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Information on EC 3.5.1.137 - N-methylcarbamate hydrolase

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EC Tree
IUBMB Comments
The enzyme catalyses the first step in the degradation of several carbamate insecticides such as carbaryl, carbofuran, isoprocarb, propoxur, aldicarb and oxamyl. It catalyses the cleavage of the ester bond to release N-methylcarbamate, which spontaneously hydrolyses to methylamine and CO2. The enzymes from several Gram-negative bacteria were shown to be located in the periplasm.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
carbaryl hydrolase, carbamate hydrolase, carbofuran hydrolase, carbamate c-n hydrolase, methyl carbamate-degrading hydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an N-methyl carbamate ester + H2O = an alcohol + methylamine + CO2
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PATHWAY SOURCE
PATHWAYS
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