmanials targeted against Leishmania donovani nicotinamidase.
Leprosy
Identification of cat leprosy bacillus grown in mice.
Neoplasms
Early effects of nicotinamide, 2,4-dichloro-phenoxy acetic acid & actinomycin-D on the synthesis of nicotinamide amidohydrolase in rumex acetosa tumour tissue.
Neuroblastoma
Purification and characterization of a nicotinamide deamidase released into the growth medium of neuroblastoma in vitro.
Photophobia
[Nicotinamidase and the so-called pyrazinamidase in mycobacteria; the simultaneous occurrence of both activites (author's transl)]
Pneumonia
Multiscale Computational Study on the Catalytic Mechanism of the Nonmetallo Amidase Maleamate Amidohydrolase (NicF).
Tuberculosis
A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.
An assessment of a multiplex PCR assay for differentiating clinically important mycobacteria based on pncA gene variation.
Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of Iran.
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase.
Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.
Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Turkey.
Comparison of MGIT 960 & pyrazinamidase activity assay for pyrazinamide susceptibility testing of Mycobacterium tuberculosis.
Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii.
Crystal structure of the yeast nicotinamidase Pnc1p.
Cytochemical and biological properties of Mycobacterium bovis BCG.
Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China.
Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing.
Effects of sorbitol and glycerol on the structure, dynamics, and stability of Mycobacterium tuberculosis pyrazinamidase.
Estimation of pyrazinamidase activity using a cell-free
Evaluation of drug susceptibility testing methods of clinical Mycobacterium tuberculosis isolates to pyrazinamide.
Extracellular enzyme activities potentially involved in the pathogenicity of Mycobacterium tuberculosis.
Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA.
Insight to pyrazinamide resistance in Mycobacterium tuberculosis by molecular docking.
Kinetics and Inhibition of Nicotinamidase from Mycobacterium tuberculosis.
Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity.
Molecular characterization of pncA gene mutations in Mycobacterium tuberculosis clinical isolates from China.
Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.
Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene.
Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds.
pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada.
pncA mutations in clinical Mycobacterium tuberculosis isolates from Korea.
Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis.
Rapid colorimetric testing for pyrazinamide susceptibility of M. tuberculosis by a PCR-based in-vitro synthesized pyrazinamidase method.
Rapid detection of Mycobacterium tuberculosis and pyrazinamide susceptibility related to pncA mutations in sputum specimens through an integrated gene-to-protein function approach.
Rapid differentiation of bovine and human tubercle bacilli based on a characteristic mutation in the bovine pyrazinamidase gene.
Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculosis drug pyrazinamide.
Revelation of enzyme activity of mutant pyrazinamidases from Mycobacterium tuberculosis upon binding with various metals using quantum mechanical approach.
Specificity and Mechanism of Acinetobacter baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide.
Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance.
The curious characteristics of pyrazinamide: a review.
The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria.
The pncA gene from naturally pyrazinamide-resistant Mycobacterium avium encodes pyrazinamidase and confers pyrazinamide susceptibility to resistant M. tuberculosis complex organisms.
[Type differentiation of tuberculosis bacteria with the aid of the nicotinamidase test.]