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Synonyms
mmp14, membrane-type 1 matrix metalloproteinase, membrane type 1 matrix metalloproteinase, membrane type-1 matrix metalloproteinase, membrane type 1-matrix metalloproteinase, matrix metalloproteinase 14, membrane type 1-mmp, mt-mmp-1, matrix metalloproteinase-14, membrane type 1 mmp,
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DX2400
human monoclonal antibody
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tissue inhibitor of metalloproteinases-2
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1-cyclopropyl-N-hydroxy-4-[(4-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl)sulfonyl]piperidine-4-carboxamide
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4-([4-[4-(2-chlorophenyl)piperazin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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4-([4-[4-(2-fluorophenyl)piperazin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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4-([4-[4-(4-chlorophenyl)piperidin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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DX-2400
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represents a highly selective fully MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocks proMMP-2 processing on tumor and endothelial cells, inhibits angiogenesis and slows tumor progression and formation of metastatic lesions in xenograft models
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epigallocatechin-3-gallate
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N-hydroxy-4-([4-[4-(2-hydroxyphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-([4-[4-(2-methoxyphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-([4-[4-(2-methylphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-([4-[4-(3-methoxyphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-([4-[4-(4-methoxy-2-methylphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-([4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-([4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-[[4-(4-phenylpiperazin-1-yl)phenyl]sulfonyl]tetrahydro-2H-pyran-4-carboxamide
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N-hydroxy-4-[[4-(4-phenylpiperidin-1-yl)phenyl]sulfonyl]tetrahydro-2H-pyran-4-carboxamide
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Tissue inhibitor of metalloproteinase-1
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TIMP-1
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additional information
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synthesis of a series of phenyl piperidine a-sulfone hydroxamate derivatives, inhibitory potencies on different MMPs, overview. No inhibition by derivatives 1-cyclopropyl-N-hydroxy-4-[[4-(4-phenylpiperazin-1-yl)phenyl]sulfonyl]piperidine-4-carboxamide, 4-([4-[4-(2,4-dimethylphenyl)piperazin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, N-hydroxy-4-[(4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxamide, N-hydroxy-4-([4-[4-(2-methoxyphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide, N-hydroxy-4-([4-[4-(2-methylphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide, 4-([4-[4-(2-chlorophenyl)piperidin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, N-hydroxy-4-[(4-[4-[2-(trifluoromethyl)phenyl]piperidin-1-yl]phenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxamide, 4-([4-[4-(2-ethoxyphenyl)piperidin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, 4-([4-[4-(4'-fluorobiphenyl-4-yl)piperidin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, and 4-[(4-[4-[2-ethyl-5-(propan-2-yl)phenyl]piperidin-1-yl]phenyl)sulfonyl]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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TIMP-2
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TIMP-2
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0.0002 mM, dose dependent
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0.01
1-cyclopropyl-N-hydroxy-4-[(4-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl)sulfonyl]piperidine-4-carboxamide
Rattus norvegicus
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pH not specified in the publication, temperature not speficied in the publication
0.01
4-([4-[4-(2-chlorophenyl)piperazin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
4-([4-[4-(2-fluorophenyl)piperazin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
4-([4-[4-(4-chlorophenyl)piperidin-1-yl]phenyl]sulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-([4-[4-(2-hydroxyphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-([4-[4-(2-methoxyphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-([4-[4-(2-methylphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.00286
N-hydroxy-4-([4-[4-(3-methoxyphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
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pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-([4-[4-(4-methoxy-2-methylphenyl)piperidin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-([4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.00822
N-hydroxy-4-([4-[4-(4-methylphenyl)piperazin-1-yl]phenyl]sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-[[4-(4-phenylpiperazin-1-yl)phenyl]sulfonyl]tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
0.01
N-hydroxy-4-[[4-(4-phenylpiperidin-1-yl)phenyl]sulfonyl]tetrahydro-2H-pyran-4-carboxamide
Rattus norvegicus
-
pH not specified in the publication, temperature not speficied in the publication
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Shofuda, K.I.; Hasenstab, D.; Kenagy, R.D.; Shofuda, T.; Li, Z.Y.; Lieber, A.; Clowes, A.W.
Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells
FASEB J.
15
2010-2012
2001
Rattus norvegicus, Homo sapiens (P50281)
brenda
Manase, K.; Endo, T.; Chida, M.; Nagasawa, K.; Honnma, H.; Yamazaki, K.; Kitajima, Y.; Goto, T.; Kanaya, M.; Hayashi, T.; Mitaka, T.; Saito, T.
Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
Reprod. Biol. Endocrinol.
4
32
2006
Rattus norvegicus
brenda
Schram, K.; Wong, M.M.; Palanivel, R.; No, E.K.; Dixon, I.M.; Sweeney, G.
Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts
J. Mol. Cell. Cardiol.
44
874-881
2008
Rattus norvegicus
brenda
Devy, L.; Huang, L.; Naa, L.; Yanamandra, N.; Pieters, H.; Frans, N.; Chang, E.; Tao, Q.; Vanhove, M.; Lejeune, A.; van Gool, R.; Sexton, D.J.; Kuang, G.; Rank, D.; Hogan, S.; Pazmany, C.; Ma, Y.L.; Schoonbroodt, S.; Nixon, A.E.; Ladner, R.C.; Hoet, R.; Henderikx, P.; Tenhoor, C.; Rabbani, S.A.; Valentino, M.
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis
Cancer Res.
69
1517-1526
2009
Macaca fascicularis, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Kolodziej, S.A.; Hockerman, S.L.; Boehm, T.L.; Carroll, J.N.; DeCrescenzo, G.A.; McDonald, J.J.; Mischke, D.A.; Munie, G.E.; Fletcher, T.R.; Rico, J.G.; Stehle, N.W.; Swearingen, C.; Becker, D.P.
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates
Bioorg. Med. Chem. Lett.
20
3557-3560
2010
Rattus norvegicus
brenda
Chiu, H.C.; Lu, Y.T.; Chin, Y.T.; Tu, H.P.; Chiang, C.Y.; Gau, C.H.; Nieh, S.; Fu, E.
Cyclosporine A inhibits the expression of membrane type-I matrix metalloproteinase in gingiva
J. Periodontal Res.
44
338-347
2009
Homo sapiens, Rattus norvegicus
brenda
Nishihara, T.; Remacle, A.; Angert, M.; Shubayev, I.; Shiryaev, S.; Liu, H.; Dolkas, J.; Chernov, A.; Strongin, A.; Shubayev, V.
Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury
J. Biol. Chem.
290
3693-3707
2015
Rattus norvegicus (Q10739)
brenda
Overland, A.C.; Insel, P.A.
Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease. A novel mechanism for GPCR-EGFR transactivation
J. Biol. Chem.
290
9941-9947
2015
Mus musculus (P53690), Rattus norvegicus (Q10739), Rattus norvegicus Sprague-Dawley (Q10739)
brenda