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Information on EC 3.5.1.133 - Nalpha-acyl-L-glutamine aminoacylase

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IUBMB Comments
Requires Zn2+. The enzyme, characterized from the bacterium Corynebacterium sp. Ax20, hydrolyses odorless Nalpha-acyl-L-glutamine conjugates of short- and medium-chain fatty acids, releasing axillary malodor compounds. While the enzyme is highly specific for the L-glutamine moiety, it is quite promiscuous regarding the acyl moiety. The two most common products of the enzyme's activity in axillary secretions are (2E)-3-methylhex-2-enoate and 3-hydroxy-3-methylhexanoate.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
acylglutamine-aminoacylase, AgaA, AMRE, axillary malodor releasing enzyme, N(alpha)-acyl-glutamine aminoacylase, N-acyl-Gln aminoacylase, N-AGA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an Nalpha-acyl-L-glutamine + H2O = L-glutamine + a carboxylate
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