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both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis
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both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis
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both ADAM10, EC 3.4.24.81, and ADAM17 are present during all stages of spermatogenesis. Protein level and cell surface localization strongly dropp in Dark segments as compared with the rest of the segments
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marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell
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within the hypothalamus, TACE is most abundantly expressed in astrocytes of the median eminence, specific changes in TACE activity are required for the normal timimg of puberty. TACE is a component of the neuron-to-glia signaling process used by glutamatergic neurons to control female sexual development
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TACE protein is localized to mononuclear cells (MNC), which infiltrate the liver from the spleen after hepatectomy. The kinetics of TACE expression is in accordance with the number of TACE-staining mononuclear cells and synchronizes with those of transforming growth factor-alpha. TACE-staining mononuclear cells partially overlapp with CD3+ T lymphocytes
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marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell
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primary cellular source of ADAM-17 in inflamed peripheral nervous system (experimental autoimmune neuritis). Not all T lymphocytes within the inflamed peripheral nervous system express ADAM-17. No ADAM-17 expressing cells are found in nerves from control animals
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the expression of TACE is increased in intermittent and prolonged hyperoxia
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expression of TACE in liver and spleen tissues after 70% partial hepatectomy is a time-dependent alteration, reaching a maximal level between 24 and 48 h and remaining elevated for more than 168 h
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Cricetulus griseus (Q923X3), Rattus norvegicus (Q9Z1K9)
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Fiorucci, S.; Antonelli, E.; Migliorati, G.; Santucci, L.; Morelli, O.; Federici, B.; Morelli, A.
TNFalpha processing enzyme inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal injury in rats
Aliment. Pharmacol. Ther.
12
1139-1153
1998
Mus musculus, Rattus norvegicus
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Rabinowitz, M.H.; Andrews, R.C.; Becherer, J.D.; Bickett, D.M.; Bubacz, D.G.; Conway, J.G.; Cowan, D.J.; Gaul, M.; Glennon, K.; Lambert, M.H.; Leesnitzer, M.A.; McDougald, D.L.; Moss, M.L.; Musso, D.L.; Rizzolio, M.C.
Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
J. Med. Chem.
44
4252-4267
2001
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Lewis
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Katakowski, M.; Chen, J.; Zhang, Z.G.; Santra, M.; Wang, Y.; Chopp, M.
Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-alpha-converting enzyme protease activity
J. Cereb. Blood Flow Metab.
27
669-678
2006
Rattus norvegicus
brenda
Lomniczi, A.; Cornea, A.; Costa, M.E.; Ojeda, S.R.
Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain
J. Neurosci.
26
51-62
2006
Rattus norvegicus
brenda
Kurz, M.; Pischel, H.; Hartung, H.; Kieseier, B.C.
Tumor necrosis factor-alpha-converting enzyme is expressed in the inflamed peripheral nervous system
J. Peripher. Nerv. Syst.
10
311-318
2005
Homo sapiens, Rattus norvegicus
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Wang, X.; Feuerstein, G.Z.; Xu, L.; Wang, H.; Schumacher, W.A.; Ogletree, M.L.; Taub, R.; Duan, J.J.; Decicco, C.P.; Liu, R.
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats
Mol. Pharmacol.
65
890-896
2004
Rattus norvegicus
brenda
Charbonneau, M.; Harper, K.; Grondin, F.; Pelmus, M.; McDonald, P.P.; Dubois, C.M.
Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells
J. Biol. Chem.
282
33714-33724
2007
Rattus norvegicus
brenda
Canault, M.; Tellier, E.; Bonardo, B.; Mas, E.; Aumailley, M.; Juhan-Vague, I.; Nalbone, G.; Peiretti, F.
FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity
J. Cell. Physiol.
208
363-372
2006
Rattus norvegicus
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Deng, X.; Lu, J.; Lehman-McKeeman, L.D.; Malle, E.; Crandall, D.L.; Ganey, P.E.; Roth, R.A.
p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine
J. Pharmacol. Exp. Ther.
326
144-152
2008
Rattus norvegicus
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Bigdeli, M.R.; Khoshbaten, A.
In vivo preconditioning with normobaric hyperoxia induces ischemic tolerance partly by triggering tumor necrosis factor-alpha converting enzyme/tumor necrosis factor-alpha/nuclear factor-kappaB
Neuroscience
153
671-678
2008
Rattus norvegicus
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Lin, X.M.; Liu, Y.B.; Zhou, F.; Wu, Y.L.; Chen, L.; Fang, H.Q.
Expression of tumor necrosis factor-alpha converting enzyme in liver regeneration after partial hepatectomy
World J. Gastroenterol.
14
1353-1357
2008
Rattus norvegicus
brenda
Xu, J.; Liu, X.; Chen, J.; Zacharek, A.; Cui, X.; Savant-Bhonsale, S.; Chopp, M.; Liu, Z.
Cell-cell interaction promotes rat marrow stromal cell differentiation into endothelial cell via activation of TACE/TNF-alpha signaling
Cell Transplant.
19
43-53
2010
Homo sapiens, Rattus norvegicus
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Dusso, A.; Arcidiacono, M.V.; Yang, J.; Tokumoto, M.
Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality
J. Steroid Biochem. Mol. Biol.
121
193-198
2010
Rattus norvegicus
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Urriola-Munoz, P.; Lizama, C.; Lagos-Cabre, R.; Reyes, J.; Moreno, R.
Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation
Biol. Res.
47
31
2014
Rattus norvegicus (Q9Z1K9)
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