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alpha-neoendorphin + H2O
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dynorphin A + H2O
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?
heparin-binding epidermal growth factor-like growth factor + H2O
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substrate is synthesized as a transmembrane protein. Enzyme enhances ectodomain shedding of substrate in coperation with tumor necrosis factor-alpha-converting enzyme. Metalloendopeptidase activity of enzyme is not required for enhancement of shedding
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malate dehydrogenase + H2O
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?
pro-tumour necrosis factor-alpha + H2O
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?
somatostatin-28 + H2O
?
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?
tumor necrosis factor-alpha + H2O
?
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?
Abz-GGGFLRRVGQ-EDDnp + H2O
?
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?
alpha-neoendorphin + H2O
?
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?
dynorphin A + H2O
?
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?
Glucagon + H2O
?
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?
N-(2-(N-methylamino)benzoyl)-GGFLRRVGK(2,4-dinitrophenyl)-NH2 + H2O
?
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-
-
-
?
PRAME190-198 + H2O
?
-
nardilysin produces precursors of tumor-associated protein PRAME(190-198) by producing cleavage after Lys200, Arg201 and Lys202 but does not excise precisely at the C terminus (Lys198)
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somatostatin-28 + H2O
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additional information
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additional information
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NRDc interacts with the NCoR/SMRT corepressor complex
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additional information
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NRDc is identifiend as a H3K4me2-binding protein. The H3K4me2-binding activity resides in the N-terminal region of NRDc
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additional information
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enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin, resulting in down-regulation of beta-amyloid protein, overview, the enzyme also enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of ADAM17, NRDc is regulatorally involved in the metabolism
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additional information
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expression of nardilysin synergistically enhances TNF-alpha-converting enzyme-induced TNF-alpha ectodomain-shedding via activation of ADAM proteases ADAM9 and ADAM10, activation is independent of protein kinase C, overview
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additional information
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the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview
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additional information
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the metalloendopeptidase cleaves N-terminal Arg or Lys residues of peptides
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additional information
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tubulin enhances the binding of NRD to functionally p42IP4
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additional information
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nardilysin can generate both N termini and C termini of CTL epitopes
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Acute Coronary Syndrome
Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome.
Acute Coronary Syndrome
Nardilysin: A potential biomarker for the early diagnosis of acute coronary syndrome.
Acute Coronary Syndrome
Reply: Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome.
Acute Coronary Syndrome
Response to Letter of Stephenson et al.: Nardilysin: A potential biomarker for the early diagnosis of acute coronary syndrome.
Adenocarcinoma
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Alzheimer Disease
Nardilysin in human brain diseases: both friend and foe.
Alzheimer Disease
Nardilysin prevents amyloid plaque formation by enhancing ?-secretase activity in an Alzheimer's disease mouse model.
Alzheimer Disease
Nardilysin, ADAM10, and Alzheimer's disease: of mice and men.
Alzheimer Disease
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains.
Alzheimer Disease
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin ?1; ADAP1) in neuroblastoma cells.
Arthritis
Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion.
Brain Diseases
Nardilysin in human brain diseases: both friend and foe.
Carcinogenesis
Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.
Carcinoma
Nardilysin protein promotes invasion of esophageal cell carcinoma (ESCC) cells through induction of MMP2 and MMP3. Immunohistochemical analysis of nardilysin in ESCC tissue.
Carcinoma, Hepatocellular
Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3.
Cerebral Infarction
Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction.
Cholangiocarcinoma
Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection.
Coma
Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction.
Down Syndrome
Nardilysin in human brain diseases: both friend and foe.
Down Syndrome
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains.
Esophageal Neoplasms
NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression.
Fatty Liver
Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
Infections
Fasciola hepatica surface tegument: glycoproteins at the interface of parasite and host.
Leukemia
Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo.
Melanoma
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Myocardial Infarction
Increased serum nardilysin is associated with worse long-term outcome of ST-elevation myocardial infarction.
Neoplasms
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Neoplasms
Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels.
Neoplasms
Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.
Neoplasms
Nardilysin in human brain diseases: both friend and foe.
Neoplasms
Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion.
Neoplasms
Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.
Neoplasms
NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression.
Neoplasms
Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection.
Neuroblastoma
Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholics.
Neuroblastoma
Expression and retinoid modulation of N-arginine dibasic convertase and an aminopeptidase-B in human neuroblastoma cell lines.
Neuroblastoma
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin ?1; ADAP1) in neuroblastoma cells.
Neuroblastoma
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-?1 (ADAP1).
Pancreatitis
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Retinal Diseases
Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus-Infected Retinal Pigment Epithelial Cells.
Stomach Neoplasms
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-?
Stroke
Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction.
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Nishi, E.; Hiraoka, Y.; Yoshida, K.; Okawa, K.; Kita, T.
Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme
J. Biol. Chem.
281
31164-31172
2006
Homo sapiens (O43847)
brenda
Hiraoka, Y.; Yoshida, K.; Ohno, M.; Matsuoka, T.; Kita, T.; Nishi, E.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
Biochem. Biophys. Res. Commun.
370
154-158
2008
Homo sapiens
brenda
Hiraoka, Y.; Ohno, M.; Yoshida, K.; Okawa, K.; Tomimoto, H.; Kita, T.; Nishi, E.
Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin
J. Neurochem.
102
1595-1605
2007
Homo sapiens
brenda
Bernstein, H.; Stricker, R.; Dobrowolny, H.; Truebner, K.; Bogerts, B.; Reiser, G.
Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons
Neuroscience
146
1513-1523
2007
Homo sapiens
brenda
Bernstein, H.G.; Stricker, R.; Lendeckel, U.; Bertram, I.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Reiser, G.
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimers disease and Down syndrome brains
Age (Dordr. )
31
11-25
2009
Homo sapiens
brenda
Korovkina, V.P.; Stamnes, S.J.; Brainard, A.M.; England, S.K.
Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium
Am. J. Physiol. Cell Physiol.
296
C433-C440
2009
Homo sapiens
brenda
Kessler, J.H.; Khan, S.; Seifert, U.; Le Gall, S.; Chow, K.M.; Paschen, A.; Bres-Vloemans, S.A.; de Ru, A.; van Montfoort, N.; Franken, K.L.; Benckhuijsen, W.E.; Brooks, J.M.; van Hall, T.; Ray, K.; Mulder, A.; Doxiadis, I.I.; van Swieten, P.F.; Overkleeft, H.S.; Prat, A.; Tomkinson, B.; Neefjes, J.; Klo, K.l.o.e.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes
Nat. Immunol.
12
45-53
2011
Homo sapiens
brenda
Borrmann, C.; Stricker, R.; Reiser, G.
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1)
Cell Tissue Res.
346
89-98
2011
Homo sapiens
brenda
Li, J.; Chu, M.; Wang, S.; Chan, D.; Qi, S.; Wu, M.; Zhou, Z.; Li, J.; Nishi, E.; Qin, J.; Wong, J.
Identification and Characteriation of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation
J. Biol. Chem.
287
10089-10098
2012
Homo sapiens (O43847)
brenda
Borrmann, C.; Stricker, R.; Reiser, G.
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin alpha1; ADAP1) in neuroblastoma cells
Neurochem. Int.
59
936-944
2011
Homo sapiens
brenda
Bernstein, H.; Stricker, R.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Trbner, K.; Reiser, G.
Nardilysin in human brain diseases: both friend and foe
Amino Acids
45
269-278
2013
Homo sapiens (O43847), Homo sapiens
brenda
Kanda, K.; Komekado, H.; Sawabu, T.; Ishizu, S.; Nakanishi, Y.; Nakatsuji, M.; Akitake-Kawano, R.; Ohno, M.; Hiraoka, Y.; Kawada, M.; Kawada, K.; Sakai, Y.; Matsumoto, K.; Kunichika, M.; Kimura, T.; Seno, H.; Nishi, E.; Chiba, T.
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-alpha
EMBO Mol. Med.
4
396-411
2012
Homo sapiens (O43847), Homo sapiens
brenda
Yoh, T.; Hatano, E.; Kasai, Y.; Fuji, H.; Nishi, K.; Toriguchi, K.; Sueoka, H.; Ohno, M.; Seo, S.; Iwaisako, K.; Taura, K.; Yamaguchi, R.; Kurokawa, M.; Fujimoto, J.; Kimura, T.; Uemoto, S.; Nishi, E.
Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection
Clin. Cancer Res.
25
619-628
2019
Homo sapiens (O43847), Homo sapiens
brenda
Chen, F.H.; Wang, Y.; Jiang, Y.X.; Zhang, G.H.; Wang, Z.M.; Yang, H.
Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction
Clin. Chim. Acta
494
8-13
2019
Homo sapiens (O43847), Homo sapiens
brenda
Kanda, K.; Sakamoto, J.; Matsumoto, Y.; Ikuta, K.; Goto, N.; Morita, Y.; Ohno, M.; Nishi, K.; Eto, K.; Kimura, Y.; Nakanishi, Y.; Ikegami, K.; Yoshikawa, T.; Fukuda, A.; Kawada, K.; Sakai, Y.; Ito, A.; Yoshida, M.; Kimura, T.; Chiba, T.; Nishi, E.; Seno, H.
Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation
JCI Insight
3
91316
2018
Homo sapiens (O43847), Homo sapiens, Mus musculus (Q8BHG1)
brenda