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Information on EC 3.5.1.124 - protein deglycase

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.124 protein deglycase
IUBMB Comments
The enzyme, previously thought to be a glyoxalase, acts on glycated L-arginine, L-lysine, and L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines. The enzyme repairs the amino acids, releasing glycolate or (R)-lactate, depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
an Nomgega-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine
+
=
+
an N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine
+
=
a [protein]-L-lysine
+
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine
+
=
a [protein]-L-cysteine
+
Synonyms
glyoxalase, dj-1 protein, park7, deglycase, parkinsonism-associated protein dj-1, glutathione-independent glyoxalase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O = a [protein]-L-lysine + lactate
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an Nomgega-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O = a [protein]-L-arginine + lactate
show the reaction diagram
(1)
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-
-
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O = a [protein]-L-cysteine + (R)-lactate
show the reaction diagram
(3)
-
-
-
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