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Information on EC 3.5.1.128 - deaminated glutathione amidase and Organism(s) Mus musculus and UniProt Accession Q8VDK1

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IUBMB Comments
The enzyme, present in animals, fungi and bacteria, is involved in clearing cells of the toxic compound deaminated glutathione, which can be produced as an unwanted side product by several transaminases.
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This record set is specific for:
Mus musculus
UNIPROT: Q8VDK1
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
At4g08790, deaminated glutathione amidase, dGSH deaminase, NIT1, Nit1 nitrilase, NIT2, nitrilase-like protein 1, PA4475, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nitrilase-like protein 1
-
dGSH deaminase
-
-
-
-
NIT1
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
N-(4-oxoglutaryl)-L-cysteinylglycine amidohydrolase
The enzyme, present in animals, fungi and bacteria, is involved in clearing cells of the toxic compound deaminated glutathione, which can be produced as an unwanted side product by several transaminases.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O
2-oxoglutarate + L-cysteinylglycine
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O
2-oxoglutarate + L-cysteinylglycine
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
deaminated glutathione, i.e. N-(4-oxoglutaryl)-L-cysteinylglycine, is exreted in large amounts in the urine of Nit1 knock-out mice
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NIT1_MOUSE
323
0
35705
Swiss-Prot
Mitochondrion (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Peracchi, A.; Veiga-da-Cunha, M.; Kuhara, T.; Ellens, K.W.; Paczia, N.; Stroobant, V.; Seliga, A.K.; Marlaire, S.; Jaisson, S.; Bommer, G.T.; Sun, J.; Huebner, K.; Linster, C.L.; Cooper, A.J.L.; Van Schaftingen, E.
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione
Proc. Natl. Acad. Sci. USA
114
E3233-E3242
2017
Homo sapiens (Q86X76), Mus musculus (Q8VDK1), Pseudomonas aeruginosa (Q9HVU6), Pseudomonas aeruginosa DSM 22644 (Q9HVU6), Saccharomyces cerevisiae (P47016), Synechocystis sp. PCC 6803 (P0DP66), Yersinia enterocolitica (P0DP68)
Manually annotated by BRENDA team