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Information on EC 3.5.1.125 - N2-acetyl-L-2,4-diaminobutanoate deacetylase for references in articles please use BRENDA:EC3.5.1.125
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EC Tree
IUBMB Comments The enzyme, found in bacteria, has no activity with (2S)-4-acetamido-2-aminobutanoate (cf. EC 3.5.4.44, ectoine hydrolase).
The expected taxonomic range for this enzyme is: Halomonas elongata
Synonyms
doeB, Helo_3664, N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase,
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N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
doeB
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gene name
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Helo_3664
gene name
N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
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N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
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(2S)-2-acetamido-4-aminobutanoate + H2O = L-2,4-diaminobutanoate + acetate
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N2-acetyl-L-2,4-diaminobutanoate amidohydrolase
The enzyme, found in bacteria, has no activity with (2S)-4-acetamido-2-aminobutanoate (cf. EC 3.5.4.44, ectoine hydrolase).
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N2-acetyl-L-2,4-diaminobutanoate + H2O
L-2,4-diaminobutanoate + acetate
N2-acetyl-L-2,4-diaminobutanoate + H2O
L-2,4-diaminobutanoate + acetate
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N2-acetyl-L-2,4-diaminobutanoate + H2O
L-2,4-diaminobutanoate + acetate
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UniProt
brenda
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UniProt
brenda
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physiological function
the degradation of ectoine proceeds via hydrolysis of ectoine by DoeA to Nalpha-acetyl-L-2,4-diaminobutanoate, followed by deacetylation to diaminobutanoate by DoeB and a transaminase reaction by DoeD leading to aspartate-semialdehyde. Deletion of doeB result in a mutant that cannot utilize ectoine as carbon and nitrogen source. Nalpha-acetyl-L-2,4-diaminobutanoate accumulates as the predominant amino-reactive solute in the mutant while no Nalpha-acetyl-L-2,4-diaminobutanoate is detectable in the wild type
physiological function
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the degradation of ectoine proceeds via hydrolysis of ectoine by DoeA to Nalpha-acetyl-L-2,4-diaminobutanoate, followed by deacetylation to diaminobutanoate by DoeB and a transaminase reaction by DoeD leading to aspartate-semialdehyde. Deletion of doeB result in a mutant that cannot utilize ectoine as carbon and nitrogen source. Nalpha-acetyl-L-2,4-diaminobutanoate accumulates as the predominant amino-reactive solute in the mutant while no Nalpha-acetyl-L-2,4-diaminobutanoate is detectable in the wild type
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DOEB_HALED
Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
342
0
36586
Swiss-Prot
A0A375HQP1_9BURK
351
0
37454
TrEMBL
A0A2Z4AH84_9BACT
360
0
40037
TrEMBL
A0A2K9ZBS6_RHILE
335
0
35579
TrEMBL
A0A4S2JK12_PHODD
337
0
37552
TrEMBL
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36600
x * 36600, calculated
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x * 36600, calculated
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x * 36600, calculated
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Schwibbert, K.; Marin-Sanguino, A.; Bagyan, I.; Heidrich, G.; Lentzen, G.; Seitz, H.; Rampp, M.; Schuster, S.C.; Klenk, H.P.; Pfeiffer, F.; Oesterhelt, D.; Kunte, H.J.
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T
Environ. Microbiol.
13
1973-1994
2011
Halomonas elongata (E1V7W0), Halomonas elongata DSM 2581 (E1V7W0)
brenda
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3.5.1.125 N2-acetyl-L-2,4-diaminobutanoate deacetylase
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