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N-acetyl-DL-methionine + H2O
methionine + acetate
N-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
-
?
N-alpha-acetyl-L-ornithine + H2O
?
-
-
-
-
?
N-formyl-L-methionine + H2O
L-methionine + formate
N2-acety-L-ornithine + H2O
L-ornithine + acetate
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
N2-acetyl-L-ornithine + H2O
L-ornithine + acetate
Nalpha-acetyl-DL-serine + H2O
DL-serine + acetate
-
-
-
-
?
Nalpha-acetyl-L-alanine + H2O
L-alanine + acetate
Nalpha-acetyl-L-asparagine + H2O
L-asparagine + acetate
-
-
-
-
?
Nalpha-acetyl-L-cysteine + H2O
L-cysteine + acetate
-
-
-
-
?
Nalpha-acetyl-L-glutamine + H2O
L-glutamine + acetate
Nalpha-acetyl-L-leucine + H2O
L-leucine + acetate
-
-
-
-
?
Nalpha-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
Nalpha-acetyl-L-methionine + H2O
acetate + L-methionine
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
Nalpha-benzoyl-L-ornithine + H2O
benzoate + ornithine
Nalpha-chloroacetylglycine + H2O
glycine + chloroacetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
Aerobacter sp.
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-acetyl-DL-methionine + H2O
methionine + acetate
-
-
-
-
?
N-formyl-L-methionine + H2O
L-methionine + formate
-
-
-
-
?
N-formyl-L-methionine + H2O
L-methionine + formate
-
-
-
-
?
N-formyl-L-methionine + H2O
L-methionine + formate
-
-
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
Aerobacter sp.
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
the enzyme controls ornithine biosynthesis via a linear pathway with downstream effects on polyamine levels. The role of this enzyme is relevant for the reproductive development of Arabidopsis thaliana, probably contributing to ensure the optimal balance between cellular C and N metabolism necessary for flowering and fruit setting
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
?
N2-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
N2-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-alanine + H2O
L-alanine + acetate
-
-
-
-
?
Nalpha-acetyl-L-alanine + H2O
L-alanine + acetate
-
-
-
-
?
Nalpha-acetyl-L-alanine + H2O
L-alanine + acetate
-
-
-
-
?
Nalpha-acetyl-L-glutamine + H2O
L-glutamine + acetate
-
-
-
-
?
Nalpha-acetyl-L-glutamine + H2O
L-glutamine + acetate
-
-
-
-
?
Nalpha-acetyl-L-glutamine + H2O
L-glutamine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
Aerobacter sp.
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-acetyl-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
Nalpha-benzoyl-L-ornithine + H2O
benzoate + ornithine
-
-
-
-
?
Nalpha-benzoyl-L-ornithine + H2O
benzoate + ornithine
-
-
-
-
?
Nalpha-benzoyl-L-ornithine + H2O
benzoate + ornithine
-
-
-
-
?
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N2-acety-L-ornithine + H2O
L-ornithine + acetate
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
N2-acety-L-ornithine + H2O
L-ornithine + acetate
Aerobacter sp.
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acety-L-ornithine + H2O
L-ornithine + acetate
-
step in arginine biosynthesis
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
the enzyme controls ornithine biosynthesis via a linear pathway with downstream effects on polyamine levels. The role of this enzyme is relevant for the reproductive development of Arabidopsis thaliana, probably contributing to ensure the optimal balance between cellular C and N metabolism necessary for flowering and fruit setting
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
-
?
N2-acetyl-L-ornithine + H2O
acetate + L-ornithine
-
-
-
?
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1,10-phenanthroline
-
zinc-specific chelator
2-(acetylamino)-6-aminoheptanedioic acid
-
-
2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid
-
slight inhibition
2-amino-6-[(4-carboxy-3-methylbutanoyl)amino]heptanedioic acid
-
slight inhibition
2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid
-
-
2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid
-
slight inhibition
3-(ethylamino)piperidin-2-one
-
-
acetate
-
product inhibition
N2-(2,2-dimethylpropanoyl)-L-ornithine
-
-
N2-(2-methylpropanoyl)-L-ornithine
-
-
N2-(ethoxycarbonyl)-L-ornithine
-
weak inhibition
N2-(methoxycarbonyl)-L-ornithine
-
-
N2-(propoxycarbonyl)-L-ornithine
-
-
N2-(tert-butoxycarbonyl)-L-ornithine
-
-
N2-(trifluoroacetyl)-L-ornithine
-
weak inhibition
N2-acetyl-D-ornithine
-
weak inhibition
N2-butanoyl-L-ornithine
-
-
N2-chloroacetyl-L-ornithine
-
-
N2-dichloroacetyl-L-ornithine
-
-
N2-propanoyl-L-ornithine
-
-
N2-trichloroacetyl-D-ornithine
-
-
N2-trichloroacetyl-L-ornithine
-
-
N2-[(propan-2-yloxy)carbonyl]-L-ornithine
-
-
N2-[[(2-methylpentan-2-yl)oxy]carbonyl]-L-ornithine
-
-
NaF
-
linear uncompetitive inhibition
ornithine
-
product inhibition
p-chloromercuribenzoate
-
-
[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]leucine
-
bestatin, competitive inhibitor
additional information
-
synthesis and inhibitory potencies of a series of Nalpha-acyl/alkyl and Nalpha-alkoxycarbonyl derivatives of D- and L-ornithinie, overview. Minimal inhibitory concentrations of inhibitors in bacteria growth inhibition studies, overview
-
additional information
-
mono-N-acyl derivatives of 2,6-diaminopimelic acid as enzyme inhibitors, overview. No inhibition by 2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid, 2-amino-6-(butanoylamino)heptanedioic acid, 2-amino-6-[(2,2-dimethylpropanoyl)amino]heptanedioic acid, 2-amino-6-(pentanoylamino)heptanedioic acid, 2-amino-6-(benzoylamino)heptanedioic acid, 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-2,2,3,3-tetrafluorobutanoyl)amino]heptanedioic acid, 2-amino-6-[(3-ethoxy-3-oxopropanoyl)amino]heptanedioic acid, and 2-amino-6-[[(2R)-4-methoxy-2-methylpent-4-enoyl]amino]heptanedioic acid
-
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0.48
2-(acetylamino)-6-aminoheptanedioic acid
Escherichia coli
-
pH 7.5, 25°C
2.11
2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid
Escherichia coli
-
pH 7.5, 25°C
2.63
2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid
Escherichia coli
-
pH 7.5, 25°C
1.28
2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid
Escherichia coli
-
pH 7.5, 25°C
2.5
3-(ethylamino)piperidin-2-one
Bacillus subtilis
-
pH 7.5, 25°C
5.4
N2-(2,2-dimethylpropanoyl)-L-ornithine
Bacillus subtilis
-
about, pH 7.5, 25°C
1.21
N2-(2-methylpropanoyl)-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.25
N2-(ethoxycarbonyl)-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
1.01
N2-(methoxycarbonyl)-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.71
N2-(propoxycarbonyl)-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.54
N2-(tert-butoxycarbonyl)-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.2
N2-(trifluoroacetyl)-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.41
N2-acetyl-D-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.42
N2-butanoyl-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.085
N2-chloroacetyl-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.34
N2-dichloroacetyl-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
2.7
N2-ethyl-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.76
N2-propanoyl-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.32
N2-trichloroacetyl-D-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
0.45
N2-trichloroacetyl-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
1.4
N2-[(propan-2-yloxy)carbonyl]-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
1.16
N2-[[(2-methylpentan-2-yl)oxy]carbonyl]-L-ornithine
Bacillus subtilis
-
pH 7.5, 25°C
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additional information
-
three-dimensional homologic structure, molecular modeling using the X-ray crystal structure of the DapE from Haemophilus influenzae, PDB ID 3IC1, as template, overview
malfunction
ornithine depletion is associated with altered levels of putrescine and spermine. Reduced AtNAOD expression results in alterations at the reproductive level, causing early flowering and impaired fruit setting
malfunction
inactivation of argE gene does not cause arginine auxotrophy or marked growth defects
malfunction
-
ornithine depletion is associated with altered levels of putrescine and spermine. Reduced AtNAOD expression results in alterations at the reproductive level, causing early flowering and impaired fruit setting
-
metabolism
-
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
metabolism
-
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
-
physiological function
involvement of N-acetylornithine deacetylase from Arabidopsis thaliana in flowering and fruit development, the enzyme is associated with ovule development, overview. The enzyme contributes to the regulation of ornithine levels in plant cells
physiological function
the enzyme controls ornithine biosynthesis via a linear pathway with downstream effects on polyamine levels. The role of this enzyme is relevant for the reproductive development of Arabidopsis thaliana, probably contributing to ensure the optimal balance between cellular C and N metabolism necessary for flowering and fruit setting
physiological function
-
involvement of N-acetylornithine deacetylase from Arabidopsis thaliana in flowering and fruit development, the enzyme is associated with ovule development, overview. The enzyme contributes to the regulation of ornithine levels in plant cells
-
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Vogel, H.J.; Bonner, D.M.
Acetylornithinase of Escherichia coli: Partial purification and some properties
J. Biol. Chem.
218
97-106
1956
Aerobacter sp., Erwinia sp., Escherichia coli, Escherichia coli 160-37, Escherichia coli ATCC 9637, Escherichia coli B / ATCC 11303, Klebsiella sp., Proteus sp., Salmonella sp., Serratia sp., Shigella sp.
brenda
Boyen, A.; Charlier, D.; Charlier, J.; Sakanyan, V.; Mett, I.; Glansdorff, N.
Acetylornithine deacetylase, succinyldiaminopimelate desuccinylase and carboxypeptidase G2 are evolutionarily related
Gene
116
1-6
1992
Escherichia coli (P23908), Escherichia coli
brenda
Meinnel, T.; Schmitt, E.; Mechulam, Y.; Blanquet, S.
Structural and biochemical characterization of the Escherichia coli arg gene product
J. Bacteriol.
174
2323-2331
1992
Escherichia coli, Saccharomyces sp., Escherichia coli 160-37, Escherichia coli ATCC 9637
brenda
Xu, Y.; Liang, Z.; Legrain, C.; Rueger, H.J.; Glansdorff, N.
Evolution of arginine biosynthesis in the bacterial domain: Novel gene-enzyme relationships from psychrophilic Moritella strains (Vibrionaceae) and evolutionary significance of N-alpha-acetyl ornithinase
J. Bacteriol.
182
1609-1615
2000
Escherichia coli, Moritella profunda, Moritella abyssi, Escherichia coli 160-37, Escherichia coli ATCC 9637
brenda
Javid-Majd, F.; Blanchard, J.S.
Mechanistic analysis of the argE-encoded N-acetylornithine deacetylase
Biochemistry
39
1285-1293
2000
Escherichia coli, Escherichia coli 160-37, Escherichia coli ATCC 9637
brenda
McGregor, W.C.; Swierczek, S.I.; Bennett, B.; Holz, R.C.
argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli contains a dinuclear metalloactive site
J. Am. Chem. Soc.
127
14100-14107
2005
Escherichia coli, Escherichia coli BL21 (DE3)
brenda
McGregor, W.C.; Swierczek, S.I.; Bennett, B.; Holz, R.C.
Characterization of the catalytically active Mn(II)-loaded argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli
J. Biol. Inorg. Chem.
12
603-613
2007
Escherichia coli
brenda
Hlavacek, J.; Picha, J.; Vanek, V.; Jiracek, J.; Slaninova, J.; Fucik, V.; Budesinsky, M.; Gilner, D.; Holz, R.C.
Inhibitors of N(alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency
Amino Acids
38
1155-1164
2010
Bacillus subtilis, Bacillus subtilis 168
brenda
Tao, Y.; Shokes, J.; McGregor, W.; Scott, R.; Holz, R.
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