Disease on EC 3.4.24.40 - serralysin
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
Atherosclerosis
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
Carcinoma
Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2.
Carcinoma, Squamous Cell
Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2.
Colorectal Neoplasms
Purification and study of anti-cancer effects of Serratia marcescens serralysin.
Dermatitis, Atopic
Inhibitory effect of arazyme on the development of atopic dermatitis-like lesions in BALB/c and Nc/Nga mice.
Fatty Liver
Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model.
Glioma
HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway.
Hyperglycemia
Combination Treatment of Arazyme and Soy Leaf Extract Attenuates Hyperglycemia and Hepatic Steatosis in High-Fat Diet-Fed C57BL/6J Mice.
Infections
A proteolytic enzyme secreted by Proteus mirabilis degrades immunoglobulins of the immunoglobulin A1 (IgA1), IgA2, and IgG isotypes.
Infections
Calcium-induced folding and stabilization of the Pseudomonas aeruginosa alkaline protease.
Infections
Interdomain Contacts and the Stability of Serralysin Protease from Serratia marcescens.
Infections
Quantitation and enzymatic activity of the alkaline protease from Pseudomonas aeruginosa in culture supernatants from clinical strains.
Infections
Rapid and efficient one-step purification of a serralysin family protease by using a p-aminobenzamidine-modified affinity medium.
Infections
Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2.
Kuru
A prion protein missense variant is integrated in kuru plaque cores in patients with Gerstmann-Sträussler syndrome.
Leishmaniasis, Visceral
Evaluation of Cysteine Protease C of Leishmania donovani in comparison with Glycoprotein 63 and Elongation Factor-1? for diagnosis of human visceral leishmaniasis and for post-treatment follow-up response.
Lung Neoplasms
Expression of chicken ovalbumin upstream promoter-transcription factor II enhances invasiveness of human lung carcinoma cells.
Malaria
Bayesian analysis of new and old malaria parasite DNA sequence data demonstrates the need for more phylogenetic signal to clarify the descent of Plasmodium falciparum.
Malaria
Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum).
Melanoma
A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.
Melanoma
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
Mouth Diseases
In vitro and in vivo studies of the Yrp1 protease from Yersinia ruckeri and its role in protective immunity against enteric red mouth disease of salmonids.
Myocardial Infarction
Influence of apelin-12 on troponin levels and the rate of MACE in STEMI patients.
Neoplasm Metastasis
ARA-linker-TGF?L3: a novel chimera protein to target breast cancer cells.
Neoplasm Metastasis
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Neoplasm Metastasis
Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer.
Neoplasm Metastasis
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
Neoplasms
A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.
Neoplasms
A Novel Peptide to Treat Oral Mucositis Blocks Endothelial and Epithelial Cell Apoptosis.
Neoplasms
Arazyme inhibits cytokine expression and upregulates skin barrier protein expression.
Neoplasms
Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model.
Neoplasms
Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues.
Neoplasms
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Neoplasms
Targeting the EGFR in cancer cells by fusion protein consisting of arazyme and third loop of TGF-alpha: an in silico study.
Neoplasms
The effects of protease I of Aspergillus oryzae (brinase) on membrane permeability and growth of Landschütz ascites tumour cells.
Neoplasms
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
Pulmonary Embolism
[Experimental pulmonary embolism in dogs. Local administration of Aspergillus-oryzae protease I]
Sepsis
Efficacies of alkaline protease, elastase and exotoxin A toxoid vaccines against gut-derived Pseudomonas aeruginosa sepsis in mice.
Starvation
Role of Clp protease subunits in degradation of carbon starvation proteins in Escherichia coli.
Stomatitis, Denture
Development of a novel denture care agent with highly active enzyme, arazyme.
Urinary Tract Infections
A proteolytic enzyme secreted by Proteus mirabilis degrades immunoglobulins of the immunoglobulin A1 (IgA1), IgA2, and IgG isotypes.
Vascular Diseases
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
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