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Information on EC 3.4.24.78 - gpr endopeptidase

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.78 gpr endopeptidase
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This record set is specific for:
UNIPROT: Q99171 not found.
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Word Map
  • 3.4.24.78
  • cohesin
  • anaphase
  • chromatid
  • securin
  • spindle
  • aneuploidy
  • centromeres
  • metaphase-to-anaphase
  • rad21
  • disjunction
  • kinetochore
  • centriole
  • kleisin
  • separase-dependent
  • missegregation
  • sister-chromatides
  • degradation
  • synthesis
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
Endopeptidase action with P4 Glu or Asp, P1 preferably Glu > Asp, P1' hydrophobic and P2' Ala
Synonyms
germinating-specific protease, GPS, germination proteinase, GPR, tepA, YmfB, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
germinating-specific protease, GPS
-
-
-
-
germination proteinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
75718-32-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
small acid-soluble protein + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
small acid-soluble protein + H2O
?
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
spores from a ymfB/gpr double mutant are more delayed in spore outgrowth and more impaired in small acid-soluble protein degradation than were spores from a gpr single mutant
physiological function
YmfB is an orphan ClpP protease involved in spore outgrowth that is dedicated to the degradation of a specialized family of small protein substrates. The function of YmfB is masked by the germination protease Gpr
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TEPA_BACSU
Bacillus subtilis (strain 168)
245
0
26918
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Traag, B.; Pugliese, A.; Setlow, B.; Setlow, P.; Losick, R.
A conserved ClpP-like protease involved in spore outgrowth in Bacillus subtilis
Mol. Microbiol.
90
160-166
2013
Bacillus subtilis (Q99171)
Manually annotated by BRENDA team