BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolytic degradation of proteins
Synonyms
mmel1, neprilysin-2, neprilysin 2, mmel2, neplp, nl1 protein, nep-like endopeptidase, membrane metallo-endopeptidase-like protein,
morePlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
82707-54-8
not distinguished from EC 3.4.24.11
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GPSGFYGVR-NH2 + H2O
GPSGFYG + VR-NH2
Q9XZ01
-
-
-
?
Drosophila tachykinin-1 + H2O
APTSS + FIGMR-amide
-
3% activity compared to Locusta tachykinin-1
-
-
?
Drosophila tachykinin-2 + H2O
APLAFYG + Leu-Arg-amide
-
33% activity compared to Locusta tachykinin-1
-
-
?
Drosophila tachykinin-3 + H2O
APTG + FTGMR-amide
-
1% activity compared to Locusta tachykinin-1
-
-
?
Drosophila tachykinin-4 + H2O
APVNS + FVGMR-amide
-
8% activity compared to Locusta tachykinin-1
-
-
?
Drosophila tachykinin-5 + H2O
APNG + FLGMR-amide
-
2% activity compared to Locusta tachykinin-1
-
-
?
Drosophila tachykinin-6 + H2O
QQR + Phe + ADFNSKFVAVR-amide
-
17% activity compared to Locusta tachykinin-1
-
-
?
Locusta tachykinin-1 + H2O
GPSGFYG + Val-amide
-
100% activity
-
-
?
locustatachykinin 1 + H2O
?
-
-
-
-
?
additional information
?
-
-
NEP2 plays a role in renal function and spermatogenesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
?
-
-
NEP2 plays a role in renal function and spermatogenesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
thiorphan
-
-
thiorphan
-
weak inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.002 - 0.003
phosphoramidon
0.002
phosphoramidon
Drosophila melanogaster
-
soluble enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C
0.003
phosphoramidon
Drosophila melanogaster
-
membrane-bound enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C
0.0005
thiorphan
Drosophila melanogaster
-
membrane-bound enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C
0.08
thiorphan
Drosophila melanogaster
-
soluble enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
expressed in cyst cells that surround the elongating spermatid bundles in adult testis
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
100000
-
soluble enzyme, SDS-PAGE
83000
-
deglycosylated enzyme, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6.5 - 8
-
activity is drastically reduced below pH 6.5 and above pH 8.0
682251
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Phenyl-Sepharose column chromatography and HiTrap Q HP column chromatography
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Drosophila melanogaster S2 cells
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Thomas, J.E.; Rylett, C.M.; Carhan, A.; Bland, N.D.; Bingham, R.J.; Shirras, A.D.; Turner, A.J.; Isaac, R.E.
Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function
Biochem. J.
386
357-366
2005
Drosophila melanogaster
brenda
Bland, N.D.; Thomas, J.E.; Audsley, N.; Shirras, A.D.; Turner, A.J.; Isaac, R.E.
Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster
Peptides
28
127-135
2007
Drosophila melanogaster, Drosophila melanogaster OregonR
brenda
Bland, N.D.; Robinson, P.; Thomas, J.E.; Shirras, A.D.; Turner, A.J.; Isaac, R.E.
Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2
Peptides
30
571-574
2009
Drosophila melanogaster (Q9XZ01), Drosophila melanogaster
brenda
3.4.24.B14 neprilysin-2
top
