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EC Tree
IUBMB Comments The enzyme, found in bacteria, has no activity with (2S)-4-acetamido-2-aminobutanoate (cf. EC 3.5.4.44, ectoine hydrolase).
The enzyme appears in viruses and cellular organisms
Synonyms
doeB ,
Helo_3664 , N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase,
more
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N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
doeB
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Helo_3664
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N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
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N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
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(2S)-2-acetamido-4-aminobutanoate + H2O = L-2,4-diaminobutanoate + acetate
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N2-acetyl-L-2,4-diaminobutanoate amidohydrolase
The enzyme, found in bacteria, has no activity with (2S)-4-acetamido-2-aminobutanoate (cf. EC 3.5.4.44, ectoine hydrolase).
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N2-acetyl-L-2,4-diaminobutanoate + H2O
L-2,4-diaminobutanoate + acetate
N2-acetyl-L-2,4-diaminobutanoate + H2O
L-2,4-diaminobutanoate + acetate
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?
N2-acetyl-L-2,4-diaminobutanoate + H2O
L-2,4-diaminobutanoate + acetate
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?
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UniProt
brenda
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UniProt
brenda
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physiological function
the degradation of ectoine proceeds via hydrolysis of ectoine by DoeA to Nalpha-acetyl-L-2,4-diaminobutanoate, followed by deacetylation to diaminobutanoate by DoeB and a transaminase reaction by DoeD leading to aspartate-semialdehyde. Deletion of doeB result in a mutant that cannot utilize ectoine as carbon and nitrogen source. Nalpha-acetyl-L-2,4-diaminobutanoate accumulates as the predominant amino-reactive solute in the mutant while no Nalpha-acetyl-L-2,4-diaminobutanoate is detectable in the wild type
physiological function
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the degradation of ectoine proceeds via hydrolysis of ectoine by DoeA to Nalpha-acetyl-L-2,4-diaminobutanoate, followed by deacetylation to diaminobutanoate by DoeB and a transaminase reaction by DoeD leading to aspartate-semialdehyde. Deletion of doeB result in a mutant that cannot utilize ectoine as carbon and nitrogen source. Nalpha-acetyl-L-2,4-diaminobutanoate accumulates as the predominant amino-reactive solute in the mutant while no Nalpha-acetyl-L-2,4-diaminobutanoate is detectable in the wild type
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DOEB_HALED
Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
342
0
36586
Swiss-Prot
-
A0A7V8V9W9_9BACT
310
0
33490
TrEMBL
-
A0A7U9QUN7_9FIRM
316
0
35090
TrEMBL
-
A0A6S7FK38_9BURK
344
0
36826
TrEMBL
-
A0A7U9N6U2_9FIRM
314
0
35019
TrEMBL
-
A0A7U9N0N7_9FIRM
311
0
34281
TrEMBL
-
A0A653Q604_9BRAD
346
0
36655
TrEMBL
-
A0A7U2PQF1_9RHOB
330
0
34834
TrEMBL
-
A0A6J5GSH5_9BURK
331
0
35838
TrEMBL
-
A0A7U9T1X4_9FIRM
316
0
35186
TrEMBL
-
A0A6J4ZXZ0_9BURK
342
0
36516
TrEMBL
-
A0A5E7KLC8_PSEFL
333
0
35356
TrEMBL
-
A0A5E6RJ11_PSEFL
333
0
35369
TrEMBL
-
B1G1E2_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
341
0
37045
TrEMBL
-
A0A6G8NS63_9BURK
346
0
36798
TrEMBL
-
A0A6J5KC09_9BURK
211
0
22000
TrEMBL
-
A0A5E7KGQ0_PSEFL
333
0
35400
TrEMBL
-
A0A5E7T2Z8_PSEFL
333
0
35346
TrEMBL
-
A0A6S7EEC3_9BURK
326
0
34185
TrEMBL
-
A0A5S9PD94_9GAMM
495
0
53679
TrEMBL
-
A0A7S4H2S6_9GAMM
337
0
35983
TrEMBL
-
A0A5E7KAW1_PSEFL
333
0
35473
TrEMBL
-
A0A5C1NHL8_9GAMM
336
0
35979
TrEMBL
-
A0A2Z4AH84_9BACT
360
0
40037
TrEMBL
-
A0A375HQP1_9BURK
351
0
37454
TrEMBL
-
A0A654BIE2_9BURK
343
0
36383
TrEMBL
-
A0A6S7DXV2_9BURK
326
0
34275
TrEMBL
-
A0A6S6ZE05_9BURK
326
0
34282
TrEMBL
-
A0A6N0YSY1_9GAMM
343
0
37435
TrEMBL
-
A0A7U9T655_9FIRM
309
0
35400
TrEMBL
-
A0A654AD21_9PSED
333
0
35334
TrEMBL
-
A0A6J5K2N9_9BURK
343
0
37192
TrEMBL
-
A0A653WC00_9GAMM
339
0
36108
TrEMBL
-
A0A2M9H570_9BURK
325
0
33707
TrEMBL
-
A0A5S9N8Q8_9GAMM
371
0
40277
TrEMBL
-
A0A6S6ZS37_9BURK
326
0
34376
TrEMBL
-
A0A7V8V8E7_9BACT
329
0
35940
TrEMBL
-
A0A5S9Q6J2_9GAMM
371
0
40438
TrEMBL
-
A0A6J5K0B9_9BURK
342
0
36517
TrEMBL
-
A0A5E8A914_9RHIZ
329
0
35250
TrEMBL
-
A0A6J4GDJ9_9FLAO
326
0
36352
TrEMBL
-
A0A5E7VJ57_PSEFL
338
0
37099
TrEMBL
-
A0A1X1PP20_9BURK
344
0
37113
TrEMBL
-
A0A6J5DFU2_9BURK
345
0
37018
TrEMBL
-
A0A653B4T2_PSEOL
333
0
35504
TrEMBL
-
A0A6L5BTC5_9PSED
338
0
37418
TrEMBL
-
A0A6J5ASQ5_9BURK
343
0
37134
TrEMBL
-
A0A6S7FEJ9_9BURK
326
0
34258
TrEMBL
-
A0A6S6ZNQ0_9BURK
326
0
34311
TrEMBL
-
A0A6J4ZQC7_9BURK
337
0
36627
TrEMBL
-
A0A508X4J8_9RHIZ
334
0
35885
TrEMBL
-
A0A5E7SKM5_PSEFL
338
0
37379
TrEMBL
-
A0A7U2K4N2_9RHOB
330
0
34591
TrEMBL
-
A0A5S9NQQ4_9GAMM
509
0
55189
TrEMBL
-
A0A5E7BP26_PSEFL
333
0
35574
TrEMBL
-
A0A6S7DW87_9BURK
357
0
37985
TrEMBL
-
A0A6S7CX46_9BURK
325
0
33515
TrEMBL
-
A0A6S7FIA0_9BURK
357
0
37840
TrEMBL
-
A0A5S9NNZ5_9GAMM
497
0
53627
TrEMBL
-
A0A6J4GHZ0_9FLAO
326
0
36266
TrEMBL
-
A0A7U9R292_9FIRM
311
0
34463
TrEMBL
-
A0A2K9ZBS6_RHILE
335
0
35579
TrEMBL
-
A0A543Q000_ACITH
300
0
33789
TrEMBL
-
A0A644Y128_9ZZZZ
314
0
34270
TrEMBL
other Location (Reliability: 1 )
A0A653E3Z8_9PSED
357
0
38416
TrEMBL
-
A0A5E6QNP0_PSEFL
338
0
37183
TrEMBL
-
A0A2N7WAA2_9BURK
348
0
37235
TrEMBL
-
A0A7U9RDU6_9FIRM
311
0
34871
TrEMBL
-
A0A6S7EEA5_9BURK
326
0
34208
TrEMBL
-
A0A7U9N6J9_9FIRM
313
0
35564
TrEMBL
-
A0A5E7TW82_PSEFL
333
0
35421
TrEMBL
-
B1G109_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
340
0
36245
TrEMBL
-
A0A5E7SY40_PSEFL
333
0
35546
TrEMBL
-
A0A6S7CFS2_9BURK
344
0
37040
TrEMBL
-
A0A346BJQ9_9BURK
330
0
35466
TrEMBL
-
A0A6S6Z066_9BURK
325
0
33812
TrEMBL
-
A0A6S6ZR54_9BURK
329
0
34581
TrEMBL
-
A0A6S7DW41_9BURK
325
0
33737
TrEMBL
-
A0A5E6XCH0_PSEFL
333
0
35546
TrEMBL
-
A0A7U9WU31_9FIRM
316
0
35230
TrEMBL
-
A0A5S9QLE1_9GAMM
356
0
38267
TrEMBL
-
A0A5E7CYD6_PSEFL
333
0
35418
TrEMBL
-
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36600
x * 36600, calculated
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?
x * 36600, calculated
?
-
x * 36600, calculated
-
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Schwibbert, K.; Marin-Sanguino, A.; Bagyan, I.; Heidrich, G.; Lentzen, G.; Seitz, H.; Rampp, M.; Schuster, S.C.; Klenk, H.P.; Pfeiffer, F.; Oesterhelt, D.; Kunte, H.J.
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T
Environ. Microbiol.
13
1973-1994
2011
Halomonas elongata (E1V7W0), Halomonas elongata DSM 2581 (E1V7W0)
brenda
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