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Information on EC 3.4.99.B1 - RCE1 and Organism(s) Mus musculus and UniProt Accession P57791

for references in articles please use BRENDA:EC3.4.99.B1
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This record set is specific for:
Mus musculus
UNIPROT: P57791
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins
Synonyms
rce1p, hrce1, ras converting enzyme 1, ras-converting enzyme 1, ras converting enzyme, ras and a-factor converting enzyme, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ras-converting enzyme 1
-
isoprenylated protein peptidase
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
148463-92-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphodiesterase 6 + H2O
?
show the reaction diagram
-
-
-
?
small GTPase RalA + H2O
?
show the reaction diagram
-
-
-
?
small GTPase RalB + H2O
?
show the reaction diagram
-
-
-
?
a-factor-CaaX + H2O
a-factor-C + aaX
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
in the absence of Rce1, splenocytes and bone marrow cells expressing oncogenic KRAS yield more and larger colonies when grown in methylcellulose. The inactivation of Rce1 worsens the myeloproliferative disease caused by oncogenic K-RAS
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
the inactivation of Rce1 actually increases peripheral leukocytosis, increases the release of immature hematopoietic cells into the circulation and the infiltration of cells into liver and spleen, and causes mice to die more rapidly
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
fibroblast
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
retinal development proceeds normally in the absence of RAS-converting enzyme 1 (Rce1), but photoreceptor cells fail to respond to light and subsequently degenerate in a rapid fashion. Phosphodiesterase 6 is unable to be transported to the outer segments in Rce1-deficient photoreceptor cells
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FACE2_MOUSE
329
0
35867
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Casey, P.J.; Rando, R.R.
Isoprenylated protein peptidase Rce1
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
2123-2127
2004
Bos taurus, Homo sapiens, Mus musculus, Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Bergo, M.O.; Lieu, H.D.; Gavino, B.J.; Ambroziak, P.; Otto, J.C.; Casey, P.J.; Walker, Q.M.; Young, S.G.
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy
J. Biol. Chem.
279
4729-4736
2004
Mus musculus
Manually annotated by BRENDA team
Michaelson, D.; Ali, W.; Chiu, V.K.; Bergo, M.; Silletti, J.; Wright, L.; Young, S.G.; Philips, M.
Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases
Mol. Biol. Cell
16
1606-1616
2005
Mus musculus
Manually annotated by BRENDA team
Wahlstrom, A.M.; Cutts, B.A.; Karlsson, C.; Andersson, K.M.; Liu, M.; Sjogren, A.K.; Swolin, B.; Young, S.G.; Bergo, M.O.
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease
Blood
109
763-768
2007
Mus musculus
Manually annotated by BRENDA team
Christiansen, J.R.; Kolandaivelu, S.; Bergo, M.O.; Ramamurthy, V.
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments
Proc. Natl. Acad. Sci. USA
108
8862-8866
2011
Mus musculus (P57791)
Manually annotated by BRENDA team
Gentry, L.R.; Nishimura, A.; Cox, A.D.; Martin, T.D.; Tsygankov, D.; Nishida, M.; Elston, T.C.; Der, C.J.
Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases
J. Biol. Chem.
290
22851-61
2015
Mus musculus (P57791)
Manually annotated by BRENDA team