Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.24.58 - russellysin and Organism(s) Daboia siamensis and UniProt Accession Q7LZ61

for references in articles please use BRENDA:EC3.4.24.58
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.58 russellysin
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Daboia siamensis
UNIPROT: Q7LZ61 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Daboia siamensis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg-/- bonds. Has no action on insulin B chain
Synonyms
rvv-x, snake venom protease, russell's viper venom factor x activator, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Blood-coagulation factor X activating enzyme
-
-
-
-
Metalloproteinase RVV-x
-
-
-
-
Proteinase, Vipera russelli
-
-
-
-
Russell's viper blood coagulation factor X activator
-
-
-
-
Russell's Viper venom factor X activator
Q7LZ61; Q4PRD1; Q4PRD2
-
Russell's viper venom factor X activator, RVV-X
-
-
-
-
RVV-X
Q7LZ61; Q4PRD1; Q4PRD2
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
79393-92-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
casein + H2O
?
show the reaction diagram
Q7LZ61; Q4PRD1; Q4PRD2
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
Q7LZ61; Q4PRD1; Q4PRD2
-
-
-
?
prothrombin + H2O
thrombin + ?
show the reaction diagram
Q7LZ61; Q4PRD1; Q4PRD2
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyroGlu-Arg-Trp
Q7LZ61; Q4PRD1; Q4PRD2
the synthetic tripeptide shows complete inhibition of the gelatinolytic activity of RVV-X at 5 mM
pyroGlu-Glu-Trp
Q7LZ61; Q4PRD1; Q4PRD2
the synthetic tripeptide shows complete inhibition of the gelatinolytic activity of RVV-X at 5 mM
pyroGlu-Lys-Trp
Q7LZ61; Q4PRD1; Q4PRD2
the synthetic tripeptide shows complete inhibition of the gelatinolytic activity of RVV-X at 5 mM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Q7LZ61: heavy chain. Q4PRD1: light chain 1. Q4PRD2: light chain 2
Q7LZ61; Q4PRD1; Q4PRD2
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Q7LZ61; Q4PRD1; Q4PRD2
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
VM3CX_DABSI
619
0
69648
Swiss-Prot
Secretory Pathway (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
93000
Q7LZ61; Q4PRD1; Q4PRD2
-
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
Q7LZ61; Q4PRD1; Q4PRD2
containing 13% carbohydrate
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
-
Q7LZ61; Q4PRD1; Q4PRD2
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
Q7LZ61; Q4PRD1; Q4PRD2
thrombin is a common hemostatic drug used in surgical practice. Investigation of a method with the optimum conditions for rapid preparation of thrombin from cryoprecipitate-depleted plasma using RVV-X
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kijkriengkraikul, N.; Nuchprayoon, I.
Study of optimum condition for rapid preparation of thrombin using Russell's Viper venom factor X activator
Open Biotechnol. J.
12
95-103
2018
Daboia siamensis (Q7LZ61 AND Q4PRD1 AND Q4PRD2)
-
Manually annotated by BRENDA team
Yee, K.T.; Pitts, M.; Tongyoo, P.; Rojnuckarin, P.; Wilkinson, M.C.
Snake venom metalloproteinases and their peptide inhibitors from myanmar Russells viper venom
Toxins
9
E15
2016
Daboia siamensis (Q7LZ61 AND Q4PRD1 AND Q4PRD2)
Manually annotated by BRENDA team