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Disease on EC 3.5.1.15 - aspartoacylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Amyloidosis
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Anemia
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
aspartoacylase deficiency
A Novel Mutation in Aspartoacylase Gene; Canavan Disease.
A review of phylogenetic and metabolic relationships between the acylamino acids, N-acetyl-L-aspartic acid and N-acetyl-L-histidine, in the vertebrate nervous system.
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination.
Aspartoacylase deficiency and Canavan disease in Saudi Arabia.
Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease.
Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brain.
Aspartoacylase deficiency in the white matter of human immunodeficiency virus encephalitis: novel mechanism in axonal damage.
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model.
Canavan disease. Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms.
Canavan disease: a novel mutation.
Canavan disease: molecular basis of aspartoacylase deficiency.
Coincident neuraminidase and aspartoacylase deficiency associated with chromosome 9Q paracentric inversion in a Saudi family.
Cranial ultrasound findings in aspartoacylase deficiency (Canavan disease).
Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: a search for substances that may have therapeutic value in the treatment of Canavan disease.
Glyceryl triacetate for Canavan disease: A low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model.
Identification and distribution of aspartoacylase in the postnatal rat brain.
Mental retardation and hypotonia seen in the knock out mouse for Canavan disease is not due to succinate semialdehyde dehydrogenase deficiency.
Metabolic changes in the knockout mouse for Canavan's disease: implications for patients with Canavan's disease.
Molecular basis of Canavan's disease: from human to mouse.
Pathogenesis of CNS involvement in disorders of amino and organic acid metabolism.
Protracted clinical course for patients with Canavan disease.
Purification and preliminary characterization of brain aspartoacylase.
Reliable prenatal diagnosis of Canavan disease (aspartoacylase deficiency): comparison of enzymatic and metabolite analysis.
SSIEM Award. Aspartoacylase deficiency: the enzyme defect in Canavan disease.
The frequency of the C854 mutation in the aspartoacylase gene in Ashkenazi Jews in Israel.
The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients.
Ultrasound findings in follow-up investigations in a case of aspartoacylase deficiency (canavan disease).
Variable course of Canavan disease in two boys with early infantile aspartoacylase deficiency.
[Canavan disease or N-acetyl aspartic aciduria: a case report]
[Megalencephaly with dystonia revealing Canavan disease].
[Neurologic diseases and chromosome 17]
Bardet-Biedl Syndrome
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Brain Diseases
Are Astrocytes the Missing Link Between Lack of Brain Aspartoacylase Activity and the Spongiform Leukodystrophy in Canavan Disease?
Protracted clinical course for patients with Canavan disease.
Brain Edema
A Novel Mutation in Aspartoacylase Gene; Canavan Disease.
Brain Injuries, Traumatic
THE MOLECULAR MECHANISMS AFFECTING N-ACETYLASPARTATE HOMEOSTASIS FOLLOWING EXPERIMENTAL GRADED TRAUMATIC BRAIN INJURY.
Breast Neoplasms
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Canavan Disease
A case of Canavan disease: the first biochemically proven case in a Japanese girl.
A mutation of aspartoacylase gene in a Turkish patient with Canavan disease.
A novel aspartoacylase (ASPA) gene mutation in Canavan disease.
A Novel Mutation in Aspartoacylase Gene; Canavan Disease.
A partial deletion of the aspartoacylase gene is the cause of Canavan disease in a family from Mexico.
A radiometric assay for aspartoacylase activity in cultured oligodendrocytes.
A review of phylogenetic and metabolic relationships between the acylamino acids, N-acetyl-L-aspartic acid and N-acetyl-L-histidine, in the vertebrate nervous system.
A structural and functional analysis of Nna1 in Purkinje cell degeneration (pcd) mice.
Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model.
Ablating the transporter NaDC3 prevents leukodystrophy in Canavan disease mice.
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease.
An atypical case of canavan disease with stroke-like presentation.
Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice.
Are Astrocytes the Missing Link Between Lack of Brain Aspartoacylase Activity and the Spongiform Leukodystrophy in Canavan Disease?
Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective.
Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination.
Aspartoacylase deficiency and Canavan disease in Saudi Arabia.
Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease.
Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brain.
Aspartoacylase deficiency in the white matter of human immunodeficiency virus encephalitis: novel mechanism in axonal damage.
Aspartoacylase gene knockout in the mouse: impact on reproduction.
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease.
Aspartoacylase is a regulated nuclear-cytoplasmic enzyme.
Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.
Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.
Astroglial Redistribution of Aquaporin 4 During Spongy Degeneration in a Canavan Disease Mouse Model.
Atypical clinical and radiological course of a patient with Canavan disease.
Atypical MRI findings in Canavan disease: a patient with a mild course.
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model.
Canavan disease and the role of N-acetylaspartate in myelin synthesis.
Canavan disease, a rare early-onset human spongiform leukodystrophy: Insights into its genesis and possible clinical interventions.
Canavan disease. Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms.
Canavan disease: a monogenic trait with complex genomic interaction.
Canavan disease: a novel mutation.
Canavan disease: a white matter disorder.
Canavan disease: biochemical and molecular studies.
Canavan disease: diagnosis and molecular analysis.
Canavan disease: genomic organization and localization of human ASPA to 17p13-ter and conservation of the ASPA gene during evolution.
Canavan disease: molecular basis of aspartoacylase deficiency.
Canavan disease: mutations among Jewish and non-jewish patients.
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.
Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease.
Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain.
Clinically Distinct Phenotypes of Canavan Disease Correlate with Residual Aspartoacylase Enzyme Activity.
Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease.
Coincident neuraminidase and aspartoacylase deficiency associated with chromosome 9Q paracentric inversion in a Saudi family.
Cranial ultrasound findings in aspartoacylase deficiency (Canavan disease).
Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme.
Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination.
Docking, molecular dynamics and free energy studies on aspartoacylase mutations involved in Canavan disease.
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease.
Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: a search for substances that may have therapeutic value in the treatment of Canavan disease.
Enhanced brain distribution of modified aspartoacylase.
Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue(,).
Expression of aspartoacylase (ASPA) and Canavan disease.
Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes.
Feline Spongy Encephalopathy With a Mutation in the ASPA Gene.
Frequency of a DNA polymorphism at position Y231 in the aspartoacylase gene and its impact on DNA-based carrier testing for Canavan disease in the Ashkenazi Jewish Population.
Genome-wide gene expression profiling and mutation analysis of Saudi patients with Canavan disease.
Glyceryl triacetate for Canavan disease: A low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model.
Identification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease.
Identification and distribution of aspartoacylase in the postnatal rat brain.
Identification and expression of eight novel mutations among non-Jewish patients with Canavan disease.
Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease.
Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease.
Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.
Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system.
Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease.
Long-term follow-up after gene therapy for canavan disease.
Loss of central auditory processing in a mouse model of Canavan disease.
Mental retardation and hypotonia seen in the knock out mouse for Canavan disease is not due to succinate semialdehyde dehydrogenase deficiency.
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.
Metabolic changes in the knockout mouse for Canavan's disease: implications for patients with Canavan's disease.
Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease.
Molecular basis of Canavan's disease: from human to mouse.
Murine aspartoacylase: cloning, expression and comparison with the human enzyme.
Mutation analysis of the aspartoacylase gene in non-Jewish patients with Canavan disease.
Mutation detection in the aspartoacylase gene in 17 patients with Canavan disease: four new mutations in the non-Jewish population.
Mutational analysis of aspartoacylase: implications for Canavan disease.
Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat.
N-acetylaspartate in the vertebrate brain: metabolism and function.
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.
N-acetylaspartic aciduria in Canavan disease: another proof in two infants.
N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.
Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI.
New T530C mutation in the aspartoacylase gene caused Canavan disease with no correlation between severity and N-acetylaspartate excretion.
Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease.
Novel mutation of aspartoacylase gene in a Turkish patient with Canavan disease.
Novel splice site mutation of aspartoacylase gene in a Turkish patient with Canavan disease.
Pathogenesis of CNS involvement in disorders of amino and organic acid metabolism.
Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain.
Protracted clinical course for patients with Canavan disease.
Purification and preliminary characterization of brain aspartoacylase.
Purification, characterization, and localization of aspartoacylase from bovine brain.
rAAV gene therapy in a Canavan's disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system.
Rapid detection of three large novel deletions of the aspartoacylase gene in non-Jewish patients with Canavan disease.
Redirecting
Reliable prenatal diagnosis of Canavan disease (aspartoacylase deficiency): comparison of enzymatic and metabolite analysis.
Reliable prenatal diagnosis of Canavan disease by measuring N-acetylaspartate in amniotic fluid using liquid chromatography tandem mass spectrometry.
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.
Restricted diffusion in Canavan disease.
Severe retinal degeneration in a patient with Canavan disease.
Spongy degeneration of the brain, Canavan disease: biochemical and molecular findings.
SSIEM Award. Aspartoacylase deficiency: the enzyme defect in Canavan disease.
Structural modeling of p.V31F variant in the aspartoacylase gene.
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy.
The frequency of the C854 mutation in the aspartoacylase gene in Ashkenazi Jews in Israel.
The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients.
The spectrum of mutations of the aspartoacylase gene in Canavan disease in non-Jewish patients.
Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse.
Two novel aspartoacylase gene (ASPA) missense mutations specific to Norwegian and Swedish patients with Canavan disease.
Two novel missense mutations in the aspartoacylase gene in a Chinese patient with congenital Canavan disease.
Ultrasound findings in follow-up investigations in a case of aspartoacylase deficiency (canavan disease).
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.
Unreliable verification of prenatal diagnosis of Canavan disease: aspartoacylase activity in deficient and normal fetal skin fibroblasts.
Upregulation of N-acetylaspartic acid resulting nitric oxide toxicity induces aspartoacylase mutations and protein interaction to cause pathophysiology seen in Canavan disease.
Variable course of Canavan disease in two boys with early infantile aspartoacylase deficiency.
White matter disease: Targeted aspartoacylase gene therapy reverts Canavan disease.
[Canavan disease or N-acetyl aspartic aciduria: a case report]
[Long term clinical course of Canavan disease--a rare Japanese case]
[Megalencephaly with dystonia revealing Canavan disease].
[Neurologic diseases and chromosome 17]
Carcinogenesis
N-Acetylaspartate (NAA) and N-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells.
Carcinoma
Differential aminoacylase expression in neuroblastoma.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Carcinoma, Renal Cell
Differential aminoacylase expression in neuroblastoma.
Deficiency Diseases
Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: a search for substances that may have therapeutic value in the treatment of Canavan disease.
Demyelinating Diseases
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.
Relationship between enzyme properties and disease progression in Canavan disease.
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.
Diabetic Neuropathies
Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy.
Dwarfism
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Encephalitis
Aspartoacylase deficiency in the white matter of human immunodeficiency virus encephalitis: novel mechanism in axonal damage.
Epilepsy
Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder.
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease.
Essential Tremor
Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.
Genetic Diseases, Inborn
A review of phylogenetic and metabolic relationships between the acylamino acids, N-acetyl-L-aspartic acid and N-acetyl-L-histidine, in the vertebrate nervous system.
Glyceryl triacetate for Canavan disease: A low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model.
Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse.
Glioma
N-Acetylaspartate (NAA) and N-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells.
Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.
Hyperlipoproteinemia Type I
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Hypoalphalipoproteinemias
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Intellectual Disability
Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system.
N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Leukoencephalopathies
White matter disease: Targeted aspartoacylase gene therapy reverts Canavan disease.
lipoprotein lipase deficiency
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Malaria
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Megalencephaly
N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.
Metabolic Diseases
Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.
N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.
Migraine Disorders
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Mucolipidoses
Coincident neuraminidase and aspartoacylase deficiency associated with chromosome 9Q paracentric inversion in a Saudi family.
Muscle Hypotonia
N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.
Preimplantation genetic diagnosis of Canavan disease.
Ultrasound findings in follow-up investigations in a case of aspartoacylase deficiency (canavan disease).
Muscular Diseases
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Neoplasms
Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest.
Bioinformatics Analysis of Stromal Molecular Signatures Associated with Breast and Prostate Cancer.
Differential aminoacylase expression in neuroblastoma.
N-Acetylaspartate (NAA) and N-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells.
Nervous System Diseases
Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective.
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease.
Enhanced brain distribution of modified aspartoacylase.
Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue(,).
Neuroblastoma
Differential aminoacylase expression in neuroblastoma.
Neurodegenerative Diseases
Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination.
Canavan disease and the role of N-acetylaspartate in myelin synthesis.
Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease.
Mutational analysis of aspartoacylase: implications for Canavan disease.
New T530C mutation in the aspartoacylase gene caused Canavan disease with no correlation between severity and N-acetylaspartate excretion.
Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain.
Rapid detection of three large novel deletions of the aspartoacylase gene in non-Jewish patients with Canavan disease.
Severe retinal degeneration in a patient with Canavan disease.
The clinical course of Canavan disease.
The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients.
The spectrum of mutations of the aspartoacylase gene in Canavan disease in non-Jewish patients.
Ultrasound findings in follow-up investigations in a case of aspartoacylase deficiency (canavan disease).
[Long term clinical course of Canavan disease--a rare Japanese case]
Obesity
Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy.
Oligodendroglioma
Acetate supplementation induces growth arrest of NG2/PDGFR?-positive oligodendroglioma-derived tumor-initiating cells.
Optic Nerve Diseases
Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse.
Osteoporosis
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Phenylketonurias
Pathogenesis of CNS involvement in disorders of amino and organic acid metabolism.
Rickets
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Seizures
Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors.
Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats.
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease.
N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.
Sialic Acid Storage Disease
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Pathogenesis of CNS involvement in disorders of amino and organic acid metabolism.
Tremor
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors.
Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats.
Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder.
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease.
Involvement of aspartoacylase in tremor expression in rats.
Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis.
von Hippel-Lindau Disease
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.