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Information on EC 3.4.24.B12 - ADAMTS5 endopeptidase
for references in articles please use BRENDA:EC3.4.24.B12preliminary BRENDA-supplied EC number
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3.4.24.B12 ADAMTS5 endopeptidaseSpecify your search results
Word Map
- 3.4.24.B12
- cartilage
- osteoarthritis
- chondrocytes
-
articular
- metalloproteinase
- collagen
- joint
-
disintegrin
- degeneration
- adamts-4
- tnf
- proteoglycans
- knee
-
intervertebral
-
degener
- synovial
- cox-2
- mmp-1
-
col2a1
- pulposus
- meniscus
- interleukin-1
-
intra-articular
- versican
-
disintegrin-like
- timp-3
-
temporomandibular
-
subchondral
-
safranin
-
cruciate
-
matrix-degrading
-
neoepitope
-
chondroprotective
-
chondrogenic
- brevican
- medicine
-
mankin
-
surgically-induced
-
oa-like
-
collagen-ii
-
meniscectomy
-
anti-catabolic
-
cartilage-degrading
-
interglobular
-
dmm-induced
-
condylar
-
oa-related
-
oa-associated
- osteophyte
-
motifs-4
-
osteoarthritis-like
The enzyme appears in viruses and cellular organisms
Synonyms
adamts-5, adamts5, aggrecanase-2, adam-ts5, aggrecanase 2, aggrecanase-, adamts11, agg-2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
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CAS REGISTRY NUMBER
COMMENTARY
405150-12-1
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
adamts5 endopeptidase deficiency
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.
adamts5 endopeptidase deficiency
ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells.
adamts5 endopeptidase deficiency
ADAMTS5 deficiency in mice does not affect cardiac function.
adamts5 endopeptidase deficiency
ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity.
adamts5 endopeptidase deficiency
Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.
adamts5 endopeptidase deficiency
Adamts5 Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor {beta}1 (TGF{beta}1) Signaling.
adamts5 endopeptidase deficiency
Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.
Adenoviridae Infections
Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5.
Aneurysm
Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture.
Aneurysm
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections.
Aneurysm, Dissecting
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis.
Aortic Valve Disease
ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells.
Arthritis
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.
Arthritis
Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines.
Arthritis
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.
Arthritis
Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.
Arthritis
Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.
Arthritis
Matrix-degrading protease ADAMTS-5 cleaves inter-?-inhibitor and release active heavy chain 2 in synovial fluids from arthritic patients.
Arthritis
The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.
Arthritis
Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis.
Arthritis, Rheumatoid
ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Arthritis, Rheumatoid
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Asthenozoospermia
An in silico analysis of human sperm genes associated with asthenozoospermia and its implication in male infertility.
Atherosclerosis
Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.
Azoospermia
ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia.
Bicuspid Aortic Valve Disease
Targeted next-generation sequencing identified ADAMTS5 as novel genetic substrate in patients with bicuspid aortic valve.
Breast Neoplasms
Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.
Breast Neoplasms
Towards the early detection of ductal carcinoma (a common type of breast cancer) using biomarkers linked to the PPAR(?) signaling pathway.
Carcinogenesis
ADAMTS5 Functions as an Anti-Angiogenic and Anti-Tumorigenic Protein Independent of Its Proteoglycanase Activity.
Carcinogenesis
Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.
Carcinogenesis
Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma.
Carcinoma
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Carcinoma, Hepatocellular
Association Between a Variant in ADAMTS5 and the Susceptibility to Hepatocellular Carcinoma in a Chinese Han Population.
Carcinoma, Hepatocellular
Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.
Carcinoma, Non-Small-Cell Lung
Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer.
Cerebrovascular Disorders
Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture.
Chondrosarcoma
NF-?? upregulates ADAMTS5 expression by direct binding after TNF-? treatment in OUMS-27 chondrosarcoma cell line.
Colorectal Neoplasms
Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.
Colorectal Neoplasms
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
Colorectal Neoplasms
microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.
Colorectal Neoplasms
Retraction Note: microRNA-140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.
Coronary Artery Disease
ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease.
Coronary Stenosis
ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease.
Diabetes, Gestational
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Down Syndrome
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Glioblastoma
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
Glioblastoma
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
Glomerulonephritis, IGA
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.
Head and Neck Neoplasms
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
Hemangioma, Cavernous, Central Nervous System
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Hemophilia A
Serological biomarkers detect active joint destruction and inflammation in patients with haemophilic arthropathy.
Hemophilia A
Serological biomarkers in hemophilic arthropathy: Can they be used to monitor bleeding and ongoing progression of blood-induced joint disease in patients with hemophilia?
Hyperalgesia
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
Hyperalgesia
Spinal Microglial Activation in a Murine Surgical Model of Knee Osteoarthritis.
Hyperalgesia
Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis.
Infertility, Male
ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia.
Insulin Resistance
ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity.
Insulin Resistance
Are serum levels of ADAMTS5, TAS and TOS at 24-28 gestational weeks associated with adverse perinatal outcomes in gestational diabetic women?
Intervertebral Disc Degeneration
ADAMTS-5 and Intervertebral Disc Degeneration: The Results of Tissue Immunohistochemistry and In Vitro Cell Culture.
Intervertebral Disc Degeneration
Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.
Intervertebral Disc Degeneration
APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.
Intervertebral Disc Degeneration
Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model.
Intervertebral Disc Degeneration
Efficiency of dual siRNA-mediated gene therapy for intervertebral disc degeneration (IVDD).
Intervertebral Disc Degeneration
Interleukin-1? exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.
Intervertebral Disc Degeneration
Resistin Promotes Intervertebral Disc Degeneration by Up-Regulation of ADAMTS-5 Through p38 MAPK Signaling Pathway.
Intervertebral Disc Degeneration
The involvement of ADAMTS-5 genetic polymorphisms in predisposition and diffusion tensor imaging alterations of lumbar disc degeneration.
Intervertebral Disc Degeneration
The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression.
Intervertebral Disc Degeneration
TNF-? and IL-1? promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
Intracranial Hemorrhages
Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture.
Joint Diseases
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Joint Instability
ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes.
Joint Instability
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.
Kashin-Beck Disease
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Leukemia
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Liver Diseases
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.
Lung Neoplasms
Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer.
Lymphatic Metastasis
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
Lymphoma
Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies.
Melanoma
Recombinant TSR1 of ADAMTS5 Suppresses Melanoma Growth in Mice via an Anti-angiogenic Mechanism.
Melanoma, Experimental
ADAMTS5 Functions as an Anti-Angiogenic and Anti-Tumorigenic Protein Independent of Its Proteoglycanase Activity.
Metabolic Diseases
Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling.
Neoplasm Metastasis
ADAMTS5 acts as a tumor suppressor by inhibiting migration, invasion and angiogenesis in human gastric cancer.
Neoplasm Metastasis
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
Neoplasm Metastasis
microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.
Neoplasm Metastasis
Retraction Note: microRNA-140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.
Neoplasm Metastasis
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Neoplasms
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis.
Neoplasms
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.
Neoplasms
ADAMTS5 acts as a tumor suppressor by inhibiting migration, invasion and angiogenesis in human gastric cancer.
Neoplasms
ADAMTS5 Functions as an Anti-Angiogenic and Anti-Tumorigenic Protein Independent of Its Proteoglycanase Activity.
Neoplasms
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Neoplasms
Astragaloside inhibits IL-1?-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.
Neoplasms
Azilsartan prevented AGE-induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4.
Neoplasms
Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression.
Neoplasms
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-?-induced activation of NF-?B pathway in chondrocytes.
Neoplasms
Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.
Neoplasms
Does it go to right address to measure amniotic fluid DAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? without an ELISA assay validation?
Neoplasms
Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.
Neoplasms
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Neoplasms
Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion.
Neoplasms
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Neoplasms
Identification of Downstream Genes of the mTOR Pathway that Predict Recurrence and Progression in Non-Muscle Invasive High-Grade Urothelial Carcinoma of the Bladder.
Neoplasms
In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.
Neoplasms
In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.
Neoplasms
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
Neoplasms
Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses.
Neoplasms
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Neoplasms
Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes.
Neoplasms
Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma.
Neoplasms
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
Neoplasms
Mechanical impact induces cartilage degradation via mitogen activated protein kinases.
Neoplasms
NF-?? upregulates ADAMTS5 expression by direct binding after TNF-? treatment in OUMS-27 chondrosarcoma cell line.
Neoplasms
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.
Neoplasms
Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer.
Neoplasms
Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.
Neoplasms
Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy.
Neoplasms
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Neoplasms
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-?B signaling pathways.
Neoplasms
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Neoplasms
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Neoplasms
Upregulation of tumor necrosis factor ? and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes.
Neurodegenerative Diseases
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Obesity
Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development.
Obesity
Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling.
Oligodendroglioma
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Osteoarthritis
10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin.
Osteoarthritis
5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2).
Osteoarthritis
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
Osteoarthritis
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Osteoarthritis
Adamts5 Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor {beta}1 (TGF{beta}1) Signaling.
Osteoarthritis
ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies.
Osteoarthritis
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Osteoarthritis
Animal models of osteoarthritis: lessons learned while seeking the 'Holy Grail'.
Osteoarthritis
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation.
Osteoarthritis
Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case-control study.
Osteoarthritis
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs.
Osteoarthritis
Changes in Synovial Fluid Biomarkers after Experimental Equine Osteoarthritis.
Osteoarthritis
Chondroprotection of PPAR? activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model.
Osteoarthritis
Cirsium japonicum var. maackii and apigenin block Hif-2?-induced osteoarthritic cartilage destruction.
Osteoarthritis
Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity.
Osteoarthritis
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
Osteoarthritis
Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.
Osteoarthritis
Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model.
Osteoarthritis
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Osteoarthritis
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.
Osteoarthritis
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Osteoarthritis
Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors.
Osteoarthritis
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
Osteoarthritis
Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT).
Osteoarthritis
Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.
Osteoarthritis
Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice.
Osteoarthritis
Elucidation of the Mechanism by Which a ADAMTS5 Gene MicroRNA-Binding Site Single Nucleotide Polymorphism Affects the Risk of Osteoarthritis.
Osteoarthritis
Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1?-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5.
Osteoarthritis
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation.
Osteoarthritis
Expression of ADAMTs-5 and TIMP-3 in the condylar cartilage of rats induced by experimentally created osteoarthritis.
Osteoarthritis
Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis.
Osteoarthritis
Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.
Osteoarthritis
Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases.
Osteoarthritis
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.
Osteoarthritis
Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis.
Osteoarthritis
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets.
Osteoarthritis
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1?.
Osteoarthritis
hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes.
Osteoarthritis
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.
Osteoarthritis
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
Osteoarthritis
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Osteoarthritis
IL-17A induction of ADAMTS-5 in differentiated THP-1 cells is modulated by the ERK signaling pathway.
Osteoarthritis
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
Osteoarthritis
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Osteoarthritis
LncRNA MALAT1/MiR-145 Adjusts IL-1?-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.
Osteoarthritis
Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes.
Osteoarthritis
Low-density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4: Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
Osteoarthritis
Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.
Osteoarthritis
Mechanical impact induces cartilage degradation via mitogen activated protein kinases.
Osteoarthritis
MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes.
Osteoarthritis
MiR-132-3p regulates ADAMTS-5 expression and promotes chondrogenic differentiation of rat mesenchymal stem cells.
Osteoarthritis
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).
Osteoarthritis
Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
Osteoarthritis
Osthole ameliorates cartilage degradation by downregulation of NF-?B and HIF-2? pathways in an osteoarthritis murine model.
Osteoarthritis
Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study.
Osteoarthritis
Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.
Osteoarthritis
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 Alleviates Diabetes Mellitus-Osteoarthritis in Rats through Attenuating Synovial Inflammation and Cartilage Injury.
Osteoarthritis
Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis.
Osteoarthritis
Purification and Activity Determination of ADAMTS-4 and ADAMTS-5 and Their Domain Deleted Mutants.
Osteoarthritis
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Osteoarthritis
Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis.
Osteoarthritis
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Osteoarthritis
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.
Osteoarthritis
Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-?B (NF-?B) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development.
Osteoarthritis
Transcriptomics of wild type and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.
Osteoarthritis
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Osteoarthritis
Validation of the Diagnostic and Prognostic Values of ADAMTS5 and FSTL1 in Osteoarthritis Rat Model.
Osteoarthritis
Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium.
Osteoarthritis
[Protective effect of LR-90 on articular cartilage in rabbit model of osteoarthritis].
Osteoarthritis
[Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].
Osteoarthritis, Knee
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
Osteoarthritis, Knee
Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee osteoarthritis.
Osteoarthritis, Knee
Elucidation of the Mechanism by Which a ADAMTS5 Gene MicroRNA-Binding Site Single Nucleotide Polymorphism Affects the Risk of Osteoarthritis.
Osteoarthritis, Knee
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Osteoarthritis, Knee
Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.
Osteophyte
Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis.
Osteophyte
Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis.
Osteoporosis
5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5.
Osteoporosis
Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases.
Periodontitis
Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues.
Pick Disease of the Brain
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Polycystic Ovary Syndrome
Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Premature Birth
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Pruritus
The role of kinin B1 and B2 receptors in the mouse model of oxazolone-induced atopic dermatitis.
receptor protein-tyrosine kinase deficiency
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
Spinal Cord Injuries
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
Spinal Cord Injuries
ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.
Stomach Neoplasms
ADAMTS5 acts as a tumor suppressor by inhibiting migration, invasion and angiogenesis in human gastric cancer.
Syndactyly
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.
Syndactyly
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.
Synovitis
Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model.
Temporomandibular Joint Disorders
Activation of ?-catenin signalling leads to temporomandibular joint defects.
Tendinopathy
ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, Z.H.; Yang, Z.Q.; He, X.J.; Wang, L.; Li, L.X.; Tu, J.B.
Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase-2 on rat costochondral chondrocytes in vitro
Acta Pharmacol. Sin.
29
1215-1226
2008
Rattus norvegicus (Q6TY19)
brenda
EXTERNAL LINKS (specific for EC-Number 3.4.24.B12)
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Release 2023.1 (January 2023)
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