Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.25.1 - proteasome endopeptidase complex and Organism(s) Drosophila melanogaster and UniProt Accession Q9V3H2

for references in articles please use BRENDA:EC3.4.25.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Drosophila melanogaster
UNIPROT: Q9V3H2 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide
cleavage of peptide bonds with very broad specificity
Synonyms
proteasome, 26s proteasome, 20s proteasome, 26 s proteasome, multicatalytic proteinase, 20 s proteasome, multicatalytic protease, 26s proteasome complex, prosome, proteasome 20s, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
26S protease
-
-
-
-
26S proteasome
27 kDa prosomal protein
-
-
-
-
30 kDa prosomal protein
-
-
-
-
Component Y8
-
-
-
-
GPRO-28
-
-
-
-
HsBPROS26
-
-
-
-
HSN3
-
-
-
-
ingensin
-
-
-
-
large multicatalytic protease
-
-
-
-
macropain
-
-
-
-
multicatalytic endopeptidase complex
-
-
-
-
Multicatalytic endopeptidase complex C7
-
-
-
-
multicatalytic protease
-
-
-
-
multicatalytic proteinase
-
-
-
-
p27K
-
-
-
-
PROS-27
-
-
-
-
PROS-30
-
-
-
-
PROS-Dm25
-
-
-
-
PROS-Dm28.1
-
-
-
-
PROS-Dm29
-
-
-
-
PROS-Dm35
-
-
-
-
Pros26.4
-
member of the AAA-ATPase subunits of the proteasome 19S regulatory particle
prosome
-
-
-
-
proteasome
-
-
-
-
proteasome 19S
-
-
Proteasome component C13
-
-
-
-
Proteasome component C2
-
-
-
-
Proteasome component C3
-
-
-
-
Proteasome component C5
-
-
-
-
Proteasome component C8
-
-
-
-
Proteasome component C9
-
-
-
-
Proteasome component DD4
-
-
-
-
Proteasome component DD5
-
-
-
-
Proteasome component pts1
-
-
-
-
RING12 protein
-
-
-
-
RN3
-
-
-
-
SCL1 suppressor protein
-
-
-
-
TAS-F22/FAFP98
-
-
-
-
TAS-G64
-
-
-
-
TCPR29
-
-
-
-
tricorn protease
-
-
-
-
tricorn proteinase
-
-
-
-
XC3
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
140879-24-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
ubiquitinylated proteins
?
show the reaction diagram
-
individual substrates unknown
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ubiquitinylated proteins
?
show the reaction diagram
-
individual substrates unknown
-
-
?
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.7 - 4.8
subunit p54, theoretically determined by GENETYX-MAC 8.0
4.93
subunit p110, theoretically determined by GENETYX-MAC 8.0
5.12
subunit p37A, theoretically determined by GENETYX-MAC 8.0
5.18
subunit p39A, theoretically determined by GENETYX-MAC 8.0
5.2
subunit p50, theoretically determined by GENETYX-MAC 8.0
5.22
subunit p48A, theoretically determined by GENETYX-MAC 8.0
5.48
subunit p97, theoretically determined by GENETYX-MAC 8.0
5.49
subunit p55, theoretically determined by GENETYX-MAC 8.0
5.66 - 6.17
subunit p42B, theoretically determined by GENETYX-MAC 8.0
5.74
subunit p37B, theoretically determined by GENETYX-MAC 8.0
5.75
subunit p48B, theoretically determined by GENETYX-MAC 8.0
5.8
subunit p30, theoretically determined by GENETYX-MAC 8.0
6.06
subunit p42A, theoretically determined by GENETYX-MAC 8.0
6.17
subunit P56, theoretically determined by GENETYX-MAC 8.0
8.44
subunit p42D, theoretically determined by GENETYX-MAC 8.0
8.51
subunit p42C, theoretically determined by GENETYX-MAC 8.0
8.9
subunit p39B, theoretically determined by GENETYX-MAC 8.0
9.04
subunit P58, theoretically determined by GENETYX-MAC 8.0
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
subunit p37A
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
before vitellogenesis (up to stage 6), there is a continuous accumulation of the proteasomes in the nucleus of the oocyte. The outset of vitellogenesis is accompanied by a sharp decline in the nuclear accumulation of the proteasomes: in a majority of the stage 10 oocytes, only weak proteasome staining is seen. In the nucleus of about 30% of the oocytes the proteasome is barely detectable
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
during the previtellogenic phase of oogenesis, the proteasomes are localized exclusively in the cytoplasm of the follicular cells. This is followed by a huge nuclear accumulation during the vitellogenic phase of oogenesis
Manually annotated by BRENDA team
-
during the previtellogenic phase of oogenesis, the proteasomes are localized exclusively in the cytoplasm of the follicular cells. This is followed by a huge nuclear accumulation during the vitellogenic phase of oogenesis
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PSDE_DROME
308
0
34401
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
102300
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
113200
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
30200
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
34400
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
37700
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
38500
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
42600
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
43800
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
44200
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
45400
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
45800
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
46900
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
47300
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
47800
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
48500
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
49300
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
56000
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
octadecamer
1 * 113200, subunit p110, + 1 * 102300, subunit p97, + 1 * 56000, subunit P58, + 1 * 49300, subunit P56, + 1 + 57700, subunit p55, + 1 * 42600, subunit p54, + 1 * 47800, subunit p50, + 1 * 46900, subunit p48A, + 1 * 48500, subunit p48B, + 1 * 45400, subunit p42A, + 1 * 47300, subunit p42B, + 1 * 45800, subunit p42C, + 1 * 44200, subunit p42D, + 1 * 43800, subunit p39A, + 1 * 38500, subunit p39B, + 1 * 37700, subunit p37A, + 1 * 34400, subunit p37B, + 1 * 30200, subunit p30, theoretically determined by GENETYX-MAC 8.0
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hilt, W.; Heinemeyer, W.; Wolf, D.H.
Studies on the yeast proteasome uncover its basic structural features and multiple in vivo functions
Enzyme Protein
47
189-201
1994
Saccharomyces cerevisiae, Oryctolagus cuniculus, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe, Thermoplasma acidophilum, Xenopus laevis
Manually annotated by BRENDA team
Rivett, J.
Proteasomes: Multicatalytic proteinase complexes
Biochem. J.
291
1-10
1993
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Thermoplasma acidophilum, Xenopus laevis
-
Manually annotated by BRENDA team
Hlzl, H.; Kapelari, B.; Kellermann, J.; Seemuller, E.; Smegi, M.; Udvardy, A.; Medalia, O.; Sperling, J.; Mller, S.A.; Engel, A.; Baumeister, W.
The regulatory complex of Drosophila melanogaster 26S proteasomes: subunit composition and localization of a deubiquitylating enzyme
J. Cell Biol.
150
119-129
2000
Drosophila melanogaster, Drosophila melanogaster (O18413), Drosophila melanogaster (P25161), Drosophila melanogaster (P26270), Drosophila melanogaster (P48601), Drosophila melanogaster (P55035), Drosophila melanogaster (Q7KMP8), Drosophila melanogaster (Q9U7A2), Drosophila melanogaster (Q9V3G7), Drosophila melanogaster (Q9V3H2), Drosophila melanogaster (Q9V3P6), Drosophila melanogaster (Q9V3V6), Drosophila melanogaster (Q9V3Z4), Drosophila melanogaster (Q9V405), Drosophila melanogaster (Q9V436), Drosophila melanogaster (Q9VW54), Drosophila melanogaster (Q9XZ61)
Manually annotated by BRENDA team
Adam, G.; Gausz, J.; Noselli, S.; Kurucz, E.; Ando, I.; Udvardy, A.
Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster
Gene Expr. Patterns
4
329-333
2004
Drosophila melanogaster
Manually annotated by BRENDA team
Mueller, D.; Nagel, A.C.; Maier, D.; Preiss, A.
A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila
J. Cell Sci.
119
250-258
2006
Drosophila melanogaster
Manually annotated by BRENDA team