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Information on EC 3.4.24.35 - gelatinase B and Organism(s) Homo sapiens and UniProt Accession P14780

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.35 gelatinase B
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: P14780 not found.
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Cleavage of gelatin types I and V and collagen types IV and V
Synonyms
mmp-9, matrix metalloproteinase-9, matrix metalloproteinase 9, gelatinase b, matrix metallopeptidase 9, matrix metalloprotease-9, mmp 9, 92-kda gelatinase, 92 kda gelatinase, 92-kda type iv collagenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
gelatinase
-
gelatinase B
-
matrix metallopeptidase 9
-
Matrix metalloproteinase 9
-
matrix metalloproteinase-9
-
progelatinase
-
92 kDa gelatinase
92 kDa type IV collagenase
-
-
92 kDa type IV collagenase proMMP-9
-
-
92-kDa Gelatinase
-
-
-
-
92-kDa gelatinase B
-
-
92-kDa Type IV collagenase
95 kDa type IV collagenase/gelatinase
-
-
-
-
Collagenase IV
-
-
-
-
Collagenase type IV
-
-
-
-
Gelatinase MMP 9
-
-
-
-
GELB
-
-
-
-
Macrophage gelatinase
-
-
-
-
matrix metallopeptidase 9
-
-
matrix metallopeptidase 9 gelatinase B
-
-
matrix metalloprotease-9
-
-
Matrix metalloproteinase 9
matrix metalloproteinase-9
metrix metalloproteinase-9
-
-
MMP 9
neutrophil collagenase
-
-
pro-matrix metalloproteinase-9
-
-
Type IV collagen metalloproteinase
-
-
-
-
Type IV collagenase
Type IV collagenase/gelatinase
Type V collagenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
146480-36-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DNP-Pro-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2 + H2O
DNP-Pro-cyclohexyl-Ala-Gly + Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2
show the reaction diagram
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
islet amyloid polypeptide + H2O
?
show the reaction diagram
enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
Mca-KPLGL-(Dpa)-AR-NH2 + H2O
?
show the reaction diagram
-
-
-
?
nonmuscular actin + H2O
?
show the reaction diagram
-
-
-
?
(7-methoxycoumarin-4-yl)-acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 + H2O
?
show the reaction diagram
-
-
?
2,4-dinitrophenyl-Pro-beta-cyclohexylalanyl-Gly-Cys(Me)-His-Ala-Lys(N-Me-2-aminobenzoyl)-NH2 + H2O
?
show the reaction diagram
-
a quenched fluorogenic substrate
-
-
?
2,4-Dinitrophenyl-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 + H2O
2,4-Dinitrophenyl-Pro-Leu-Gly + Leu-Trp-Ala-D-Arg-NH2
show the reaction diagram
-
and peptide substrates derived from, utility of substrate mapping form examining the subsite specificities and the optimization of proteinase substrates
-
?
65000 MW form of vitronectin + H2O
?
show the reaction diagram
-
-
-
-
?
Ac-L-Pro-L-Pro(OH)-Gly-L-Gln-Gly-L-Ala-L-Thr-Gly-L-Glu-L-Pro(OH)-Gly-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
actin + H2O
?
show the reaction diagram
-
-
-
-
?
Aggrecan core protein + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-enolase + H2O
?
show the reaction diagram
-
-
-
-
?
annexin I + H2O
?
show the reaction diagram
-
-
-
-
?
Arp2/3 complex subunit + H2O
?
show the reaction diagram
-
-
-
-
?
betaB1 crystallin + H2O
?
show the reaction diagram
-
main enzyme substrate in lens extract
-
-
?
citrate synthase + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
Collagen type I + H2O
?
show the reaction diagram
Collagen type III + H2O
?
show the reaction diagram
collagen type IV + H2O
?
show the reaction diagram
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type XI + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
-
-
-
-
?
ephB1 + H2O
?
show the reaction diagram
-
-
-
?
epidermal growth factor + H2O
?
show the reaction diagram
ezrin + H2O
?
show the reaction diagram
-
-
-
-
?
fibrillar collagen + H2O
?
show the reaction diagram
filamin B + H2O
?
show the reaction diagram
-
-
-
-
?
fragments of human collagen type II + H2O
?
show the reaction diagram
-
fragments obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes
-
-
?
Galectin-3 + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
gelsolin + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 27 + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 70 + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 90 + H2O
?
show the reaction diagram
-
-
-
-
?
histidyl-tRNA synthetase + H2O
?
show the reaction diagram
-
-
-
-
?
HMGB1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
L-Pro-L-Pro(OH)-Gly-L-Gln-Gly-L-Ala-L-Thr-Gly-L-Glu-L-Pro(OH)-Gly-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
LS276-THP + H2O
?
show the reaction diagram
-
development and evaluation of an activatable NIR fluorescent probe LS276-THP for in vivo detection of cancer-related matrix metalloproteinase activity based on a triplehelical peptide substrate with high specificity for MMP-2 and MMP-9 relative to other members of the MMP family, overview. Triple-helical peptides are suitable for highly specific in vivo detection of tumor-related MMP-2 and MMP-9 activity
-
-
?
moesin + H2O
?
show the reaction diagram
-
-
-
-
?
N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-7-methoxycoumarin-4-yl acetyl + H2O
?
show the reaction diagram
-
-
-
?
N-alpha-benzoyl-arginine p-nitroanilide + H2O
N-alpha-benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
i.e. BAPNA
-
-
?
Neonatal human proteoglycan + H2O
?
show the reaction diagram
-
poor substrate, cleavage of the His16-Ile17 bond
-
-
?
nucleolin + H2O
?
show the reaction diagram
-
-
-
-
?
peptide A13 + H2O
?
show the reaction diagram
-
-
-
?
peptide A13R + H2O
?
show the reaction diagram
-
-
-
?
peptide A3 + H2O
?
show the reaction diagram
-
-
-
?
peptide A34 + H2O
?
show the reaction diagram
-
-
-
?
peptide B74 + H2O
?
show the reaction diagram
-
-
-
?
peptide C15 + H2O
?
show the reaction diagram
-
non-selective peptide substrate
-
?
peptide C9 + H2O
?
show the reaction diagram
-
-
-
?
peptide m1A11 + H2O
?
show the reaction diagram
-
non-selective peptide substrate
-
?
Proteoglycan + H2O
?
show the reaction diagram
-
-
-
-
?
snRNP D3 + H2O
?
show the reaction diagram
-
-
-
-
?
stathmin + H2O
?
show the reaction diagram
-
-
-
-
?
stromelysin 1 + H2O
?
show the reaction diagram
-
-
?
stromelysin1 + H2O
?
show the reaction diagram
-
-
-
?
succinylated gelatin + H2O
?
show the reaction diagram
-
-
-
-
?
tubulin + H2O
?
show the reaction diagram
-
-
-
-
?
Type IV collagen + H2O
?
show the reaction diagram
-
-
-
-
?
type V collagen + H2O
?
show the reaction diagram
-
-
-
-
?
type XI collagen + H2O
?
show the reaction diagram
-
-
-
-
?
Vitronectin + H2O
?
show the reaction diagram
-
65000 MW and 75000 MW form of vitronectin
-
-
?
vitronectin of MW 65000 + H2O
?
show the reaction diagram
-
-
-
-
?
vitronectin of MW 75000 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Gelatin + H2O
?
show the reaction diagram
islet amyloid polypeptide + H2O
?
show the reaction diagram
enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
Aggrecan core protein + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
-
MMP-9 inhibits collagen-induced platelet aggregation
-
-
?
Collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type XI + H2O
?
show the reaction diagram
-
-
-
-
?
epidermal growth factor + H2O
?
show the reaction diagram
-
MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of epidermal growth factor, EGF, and membrane-bound EGF-like ligands and activating epidermal growth factor receptor
-
-
?
fibrillar collagen + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Calcium
-
required
Zinc
-
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha-linolenic acid
-
antibody REGA-3G12
highly selective, potent MMP-9 inhibition, the antibody recognizes the N-terminal part, not the C-terminal hemopexin and O-glycosylated domains, epitope mapping, overview
-
docosahexaenoic acid
-
EDTA
2 mM, severely inhibits enzyme activity due to chelation of metal ions
gamma-linolenic acid
-
hemopexin domain of MMP-9
the hemopexin domain of MMP-9 inhibits the degradation of gelatin. It also abolishes the degradation of gelatin by MMP-2. Blades 1 and 4 of the PEX9 domain are responsible for the gelatin degradation inhibitory activity of PEX9. The hemopexin domain of MMP-9 does not prevent the degradation of other MMP-9 substrates, such as a fluorogenic peptide, alphaB crystalline, or nonmuscular actin
-
isovitexin
interacts with enzyme residues Glu241, Ala242, Pro255, Pro254, Thr251, Leu222, Tyr248, Arg241, Met247, His226, and Glu227, binding structure analysis, and modeling, overview
linoleic acid
-
MMP-9 inhibitor I
-
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
NNGH
oleic acid
-
reversion-inducing cysteine-rich protein with Kazal motifs
-
-
Tissue inhibitor of metalloproteinase-1
-
-
Tissue inhibitor of metalloproteinase-2
-
-
tissue inhibitor of metalloproteinases 1
-
vitexin
interacts with enzyme residues Gly186, Pro246, His236, Met247, Tyr248, Val223, and Leu188, binding structure analysis, and modeling, overview
(2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-isopropionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
-
-
1,10-phenanthroline
2-[(biphenyl-4-ylsulfonyl)(isobutyl)amino]-N-hydroxyacetamide
-
50% inhibition at 34 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
3',4',5,6,7,8-hexamethoxyflavone
-
i.e. nobiletin
3',4'-di-O-methylbutin-7-O-[(6''->1''')-3''',11'''-dimethyl-7'''-methylenedodeca-3''',10'''-dienyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
3',4'-di-O-methylquercetin-7-O-[(4''->13''')-2''',6''',10''',14'''-tetramethylhexadec-13'''-ol-14'''-enyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
-
-
3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
-
-
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
-
-
4'-O-methylbutin-7-O-[(6->1''')-3''',11'''-dimethyl-7'''-hydroxymethylenedodecanyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
4'-O-methylkaempferol-3-O-[(4''->13''')-2''',6''',10''',14'''-tetramethylhexadecan-13'''-olyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
5-(1,5-dihydroxypentan-3-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-hydroxybutan-2-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(3-(1-nitrooxy-methyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(4-(1-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperazin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(bis-(2-nitrooxy-ethyl)-amino)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(methyl-(2-nitrooxy-ethyl)-amino)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[3-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[4-(2-hydroxyethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[4-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
Ag-3340
-
i.e. N-hydroxy-2,2-dimethyl-4-[(4-phenoxyphenyl)sulfonyl]thiomorpholine-3-carboxamide, 50% inhibition at 0.26 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
carboxy-derivatized glucosamine
-
62% inhibition of MMP-9 at 0.5 mg/ml
-
CGS27023A
-
50% inhibition at 8 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
chitooligosaccharides
-
different molecular weight, inhibit both MMP-9 expression and activity, especially 1- to 3-kDa chitooligosaccharides, chitooligosaccharides-I in HT-1080 cells
D-penicillamine
-
10 mg/l, 43% inhibition
ilomastat
Immunoglobulins purified from antisera raised against gelatinase
-
-
-
N-hydroxy-2-(isobutyl[(4-methoxyphenyl)sulfonyl]amino)acetamide
-
50% inhibition at 2.9 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
norcantharidin
-
i.e. exo-7-oxabicylo-[2.2.1] heptane-2,3-dicarboxylic anhydride, norcantharidin inhibits gelatinase activity of MM-9 in a concentration- and time-dependent manner
o-phenanthroline
-
-
polyhistidine
-
0.001 mM, 68% inhibition
proanthocyanidins
-
from the american cranberry, Vaccinium macrocarpon, decrease cellular viability of DU-145 cells via inhibition of MMP-9. The proanthocyanidins PACs increase the expression of TIMP-2, a known inhibitor of MMP activity, and decrease the expression of EMMPRIN, an inducer of MMP expression. Cranberry proanthocyanidins decrease MMP activity through the induction and/or inhibition of specific temporal MMP regulators, and by affecting either the phosphorylation status and/or expression of MAP kinase, PI-3 kinase, NF-kappaB and AP-1 pathway proteins
-
procyanidin oligomers
-
from Japanese quince, Chaenomeles japonica, fruit inhibit activity of MMP-9
-
REGA-3G12 scFv with (His6)2
-
monoclonal antibody REGA-3G12 single-chain variable fragment, 0.005 mM, 66% inhibition
-
TIMP-1
-
TIMP-1/2
-
-
-
TIMP-2
-
TIMP-4
-
-
-
TIMP1
-
interaction analysis and structure modeling, overview
-
TIMP2
-
interaction analysis and structure modeling, overview
-
Tissue inhibitor
-
tissue inhibitor of matrix metalloproteinase 1
-
strong inhibitor of MMP-9
-
tissue inhibitor of matrix metalloproteinase-1
-
TIMP-1
-
tissue inhibitor of metalloproteinase TIMP-1
-
-
tissue inhibitor of metalloproteinase TIMP-2
-
-
Tissue inhibitor of metalloproteinase-1
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3,7,8-tetrachlorodibenzo-p-dioxin
-
both MMP-9 mRNA expression and enzymatic activity are gradually increased with the concentration increase of 2,3,7,8-tetrachlorodibenzo-p-dioxin in media and these changes can be reversed by resveratrol treatment in a dose-dependent manner, c-Jun mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced MMP-9 expression and activity
4-amino phenylmercuric acetate
-
pro-MMP-9 is activated with 1 mM 4-amino phenylmercuric acetate in assay buffer at 37°C for 1.5 h
4-aminophenylmercuric acetate
APMA
-
-
interleukin-1
-
-
-
interleukin-1beta
-
-
-
matrix metalloproteinase 3
-
converts inactive pro-MMP-9 to active MMP-9
-
phorbol 12-myristate 13-acetate
tumor necrosis factor-alpha
-
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0015
65000 MW form of vitronectin
-
-
-
0.00422 - 0.00496
N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-7-methoxycoumarin-4-yl acetyl
0.000013 - 0.000025
stromelysin1
-
0.0013
vitronectin
-
75000 MW form
-
additional information
additional information
-
detailed binding kinetics
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04 - 8.67
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2
0.00041 - 0.0019
stromelysin 1
-
0.0005
vitronectin of MW 65000
-
-
-
0.000333
vitronectin of MW 75000
-
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00000713 - 0.00000817
TIMP-1
-
0.0000259 - 0.0000361
TIMP-2
-
additional information
additional information
-
detailed binding kinetics
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000045
(2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.01
(2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
Homo sapiens
-
above
0.000017
(2E)-3-(N-hydroxycarbamoyl)-2-isopropionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.000038
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.000974
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.017 - 0.0209
3',4',5,6,7,8-hexamethoxyflavone
0.0108 - 0.0123
3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
0.0164 - 0.0169
3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
0.0037 - 0.0055
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
0.000026
5-(1,5-dihydroxypentan-3-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000145
5-(4-hydroxybutan-2-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000104
5-(4-phenoxyphenyl)-5-(3-(1-nitrooxy-methyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000152
5-(4-phenoxyphenyl)-5-(4-(1-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000092
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperazin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000202
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000091
5-(4-phenoxyphenyl)-5-(bis-(2-nitrooxy-ethyl)-amino)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000048
5-(4-phenoxyphenyl)-5-(methyl-(2-nitrooxy-ethyl)-amino)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.0000062
5-[3-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.0000081
5-[4-(2-hydroxyethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000012
5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000097
5-[4-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.0000002 - 0.0000005
ilomastat
additional information
additional information
Homo sapiens
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
7.6
assay at
7.8
gelatinolytic activity
6.8
-
assay at
7.4
-
assay at
7.5
-
assay at
8.3
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20 - 22
assay at
25 - 37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
increased enzyme expression, the positive ratio of MMP-9 tends to increase from Grade II to Grade IV glioma and strong positive MMP-9 staining is more frequently detected in high-grade glioma, association between matrix metalloproteinase-9 expression and survival of patients
Manually annotated by BRENDA team
localized mainly in the cytoplasm of neoplastic astrocytes
Manually annotated by BRENDA team
the enzyme is upregulated compared to control brain
Manually annotated by BRENDA team
Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host. Analysis of the patterns of matrix metalloproteinase 9 (MMP-9) and 2 (MMP-2) isoforms in sputum samples, overview. Variations in MMP-9 isoforms are observed, which coincide with the progression of tuberculosis infection
Manually annotated by BRENDA team
-
enzyme expression is slightly induced by HIV and strongly induced by TNF alpha, while matrix metalloproteinase MMP-2 and tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 are only slightly affected. Astrocytes are a major source of enzyme in the inflamed brain
Manually annotated by BRENDA team
-
MMP-9 secretion
Manually annotated by BRENDA team
-
from femoral condyles in the knee
Manually annotated by BRENDA team
-
expression and activity of MMP-9 during premature rupture of chorioamniotic membranes, secretion of proMMP-9 from the amniochorion after application of lipopolysacchride to either sides of the membrane is increased, overview
Manually annotated by BRENDA team
-
demineralized dentin matrix, extraction is best at acidic conditions of pH 2-3 compared to pH 7.4-EDTA-containing extracts
Manually annotated by BRENDA team
-
colon adenocarcinoma cell line
Manually annotated by BRENDA team
-
MMP-9 is expressed at very low levels in endometrioid adenocarcinoma cells
Manually annotated by BRENDA team
-
increased MMP-9 levels
Manually annotated by BRENDA team
-
airway
Manually annotated by BRENDA team
-
tumor periphery
Manually annotated by BRENDA team
-
neutrophil, commercial preparation
Manually annotated by BRENDA team
-
colon adenocarcinoma cell line
Manually annotated by BRENDA team
-
leukemia cell line, secretion of MMP-9
Manually annotated by BRENDA team
-
expression analysis of MMP 9 in benign, premalignant and malignant laryngeal lesions, e.g. carcinoma and dysplasia, the enzyme is upregulated in malignant tissue, immunohistochemic analysis, overview
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
the level of MMP-9 activity in lens epithelial cells is highest in eyes with cortical cataract
Manually annotated by BRENDA team
-
from surgical lobectomy for lung cancer
Manually annotated by BRENDA team
-
polymorphonuclear lymphocytes
Manually annotated by BRENDA team
-
treatment of blood-derived mast cells with TNF-alpha significantly increases expression of enzyme mRNA and upregulates enzyme activity. TNF-alpha also increases the invasiveness of mast cells across Matrigel-coated membranes. INF-gamma is inhibitory to enzyme mRNA and protein expression
Manually annotated by BRENDA team
-
cell expression system
Manually annotated by BRENDA team
-
atrophic acnd nonatrophic oral lichen planus
Manually annotated by BRENDA team
-
periapical ligament
Manually annotated by BRENDA team
-
no association between plasma MMP-9 activity and the concentrations of lead in whole blood or plasma, overview
Manually annotated by BRENDA team
-
primary bronchial epithelial cell
Manually annotated by BRENDA team
-
MMP-9 is expressed at very low levels in serous cystoadenocarcinoma cells
Manually annotated by BRENDA team
-
stromal cells are the major source of MMP-9
Manually annotated by BRENDA team
-
colon adenocarcinoma cell line
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
-
-
Manually annotated by BRENDA team
additional information
-
secretion of proMMP-9 from the amniochorion after application of lipopolysacchride to either sidesof the membrane is increased, overview
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
malfunction
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MMP9_HUMAN
707
0
78458
Swiss-Prot
Secretory Pathway (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
228300
enzyme multimer/trimer, PAGE, structure analysis by AFM
65000
x * 65000, active matured, truncated enzyme form lacking both the N- and C-terminal domains, SDS-PAGE, x * 82000, activated mature enzyme, SDS-PAGE
65000 - 82000
major circulating MMP-9 enzyme forms: 92 kDa proMMP-9, and active 82 kDa and 65 kDa enzyme forms
82000
x * 65000, active matured, truncated enzyme form lacking both the N- and C-terminal domains, SDS-PAGE, x * 82000, activated mature enzyme, SDS-PAGE
89300
x * 89300, about, SDS-PAGE, the natural zymogen proMMP-9 occurs as monomers, homomultimers and heterocomplexes. MMP-9 homomultimers are reduction-sensitive trimers, three-dimensional structure molecular modeling, overview. Homomultimerization of the enzyme involves cysteine bridge formation. The zymogen proMMP-9 monomer includes the propeptide, the fibronectin-like domain, the Zn2+ -binding domain, the catalytic domain, the flexible OG domain, and the haemopexin-like domain
92000
SDS-PAGE
130000
200000
-
the molecular weight of proMMP-9 is about 200000 Da, SDS-PAGE
20947
-
x * 70795, calculated, enzyme mutant E402A, x * 20947, calculated, isolated enzyme collagen-binding domain
210000
dimeric form, SDS-PAGE
220000
-
native PAGE
225000
65000
-
4-aminophenylmercuric acetate produces not only the 82000 Da active enzyme but also a C-terminal truncated form of approximately 65000 Da with activity comparable to that of the 82000 Da form
67000
-
active form of MMP-9, SDS-PAGE
70795
-
x * 70795, calculated, enzyme mutant E402A, x * 20947, calculated, isolated enzyme collagen-binding domain
72000
-
active form of MMP-9, SDS-PAGE
78000
-
active form of MMP-9, SDS-PAGE
82000
84000
86000
88000
-
activated enzyme
94000
-
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
homodimer
monomer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
the enzyme is O-glycosylated at Trp116-Lys214 sequence of the C-terminal part
proteolytic modification
glycoprotein
proteolytic modification
additional information
-
activation of pro-MMP-2 by 4-aminophenylmercuric acetate
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E402A
E412D
-
site-directed mutagenesis
P574R
-
the mutant is associated with a non-significant decreased risk of coronary artery disease when compared with the wild type genotype
R279Q
R668Q
-
the mutant is associated with a non-significant decreased risk of coronary artery disease when compared with the wild type genotype
additional information
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, stored in 50% glycerol, complete retention of activity forat least 1 month
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native enzyme from serum samples by concanavalin-A and gelatin afffinity chromatography, and ultrafiltration
purification, refolding and in vitro recovery of active full length recombinant human gelatinase MMP-9
recombinant wild-type and mutant zymogen from Sf9 insect cells by gelatin affinity chromatography
catalytic domain of mutated enzyme
-
gelatin Sepharose 4B bead chromatography
-
gelatin-Sepharose column chromatography
-
native MMP-9 from dentin inculding serial dilutions, method development
-
recombinant enzyme
-
recombinant full-length pro-MMP-9 from Spodoptera frugiperda Sf9 cells
-
recombinant full-length proMMP-9 and mutant enzymes from Spodoptera frugiperda Sf9 insect cells
-
recombinant MMP-9 from Spodoptera frugiperda Sf9 cells
-
SC40-transformed cells
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in the form of inclusion bodies in Escherichia coli BL21, using pET21a vector
expresssion of wild-type MMP-9 and truncated versions in insect cells
gene MMP-9, quantitative real time PCR expression analysis in glioblastoma
gene MMP9, quantitative real-time PCR enzyme expression analysis
gene MMP9, quantitative RT-PCR enzyme expression analysis
recombinant expression of the wild-type and mutant zymogen in Spodoptera frugiperda Sf9 cells
cDNA of the mutated enzyme used to transfect HEK 293 cells
-
expressed in baculovirus-infected Spodoptera frugiperda IPLB-Sf21 AE cells
-
expressed in CT-26 cells
-
expressed in immortalized keratinocytes, transduced by lentivrus
-
expression in H9C2 cell
-
expression of full-length pro-MMP-9 in Spodoptera frugiperda Sf9 cells
-
expression of full-length proMMP-9 and of mutant enzymes in Spodoptera frugiperda Sf9 insect cells using the baculovirus infection system
-
expression of MMP-9 in Spodoptera frugiperda Sf9 cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
islet MMP-9 mRNA levels are decreased in type 2 diabetic subjects
Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host
0.025 mM panduratin A markedly down-regulates MMP-9 expression
-
0.025-0.1 mM 6-hydroxydopamine and 0.05-0.5 mM 1-methyl-4-phenylpyridinium ion increase MMP-9 gene expression in a dose-dependent manner by inducing nuclear factor-kappaB and AP-1 binding to the MMP-9 promoter, N-acetylcysteine suppresses both 6-hydroxydopamine- and 1-methyl-4-phenylpyridinium ion-induced MMP-9 promoter activities, LY294002, suppresses 6-hydroxydopamine- and 1-methyl-4-phenylpyridinium ion-induced MMP-9 promoter activities, whereas SB203580 inhibits 6-hydroxydopamine-, but not 1-methyl-4-phenylpyridinium ion-induced promoter activity, neither PD98059 nor SP600125 influence 6-hydroxydopamine or 1-methyl-4-phenylpyridinium ion-induced MMP-9 promoter activity
-
10 ng/ml transforming growth factor-beta1 and 10 ng/ml transforming growth factor-beta2 enhance the secretion of matrix metalloproteinase-9 in PC-3 cells 5.4fold and 4.3fold, respectively
-
10 nM 12-O-tetradecanoyl phorbol-13-acetate induces MMP-9 expression (9728.9% of the control) after 24 h by the suppression of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells, 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is significantly inhibited by UO126, but not by SP600125 and SB203580
-
10% (v/v) Porphyromonas gingivalis supernatant induces about 2.5fold increased MMP-9 expression in human oral epidermoid cells
-
12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is decreased by 324.8% by 0.1 mM silibinin
-
20 mg doxycycline decreases MMP-9 levels after 1 month, 20 mg doxycycline decreases endometrial MMP-9 at 1 and 6 months compared to baseline
-
a significant increase in MMP-9 is observed in pulmonary tuberculosis patients as compared to healthy controls
-
A3 receptor stimulation induces an increase of MMP-9 protein levels in cellular extracts of U87MG cells by phosphorylation of extracellular signal-regulated protein kinases, c-Jun N-terminal kinase/stress-activated protein kinase, protein kinase B, and activator protein 1. A3 receptor activation stimulates also an increase of extracellular MMP-9 in the supernatants from U87MG glioblastoma cells
-
active treatment with uric acid (0.5 or 1.0 mg) is associated with reduced levels of active MMP-9 at the end of infusion
-
after 24 h incubation, 0.05 mg/ml aspirin inhibits MMP-9 mRNA expression by 50%. MMP-9 mRNA expression and release are inhibited by fenofibrate (0.1 mM) and 15d-prostaglandin J2 (0.005 mM)
-
aqueous extract isolated from Prunella vulgaris suppresses 12-phorbol 13-myristate acetate-enhanced expression of MMP-9 protein, mRNA and transcription activity levels through suppression of nuclear factor-kappaB activation
-
berberine inhibits the expression of MMP-9 at both the mRNA and protein levels in a dose-dependent manner (0.005-0.05 mM) by suppressing the activation of p38 pathway in phorbol 12-myristate 13-acetate-induced macrophages
-
C-reactive protein increases the expression and activity of MMP-9 in a dose-dependent manner in human THP-1 cells
-
circulating MMP-9 concentrations are higher in patients with abdominal aortic aneurysm than those in subjects without abdominal aortic aneurysm
-
diet-induced long-term weight loss decreases MMP-9
-
Dz13 upregulates the matrix metalloproteinase-9 in cultured tumor cells
-
epidermal growth factor contributes to prostate cancer metastasis through stimulating MMP-9 secretion from prostate cancer cells
-
exposure of KB cells to Porphyromonas gingivalis supernatant (10% v/v) up-regulates the expression of MMP-9 protein and gene, the JNK inhibitor SP600125 (0.02 mM) significantly attenuates MMP-9 gene expression in KB cells in response to Porphyromonas gingivalis supernatant. JNK and AP-1 are the major signaling for Porphyromonas gingivalis supernatant-stimulated MMP-9 expression in KB cells
-
heregulin-beta1 stimulates MMP-9 secretion and activation via a transcriptional regulation in human breast cancer cells
-
higher plasma MMP-9 concentrations are found in periodontal disease patients compared with healthy controls
-
homocysteine increases mRNA expression of MMP-9
-
immune cell secretion of MMP-9 decreases by 58% after 3 months of omega-3 fatty acid supplementation when compared with baseline levels in patients with relapsing-remitting multiple sclerosis
-
in sections of ectopic tumors treated with Dz13, MMP-9 is downregulated
-
in the human vascular endothelium, simvastatin and atorvastatin (0.0001-0.01 mM) reduce MMP-9 expression and activity
-
induction of MMP-9 expression and activity is significantly inhibited by 0.001 mM of the specific cPLA2alpha inhibitor
-
interferon-gamma suppresses MMP-9 expression
-
interleukin 1beta, interleukin-6, and tumor necrosis factor -alpha stimulate MMP-9 expression
-
leucine-zipper and sterile-alpha motif kinase reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells
-
levels of MMP-9 in choriodecidua and amnion increases 4 and 8fold, respectively, after simultaneous infection with Escherichia coli added to either the amniotic or the choriodecidual face or to both
-
levonorgestrel subcutaneous implant increases serum MMP-9 levels after 1 month
-
matrix metalloproteinase-9 is significantly increased after 8 weeks of very low energy diet-induced weight loss
-
MMP-9 is moderately induced by Fusobacterium nucleatum and considerably induced by phorbol 12-myristate-13-acetate in gingival epithelial cells, MMP-9 mRNA up-regulation occurs at 3 h, whereas MMP-9 secretion and activity in cell-free supernatants occurs at 12 h
-
MMP-9 is significantly increased in the infarcted tissue compared to the contralateral hemisphere after ischemic stroke
-
MMP-9 mRNA expression and release are induced by 0.002 mM prostaglandin E2
-
MMP-9 protein and mRNA levels are decreased up to 43% after treatment with 0.025 mM panduratin A
-
N-2-(4-bromophenyl) ethyl caffeamide inhibits MMP-9 production through the nuclear-targeted down-regulation of nuclear factor-kappaB signaling in human monocytic cells
-
no significant difference is observed in the levels of MMP-9 in culture filtrate antigen and live Mycobacterium tuberculosis-stimulated as well as unstimulated cultures of both healthy controls and pulmonary tuberculosis patients
-
non-surgical periodontal therapy decreases blood plasma MMP-9 concentration by 39%
-
norcantharidin downregulates MMP-9 mRNA and protein expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells, norcantharidin at 0.1 mM completely abolishes the expression of MMP-9 mRNA at 48 h
-
nuclear factor-kappaB is a key transcription factor for the production of MMP-9, tumor necrosis factor-alpha induces expression of MMP-9 at both mRNA and protein levels, tumor necrosis factor-alpha-induced expression of MMP-9 is completely blocked by N-2-(4-bromophenyl) ethyl caffeamide in a concentration-dependent (0.001-0.02 mM) manner
-
obese individuals show increased activity of MMP-9/LCN2 complex, while a positive correlation between MMP-9 activity and body mass index is observed
-
overexpression of reversion-inducing cysteine-rich protein with Kazal motifs in HT-1080 cells decreases MMP-9 mRNA levels, reversion-inducing cysteine-rich protein with Kazal motifs-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element and KB sites
-
penta-O-galloyl-beta-D-glucose inhibits epidermal growth factor-induced MMP-9 expression in a dose- and time-dependent manner by reducing the MMP-9 transcriptional activity
-
propranolol significantly reduces MMP-9 secretion upon treatment with phorbol 12-myristate 13-acetate which is correlated with a decrease in MMP-9 gene expression
-
pterostilbene (i.e. trans-3,5-dimethoxy-4'-hydroxystilbene) down-regulates matrix metalloproteinase-9 activity and inhibits protein and mRNA expression of MMP-9 driven by heregulin-beta1
-
serum MMP-9 concentrations are significantly higher in patients with non-herpetic acute limbic encephalitis in acute and convalescent stages than in control patients
-
silibinin suppresses 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression through inhibition of COX-2 (106% decrease of expression at 0.2 mM silibinin), 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is inhibited by celecoxib in a dose-dependent fashion, 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is decreased by UO126
-
Skp2 overexpression increases the expression of MMP-9, Sp1 is involved in the induction of MMP-9 by Skp2
-
tear MMP-9 activity is significantly higher in patients with dysfunctional tear syndrome, this activity is associated with increased mRNA expression of MMP-9
-
the antihemorrhagic effect of PJ34, a potent PARP inhibitor, is associated with a 57% decrease in MMP-9 overexpression, glucocorticoid increases TIMP-1 in the brain endothelial cell line cEND to reduce the levels of MMP-9
-
the early increase in MMP-9 blood plasma activity in patients with acute coronary syndrome is related to MMPs activation in the unstable atherosclerotic plaque
-
the ethanolic extract from Kaempferia pandurata significantly decreases MMP-9 expression at both protein and mRNA levels in a dose-dependent manner(0.002-0.01 mg/ml). Treatment of ethanolic Kaempferia pandurata extract at 0.002, 0.005 and 0.01 mg/ml shows decreases in MMP-9 mRNA levels up to 10%, 13%, and 45%, respectively. Kaempferia pandurata interfers Porphyromonas gingivalis supernatant-induced MMP-9 expression in the oral epidermoid cell line ATCC CCL-17
-
the expression of MMP-9 in neoplastic and inflammatory cells increases with more advance tumor stage, depth of tumor invasion and presence of lymph node as well as distant metastases
-
the expression of MMP-9 is elevated after cerebral ischemia, expression of MMP-9 increases after permanent middle cerebral artery occlusion and transient middle cerebral artery occlusion. interleukin-1beta, tissue necrosis factor-alpha, fibroblast growth facor, and epidermal growth factor can stimulate the secretion of MMP-9
-
the interleukin-1beta-induced MMP-9 gene expression is mediated through the activation of p42/p44 mitogen-activated protein kinase, p38 mitogen-activated protein kinase, and JNK1/2 in A-549 cells. The interleukin-1beta-induced MMP-9 gene expression is also mediated through the translocation of NF-kappaB (p65) into the nucleus and the degradation of IkappaBalpha
-
the level of MMP-9 expression was significantly increased by 4945% and 4412% of the control level following treatment with 20 nM 12-O-tetradecanoyl phorbol-13-acetate in breast cancer cells
-
the serum MMP-9 level is significantly higher in moyamoya disease than in healthy controls
-
there is a highly significant relationship between the expression of MMP-9 and macrophage count in eosinophilic granulomas
-
there is no MMP-9 mRNA elevation in mononuclear cells
-
there is significant reduction in MMP-9 expression on day 7 in all cases, it decreases considerably on day 14 and is almost negligible on day 21 reflecting corneal healing with succinylated collagen bandage lenses
-
thrombin stimulation induces MMP-9 secretion of monocytes dose- and time-dependently through activation of extracellular signaling-regulated protein kinase 1/2 and p38. Thrombin up-regulates mRNA and protein levels of MMP-9. NFkappaB activation is necessary for thrombin-induced MMP-9 upregulation in human monocytes. 1,2-bis (aminophenoxy) ethane-N,N,N',N'-tetraacetoxymethyl ester, a Ca2+ chelator, abolishes the thrombin-induced MMP-9 secretion
-
treatment with 0.05 mM glycitein downregulates MMP-9 gene expression and inhibits the phorbol myristate acetate-induced MMP-9 secretion in U87MGcells
-
TX-1877 significantly inhibits expression of MMP-9
-
vitamin D3 significantly reduces the MMP-9 level in antigen stimulated and unstimulated cultures of pulmonary tuberculosis as compared to healthy controls
-
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
the effect of pH (in the range of 4.5-9.5) is investigated on the refolding of recombinant human MMP-9 by urea gradient method. Maximum recovery is obtained at pH 7.8 (with NaCl and Tris-HCl buffer)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
matrix metalloproteinase-9 expression in glioma is an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of astrocytic glioma
medicine
diagnostics
drug development
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Netzel-Arnett, S.; Sang, Q.X.; Moore, W.G.I.; Navre, M.; Birkedal-Hansen, H.; van Wart, H.E.
Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin)
Biochemistry
32
6427-6432
1993
Homo sapiens
Manually annotated by BRENDA team
Nguyen, Q.; Murphy, G.; Hughes, C.E.; Mort, J.S.; Roughley, P.J.
Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein
Biochem. J.
295
595-598
1993
Homo sapiens
Manually annotated by BRENDA team
Ochieng, J.; Fridman, R.; Nangia-Makker, P.; Kleiner, D.E.; Liotta, L.A.; Stetler-Stevenson, W.G.; Raz, A.
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9
Biochemistry
33
14109-14114
1994
Homo sapiens
Manually annotated by BRENDA team
Allan, J.A.; Docherty, A.J.P.; Barker, P.J.; Huskisson, N.S.; Reynolds, J.J.; Murphy, G.
Binding of gelatinases A and B to type-I collagen and other matrix components
Biochem. J.
309
299-306
1995
Homo sapiens
Manually annotated by BRENDA team
Imai, K.; Shikata, H.; Okada, Y.
Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7 and -9
FEBS Lett.
369
249-251
1995
Homo sapiens
Manually annotated by BRENDA team
Wilhelm, S.M.; Collier, I.E.; Marmer, B.L.; Eisen, A.Z.; Grant, G.A.; Goldberg, G.I.
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages [published erratum appears in J Biol Chem 1990 Dec 25;265(36):22570]
J. Biol. Chem.
264
17213-17221
1989
Homo sapiens
Manually annotated by BRENDA team
O'Connelll, J.P.; Willenbrock, F.; Docherty, A.J.P.; Eaton, D.; Murphy, G.
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B
J. Biol. Chem.
269
14967-14973
1994
Homo sapiens
Manually annotated by BRENDA team
McGeehan, G.M.; Bickett, D.M.; Green, M.; Kassel, D.; Wiseman, J.S.; Berman, J.
Characterization of the peptide substrate specificities of interstitial collagenase and 92-kDa gelatinase. Implications for substrate optimization
J. Biol. Chem.
269
32814-32820
1994
Homo sapiens
Manually annotated by BRENDA team
Sires, U.I.; Dublet, B.; Aubert-Foucher, E.; van der Rest, M.; Welgus, H.G.
Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase
J. Biol. Chem.
270
1062-1067
1995
Homo sapiens
Manually annotated by BRENDA team
Morel, F.; Berthier, S.; Guillot, M.; Zaoui, P.; Massoubre, C.; Didier, F.; Vignais, P.V.
Human neutrophil gelatinase is a collagenase type IV
Biochem. Biophys. Res. Commun.
191
269-274
1993
Homo sapiens
Manually annotated by BRENDA team
Pourmotabbed, T.; Aelion, J.A.; Tyrrell, D.; Hasty, K.A.; Bu, C.H.; Mainardi, C.L.
Role of the conserved histidine and aspartic acid residues in activity and stabilization of human gelatinase B: an example of matrix metalloproteinases
J. Protein Chem.
14
527-535
1995
Homo sapiens
Manually annotated by BRENDA team
Ochieng, J.; Warfield, P.; Green, B.
Interactions of gelatinases with soluble and immobilized fetuin and asialofetuin
Arch. Biochem. Biophys.
322
250-255
1995
Homo sapiens
Manually annotated by BRENDA team
Makowski, G.S.; Ramsby, M.L.
Binding of matrix metalloproteinase 9 to fibrin is mediated by amorphous calcium-phosphate
Inflammation
22
599-617
1998
Homo sapiens
Manually annotated by BRENDA team
Olson, M.W.; Bernardo, M.M.; Pietila, M.; Gervasi, D.C.; Toth, M.; Kotra, L.P.; Massova, I.; Mobashery, S.; Fridman, R.
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1
J. Biol. Chem.
275
2661-2668
2000
Homo sapiens (P45452)
Manually annotated by BRENDA team
Kleifeld, O.; Van den Steen, P.E.; Frenkel, A.; Cheng, F.; Jiang, H.L.; Opdenakker, G.; Sagi, I.
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils
J. Biol. Chem.
275
34335-34343
2000
Homo sapiens
Manually annotated by BRENDA team
Chen, E.I.; Li, W.; Godzik, A.; Howard, E.W.; Smith, J.W.
A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9
J. Biol. Chem.
278
17158-17163
2003
Homo sapiens
Manually annotated by BRENDA team
George, H.J.; Marchand, P.; Murphy, K.; Wiswall, B.H.; Dowling, R.; giannaras, J.; Hollis, G.F.; Trzaskos, J.M.; Copeland, R.A.
Recombinant human 92-kDa type IV collagenase/gelatinase from baculovirus-infected insect cells: expression, purification, and characterization
Protein Expr. Purif.
10
154-161
1997
Homo sapiens
Manually annotated by BRENDA team
Xu, X.; Chen, Z.; Wang, Y.; Yamada, Y.; Steffensen, B.
Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
Biochem. J.
392
127-134
2005
Homo sapiens
Manually annotated by BRENDA team
Hu, J.; Van den Steen, P.E.; Houde, M.; Ilenchuk, T.T.; Opdenakker, G.
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity. Comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody
Biochem. Pharmacol.
67
1001-1009
2004
Homo sapiens
Manually annotated by BRENDA team
Van den Steen, P.E.; Proost, P.; Brand, D.D.; Kang, A.H.; Van Damme, J.; Opdenakker, G.
Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B
Biochemistry
43
10809-10816
2004
Homo sapiens
Manually annotated by BRENDA team
Rossello, A.; Nuti, E.; Orlandini, E.; Carelli, P.; Rapposelli, S.; Macchia, M.; Minutolo, F.; Carbonaro, L.; Albini, A.; Benelli, R.; Cercignani, G.; Murphy, G.; Balsamo, A.
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
Bioorg. Med. Chem.
12
2441-2450
2004
Homo sapiens
Manually annotated by BRENDA team
Meyer, E.; Vollmer, J.Y.; Bovey, R.; Stamenkovic, I.
Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis
Cancer Res.
65
4261-4272
2005
Homo sapiens
Manually annotated by BRENDA team
Chintala, S.K.; Wang, N.; Diskin, S.; Mattox, C.; Kagemann, L.; Fini, M.E.; Schuman, J.S.
Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs
Exp. Eye Res.
81
429-436
2005
Homo sapiens
Manually annotated by BRENDA team
Descamps, F.J.; Martens, E.; Kangave, D.; Struyf, S.; Geboes, K.; Van Damme, J.; Opdenakker, G.; Abu El-Asrar, A.M.
The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage
Exp. Eye Res.
83
401-407
2006
Homo sapiens
Manually annotated by BRENDA team
Abu El-Asrar, A.M.; Struyf, S.; Van den Broeck, C.; Van Damme, J.; Opdenakker, G.; Geboes, K.; Kestelyn, P.
Expression of chemokines and gelatinase B in sympathetic ophthalmia
Eye
21
649-657
2006
Homo sapiens
Manually annotated by BRENDA team
Descamps, F.J.; Martens, E.; Proost, P.; Starckx, S.; Van den Steen, P.E.; Van Damme, J.; Opdenakker, G.
Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin
FASEB J.
19
29-35
2005
Homo sapiens
Manually annotated by BRENDA team
Di Carlo, A.; Terracciano, D.; Mariano, A.; Macchia, V.
Matrix metalloproteinase-2 and matrix metalloproteinase-9 type IV collagenases in serum of patients with pleural effusions
Int. J. Oncol.
26
1363-1368
2005
Homo sapiens
Manually annotated by BRENDA team
Di Girolamo, N.; Indoh, I.; Jackson, N.; Wakefield, D.; McNeil, H.P.; Yan, W.; Geczy, C.; Arm, J.P.; Tedla, N.
Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration
J. Immunol.
177
2638-2650
2006
Homo sapiens
Manually annotated by BRENDA team
Shimanovich, I.; Mihai, S.; Oostingh, G.J.; Ilenchuk, T.T.; Broecker, E.B.; Opdenakker, G.; Zillikens, D.; Sitaru, C.
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid
J. Pathol.
204
519-527
2004
Homo sapiens
Manually annotated by BRENDA team
Leveque, T.; Le Pavec, G.; Boutet, A.; Tardieu, M.; Dormont, D.; Gras, G.
Differential regulation of gelatinase A and B and TIMP-1 and -2 by TNFalpha and HIV virions in astrocytes
Microbes Infect.
6
157-163
2004
Homo sapiens
Manually annotated by BRENDA team
Lindberg, R.L.; Sorsa, T.; Tervahartiala, T.; Hoffmann, F.; Mellanen, L.; Kappos, L.; Schaad, U.B.; Leib, S.L.; Leppert, D.
Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children
Neuropathol. Appl. Neurobiol.
32
304-317
2006
Homo sapiens
Manually annotated by BRENDA team
Di Carlo, A.; Terracciano, D.; Mariano, A.; Macchia, V.
Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors
Oncol. Rep.
15
1321-1326
2006
Homo sapiens
Manually annotated by BRENDA team
Zhang, L.; Shi, J.; Feng, J.; Klocker, H.; Lee, C.; Zhang, J.
Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer
Prostate Cancer Prostatic. Dis.
7
327-332
2004
Homo sapiens
Manually annotated by BRENDA team
Adair, J.C.; Charlie, J.; Dencoff, J.E.; Kaye, J.A.; Quinn, J.F.; Camicioli, R.M.; Stetler-Stevenson, W.G.; Rosenberg, G.A.
Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease
Stroke
35
e159-e162
2004
Homo sapiens
Manually annotated by BRENDA team
Unsal, D.; Akyurek, N.; Uner, A.; Erpolat, O.P.; Han, U.; Akmansu, M.; Mentes, B.B.; Dursun, A.
Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy
Am. J. Clin. Oncol.
31
55-63
2008
Homo sapiens
Manually annotated by BRENDA team
Barbosa, F.; Gerlach, R.F.; Tanus-Santos, J.E.
Matrix metalloproteinase-9 activity in plasma correlates with plasma and whole blood lead concentrations
Basic Clin. Pharmacol. Toxicol.
98
559-564
2006
Homo sapiens
Manually annotated by BRENDA team
Geurts, N.; Martens, E.; Van Aelst, I.; Proost, P.; Opdenakker, G.; Van den Steen, P.E.
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3
Biochemistry
47
2689-2699
2008
Homo sapiens
Manually annotated by BRENDA team
Martens, E.; Leyssen, A.; Van Aelst, I.; Fiten, P.; Piccard, H.; Hu, J.; Descamps, F.J.; Van den Steen, P.E.; Proost, P.; Van Damme, J.; Liuzzi, G.M.; Riccio, P.; Polverini, E.; Opdenakker, G.
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains
Biochim. Biophys. Acta
1770
178-186
2007
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Moroy, G.; Denhez, C.; El Mourabit, H.; Toribio, A.; Dassonville, A.; Decarme, M.; Renault, J.H.; Mirand, C.; Bellon, G.; Sapi, J.; Alix, A.J.; Hornebeck, W.; Bourguet, E.
Simultaneous presence of unsaturation and long alkyl chain at P1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies
Bioorg. Med. Chem.
15
4753-4766
2007
Homo sapiens
Manually annotated by BRENDA team
Mendis, E.; Kim, M.M.; Rajapakse, N.; Kim, S.K.
Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells
Bioorg. Med. Chem. Lett.
16
3105-3110
2006
Homo sapiens
Manually annotated by BRENDA team
Soeder, S.; Roach, H.I.; Oehler, S.; Bau, B.; Haag, J.; Aigner, T.
MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage
Clin. Exp. Rheumatol.
24
302-304
2006
Homo sapiens
Manually annotated by BRENDA team
Lee, Y.M.; Lee, J.J.; Shen, M.Y.; Hsiao, G.; Sheu, J.R.
Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation
Eur. J. Pharmacol.
537
52-58
2006
Homo sapiens
Manually annotated by BRENDA team
Bigg, H.F.; Rowan, A.D.; Barker, M.D.; Cawston, T.E.
Activity of matrix metalloproteinase-9 against native collagen types I and III
FEBS J.
274
1246-1255
2007
Homo sapiens
Manually annotated by BRENDA team
Abdallah, M.A.; Kang, S.; Nakajima, S.T.; Gercel-Taylor, C.
Matrix metalloproteinase-9 activity in the plasma of patients after surgical resection of endometriomas
Fertil. Steril.
85
1847-1848
2006
Homo sapiens
Manually annotated by BRENDA team
Peschos, D.; Damala, C.; Stefanou, D.; Tsanou, E.; Assimakopoulos, D.; Vougiouklakis, T.; Charalabopoulos, K.; Agnantis, N.J.
Expression of matrix metalloproteinase-9 (gelatinase B) in benign, premalignant and malignant laryngeal lesions
Histol. Histopathol.
21
603-608
2006
Homo sapiens
Manually annotated by BRENDA team
Cho, Y.B.; Lee, W.Y.; Song, S.Y.; Shin, H.J.; Yun, S.H.; Chun, H.K.
Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer
Hum. Pathol.
38
1603-1610
2007
Homo sapiens
Manually annotated by BRENDA team
Strek, M.; Gorlach, S.; Podsedek, A.; Sosnowska, D.; Koziolkiewicz, M.; Hrabec, Z.; Hrabec, E.
Procyanidin oligomers from Japanese quince (Chaenomeles japonica) fruit inhibit activity of MMP-2 and MMP-9 metalloproteinases
J. Agric. Food Chem.
55
6447-6452
2007
Homo sapiens
Manually annotated by BRENDA team
Vempati, P.; Karagiannis, E.D.; Popel, A.S.
A biochemical model of matrix metalloproteinase 9 activation and inhibition
J. Biol. Chem.
282
37585-37596
2007
Homo sapiens
Manually annotated by BRENDA team
Mazzoni, A.; Mannello, F.; Tay, F.R.; Tonti, G.A.; Papa, S.; Mazzotti, G.; Di Lenarda, R.; Pashley, D.H.; Breschi, L.
Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin
J. Dent. Res.
86
436-440
2007
Homo sapiens
Manually annotated by BRENDA team
Ho, T.Y.; Yan, W.; Bagnell, C.A.
Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kappaB pathway in human THP-1 cells
J. Leukoc. Biol.
81
1303-1310
2007
Homo sapiens
Manually annotated by BRENDA team
Van Ta, Q.; Kim, M.M.; Kim, S.K.
Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080)
Mar. Biotechnol.
8
593-599
2007
Homo sapiens
Manually annotated by BRENDA team
Garcia-Lopez, G.; Vadillo-Ortega, F.; Merchant-Larios, H.; Maida-Claros, R.; Osorio, M.; Soriano-Becerril, D.; Flores-Herrera, H.; Beltran-Montoya, J.; Garfias-Becerra, Y.; Zaga-Clavellina, V.
Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes
Mol. Hum. Reprod.
13
409-418
2007
Homo sapiens
Manually annotated by BRENDA team
Rosenblum, G.; Van den Steen, P.E.; Cohen, S.R.; Grossmann, J.G.; Frenkel, J.; Sertchook, R.; Slack, N.; Strange, R.W.; Opdenakker, G.; Sagi, I.
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B
Structure
15
1227-1236
2007
Homo sapiens
Manually annotated by BRENDA team
Dragutinovic, V.V.; Radovanovic, N.S.; Izrael-Zivkovic, L.T.; Vrvic, M.M.
Detection of gelatinase B activity in serum of gastric cancer patients
World J. Gastroenterol.
12
105-109
2006
Homo sapiens
Manually annotated by BRENDA team
Bhattacharyya, S.; Tobacman, J.K.
Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation
Clin. Exp. Metastasis
26
535-545
2009
Homo sapiens
Manually annotated by BRENDA team
Lin, C.K.; Chao, T.K.; Yu, C.P.; Yu, M.H.; Jin, J.S.
The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters
APMIS
117
162-175
2009
Homo sapiens
Manually annotated by BRENDA team
Hlawaty, H.; Jacob, M.P.; Louedec, L.; Letourneur, D.; Brink, C.; Michel, J.B.; Feldman, L.; Baeck, M.
Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis
Arterioscler. Thromb. Vasc. Biol.
29
518-524
2009
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Moore, R.M.; Novak, J.B.; Kumar, D.; Mansour, J.M.; Mercer, B.M.; Moore, J.J.
Alpha-lipoic acid inhibits tumor necrosis factor-induced remodeling and weakening of human fetal membranes
Biol. Reprod.
80
781-787
2009
Homo sapiens
Manually annotated by BRENDA team
Figueira, R.C.; Gomes, L.R.; Neto, J.S.; Silva, F.C.; Silva, I.D.; Sogayar, M.C.
Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential
BMC Cancer
9
20
2009
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Peng, T.L.; Chen, J.; Mao, W.; Song, X.; Chen, M.H.
Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9
BMC Cell Biol.
10
27
2009
Homo sapiens
Manually annotated by BRENDA team
Zhou, L.; Yan, C.; Gieling, R.G.; Kida, Y.; Garner, W.; Li, W.; Han, Y.P.
Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1
BMC Immunol.
10
15
2009
Homo sapiens
Manually annotated by BRENDA team
Miyake, K.; Shimada, M.; Nishioka, M.; Sugimoto, K.; Batmunkh, E.; Uto, Y.; Nagasawa, H.; Hori, H.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer
Cancer Chemother. Pharmacol.
64
885-892
2009
Homo sapiens
Manually annotated by BRENDA team
Wu, J.M.; Sheng, H.; Saxena, R.; Skill, N.J.; Bhat-Nakshatri, P.; Yu, M.; Nakshatri, H.; Maluccio, M.A.
NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy
Cancer Lett.
278
145-155
2009
Homo sapiens
Manually annotated by BRENDA team
Bin Hafeez, B.; Adhami, V.M.; Asim, M.; Siddiqui, I.A.; Bhat, K.M.; Zhong, W.; Saleem, M.; Din, M.; Setaluri, V.; Mukhtar, H.
Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
Clin. Cancer Res.
15
452-459
2009
Homo sapiens
Manually annotated by BRENDA team
Bjarnegard, N.; Arnqvist, H.J.; Lindstroem, T.; Jonasson, L.; Joensson, A.; Laenne, T.
Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus
Diab. Vasc. Dis. Res.
6
25-31
2009
Homo sapiens
Manually annotated by BRENDA team
Khademi, M.; Bornsen, L.; Rafatnia, F.; Andersson, M.; Brundin, L.; Piehl, F.; Sellebjerg, F.; Olsson, T.
The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers
Eur. J. Neurol.
16
528-536
2009
Homo sapiens
Manually annotated by BRENDA team
Choi, S.J.; Jung, K.L.; Oh, S.Y.; Kim, J.H.; Roh, C.R.
Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition
Eur. J. Obstet. Gynecol. Reprod. Biol.
142
43-47
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.; Zhang, W.; Geng, N.; Tian, K.; Jack Windsor, L.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus
Head Neck
30
1237-1245
2008
Homo sapiens
Manually annotated by BRENDA team
Meijer, M.J.; Mieremet-Ooms, M.A.; Sier, C.F.; van Hogezand, R.A.; Lamers, C.B.; Hommes, D.W.; Verspaget, H.W.
Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohns disease
Inflamm. Bowel Dis.
15
84-92
2009
Homo sapiens
Manually annotated by BRENDA team
Saussez, S.; Cludts, S.; Capouillez, A.; Mortuaire, G.; Smetana, K.; Kaltner, H.; Andre, S.; Leroy, X.; Gabius, H.J.; Decaestecker, C.
Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7
Int. J. Oncol.
34
433-439
2009
Homo sapiens
Manually annotated by BRENDA team
Cao, J.; Tang, M.; Li, W.L.; Xie, J.; Du, H.; Tang, W.B.; Wang, H.; Chen, X.W.; Xiao, H.; Li, Y.
Upregulation of activator protein-4 in human colorectal cancer with metastasis
Int. J. Surg. Pathol.
17
16-21
2009
Homo sapiens
Manually annotated by BRENDA team
Lawrence, B.J.; Maase, E.L.; Lin, H.K.; Madihally, S.V.
Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa
J. Biomed. Mater. Res. A
88
634-643
2009
Homo sapiens
Manually annotated by BRENDA team
Alapure, B.V.; Praveen, M.R.; Gajjar, D.; Vasavada, A.R.; Rajkumar, S.; Johar, K.
Matrix metalloproteinase-9 activity in human lens epithelial cells of cortical, posterior subcapsular, and nuclear cataracts
J. Cataract. Refract. Surg.
34
2063-2067
2008
Homo sapiens
Manually annotated by BRENDA team
Montagnana, M.; Lippi, G.; Albiero, A.; Scevarolli, S.; Salvagno, G.L.; Franchi, M.; Guidi, G.C.
Evaluation of metalloproteinases 2 and 9 and their inhibitors in physiologic and pre-eclamptic pregnancy
J. Clin. Lab. Anal.
23
88-92
2009
Homo sapiens
Manually annotated by BRENDA team
Itoh, T.; Nakamura, H.; Kishi, J.; Hayakawa, T.
The activation of matrix metalloproteinases by a whole-cell extract from Prevotella nigrescens
J. Endod.
35
55-59
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, X.; Town, J.R.; Li, F.; Zhang, X.; Cockcroft, D.W.; Gordon, J.R.
ELR-CXC chemokine receptor antagonism targets inflammatory responses at multiple levels
J. Immunol.
182
3213-3222
2009
Homo sapiens
Manually annotated by BRENDA team
Chung, I.M.; Ahmad, A.; Ali, M.; Lee, O.K.; Kim, M.Y.; Kim, J.H.; Yoon, D.Y.; Peebles, C.A.; San, K.Y.
Flavonoid glucosides from the hairy roots of Catharanthus roseus
J. Nat. Prod.
72
613-620
2009
Homo sapiens
Manually annotated by BRENDA team
Santra, M.; Santra, S.; Roberts, C.; Zhang, R.L.; Chopp, M.
Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion
J. Neurochem.
108
231-245
2009
Homo sapiens
Manually annotated by BRENDA team
Castillo, J.; Alvarez-Sabin, J.; Martinez-Vila, E.; Montaner, J.; Sobrino, T.; Vivancos, J.; Vivancos, J.
Inflammation markers and prediction of post-stroke vascular disease recurrence: the MITICO study
J. Neurol.
256
217-224
2009
Homo sapiens
Manually annotated by BRENDA team
Poyer, F.; Coquerel, B.; Pegahi, R.; Cazin, L.; Norris, V.; Vannier, J.P.; Lamacz, M.
Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute lymphoblastic leukemia
Leuk. Res.
33
407-417
2009
Homo sapiens
Manually annotated by BRENDA team
Sen, T.; Moulik, S.; Dutta, A.; Choudhury, P.R.; Banerji, A.; Das, S.; Roy, M.; Chatterjee, A.
Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7
Life Sci.
84
194-204
2009
Homo sapiens
Manually annotated by BRENDA team
Solakivi, T.; Kunnas, T.; Kaerkkaeinen, S.; Jaakkola, O.; Nikkari, S.T.
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells
Lipids Health Dis.
8
11
2009
Homo sapiens
Manually annotated by BRENDA team
Leung, J.C.; Chan, L.Y.; Tam, K.Y.; Tang, S.C.; Lam, M.F.; Cheng, A.S.; Chu, K.M.; Lai, K.N.
Regulation of CCN2/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis
Nephrol. Dial. Transplant.
24
458-469
2009
Homo sapiens
Manually annotated by BRENDA team
Roomi, M.W.; Monterrey, J.C.; Kalinovsky, T.; Rath, M.; Niedzwiecki, A.
Distinct patterns of matrix metalloproteinase-2 and -9 expression in normal human cell lines
Oncol. Rep.
21
821-826
2009
Homo sapiens
Manually annotated by BRENDA team
Acera, A.; Rocha, G.; Vecino, E.; Lema, I.; Duran, J.A.
Inflammatory markers in the tears of patients with ocular surface disease
Ophthalmic Res.
40
315-321
2008
Homo sapiens
Manually annotated by BRENDA team
Vairaktaris, E.; Serefoglou, Z.; Avgoustidis, D.; Yapijakis, C.; Critselis, E.; Vylliotis, A.; Spyridonidou, S.; Derka, S.; Vassiliou, S.; Nkenke, E.; Patsouris, E.
Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer
Oral Oncol.
45
247-253
2009
Homo sapiens
Manually annotated by BRENDA team
Carneiro, E.; Menezes, R.; Garlet, G.P.; Garcia, R.B.; Bramante, C.M.; Figueira, R.; Sogayar, M.; Granjeiro, J.M.
Expression analysis of matrix metalloproteinase-9 in epithelialized and nonepithelialized apical periodontitis lesions
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
107
127-132
2009
Homo sapiens
Manually annotated by BRENDA team
Lee, J.I.; Jin, B.H.; Kim, M.A.; Yoon, H.J.; Hong, S.P.; Hong, S.D.
Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
107
678-684
2009
Homo sapiens
Manually annotated by BRENDA team
Baba, H.; Ohtsuka, Y.; Fujii, T.; Haruna, H.; Nagata, S.; Kobayashi, H.; Yamataka, A.; Shimizu, T.; Miyano, T.; Yamashiro, Y.
Immunological investigation of the hepatic tissue from infants with biliary atresia
Pediatr. Surg. Int.
25
157-162
2009
Homo sapiens
Manually annotated by BRENDA team
Seeger, F.H.; Chen, L.; Spyridopoulos, I.; Altschmied, J.; Aicher, A.; Haendeler, J.
Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells
PLoS ONE
4
e4529
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Higashimoto, Y.; Iwata, T.; Okada, M.; Satoh, H.; Fukuda, K.; Tohda, Y.
Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease
Respir. Med.
103
1231-1238
2009
Homo sapiens
Manually annotated by BRENDA team
Barlas, I.O.; Sezgin, M.; Erdal, M.E.; Sahin, G.; Ankarali, H.C.; Altintas, Z.M.; Tuerkmen, E.
Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms)
Rheumatol. Int.
29
383-388
2009
Homo sapiens
Manually annotated by BRENDA team
Borthwick, L.A.; Parker, S.M.; Brougham, K.A.; Johnson, G.E.; Gorowiec, M.R.; Ward, C.; Lordan, J.; Corris, P.; Kirby, J.A.; Fisher, A.J.
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation
Thorax
64
770-777
2009
Homo sapiens
Manually annotated by BRENDA team
Yeh, M.H.; Kao, S.T.; Hung, C.M.; Liu, C.J.; Lee, K.H.; Yeh, C.C.
Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells
Toxicol. Lett.
184
204-210
2009
Homo sapiens
Manually annotated by BRENDA team
Yanti, H.K.; Lee, M.; Kim, D.; Hwang, J.K.
Inhibitory effect of panduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells
Biol. Pharm. Bull.
32
1770-1775
2009
Homo sapiens
Manually annotated by BRENDA team
Grierson, C.; Miller, D.; Lapan, P.; Brady, J.
Utility of combining MMP-9 ELISA and MMP-9 activity assay data to monitor plasma enzyme specific-activity
Anal. Biochem.
404
232-234
2010
Homo sapiens
Manually annotated by BRENDA team
Zyada, M.M.
Expression of matrix metalloproteinase-9 and significance of a macrophage assay in eosinophilic granuloma
Ann. Diagn. Pathol.
13
367-372
2009
Homo sapiens
Manually annotated by BRENDA team
Chang, C.J.; Hsu, L.A.; Ko, Y.H.; Chen, P.L.; Chuang, Y.T.; Lin, C.Y.; Liao, C.H.; Pang, J.H.
Thrombin regulates matrix metalloproteinase-9 expression in human monocytes
Biochem. Biophys. Res. Commun.
385
241-246
2009
Homo sapiens
Manually annotated by BRENDA team
Gessi, S.; Sacchetto, V.; Fogli, E.; Merighi, S.; Varani, K.; Baraldi, P.G.; Tabrizi, M.A.; Leung, E.; Maclennan, S.; Borea, P.A.
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors
Biochem. Pharmacol.
79
1483-1495
2010
Homo sapiens
Manually annotated by BRENDA team
Yanti, H.; Oh, H.I.; Anggakusuma, H.I.; Hwang, J.K.
Effects of panduratin A isolated from Kaempferia pandurata ROXB. on the expression of matrix metalloproteinase-9 by porphyromonas gingivalis supernatant-induced KB cells
Biol. Pharm. Bull.
32
110-115
2009
Homo sapiens
Manually annotated by BRENDA team
Xue, J.; Hua, Y.N.; Xie, M.L.; Gu, Z.L.
Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells
Biomed. Pharmacother.
64
118-123
2010
Homo sapiens
Manually annotated by BRENDA team
Tan, M.L.; Choong, P.F.; Dass, C.R.
Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
Cancer Cell Int.
10
9-9
2010
Homo sapiens
Manually annotated by BRENDA team
Hung, W.C.; Tseng, W.L.; Shiea, J.; Chang, H.C.
Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells
Cancer Lett.
288
156-161
2010
Homo sapiens
Manually annotated by BRENDA team
Takagi, S.; Simizu, S.; Osada, H.
RECK negatively regulates matrix metalloproteinase-9 transcription
Cancer Res.
69
1502-1508
2009
Homo sapiens
Manually annotated by BRENDA team
Massaro, M.; Zampolli, A.; Scoditti, E.; Carluccio, M.A.; Storelli, C.; Distante, A.; De Caterina, R.
Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability
Cardiovasc. Res.
86
311-320
2010
Homo sapiens
Manually annotated by BRENDA team
Lin, C.C.; Kuo, C.T.; Cheng, C.Y.; Wu, C.Y.; Lee, C.W.; Hsieh, H.L.; Lee, I.T.; Yang, C.M.
IL-1beta promotes A549 cell migration via MAPKs/AP-1- and NF-kappaB-dependent matrix metalloproteinase-9 expression
Cell. Signal.
21
1652-1662
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.J.; Chang, W.M.; Liu, Y.W.; Lee, C.Y.; Jang, Y.H.; Kuo, C.D.; Liao, H.F.
A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells
Chem. Biol. Interact.
181
440-446
2009
Homo sapiens
Manually annotated by BRENDA team
Chou, Y.C.; Sheu, J.R.; Chung, C.L.; Chen, C.Y.; Lin, F.L.; Hsu, M.J.; Kuo, Y.H.; Hsiao, G.
Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells
Chem. Biol. Interact.
184
403-412
2010
Homo sapiens
Manually annotated by BRENDA team
Lee, E.J.; Kim, S.Y.; Hyun, J.W.; Min, S.W.; Kim, D.H.; Kim, H.S.
Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression
Chem. Biol. Interact.
185
18-24
2010
Homo sapiens
Manually annotated by BRENDA team
Sakata, K.; Hamaoka, K.; Ozawa, S.; Niboshi, A.; Yahata, T.; Fujii, M.; Hamaoka, A.; Toiyama, K.; Nishida, M.; Itoi, T.
Matrix metalloproteinase-9 in vascular lesions and endothelial regulation in Kawasaki disease
Circ. J.
74
1670-1675
2010
Homo sapiens
Manually annotated by BRENDA team
Gai, X.; Lan, X.; Luo, Z.; Wang, F.; Liang, Y.; Zhang, H.; Zhang, W.; Hou, J.; Huang, M.
Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients
Clin. Chim. Acta
408
105-109
2009
Homo sapiens
Manually annotated by BRENDA team
Marcaccini, A.M.; Novaes, A.B.; Meschiari, C.A.; Souza, S.L.; Palioto, D.B.; Sorgi, C.A.; Faccioli, L.H.; Tanus-Santos, J.E.; Gerlach, R.F.
Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy
Clin. Chim. Acta
409
117-122
2009
Homo sapiens
Manually annotated by BRENDA team
Anand, S.P.; Selvaraj, P.
Effect of 1, 25 dihydroxyvitamin D(3) on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis
Clin. Immunol.
133
126-131
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, S.; Choksuchat, C.; Zhao, Y.; Ballagh, S.A.; Kovalevsky, G.A.; Archer, D.F.
Effects of doxycycline on serum and endometrial levels of MMP-2, MMP-9 and TIMP-1 in women using a levonorgestrel-releasing subcutaneous implant
Contraception
79
469-478
2009
Homo sapiens
Manually annotated by BRENDA team
Dong, X.; Song, Y.N.; Liu, W.G.; Guo, X.L.
MMP-9, a potential target for cerebral ischemic treatment
Curr. Neuropharmacol.
7
269-275
2009
Homo sapiens
Manually annotated by BRENDA team
Pan, M.H.; Lin, Y.T.; Lin, C.L.; Wei, C.S.; Ho, C.T.; Chen, W.J.
Suppression of heregulin-beta1/HER2-modulated invasive and aggressive phenotype of breast carcinoma by pterostilbene via inhibition of matrix metalloproteinase-9, p38 kinase cascade and Akt activation
Evid. Based. Complement Alternat. Med.
2011
562187
2011
Homo sapiens
Manually annotated by BRENDA team
Mroczko, B.; Lukaszewicz-Zajac, M.; Guzinska-Ustymowicz, K.; Gryko, M.; Czyzewska, J.; Kemona, A.; Kedra, B.; Szmitkowski, M.
Expression of matrix metalloproteinase-9 in the neoplastic and interstitial inflammatory infiltrate cells in gastric cancer
Folia Histochem. Cytobiol.
47
491-496
2009
Homo sapiens
Manually annotated by BRENDA team
Choi, J.H.; Han, E.H.; Hwang, Y.P.; Choi, J.M.; Choi, C.Y.; Chung, Y.C.; Seo, J.K.; Jeong, H.G.
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression
Food Chem. Toxicol.
48
564-571
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bittner, A.; Alcaino, H.; Castro, P.F.; Perez, O.; Corbalan, R.; Troncoso, R.; Chiong, M.; Mellado, R.; Moraga, F.; Zanolli, D.; Winter, J.L.; Zamorano, J.J.; Diaz-Araya, G.; Lavandero, S.
Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome
Int. J. Cardiol.
143
98-100
2009
Homo sapiens
Manually annotated by BRENDA team
Huang, Z.; Wang, L.; Meng, S.; Wang, Y.; Chen, T.; Wang, C.
Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages
Int. J. Cardiol.
146
153-158
2009
Homo sapiens
Manually annotated by BRENDA team
Tagami, K.; Yujiri, T.; Takahashi, T.; Kizuki, N.; Tanaka, Y.; Mitani, N.; Nakamura, Y.; Ariyoshi, K.; Ando, T.; Gondo, T.; Tanizawa, Y.
Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
Int. J. Hematol.
90
248-252
2009
Homo sapiens
Manually annotated by BRENDA team
Cauwe, B.; Martens, E.; Proost, P.; Opdenakker, G.
Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates
Integr. Biol. (Camb.)
1
404-426
2009
Homo sapiens
Manually annotated by BRENDA team
Takagi, H.; Manabe, H.; Kawai, N.; Goto, S.N.; Umemoto, T.
Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis
Interact. Cardiovasc. Thorac. Surg.
9
437-440
2009
Homo sapiens
Manually annotated by BRENDA team
Chotikavanich, S.; de Paiva, C.S.; Li, d.e..Q.; Chen, J.J.; Bian, F.; Farley, W.J.; Pflugfelder, S.C.
Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome
Invest. Ophthalmol. Vis. Sci.
50
3203-3209
2009
Homo sapiens
Manually annotated by BRENDA team
Kuo, P.T.; Lin, T.P.; Liu, L.C.; Huang, C.H.; Lin, J.K.; Kao, J.Y.; Way, T.D.
Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression
J. Agric. Food Chem.
57
3331-3339
2009
Homo sapiens
Manually annotated by BRENDA team
Ardi, V.C.; Van den Steen, P.E.; Opdenakker, G.; Schweighofer, B.; Deryugina, E.I.; Quigley, J.P.
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
J. Biol. Chem.
284
25854-25866
2009
Homo sapiens
Manually annotated by BRENDA team
Gaudet, J.G.; Yocum, G.T.; Lee, S.S.; Granat, A.; Mikami, M.; Connolly, E.S.; Heyer, E.J.
MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery
J. Clin. Neurosci.
17
436-440
2010
Homo sapiens
Manually annotated by BRENDA team
Montreekachon, P.; Chotjumlong, P.; Reutrakul, V.; Krisanaprakornkit, S.
Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation
J. Dent. Res.
88
1031-1036
2009
Homo sapiens
Manually annotated by BRENDA team
Yanti, S.C.; Anggakusuma, S.C.; Gwon, S.H.; Hwang, J.K.
Kaempferia pandurata Roxb. inhibits Porphyromonas gingivalis supernatant-induced matrix metalloproteinase-9 expression via signal transduction in human oral epidermoid cells
J. Ethnopharmacol.
123
315-324
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Kim, S.H.; Hur, S.M.; Lee, S.K.; Kim, W.W.; Kim, J.S.; Kim, J.H.; Choe, J.H.; Nam, S.J.; Lee, J.E.; Yang, J.H.
Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells
J. Ethnopharmacol.
126
252-257
2009
Homo sapiens
Manually annotated by BRENDA team
Sheng, F.; Cheng, L.; Zeng, Q.; Gao, W.
Increased expression and activity of MMP-9 in C-reactive protein-induced human THP-1 mononuclear cells is related to activation of nuclear factor kappa-B
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
399-403
2009
Homo sapiens
Manually annotated by BRENDA team
Lolmede, K.; Campana, L.; Vezzoli, M.; Bosurgi, L.; Tonlorenzi, R.; Clementi, E.; Bianchi, M.E.; Cossu, G.; Manfredi, A.A.; Brunelli, S.; Rovere-Querini, P.
Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
J. Leukoc. Biol.
85
779-787
2009
Homo sapiens
Manually annotated by BRENDA team
Catalan, V.; Gomez-Ambrosi, J.; Rodriguez, A.; Ramirez, B.; Silva, C.; Rotellar, F.; Gil, M.J.; Cienfuegos, J.A.; Salvador, J.; Fruehbeck, G.
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans
J. Mol. Med.
87
803-813
2009
Homo sapiens
Manually annotated by BRENDA team
Fernandes, K.S.; Brum, D.G.; Sandrim, V.C.; Guerreiro, C.T.; Barreira, A.A.; Tanus-Santos, J.E.
Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease
J. Neuroimmunol.
214
128-131
2009
Homo sapiens
Manually annotated by BRENDA team
Ichiyama, T.; Takahashi, Y.; Matsushige, T.; Kajimoto, M.; Fukunaga, S.; Furukawa, S.
Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in non-herpetic acute limbic encephalitis
J. Neurol.
256
1846-1850
2009
Homo sapiens
Manually annotated by BRENDA team
Amaro, S.; Obach, V.; Cervera, A.; Urra, X.; Gomez-Choco, M.; Planas, A.M.; Chamorro, A.
Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept study
J. Neurol.
256
651-656
2009
Homo sapiens
Manually annotated by BRENDA team
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, F.; Zhang, Q.; Kang, C.; Cui, X.; Wang, T.; Xu, P.; Zhou, X.; Liu, J.; Song, X.
Suppression of matrix metalloproteinase-9 expression by RNA interference inhibits SGC7901 gastric adenocarcinoma cell growth and invasion in vitro and in vivo
Med. Oncol.
27
774-784
2010
Homo sapiens
Manually annotated by BRENDA team
Madsen, E.L.; Bruun, J.M.; Skogstrand, K.; Hougaard, D.M.; Christiansen, T.; Richelsen, B.
Long-term weight loss decreases the nontraditional cardiovascular risk factors interleukin-18 and matrix metalloproteinase-9 in obese subjects
Metab. Clin. Exp.
58
946-953
2009
Homo sapiens
Manually annotated by BRENDA team
Zhi, H.; Wang, H.; Ren, L.; Shi, Z.; Peng, H.; Cui, L.; Ma, G.; Ye, X.; Feng, Y.; Shen, C.; Zhai, X.; Zhang, C.; Zen, K.; Liu, N.
Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population
Mol. Biol. Rep.
37
13-20
2010
Homo sapiens
Manually annotated by BRENDA team
Cheng, Y.C.; Kuo, W.W.; Wu, H.C.; Lai, T.Y.; Wu, C.H.; Hwang, J.M.; Wang, W.H.; Tsai, F.J.; Yang, J.J.; Huang, C.Y.; Chu, C.H.
ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells
Mol. Cell. Biochem.
325
69-77
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, S.Y.; Woo, M.S.; Park, J.S.; Kim, H.S.
Regulation of matrix metalloproteinase-9 gene expression in MPP+- or 6-OHDA-treated human neuroblastoma SK-N-BE(2)C cells
Neurochem. Int.
56
437-442
2010
Homo sapiens
Manually annotated by BRENDA team
Rybakowski, J.K.; Skibinska, M.; Leszczynska-Rodziewicz, A.; Kaczmarek, L.; Hauser, J.
Matrix metalloproteinase-9 gene and bipolar mood disorder
Neuromolecular Med.
11
128-132
2009
Homo sapiens
Manually annotated by BRENDA team
Hadassah, J.; Bhuvaneshwari, N.; Rao, U.; Sehgal, P.K.
Evaluation of succinylated collagen bandage lenses in corneal healing by the expression of matrix metalloproteinases (MMP-2 and MMP-9) in tear fluid
Ophthalmic Res.
42
64-72
2009
Homo sapiens
Manually annotated by BRENDA team
Liu, C.J.; Chang, K.W.; Lin, S.C.; Cheng, H.W.
Presurgical serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in oral squamous cell carcinoma
Oral Oncol.
45
920-925
2009
Homo sapiens
Manually annotated by BRENDA team
Annabi, B.; Lachambre, M.P.; Plouffe, K.; Moumdjian, R.; Beliveau, R.
Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion
Pharmacol. Res.
60
438-445
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Choi, J.H.; Lim, H.I.; Lee, S.K.; Kim, W.W.; Kim, J.S.; Kim, J.H.; Choe, J.H.; Yang, J.H.; Nam, S.J.; Lee, J.E.
Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells
Phytomedicine
16
573-580
2009
Homo sapiens
Manually annotated by BRENDA team
Shinto, L.; Marracci, G.; Baldauf-Wagner, S.; Strehlow, A.; Yadav, V.; Stuber, L.; Bourdette, D.
Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis
Prostaglandins Leukot. Essent. Fatty Acids
80
131-136
2009
Homo sapiens
Manually annotated by BRENDA team
Konrad, L.; Scheiber, J.A.; Schwarz, L.; Schrader, A.J.; Hofmann, R.
TGF-beta1 and TGF-beta2 strongly enhance the secretion of plasminogen activator inhibitor-1 and matrix metalloproteinase-9 of the human prostate cancer cell line PC-3
Regul. Pept.
155
28-32
2009
Homo sapiens
Manually annotated by BRENDA team
Jiang, Z.; Sui, T.; Wang, B.
Relationships between MMP-2, MMP-9, TIMP-1 and TIMP-2 levels and their pathogenesis in patients with lupus nephritis
Rheumatol. Int.
30
1219-1226
2009
Homo sapiens
Manually annotated by BRENDA team
Rybakowski, J.K.; Skibinska, M.; Kapelski, P.; Kaczmarek, L.; Hauser, J.
Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia
Schizophr. Res.
109
90-93
2009
Homo sapiens
Manually annotated by BRENDA team
Fujimura, M.; Watanabe, M.; Narisawa, A.; Shimizu, H.; Tominaga, T.
Increased expression of serum matrix metalloproteinase-9 in patients with moyamoya disease
Surg. Neurol.
72
476-480
2009
Homo sapiens
Manually annotated by BRENDA team
Reiss, M.J.; Han, Y.P.; Garcia, E.; Goldberg, M.; Yu, H.; Garner, W.L.
Matrix metalloproteinase-9 delays wound healing in a murine wound model
Surgery
147
295-302
2010
Homo sapiens
Manually annotated by BRENDA team
Rahko, E.; Kauppila, S.; Paeaekkoe, P.; Blanco, G.; Apaja-Sarkkinen, M.; Talvensaari-Mattila, A.; Turpeenniemi-Hujanen, T.; Jukkola, A.
Immunohistochemical study of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinase 1 in benign and malignant breast tissue--strong expression in intraductal carcinomas of the breast
Tumour Biol.
30
257-264
2009
Homo sapiens
Manually annotated by BRENDA team
Akers, W.J.; Xu, B.; Lee, H.; Sudlow, G.; Fields, G.B.; Achilefu, S.; Edwards, W.B.
Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe
Bioconjug. Chem.
23
656-663
2012
Homo sapiens
Manually annotated by BRENDA team
Oshitari, T.; Okuyama, Y.; Miyata, Y.; Kosano, H.; Takahashi, H.; Natsugari, H.
Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production
Bioorg. Med. Chem. Lett.
21
4540-4544
2011
Homo sapiens
Manually annotated by BRENDA team
Tarr, G.P.; Williams, M.J.; Phillips, L.V.; van Rij, A.M.; Jones, G.T.
Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity
Clin. Biochem.
44
1480-1482
2011
Homo sapiens
Manually annotated by BRENDA team
Ruggiero, E.; Toschi, E.; Federico, M.
The activity of matrix metalloproteinase-9 is part of the mechanism of cell-to-cell HIV-1 endocytosis in dendritic cells
Curr. Drug Discov. Technol.
8
112-118
2011
Homo sapiens
Manually annotated by BRENDA team
Deziel, B.A.; Patel, K.; Neto, C.; Gottschall-Pass, K.; Hurta, R.A.
Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways
J. Cell. Biochem.
111
742-754
2010
Homo sapiens
Manually annotated by BRENDA team
Wang, J.; O'Sullivan, S.; Harmon, S.; Keaveny, R.; Radomski, M.W.; Medina, C.; Gilmer, J.F.
Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion
J. Med. Chem.
55
2154-2162
2012
Homo sapiens
Manually annotated by BRENDA team
Perng, D.W.; Chang, K.T.; Su, K.C.; Wu, Y.C.; Chen, C.S.; Hsu, W.H.; Tsai, C.M.; Lee, Y.C.
Matrix metalloprotease-9 induces transforming growth factor-beta1 production in airway epithelium via activation of epidermal growth factor receptors
Life Sci.
89
204-212
2011
Homo sapiens
Manually annotated by BRENDA team
Zaga-Clavellina, V.; Garcia-Lopez, G.; Flores-Pliego, A.; Merchant-Larios, H.; Vadillo-Ortega, F.
In vitro secretion and activity profiles of matrix metalloproteinases, MMP-9 and MMP-2, in human term extra-placental membranes after exposure to Escherichia coli
Reprod. Biol. Endocrinol.
9
13
2011
Homo sapiens
Manually annotated by BRENDA team
Vandooren, J.; Born, B.; Solomonov, I.; Zajac, E.; Saldova, R.; Senske, M.; Ugarte-Berzal, E.; Martens, E.; Van Den Steen, P.; Van Damme, J.; Garcia-Pardo, A.; Froeyen, M.; Deryugina, E.; Quigley, J.; Moestrup, S.; Rudd, P.; Sagi, I.; Opdenakker, G.
Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1
Biochem. J.
465
259-270
2015
Homo sapiens (P14780)
Manually annotated by BRENDA team
Musumeci, G.; Magro, G.; Cardile, V.; Coco, M.; Marzagalli, R.; Castrogiovanni, P.; Imbesi, R.; Graziano, A.; Barone, F.; Di Rosa, M.; Castorina, S.; Castorina, A.
Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme
Cell Tissue Res.
362
45-60
2015
Homo sapiens (P14780)
Manually annotated by BRENDA team
Bellini, T.; Trentini, A.; Manfrinato, M.; Tamborino, C.; Volta, C.; Di Foggia, V.; Fainardi, E.; Dallocchio, F.; Castellazzi, M.
Matrix metalloproteinase-9 activity detected in body fluids is the result of two different enzyme forms
J. Biochem.
151
493-499
2012
Homo sapiens (P14780)
Manually annotated by BRENDA team
Aston-Mourney, K.; Zraika, S.; Udayasankar, J.; Subramanian, S.; Green, P.; Kahn, S.; Hull, R.
Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide
J. Biol. Chem.
288
3553-3559
2013
Homo sapiens (P14780), Homo sapiens, Mus musculus (P41245), Mus musculus, Mus musculus C57BL/6 x DBA/2 (P41245)
Manually annotated by BRENDA team
Zhao, J.; Li, G.; Zhao, Z.; Wang, J.; Gao, G.; He, S.
Matrix metalloproteinase-9 expression is increased in astrocytic glioma and associated with prognosis of patients
Jpn. J. Clin. Oncol.
42
1060-1065
2012
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Meffert, P.; Tscheuschler, A.; Beyersdorf, F.; Heilmann, C.; Kocher, N.; Uffelmann, X.; Discher, P.; Rylski, B.; Siepe, M.; Kari, F.A.
Characterization of serum matrix metalloproteinase 2/9 levels in patients with ascending aortic aneurysms
Interact. Cardiovasc. Thorac. Surg.
24
20-26
2017
Homo sapiens (P14780)
Manually annotated by BRENDA team
Ugarte-Berzal, E.; Vandooren, J.; Bailon, E.; Opdenakker, G.; Garcia-Pardo, A.
Inhibition of MMP-9-dependent degradation of gelatin, but not other MMP-9 substrates, by the MMP-9 hemopexin domain blades 1 and 4
J. Biol. Chem.
291
11751-11760
2016
Homo sapiens (P14780)
Manually annotated by BRENDA team
Baez, I.B.; Sampieri, C.L.; Solano, F.C.; Martinez Cazares, M.T.; Montero, H.; Cuevas, R.Z.
Activity of matrix metalloproteinase 2 and 9 isoforms in sputum samples from individuals infected with M. tuberculosis
Microb. Pathog.
135
103607
2019
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Nat. Prod. Res.
33
1765-1768
2019
Homo sapiens (P14780)
Manually annotated by BRENDA team
Mohseni, S.; Moghadam, T.T.; Dabirmanesh, B.; Khajeh, K.
Expression, purification, refolding and invitro recovery of active full length recombinant human gelatinase MMP-9 in Escherichia coli
Protein Expr. Purif.
126
42-48
2016
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Nicolai, E.; Sinibaldi, F.; Sannino, G.; Lagana, G.; Basoli, F.; Licoccia, S.; Cozza, P.; Santucci, R.; Piro, M.C.
Omega-3 and omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity
Protein J.
36
278-285
2017
Homo sapiens (P14780)
Manually annotated by BRENDA team