Reference on EC 3.4.24.81 - ADAM10 endopeptidase
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Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
J. Biol. Chem.
276
37743-37746
2001
Homo sapiens, Mus musculus
Lopez-Perez, E.; Zhang, Y.; Frank, S.J.; Creemers, J.; Seidah, N.; Checler, F.
Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
J. Neurochem.
76
1532-1539
2001
Homo sapiens
Anders, A.; Gilbert, S.; Garten, W.; Postina, R.; Fahrenholz, F.
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases
FASEB J.
15
1837-1839
2001
Bos taurus, Homo sapiens
Lemjabbar, H.; Basbaum, C.
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
Nat. Med.
8
41-46
2002
Homo sapiens
Gutwein, P.; Mechtersheimer, S.; Riedle, S.; Stoeck, A.; Gast, D.; Joumaa, S.; Zentgraf, H.; Fogel, M.; Altevogt, P.
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles
FASEB J.
17
292-294
2003
Homo sapiens
Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
Biochem. Biophys. Res. Commun.
301
231-235
2003
Homo sapiens
Gatta, L.B.; Albertini, A.; Ravid, R.; Finazzi, D.
Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus
NeuroReport
13
2031-2033
2002
Homo sapiens
Colciaghi, F.; Borroni, B.; Pastorino, L.; Marcello, E.; Zimmermann, M.; Cattabeni, F.; Padovani, A.; Di Luca, M.
alpha-secretase ADAM10 as well as aAPPs is reduced in platelets and CSF of Alzheimer Disease patients
Mol. Med.
8
67-74
2002
Homo sapiens
Yan, Y.; Shirakabe, K.; Werb, Z.
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
J. Cell Biol.
158
221-226
2002
Chlorocebus aethiops, Homo sapiens
Murai, T.; Miyauchi, T.; Yanagida, T.; Sako, Y.
Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
Biochem. J.
395
65-71
2006
Homo sapiens
Janes, P.W.; Saha, N.; Barton, W.A.; Kolev, M.V.; Wimmer-Kleikamp, S.H.; Nievergall, E.; Blobel, C.P.; Himanen, J.P.; Lackmann, M.; Nikolov, D.B.
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
Cell
123
291-304
2005
Bos taurus
McCulloch, D.R.; Akl, P.; Samaratunga, H.; Herington, A.C.; Odorico, D.M.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP
Clin. Cancer Res.
10
314-323
2004
Homo sapiens
Ludwig, A.; Hundhausen, C.; Lambert, M.H.; Broadway, N.; Andrews, R.C.; Bickett, D.M.; Leesnitzer, M.A.; Becherer, J.D.
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
Comb. Chem. High Throughput Screen.
8
161-171
2005
Homo sapiens
Asayesh, A.; Alanentalo, T.; Khoo, N.K.; Ahlgren, U.
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments
Dev. Dyn.
232
1105-1114
2005
Mus musculus
Reiss, K.; Maretzky, T.; Ludwig, A.; Tousseyn, T.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
EMBO J.
24
742-752
2005
Mus musculus
Allinson, T.M.; Parkin, E.T.; Condon, T.P.; Schwager, S.L.; Sturrock, E.D.; Turner, A.J.; Hooper, N.M.
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein
Eur. J. Biochem.
271
2539-2547
2004
Homo sapiens
Sanderson, M.P.; Erickson, S.N.; Gough, P.J.; Garton, K.J.; Wille, P.T.; Raines, E.W.; Dunbar, A.J.; Dempsey, P.J.
ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
J. Biol. Chem.
280
1826-1837
2005
Mus musculus
Obregon, D.F.; Rezai-Zadeh, K.; Bai, Y.; Sun, N.; Hou, H.; Ehrhart, J.; Zeng, J.; Mori, T.; Arendash, G.W.; Shytle, D.; Town, T.; Tan, J.
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced a-secretase cleavage of amyloid precursor protein
J. Biol. Chem.
281
16419-16427
2006
Mus musculus
Reiss, K.; Maretzky, T.; Haas, I.G.; Schulte, M.; Ludwig, A.; Frank, M.; Saftig, P.
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion
J. Biol. Chem.
281
21735-21744
2006
Mus musculus
Zimmermann, M.; Gardoni, F.; Marcello, E.; Colciaghi, F.; Borroni, B.; Padovani, A.; Cattabeni, F.; Di Luca, M.
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
J. Neurochem.
90
1489-1499
2004
Homo sapiens
Bandyopadhyay, S.; Hartley, D.M.; Cahill, C.M.; Lahiri, D.K.; Chattopadhyay, N.; Rogers, J.T.
Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase
J. Neurosci. Res.
84
106-118
2006
Homo sapiens
Budagian, V.; Bulanova, E.; Orinska, Z.; Duitman, E.; Brandt, K.; Ludwig, A.; Hartmann, D.; Lemke, G.; Saftig, P.; Bulfone-Paus, S.
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum
Mol. Cell. Biol.
25
9324-9339
2005
Mus musculus
Anders, L.; Mertins, P.; Lammich, S.; Murgia, M.; Hartmann, D.; Saftig, P.; Haass, C.; Ullrich, A.
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenins transcriptional activity
Mol. Cell. Biol.
26
3917-3934
2006
Mus musculus
Uemura, K.; Kihara, T.; Kuzuya, A.; Okawa, K.; Nishimoto, T.; Ninomiya, H.; Sugimoto, H.; Kinoshita, A.; Shimohama, S.
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1
Neurosci. Lett.
402
278-283
2006
Homo sapiens
Maretzky, T.; Reiss, K.; Ludwig, A.; Buchholz, J.; Scholz, F.; Proksch, E.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
Proc. Natl. Acad. Sci. USA
102
9182-9187
2005
Homo sapiens, Mus musculus
Schramme, A.; Abdel-Bakky, M.S.; Kaempfer-Kolb, N.; Pfeilschifter, J.; Gutwein, P.
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
Biochem. Biophys. Res. Commun.
370
311-316
2008
Homo sapiens
Ko, S.; Lin, S.; Wong, Y.; Liu, C.; Chang, K.; Liu, T.
Increase of disintegrin and metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma
Cancer Lett.
245
33-43
2007
Homo sapiens
Gavert, N.; Sheffer, M.; Raveh, S.; Spaderna, S.; Shtutman, M.; Brabletz, T.; Barany, F.; Paty, P.; Notterman, D.; Domany, E.; Ben-Zeev, A.
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
Cancer Res.
67
7703-7712
2007
Homo sapiens
Smith, C.; Halvorsen, B.; Otterdal, K.; Waehre, T.; Yndestad, A.; Fevang, B.; Sandberg, W.J.; Breland, U.M.; Froland, S.S.; Oie, E.; Gullestad, L.; Damas, J.K.; Aukrust, P.
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc. Res.
79
195-203
2008
Homo sapiens
Schulte, M.; Reiss, K.; Lettau, M.; Maretzky, T.; Ludwig, A.; Hartmann, D.; de Strooper, B.; Janssen, O.; Saftig, P.
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
Cell Death Differ.
14
1040-1049
2007
Homo sapiens
Conrad, D.H.; Ford, J.W.; Sturgill, J.L.; Gibb, D.R.
CD23: an overlooked regulator of allergic disease
Curr. Allergy Asthma Rep.
7
331-337
2007
Homo sapiens
Deuss, M.; Reiss, K.; Hartmann, D.
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17
Curr. Alzheimer Res.
5
187-201
2008
Drosophila melanogaster, Mus musculus
Hakulinen, J.; Keski-Oja, J.
ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells
J. Biol. Chem.
281
21369-21376
2006
Homo sapiens
Lemieux, G.A.; Blumenkron, F.; Yeung, N.; Zhou, P.; Williams, J.; Grammer, A.C.; Petrovich, R.; Lipsky, P.E.; Moss, M.L.; Werb, Z.
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
J. Biol. Chem.
282
14836-14844
2007
Homo sapiens
Moss, M.L.; Bomar, M.; Liu, Q.; Sage, H.; Dempsey, P.; Lenhart, P.M.; Gillispie, P.A.; Stoeck, A.; Wildeboer, D.; Bartsch, J.W.; Palmisano, R.; Zhou, P.
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
J. Biol. Chem.
282
35712-35721
2007
Mus musculus
Martin, L.; Fluhrer, R.; Reiss, K.; Kremmer, E.; Saftig, P.; Haass, C.
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
J. Biol. Chem.
283
1644-1652
2008
Homo sapiens
Kaczur, V.; Puskas, L.G.; Nagy, Z.U.; Miled, N.; Rebai, A.; Juhasz, F.; Kupihar, Z.; Zvara, A.; Hackler, L.J.; Farid, N.R.
Cleavage of human thyrotropin receptor by ADAM10 is regulated by thyrotropin
J. Mol. Recognit.
20
392-404
2007
Homo sapiens (O14672), Homo sapiens
Albrecht, S.; Wang, S.; Holz, A.; Bergter, A.; Paululat, A.
The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster
Mech. Dev.
123
372-387
2006
Drosophila melanogaster, Drosophila melanogaster Oregon R
Dehmel, T.; Janke, A.; Hartung, H.P.; Goebel, H.H.; Wiendl, H.; Kieseier, B.C.
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
Neurobiol. Dis.
25
665-674
2007
Homo sapiens
Clement, A.B.; Hanstein, R.; Schroeder, A.; Nagel, H.; Endres, K.; Fahrenholz, F.; Behl, C.
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress
Neuroscience
152
459-468
2008
Mus musculus
Chen, C.D.; Podvin, S.; Gillespie, E.; Leeman, S.E.; Abraham, C.R.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Proc. Natl. Acad. Sci. USA
104
19796-19801
2007
Homo sapiens
Rapti, M.; Atkinson, S.J.; Lee, M.H.; Trim, A.; Moss, M.; Murphy, G.
The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
Biochem. J.
411
433-439
2008
Homo sapiens
Escrevente, C.; Morais, V.A.; Keller, S.; Soares, C.M.; Altevogt, P.; Costa, J.
Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme
Biochim. Biophys. Acta
1780
905-913
2008
Bos taurus, Homo sapiens
Esselens, C.W.; Malapeira, J.; Colome, N.; Moss, M.; Canals, F.; Arribas, J.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17
Biol. Chem.
389
1075-1084
2008
Homo sapiens
Prinzen, C.; Truembach, D.; Wurst, W.; Endres, K.; Postina, R.; Fahrenholz, F.
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
BMC Genomics
10
66
2009
Bos taurus
Schulz, B.; Pruessmeyer, J.; Maretzky, T.; Ludwig, A.; Blobel, C.P.; Saftig, P.; Reiss, K.
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
Circ. Res.
102
1192-1201
2008
Homo sapiens
Raucci, A.; Cugusi, S.; Antonelli, A.; Barabino, S.M.; Monti, L.; Bierhaus, A.; Reiss, K.; Saftig, P.; Bianchi, M.E.
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
FASEB J.
22
3716-3727
2008
Homo sapiens, Mus musculus
Freese, C.; Garratt, A.N.; Fahrenholz, F.; Endres, K.
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
FEBS J.
276
1568-1580
2009
Homo sapiens, Mus musculus
Oh, S.T.; Schramme, A.; Stark, A.; Tilgen, W.; Gutwein, P.; Reichrath, J.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas
J. Cutan. Pathol.
36
395-401
2009
Homo sapiens
Arduise, C.; Abache, T.; Li, L.; Billard, M.; Chabanon, A.; Ludwig, A.; Mauduit, P.; Boucheix, C.; Rubinstein, E.; Le Naour, F.
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor
J. Immunol.
181
7002-7013
2008
Homo sapiens
Parkin, E.; Harris, B.
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10
J. Neurochem.
108
1464-1479
2009
Homo sapiens
Kohutek, Z.A.; diPierro, C.G.; Redpath, G.T.; Hussaini, I.M.
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration
J. Neurosci.
29
4605-4615
2009
Mus musculus
Dehmel, T.; Goebel, H.H.; Hartung, H.P.; Lehmann, H.; Wiendl, H.; Kieseier, B.C.
The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers
Muscle Nerve
38
1049-1051
2008
Homo sapiens
Qin, W.; Ho, L.; Wang, J.; Peskind, E.; Pasinetti, G.M.
S100A7, a novel Alzheimers disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10
PLoS ONE
4
e4183
2009
Homo sapiens
Riedle, S.; Kiefel, H.; Gast, D.; Bondong, S.; Wolterink, S.; Gutwein, P.; Altevogt, P.
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
Biochem. J.
420
391-402
2009
Homo sapiens
Caescu, C.I.; Jeschke, G.R.; Turk, B.E.
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
Biochem. J.
424
79-88
2009
Mus musculus
Dittmer, A.; Hohlfeld, K.; Luetzkendorf, J.; Mueller, L.P.; Dittmer, J.
Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10
Cell. Mol. Life Sci.
66
3053-3065
2009
Homo sapiens
Mezyk-Kopec R.; Bzowska, M.; Stalinska, K.; Chelmicki, T.; Podkalicki, M.; Jucha, J.; Kowalczyk, K.; Mak, P.; Bereta, J.
Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts
Cytokine
46
309-315
2009
Mus musculus
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermatoendocrinol.
1
46-53
2009
Homo sapiens
Tippmann, F.; Hundt, J.; Schneider, A.; Endres, K.; Fahrenholz, F.
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
FASEB J.
23
1643-1654
2009
Homo sapiens
Xu, D.; Sharma, C.; Hemler, M.E.
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein
FASEB J.
23
3674-3681
2009
Homo sapiens
Endres, K.; Fahrenholz, F.
Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
FEBS J.
277
1585-1596
2010
Homo sapiens, Mus musculus
Kim, M.; Suh, J.; Romano, D.; Truong, M.H.; Mullin, K.; Hooli, B.; Norton, D.; Tesco, G.; Elliott, K.; Wagner, S.L.; Moir, R.D.; Becker, K.D.; Tanzi, R.E.
Potential late-onset Alzheimers disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
Hum. Mol. Genet.
18
3987-3996
2009
Homo sapiens
Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17
Immunology
130
83-91
2010
Homo sapiens
Tousseyn, T.; Thathiah, A.; Jorissen, E.; Raemaekers, T.; Konietzko, U.; Reiss, K.; Maes, E.; Snellinx, A.; Serneels, L.; Nyabi, O.; Annaert, W.; Saftig, P.; Hartmann, D.; De Strooper, B.
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase
J. Biol. Chem.
284
11738-11747
2009
Mus musculus (O35598)
Franzke, C.W.; Bruckner-Tuderman, L.; Blobel, C.P.
Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9
J. Biol. Chem.
284
23386-23396
2009
Mus musculus
van Tetering, G.; van Diest, P.; Verlaan, I.; van der Wall, E.; Kopan, R.; Vooijs, M.
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
J. Biol. Chem.
284
31018-31027
2009
Mus musculus
Marcello, E.; Gardoni, F.; Di Luca, M.; Perez-Otano, I.
An arginine stretch limits ADAM10 exit from the endoplasmic reticulum
J. Biol. Chem.
285
10376-10384
2010
Mus musculus
Ratchford, A.M.; Baker, O.J.; Camden, J.M.; Rikka, S.; Petris, M.J.; Seye, C.I.; Erb, L.; Weisman, G.A.
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells
J. Biol. Chem.
285
7545-7555
2010
Homo sapiens
Jorissen, E.; Prox, J.; Bernreuther, C.; Weber, S.; Schwanbeck, R.; Serneels, L.; Snellinx, A.; Craessaerts, K.; Thathiah, A.; Tesseur, I.; Bartsch, U.; Weskamp, G.; Blobel, C.P.; Glatzel, M.; De Strooper, B.; Saftig, P.
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
J. Neurosci.
30
4833-4844
2010
Mus musculus
Le Gall, S.M.; Bobe, P.; Reiss, K.; Horiuchi, K.; Niu, X.D.; Lundell, D.; Gibb, D.R.; Conrad, D.; Saftig, P.; Blobel, C.P.
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha
Mol. Biol. Cell
20
1785-1794
2009
Mus musculus
Bozkulak, E.C.; Weinmaster, G.
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
Mol. Cell. Biol.
29
5679-5695
2009
Mus musculus
Endres, K.; Mitteregger, G.; Kojro, E.; Kretzschmar, H.; Fahrenholz, F.
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
Neurobiol. Dis.
36
233-241
2009
Mus musculus
Janes, P.W.; Wimmer-Kleikamp, S.H.; Frangakis, A.S.; Treble, K.; Griesshaber, B.; Sabet, O.; Grabenbauer, M.; Ting, A.Y.; Saftig, P.; Bastiaens, P.I.; Lackmann, M.
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10
PLoS Biol.
7
e1000215
2009
Mus musculus
Jacobsen, K.T.; Adlerz, L.; Multhaup, G.; Iverfeldt, K.
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases
J. Biol. Chem.
285
10223-10231
2010
Homo sapiens
Endres, K.; Fahrenholz, F.
Regulation of alpha-secretase ADAM10 expression and activity
Exp. Brain Res.
2011
1-10
2011
Homo sapiens
-
Kim, J.; Lilliehook, C.; Dudak, A.; Prox, J.; Saftig, P.; Federoff, H.J.; Lim, S.T.
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10)
J. Biol. Chem.
285
22919-22926
2010
Mus musculus
Garbers, C.; Jaenner, N.; Chalaris, A.; Moss, M.L.; Floss, D.M.; Meyer, D.; Koch-Nolte, F.; Rose-John, S.; Scheller, J.
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
J. Biol. Chem.
286
14804-14811
2011
Mus musculus
Bouillot, S.; Tillet, E.; Carmona, G.; Prandini, M.H.; Gauchez, A.S.; Hoffmann, P.; Alfaidy, N.; Cand, F.; Huber, P.
Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia
J. Biol. Chem.
286
15195-15204
2011
Homo sapiens
Gibb, D.R.; El Shikh, M.; Kang, D.J.; Rowe, W.J.; El Sayed, R.; Cichy, J.; Yagita, H.; Tew, J.G.; Dempsey, P.J.; Crawford, H.C.; Conrad, D.H.
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
J. Exp. Med.
207
623-635
2010
Mus musculus
Chaimowitz, N.S.; Martin, R.K.; Cichy, J.; Gibb, D.R.; Patil, P.; Kang, D.J.; Farnsworth, J.; Butcher, E.C.; McCright, B.; Conrad, D.H.
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture
J. Immunol.
187
5114-5122
2011
Mus musculus
Blume, K.E.; Soeroes, S.; Keppeler, H.; Stevanovic, S.; Kretschmer, D.; Rautenberg, M.; Wesselborg, S.; Lauber, K.
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic find-me signal
J. Immunol.
188
135-145
2012
Homo sapiens
Malinverno, M.; Carta, M.; Epis, R.; Marcello, E.; Verpelli, C.; Cattabeni, F.; Sala, C.; Mulle, C.; Di Luca, M.; Gardoni, F.
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
J. Neurosci.
30
16343-16355
2010
Mus musculus
Solanas, G.; Cortina, C.; Sevillano, M.; Batlle, E.
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
Nat. Cell Biol.
13
1100-1107
2011
Canis lupus familiaris
Hogl, S.; Kuhn, P.H.; Colombo, A.; Lichtenthaler, S.F.
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
PLoS ONE
6
e21337
2011
Homo sapiens
Nagara, Y.; Hagiyama, M.; Hatano, N.; Futai, E.; Suo, S.; Takaoka, Y.; Murakami, Y.; Ito, A.; Ishiura, S.
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex
Biochem. Biophys. Res. Commun.
417
462-467
2012
Homo sapiens (O14672)
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2014
Homo sapiens (O14672), Homo sapiens
Urriola-Munoz, P.; Lizama, C.; Lagos-Cabre, R.; Reyes, J.; Moreno, R.
Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation
Biol. Res.
47
31
2014
Rattus norvegicus (Q10743)
Tsai, Y.; Vandussen, K.; Sawey, E.; Wade, A.; Kasper, C.; Rakshit, S.; Bhatt, R.; Stoeck, A.; Maillard, I.; Crawford, H.; Samuelson, L.; Dempsey, P.
ADAM10 regulates notch function in intestinal stem cells of mice
Gastroenterology
147
822-834.e13
2014
Mus musculus
Guo, Q.; Wang, Y.; Tripathi, P.; Manda, K.; Mukherjee, M.; Chaklader, M.; Austin, P.; Surendran, K.; Chen, F.
Adam10 mediates the choice between principal cells and intercalated cells in the kidney
J. Am. Soc. Nephrol.
26
149-159
2015
Mus musculus
Breshears, L.M.; Schlievert, P.M.; Peterson, M.L.
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1)
J. Biol. Chem.
287
32578-32587
2012
Homo sapiens (O14672), Homo sapiens
Minond, D.; Cudic, M.; Bionda, N.; Giulianotti, M.; Maida, L.; Houghten, R.; Fields, G.
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates
J. Biol. Chem.
287
36473-36487
2012
Homo sapiens (O14672)
Herzog, C.; Haun, R.S.; Ludwig, A.; Shah, S.V.; Kaushal, G.P.
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A
J. Biol. Chem.
289
13308-13322
2014
Mus musculus (O35598)
Powers, M.; Kim, H.; Wang, Y.; Wardenburg, J.
ADAM10 mediates vascular injury induced by Staphylococcus aureus alpha-hemolysin
J. Infect. Dis.
206
352-356
2012
Mus musculus (O35598), Mus musculus
Hofmann, S.; Vgtle, T.; Bender, M.; Rose-John, S.; Nieswandt, B.
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets
J. Thromb. Haemost.
10
2581-2592
2012
Homo sapiens (O14672), Mus musculus (O35598)
Shitomi, Y.; Thogersen, I.; Ito, N.; Leitinger, B.; Enghild, J.; Itoh, Y.
ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)
Mol. Biol. Cell
26
659-673
2015
Homo sapiens (O14672)
Chaimowitz, N.; Kang, D.; Dean, L.; Conrad, D.
ADAM10 regulates transcription factor expression required for plasma cell function
PLoS ONE
7
e42694
2012
Mus musculus (O35598)
Raikwar, N.; Liu, K.; Thomas, C.
N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain
PLoS ONE
9
e112794
2014
Homo sapiens (O14672)
Loreto, C.; Chiarenza, G.P.; Musumeci, G.; Castrogiovanni, P.; Imbesi, R.; Ruggeri, A.; Almeida, L.E.; Leonardi, R.
ADAM10 localization in temporomandibular joint disk with internal derangement an ex vivo immunohistochemical study
Acta Histochem.
118
293-298
2016
Homo sapiens
Tan, Y.; Fu, R.; Liu, J.; Wu, Y.; Wang, B.; Jiang, N.; Nie, P.; Cao, H.; Yang, Z.; Fang, B.
ADAM10 is essential for cranial neural crest-derived maxillofacial bone development
Biochem. Biophys. Res. Commun.
475
308-314
2016
Mus musculus (O35598), Mus musculus
von Hoven, G.; Rivas, A.J.; Neukirch, C.; Klein, S.; Hamm, C.; Qin, Q.; Meyenburg, M.; Fueser, S.; Saftig, P.; Hellmann, N.; Postina, R.; Husmann, M.
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus alpha-toxin action
Biochem. J.
473
1929-1940
2016
Homo sapiens (O14672), Homo sapiens
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2015
Homo sapiens (O14672), Homo sapiens
Dempsey, P.J.
Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis
Biochim. Biophys. Acta Mol. Cell Res.
1864
2228-2239
2017
Mus musculus
Vincent, B.
Regulation of the alpha-secretase ADAM10 at transcriptional, translational and post-translational levels
Brain Res. Bull.
126
154-169
2016
Homo sapiens (O14672)
You, B.; Shan, Y.; Shi, S.; Li, X.; You, Y.
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma
Cancer Sci.
106
1506-1514
2015
Homo sapiens (O14672), Homo sapiens
Altmeppen, H.C.; Prox, J.; Krasemann, S.; Puig, B.; Kruszewski, K.; Dohler, F.; Bernreuther, C.; Hoxha, A.; Linsenmeier, L.; Sikorska, B.; Liberski, P.P.; Bartsch, U.; Saftig, P.; Glatzel, M.
The sheddase ADAM10 is a potent modulator of prion disease
eLife
4
e04260
2015
Mus musculus (O35598)
Kuhn, P.H.; Colombo, A.V.; Schusser, B.; Dreymueller, D.; Wetzel, S.; Schepers, U.; Herber, J.; Ludwig, A.; Kremmer, E.; Montag, D.; Mueller, U.; Schweizer, M.; Saftig, P.; Braese, S.; Lichtenthaler, S.F.
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
eLife
5
e12748
2016
Mus musculus (O35598), Mus musculus
Endres, K.; Deller, T.
Regulation of alpha-secretase ADAM10 in vitro and in vivo Genetic, epigenetic, and protein-based mechanisms
Front. Mol. Neurosci.
10
56
2017
Homo sapiens (O14672), Homo sapiens
Ruiz-Arroyo, V.M.; Garcia-Robles, I.; Ochoa-Campuzano, C.; Goig, G.A.; Zaitseva, E.; Baaken, G.; Martinez-Ramirez, A.C.; Rausell, C.; Real, M.D.
Validation of ADAM10 metalloprotease as a Bacillus thuringiensis Cry3Aa toxin functional receptor in Colorado potato beetle (Leptinotarsa decemlineata)
Insect Mol. Biol.
26
204-214
2017
Leptinotarsa decemlineata (A0A1L2JAW4), Leptinotarsa decemlineata
Lundgren, J.L.; Ahmed, S.; Schedin-Weiss, S.; Gouras, G.K.; Winblad, B.; Tjernberg, L.O.; Frykman, S.
ADAM10 and BACE1 are localized to synaptic vesicles
J. Neurochem.
135
606-615
2015
Rattus norvegicus (O10743)
Siney, E.J.; Holden, A.; Casselden, E.; Bulstrode, H.; Thomas, G.J.; Willaime-Morawek, S.
Metalloproteinases ADAM10 and ADAM17 mediate migration and differentiation in glioblastoma sphere-forming cells
Mol. Neurobiol.
54
3893-3905
2017
Homo sapiens (O14672), Homo sapiens
Madoux, F.; Dreymuller, D.; Pettiloud, J.P.; Santos, R.; Becker-Pauly, C.; Ludwig, A.; Fields, G.B.; Bannister, T.; Spicer, T.P.; Cudic, M.; Scampavia, L.D.; Minond, D.
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
Sci. Rep.
6
11
2016
Homo sapiens (O14672)
Riethmueller, S.; Ehlers, J.C.; Lokau, J.; Duesterhoeft, S.; Knittler, K.; Dombrowsky, G.; Groetzinger, J.; Rabe, B.; Rose-John, S.; Garbers, C.
Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17
Sci. Rep.
6
25550
2016
Homo sapiens (O14672)
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