Information on EC 3.4.24.3 - microbial collagenase and Organism(s) Hathewaya histolytica and UniProt Accession Q9X721

-

metallopeptidase

Zn2+

isoamyl-phosphonyl-Gly-Pro-Ala

peptidomimetic inhibitor, binds to the edge strand in an antiparallel orientation

718155

Zn2+

catalytic zinc ion, dependent on

1,10-phenanthroline

-

The half maximal inhibitory concentrations of the catalytic domains for 1,10-phenanthroline are significantly decreased for both isoforms ColG and ColH in the presence of the N-terminal His6-tag

696539

2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid

-

2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide

-

2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide

-

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid

-

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid

-

2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid

-

2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid

-

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid

-

2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide

-

2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid

-

2-mercaptoethanol

-

2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid

-

2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid

-

2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide

-

2-[benzyl(benzylsulfonyl)amino]propanoic acid

-

2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(methylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide

-

2-[benzyl(methylsulfonyl)amino]propanoic acid

-

2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide

-

2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide

-

2-[benzyl(phenylsulfonyl)amino]propanoic acid

-

2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid

-

2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide

-

2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid

-

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide

-

2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide

-

2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid

-

2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid

-

2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide

-

2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid

-

2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

2-[benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid

-

2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide

-

2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide

-

2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide

-

2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid

-

2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid

-

2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide

-

2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid

-

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid

-

2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide

-

2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid

-

2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid

-

2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide

-

2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid

-

2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid

-

2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid

-

2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid

-

2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide

-

2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid

-

2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide

-

2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid

-

3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid

-

3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide

-

3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide

-

3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid

-

4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid

-

4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid

-

4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide

-

4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide

-

4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid

-

batimastat

-

i.e. BB-94

BAY 12-9566

-

EGTA

Ca2+ chelation by EGTA induces interdomain conformational changes with an increase in the percent polydispersity as the Ca2+ is chelated, suggesting an increase in protein flexibility. The thermostability is decreased by Ca2+ chelation

erucic acid

-

IC50: 0.415 mM

glutathione

-

reduced

heptadecanoic acid

-

IC50: 0.03 mM

i-C5H11-PO(OH)-Gly-Pro-Ala

-

655500, 656374

linoleic acid

-

IC50: 0.375 mM

linolenic acid

-

IC50: 0.46 mM

marimastat

-

i.e. BB-2516

myristic acid

-

IC50: 0.27 mM

N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine

-

N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine

-

N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine

-

N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine

-

N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine

-

N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine

-

N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine

-

N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(2,4-dinitrophenyl)sulfanyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfanyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfanyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine

-

N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine

-

N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide

-

N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine

-

N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[[(2-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

-

N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide

-

N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide

-

N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide

-

N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide

-

nonadecanoic acid

-

0.045 mM

oleic acid

-

IC50: 0.46 mM

p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid

-

655500, 656374

palmitic acid

-

IC50: 0.035 mM

palmitoleic acid

-

IC50: 0.405 mM

pentadecanoic acid

-

IC50: 0.125 mM

Pro6-Gly-Pro-Gly

-

Pro6-Gly-Pro-Gly-H

-

stearic acid

-

IC50: 0.03 mM

Tannic acid

-

competitive, almost complete inhibition. Pretreatment of collagen fibers with tannic acid results in polymerization and complex formation

tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate

-

tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate

-

tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate

-

trocade

-

i.e. RO-22-3555

[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester

-

[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester

-

[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester

-

additional information

-

0.71

Carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala

-

0.269 - 1.26

furylacryloyl-Leu-Gly-Pro-Ala

0.555

N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala

-

pH 7.5, 25°C

additional information

-

0.092 - 15.9

furylacryloyl-Leu-Gly-Pro-Ala

0.0056

2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid

-

pH 7.5, 25°C

0.000012

2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide

-

pH 7.5, 25°C

0.000006

2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide

-

pH 7.5, 25°C

0.0074

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000021

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000024

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0073

2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid

-

pH 7.5, 25°C

0.0042

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000009

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.00001

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0048

2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid

-

pH 7.5, 25°C

0.01

2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000033

2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000034

2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

pH 7.5, 25°C

0.011

2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid

-

pH 7.5, 25°C

0.0083

2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

pH 7.5, 25°C

0.00003

2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.00003

2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0088

2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid

-

pH 7.5, 25°C

0.0091

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000031

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000033

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide

-

pH 7.5, 25°C

0.01

2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid

-

pH 7.5, 25°C

0.000006

2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0006

2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid

-

pH 7.5, 25°C

0.0036

2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0014

2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.002

2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.015

2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.00004

2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000043

2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.017

2-[benzyl(benzylsulfonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.018

2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.0001

2-[benzyl(methylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000103

2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.02

2-[benzyl(methylsulfonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0033

2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.0014

2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000005

2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.02

2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000054

2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000051

2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.022

2-[benzyl(phenylsulfonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0021

2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.00001

2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000011

2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0024

2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.008

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000012

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000017

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

pH 7.5, 25°C

0.000014

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.009

2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0069

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000015

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000015

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

pH 7.5, 25°C

0.000015

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0064

2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0075

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000019

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000021

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

pH 7.5, 25°C

0.000018

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0082

2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.007

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000013

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000016

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide

-

pH 7.5, 25°C

0.000015

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0071

2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid

-

pH 7.5, 25°C

0.000019

2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide

-

pH 7.5, 25°C

0.000008

2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide

-

pH 7.5, 25°C

0.003

2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid

-

pH 7.5, 25°C

0.0031

2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid

-

pH 7.5, 25°C

0.00001

2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide

-

pH 7.5, 25°C

0.0025

2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid

-

pH 7.5, 25°C

0.000008

2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

pH 7.5, 25°C

0.0019

2-[benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid

-

pH 7.5, 25°C

0.000008

2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

pH 7.5, 25°C

0.000009

2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

pH 7.5, 25°C

0.00001

2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide

-

pH 7.5, 25°C

0.000006

2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide

-

pH 7.5, 25°C

0.000009

2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide

-

pH 7.5, 25°C

0.00004

2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide

-

pH 7.5, 25°C

0.000011

2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0051

2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0061

2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000018

2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.007

2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000008

2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.00001

2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0071

2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid

-

pH 7.5, 25°C

0.004

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000011

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000014

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0047

2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0053

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000018

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000021

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0059

2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0062

2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000012

2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.0032

2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000007

2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.0033

2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000007

2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.0023

2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000007

2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.0045

2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.003

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000011

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000011

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.003

2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0051

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000011

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000012

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0052

2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.000012

2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0063

2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid

-

pH 7.5, 25°C

0.0006

2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000006

2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.0035

2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.00001

2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.01

2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000036

2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000037

2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.011

2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0024

2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000008

2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.0024

2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.011

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000044

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000044

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.013

2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.012

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000042

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000045

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.013

2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.01

2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.00003

2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000032

2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.01

2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0063

2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000017

2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.00002

2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.015

2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000033

2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.016

2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.005

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000015

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000015

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0055

2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.006

2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000013

2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000015

2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.006

2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid

-

pH 7.5, 25°C

0.041

2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000065

2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000068

2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.04

2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0018

2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.000007

2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0032

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.00001

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000012

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0031

2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0004

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000005

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000006

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0005

2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0056

2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000052

2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.00005

2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0055

2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0033

2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid

-

pH 7.5, 25°C

0.000047

2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide

-

pH 7.5, 25°C

0.000048

2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0036

2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid

-

pH 7.5, 25°C

0.0068

2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0022

2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

pH 7.5, 25°C

0.000012

2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide

-

pH 7.5, 25°C

0.0036

2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0027

2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

pH 7.5, 25°C

0.0062

2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid

-

pH 7.5, 25°C

0.000008

3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid

-

pH 7.5, 25°C

0.0045

3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid

-

pH 7.5, 25°C

0.000009

3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide

-

pH 7.5, 25°C

0.000009

3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide

-

pH 7.5, 25°C

0.0041

3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid

-

pH 7.5, 25°C

0.000007

4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid

-

pH 7.5, 25°C

0.0029

4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid

-

pH 7.5, 25°C

0.000008

4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide

-

pH 7.5, 25°C

0.000007

4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide

-

pH 7.5, 25°C

0.0038

4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid

-

pH 7.5, 25°C

0.016

i-C5H11-PO(OH)-Gly-Pro-Ala

-

pH 7.5, 25°C

655500, 656374

0.04

N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine

-

pH 7.5, 25°C

0.021

N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine

-

pH 7.5, 25°C

0.005

N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine

-

pH 7.5, 25°C

0.0016

N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine

-

pH 7.5, 25°C

0.0015

N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine

-

pH 7.5, 25°C

0.0004 - 0.024

N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine

0.002 - 0.0024

N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine

0.0068

N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0055

N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.0041

N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0049

N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0058

N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.0024

N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0031

N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0076

N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.005

N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.01

N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0068

N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.013

N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0074

N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.012

N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.01

N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.006

N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.018

N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0051

N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0015

N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.003

N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0052

N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0033

N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.004

N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.0034

N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.0036

N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.0041

N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine

-

pH 7.5, 25°C

0.0005

N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.0021

N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine

-

pH 7.5, 25°C

0.016

N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

pH 7.5, 25°C

0.000006

N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide

-

pH 7.5, 25°C

0.003

N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

pH 7.5, 25°C

0.0024

N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

pH 7.5, 25°C

0.0027

N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine

-

pH 7.5, 25°C

0.000189

N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000028

N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.00015

N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000021

N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.000061

N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.000043

N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.00002

N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.000045

N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.00004

N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000015

N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.00017

N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000021

N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.000125

N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000014

N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.000009

N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.000026

N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.000025

N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000007

N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.000163

N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000018

N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.00014

N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000013

N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.00005

N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.00006

N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000013

N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.000007

N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.000033

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.00001

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.000021

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000006

N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.000165

N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000133

N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000018

N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.000055

N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.000042

N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000018

N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.000019

N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.00004

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.000015

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.000038

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000012

N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.000125

N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine

-

pH 7.5, 25°C

0.000016

N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate

-

pH 7.5, 25°C

0.000015

N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.00001

N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.000086

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine

-

pH 7.5, 25°C

0.000013

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate

-

pH 7.5, 25°C

0.000035

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine

-

pH 7.5, 25°C

0.000008

N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate

-

pH 7.5, 25°C

0.003

N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine

-

pH 7.5, 25°C

0.000076

N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide

-

pH 7.5, 25°C

0.000008

N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide

-

pH 7.5, 25°C

0.000009

N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide

-

pH 7.5, 25°C

0.0000005 - 0.000058

N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide

0.000007

N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide

-

pH 7.5, 25°C

0.000017

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide

-

pH 7.5, 25°C

0.000022

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide

-

pH 7.5, 25°C

0.000013

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide

-

pH 7.5, 25°C

0.000071

N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide

-

pH 7.5, 25°C

0.000006

N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide

-

pH 7.5, 25°C

0.000077

N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000014

N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000015

N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000016

N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000015

N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000009

N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.00001

N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000017

N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000033

N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000015

N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000035

N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000018

N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000036

N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.00003

N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000045

N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000015

N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000008

N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000008 - 0.000009

N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

0.00001

N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.00001

N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000054

N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000092

N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide

-

pH 7.5, 25°C

0.000011

N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide

-

pH 7.5, 25°C

0.000005 - 0.34

p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid

0.34

Pro6-Gly-Pro-Gly

-

pH 7.5, 25°C

0.000005

Pro6-Gly-Pro-Gly-H

-

pH 7.5, 25°C

0.02

Tannic acid

-

pH 7.5, 25°C

0.000008

tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate

-

pH 7.5, 25°C

0.000009

tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate

-

pH 7.5, 25°C

0.000008

tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate

-

pH 7.5, 25°C

0.000007

[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester

-

pH 7.5, 25°C

0.000009

[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester

-

pH 7.5, 25°C

0.000007

[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester

-

pH 7.5, 25°C

additional information

-

inhibition kinetics using diverse variants of 5-amino-2-mercapto-1,3,4-thiadiazoles, overview

-

0.025 - 0.15

1,10-phenanthroline

0.035

cabozantinib

Hathewaya histolytica

-

IC50: 0.035 mM

0.415

erucic acid

Hathewaya histolytica

-

IC50: 0.415 mM

0.03

heptadecanoic acid

Hathewaya histolytica

-

IC50: 0.03 mM

0.375

linoleic acid

Hathewaya histolytica

-

IC50: 0.375 mM

0.46

linolenic acid

Hathewaya histolytica

-

IC50: 0.46 mM

0.27

myristic acid

Hathewaya histolytica

-

IC50: 0.27 mM

0.46

oleic acid

Hathewaya histolytica

-

IC50: 0.46 mM

0.405

palmitoleic acid

Hathewaya histolytica

-

IC50: 0.405 mM

0.125

pentadecanoic acid

Hathewaya histolytica

-

IC50: 0.125 mM

0.03

stearic acid

Hathewaya histolytica

-

IC50: 0.03 mM

0.5

additional information

Hathewaya histolytica

-

no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid

-

additional information

7.5

assay at

6.3 - 8.8

-

6.5 - 8.8

-

37088

7

7.5

-

assay at

684110

5 - 11

25

assay at

37

-

assay at

683752, 684110, 755081

commercial preparation

culture filtrate

-

37097

culture medium

-

37091, 37098

extracellular

-

evolution

physiological function

evolution

physiological function

additional information

10 entries

Q9X721 pBLAST

COLG_HATHI

1118

0

126242

Swiss-Prot

Show Sequence

-

11 entries

113897

sequence calculation, mature enzyme

126239

type beta bond, sequence calculation, immature enzyme

100000

110000

-

? * 110000, delta, SDS-PAGE

112000

-

ultracentrifugation

37092

112021

sequence calculation, mature enzyme

113000

-

mass spectrometry

37111

113866

-

x * 113866, mass spectrometry, full length enzyme containing two collagen-binding domains

718435

114000

1 * 114000, calculated

114200

11470

-

mutant enzyme S906F in presence of 1 mM Ca2+, gel filtration

115000

-

? * 115000, beta, SDS-PAGE

116375

sequence calculation, immature enzyme

11750

-

mutant enzyme S906A in presence of 1 mM Ca2+, gel filtration

11810

-

mutant enzyme Q972A in presence of 1 mM Ca2+, gel filtration

119000

gel filtration, presence of EGTA

11910

-

mutant enzyme V973A in presence of 1 mM Ca2+, gel filtration

11920

-

wild-type enzyme in presence of 1 mM Ca2+, gel filtration

120000

-

gel filtration

125000

-

? * 125000, zeta, SDS-PAGE

13720

-

mutant enzyme E901A in presence of 1 mM Ca2+, gel filtration

13750

-

mutant enzyme D904A in presence of 1 mM Ca2+, gel filtration

14390

-

mutant enzyme E899A in presence of 1 mM Ca2+, gel filtration

147200

-

gel filtration

15370

-

mutant enzyme D930A in presence of 1 mM Ca2+, gel filtration

15420

-

mutant enzyme D930A in presence of 1 mM EDTA, gel filtration

15730

-

mutant enzyme N903A in presence of 1 mM Ca2+, gel filtration

15790

-

mutant enzyme D927A in presence of 1 mM Ca2+, gel filtration

15890

-

mutant enzyme E899A in presence of 1 mM EDTA, gel filtration

16160

-

mutant enzyme D904A in presence of 1 mM EDTA, gel filtration

16190

-

mutant enzyme D927A in presence of 1 mM EDTA, gel filtration

16410

-

mutant enzyme S906A in presence of 1 mM EDTA, gel filtration

16430

-

wild-type enzyme in presence of 1 mM EGTA, gel filtration

16470

-

mutant enzyme Q972A in presence of 1 mM EDTA, gel filtration

16510

-

mutant enzyme V973A in presence of 1 mM EDTA, gel filtration

16530

-

mutant enzyme N903A in presence of 1 mM EDTA, gel filtration

16650

-

mutant enzyme S906F in presence of 1 mM EDTA, gel filtration

68000

-

? * 68000, alpha, SDS-PAGE

70000

-

gel filtration

37098

72000

-

1 * 72000, IIIb, SDS-PAGE

37099

76000

-

? * 76000, C3, SDS-PAGE

79000

-

? * 79000, gamma, SDS-PAGE

81000

-

1 * 81000, I, II, IIIa, SDS-PAGE

37099

82000

gel filtration

92000

-

? * 92000, C2, SDS-PAGE

96000

-

? * 96000, C1, SDS-PAGE

additional information

-

MW of various C-terminal segments

?

10 entries

monomer

additional information

17 entries

no modification

-

C1: no carbohydrate

apo-enzyme, free enzyme and in complex with inhibitor isoamyl-phosphonyl-Gly-Pro-Ala, to 2.55 A, 2.8 A and 3.25 A resolution. Structure shows a distinct segmentation of the N-terminal collagenase module, residues Tyr119-Gly790, forming a saddle-shaped two-domain architecture. The smaller N-terminal saddle flap serves as an activator domain, residues Tyr119-Asp388, and comprises an array of 12 parallel alpha-helices. The catalytic subdomain, residues Asp398-Gln669, adopts a thermolysin-like peptidase fold of mixed alpha and beta type. Leu517-Leu534 form the central helix of the fold and contain the Zn2+-binding 523-HEXXH-527 motif

718155

crystal structure determination and analysis

crystal structure of ColG collagen-binding domain s3b, to 2.0 A resolution. All but one residue, whose side chain chelates with Ca2+, are conserved

crystal structures of the collagenase unit of ColG in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity

purified recombinant His-tagged catalytic domain of collagenase G, sitting drop vapour diffusion method, 10 mg/ml protein in 25 mM Tris, pH 7.5, and 50 mM NaCl, mixed with reservoir solution containing 0.12 M sodium citrate and 23% v/v PEG 3350 at 20°C, 10 days, X-ray diffraction structure determination and anaylsis at 2.75 A resolution

X-ray crystal structures of Ca2+-bound domain apo s2 to 1.4 A and 1.6 A resolution. ColG-derived domains lack surface aromatic residues, suggesting that the domain is less directly involved in interactions with collagen than that in isoform ColH. The domains are extremely stable in the presence of physiological concentrations of Ca2+

733013

crystal structures of ColH collagen-binding domain, to 2.0 A resolution. All but one residue, whose side chain chelates with Ca2+, are conserved. The dual Ca2+ binding site in s3 is completed by an unconserved aspartate. Domain s3 gains thermal stability, comparable to domain s3b of isoform ColG, by binding to Ca2+. holo s3 is also stabilized against chemical denaturants urea and guanidine HCl. The general shape of the binding pocket is retained by altered loop structures and side chain positions. Domain s3 also binds asymmetrically to minicollagen

crystal structures of the peptidase domains of ColH in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. In the unliganded ColH structure, the quaternary subdomain dynamics is modulated by an aspartate switch motion that binds to the catalytic zinc. One calcium binding site is in proximity to the catalytic zinc. Both ions are required for full activity. Loops close to the active site serve as characteristic substrate selectivity filter. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity

hanging drop vapor diffusion method, structure of the collagen-binding domain with an N-terminal domain linker from class I collagenase, determined at 1.0 A resolution in the absence of Ca2+ and at 1.65 A resolution in the presence of calcium

-

X-ray crystal structures of Ca2+-bound domains holo s2b to 1.4 A resolution, and holo s2a to 1.9 A resolution, as well as of Ca2+-free apo s2a to 1.8 A resolution. ColH-derived domains exhibit exposed aromatic residues and are found in M9B collagenases with a single collagen-binding domain. The domains are extremely stable in the presence of physiological concentrations of Ca2+

733013

D904A

-

mutant enzyme with increased MW in presence of Ca2+ and decreased MW in presence of 1 mM EGTA, determined by gel filtration

D927A

-

mutant enzyme with increased MW in presence of Ca2+ and slightly decreased MW in presence of 1 mM EGTA, determined by gel filtration

D930A

-

mutant enzyme with increased MW in presence of Ca2+ and slightly decreased MW in presence of 1 mM EGTA, determined by gel filtration

E414Q

-

mutant enzyme with a with a lower level of hydrolytic activity against insoluble collagen compared to wild-type enzyme

E899A

-

mutant enzyme with increased MW in presence of Ca2+ and decreased MW in presence of 1 mM EGTA, determined by gel filtration

E901A

-

mutant enzyme with increased MW in presence of Ca2+ and decreased MW in presence of 1 mM EGTA, determined by gel filtration

G426V

-

isoform ColH, complete loss of enzymatic activity

696539

N903A

-

mutant enzyme with increased MW in presence of Ca2+ and slightly increased MW in presence of 1 mM EGTA, determined by gel filtration

Q972A

-

mutant enzyme with slightly decreased MW in presence of Ca2+

S906A

-

mutant enzyme with slightly decreased MW in presence of Ca2+

S906F

-

mutant enzyme with slightly decreased MW in presence of Ca2+ ad slightly increased MW in presence of 1 mM EGTA, determined by gel filtration

additional information

11 entries

40

-

3 h, Ca2+ added

49

melting point, presence of EGTA. Addition of excess Ca2+ restores melting point to 54°C

50

-

2 h, Ca2+ added

54

melting point

60

-

5 min, complete inactivation

70.2

melting temperature of domain s3, presence of EDTA

94.1

melting temperature of domain s3, presence of Ca2+

additional information

-

Ca2+ stabilizes

-

37092, 37094

-20°C

-

37091

-20°C, lyophilized enzyme: 5 years, solutions: several months

-

37089

37°C, loss of 10% activity after 24 h and of 30% after 48 h, crude commercial preparation, overview

-

684110

recombinant catalytic domain of His-tagged collagenase G from Escherichia coli strain BL21 (DE3) by nickel affinity chromatography and gel filtration to about 95% purity

recombinant STrep- and His6-tagged ColG from Escherichia coli strain BL21(DE3) by Strep-Tactin affinity and nickel affinity chromatography, cleavage of the Strept-tag, and gel filtration

-

-

37089, 37090, 37091, 37093, 37094, 37095, 37097, 37098, 37099, 718435

consists of four segments: S1, S2a, S2b and S3

-

37109

expressed in Bacillus subtilis

-

37109, 37111

full-length type I collagenase and C-terminal fragments

-

ligands for chromatographic purification

-

81585

-

gene colG

gene colG, expression of the catalytic domain of N-terminally His-tagged, separated from ColG by a TEV cleavage site, collagenase G in Escherichia coli strain BL21 (DE3)

recombinant expression of ColG fused to a Strep-tag II and a His6-tag at the N- and C-termini, respectively, in Escherichia coli strain BL21(DE3)

-

expressed in Bacillus subtilis

-

37109, 37111

expression in Escherichia coli

gene colH

pharmacology

mechanism of action of collagenase clostridium histolyticum for clinical application

medicine

pharmacology

mechanism of action of collagenase clostridium histolyticum for clinical application

37088

Appel, W.

Kollagenasen

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

1

1098-1104

1974

Clostridium capitorale, Hathewaya histolytica, Clostridium perfringens, Clostridium welchii, Mycobacterium tuberculosis, Pseudomonas aeruginosa

-

37089

Peterkofsky, B.

Bacterial collagenases

Methods Enzymol.

82

453-471

1982

Hathewaya histolytica, Vibrio sp., Vibrio sp. B-30

-

37090

Kono, T.

Purification and partial characterization of collagenolytic enzymes from Clostridium histolyticum

Biochemistry

7

1106-1114

1968

Hathewaya histolytica

4297964

37091

Bicsak, T.A.; Harper, E.

Purification of nonspecific protease-free collagenase from Clostridium histolyticum

Anal. Biochem.

145

286-291

1985

Hathewaya histolytica

2990251

37092

Mandl, I.; Keller, S.; Manahan, J.

Multiplicity of Clostridium histolyticum collagenases

Biochemistry

3

1737-1741

1964

Hathewaya histolytica

14240635

Sugasawara, R.; Harper, E.

Purification and characterization of three forms of collagenase from Clostridium histolyticum

Biochemistry

23

5175-5181

1984

Hathewaya histolytica

6095892

Soru, E.; Zaharia, O.

Clostridium histolyticum collagenase. II. Partial characterization

Enzymologia

43

45-55

1972

Hathewaya histolytica

4340512

Soru, E.; Zaharia, O.; Szabados, J.; Rudescu, K.; Bittner, J.; Ficiu, S.

Purification by molecular sieve chromatography on polyacrylamide Bio Gel P-300 of Clostridium histolyticum collagenase

Enzymologia

39

33-48

1970

Hathewaya histolytica

4322486

37096

Bond, M.D.; van Wart, H.E.

Characterization of the individual collagenases from Clostridium histolyticum

Biochemistry

23

3085-3091

1984

Hathewaya histolytica

6087888

37097

Bond, M.D.; van Wart, H.E.

Purification and separation of individual collagenases of Clostridium histolyticum using red dye ligand chromatography

Biochemistry

23

3077-3085

1984

Hathewaya histolytica

6087887

37098

Emoed, I.; Tong, N.T.; Keil, B.

Chemical characterization of the homogeneous collagenase from Clostridium histolyticum

Biochim. Biophys. Acta

659

283-291

1981

Hathewaya histolytica

6266487

37099

Lwebuga-Mukasa, J.S.; Harper, E.; Taylor, P.

Collagenase enzymes from Clostridium: characterization of individual enzymes

Biochemistry

15

4736-4741

1976

Hathewaya histolytica

184822

37109

Matsushita, O.; Jung, C.M.; Minami, J.; Katayama, S.; Nishi, N.; Okabe, A.

A study of the collagen-binding domain of a 116-kDa Clostridium histolyticum collagenase

J. Biol. Chem.

273

3643-3648

1998

Hathewaya histolytica

9452493

37111

Jung, C.M.; Matsushita, O.; Katayama, S.; Minami, J.; Ohhira, I.; Okabe, A.

Expression of the colH gene encoding Clostridium histolyticum collagenase in Bacillus subtilis and its application to enzyme purification

Microbiol. Immunol.

40

923-929

1996

Hathewaya histolytica

9013490

37112

Vos-Scheperkeuter, G.H.; Vonk, M.W.A.; Wolters, G.H.J.; van Schilfgaarde, R.

Collagen degradation by three Clostridium histolyticum collagenase fractions with different substrate specificities

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Hathewaya histolytica

8171590

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Van Wart, H.E.; Steinbrink, D.R.

Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum

Biochemistry

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Hathewaya histolytica

3002445

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French, M.F.; Bhown, A.; van Wart, H.E.

Identification of Clostridium histolyticum collagenase hyperreactive sites in type I, II, and III collagens: lack of correlation with local triple helical stability

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Hathewaya histolytica

1325154

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Em�d, I.; Keil, B.

Five Sepharose-bound ligands for the chromatographic purification of Clostridium collagenase and clostripain

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Hathewaya histolytica

192599

Ilies, M.; Banciu, M.D.; Scozzafava, A.; Ilies, M.A.; Caproiu, M.T.; Supuran, C.T.

Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties

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2003

Hathewaya histolytica

12713832

Scozzafava, A.; Supuran, C.T.

Protease inhibitors. Part 8. Synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties

Bioorg. Med. Chem.

8

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2000

Hathewaya histolytica

10732980

Wilson, J.J.; Matsushita, O.; Okabe, A.; Sakon, J.

A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation

EMBO J.

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2003

Hathewaya histolytica

12682007

Supuran, C.T.; Scozzafava, A.

Protease inhibitors. Part 7 Inhibition of Clostridium histolyticum collagenase with sulfonylated derivatives of l-valine hydroxamate

Eur. J. Pharm. Sci.

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2000

Hathewaya histolytica

10699384

Matsushita, O.; Koide, T.; Kobayashi, R.; Nagata, K.; Okabe, A.

Substrate recognition by the collagen-binding domain of Clostridium histolyticum class I collagenase

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Hathewaya histolytica

11121400

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Hu, Y.; Webb, E.; Singh, J.; Morgan, B.A.; Gainor, J.A.; Gordon, T.D.; Siahaan, T.J.

Rapid determination of substrate specificity of Clostridium histolyticum beta-collagenase using an immobilized peptide library

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2002

Hathewaya histolytica

11724807

Supuran, C.T.; Briganti, F.; Mincione, G.; Scozzafava, A.

Protease inhibitors: synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of Clostridium histolyticum collagenase

J. Enzyme Inhib.

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2000

Hathewaya histolytica

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Rennert, B.; Melzig, M.F.

Free fatty acids inhibit the activity of Clostridium histolyticum collagenase and human neutrophil elastase

Planta Med.

68

767-769

2002

Hathewaya histolytica

12357383

Eckhard, U.; Nuess, D.; Ducka, P.; Schoenauer, E.; Brandstetter, H.

Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum

Acta Crystallogr. Sect. F

64

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2008

Hathewaya histolytica (Q9X721), Hathewaya histolytica

18453715

Jamloki, A.; Karthikeyan, C.; Hari Narayana Moorthy, N.S.; Trivedi, P.

QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase

Bioorg. Med. Chem. Lett.

16

3847-3854

2006

Hathewaya histolytica

16682189

683379

Foti, C.; Conserva, A.; Casulli, C.; Scrimieri, V.; Pepe, M.L.; Quaranta, D.

Contact dermatitis with clostridiopeptidase A contained in Noruxol ointment

Contact Derm.

56

361-362

2007

Hathewaya histolytica

17577383

683752

Toledano, M.; Osorio, R.; Osorio, E.; Aguilera, F.S.; Yamauti, M.; Pashley, D.H.; Tay, F.

Effect of bacterial collagenase on resin-dentin bonds degradation

J. Mater. Sci. Mater. Med.

18

2355-2361

2007

Hathewaya histolytica

17569004

684110

Metzmacher, I.; Ruth, P.; Abel, M.; Friess, W.

In vitro binding of matrix metalloproteinase-2 (MMP-2), MMP-9, and bacterial collagenase on collagenous wound dressings

Wound Repair Regen.

15

549-555

2007

Hathewaya histolytica

17650099

696539

Eckhard, U.; Schoenauer, E.; Ducka, P.; Briza, P.; Nuess, D.; Brandstetter, H.

Biochemical characterization of the catalytic domains of three different clostridial collagenases

Biol. Chem.

390

11-18

2009

Hathewaya histolytica, Clostridium tetani

18937627

717249

Spiriti, J.; van der Vaart, A.

Mechanism of the calcium-induced trans-cis isomerization of a non-prolyl peptide bond in Clostridium histolyticum collagenase

Biochemistry

49

5314-5320

2010

Hathewaya histolytica

20499930

717687

Shi, L.; Ermis, R.; Garcia, A.; Telgenhoff, D.; Aust, D.

Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration

Int. Wound J.

7

87-95

2010

Hathewaya histolytica

20529148

717707

Camp, R.J.; Liles, M.; Beale, J.; Saeidi, N.; Flynn, B.P.; Moore, E.; Murthy, S.K.; Ruberti, J.W.

Molecular mechanochemistry: low force switch slows enzymatic cleavage of human type I collagen monomer

J. Am. Chem. Soc.

133

4073-4078

2011

Hathewaya histolytica

21348512

Krishnamoorthy, G.; Sehgal, P.K.; Mandal, A.B.; Sadulla, S.

Studies on collagen-tannic acid-collagenase ternary system: Inhibition of collagenase against collagenolytic degradation of extracellular matrix component of collagen

J. Enzyme Inhib. Med. Chem.

27

451-457

2011

Hathewaya histolytica

21823836

718155

Eckhard, U.; Schoenauer, E.; Nuess, D.; Brandstetter, H.

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

Nat. Struct. Mol. Biol.

18

1109-1114

2011

Hathewaya histolytica (Q9X721), Hathewaya histolytica

21947205

718435

Breite, A.G.; McCarthy, R.C.; Dwulet, F.E.

Characterization and functional assessment of Clostridium histolyticum class I (C1) collagenases and the synergistic degradation of native collagen in enzyme mixtures containing class II (C2) collagenase

Transplant. Proc.

43

3171-3175

2011

Hathewaya histolytica

22099748

733013

Bauer, R.; Janowska, K.; Taylor, K.; Jordan, B.; Gann, S.; Janowski, T.; Latimer, E.C.; Matsushita, O.; Sakon, J.

Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH

Acta Crystallogr. Sect. D

71

565-577

2015

Hathewaya histolytica (Q46085), Hathewaya histolytica (Q9X721), Hathewaya histolytica

25760606

Ohbayashi, N.; Yamagata, N.; Goto, M.; Watanabe, K.; Yamagata, Y.; Murayama, K.

Enhancement of the structural stability of full-length clostridial collagenase by calcium ions

Appl. Environ. Microbiol.

78

5839-5844

2012

Hathewaya histolytica (Q46085), Hathewaya histolytica

22685155

733994

Rathore, S.; Gangwal, M.; Paliwal, D.

Role of molecular redundancy in modeling of clostridium histolyticum collagenase inhibitory activity of sulfonyl-1-amine hydroxamates

Int. J. Chem. Sci.

11

911-924

2013

Hathewaya histolytica

-

Bauer, R.; Wilson, J.J.; Philominathan, S.T.; Davis, D.; Matsushita, O.; Sakon, J.

Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum

J. Bacteriol.

195

318-327

2013

Hathewaya histolytica (Q46085), Hathewaya histolytica (Q9X721)

23144249

Eckhard, U.; Schoenauer, E.; Brandstetter, H.

Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T

J. Biol. Chem.

288

20184-20194

2013

Hathewaya histolytica (Q46085), Hathewaya histolytica (Q9X721), Clostridium tetani (Q899Y1), Clostridium tetani E88 (Q899Y1)

23703618

734583

Uchida, K.; Matsushita, O.; Nishi, N.; Inoue, G.; Horikawa, K.; Takaso, M.

Enhancement of periosteal bone formation by basic fibroblast-derived growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase

J. Tissue Eng. Regen. Med.

11

1165-1172

2017

Hathewaya histolytica (Q46085), Hathewaya histolytica

25783848

753118

Smeraglia, F.; Del Buono, A.; Maffulli, N.

Collagenase Clostridium histolyticum in Dupuytrens contracture a systematic review

Br. Med. Bull.

118

149-158

2016

Hathewaya histolytica

27151958

Duarte, A.; Correia, A.; Esteves, A.

Bacterial collagenases - a review

Crit. Rev. Microbiol.

42

106-126

2016

Vibrio mimicus (O67990), Clostridium perfringens (P43153), Vibrio alginolyticus (P43154), Hathewaya histolytica (Q46085), Hathewaya histolytica (Q9X721), Bacillus cereus (Q4V1V2), Bacillus cereus (Q81DA6), Vibrio parahaemolyticus RIMD 2210633 (Q56696), Vibrio parahaemolyticus (Q9AMB9), Vibrio cholerae serotype O1 (Q9KRJ0), Bacillus cereus ATCC 14579 (Q81DA6), Bacillus cereus NRRL B-3711 (Q81DA6), Bacillus cereus NCIMB 9373 (Q81DA6), Bacillus cereus DSM 31 (Q81DA6), Clostridium perfringens type A (P43153), Bacillus cereus NBRC 15305 (Q81DA6), Clostridium perfringens 13 (P43153), Bacillus cereus ZK (Q4V1V2), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KRJ0), Bacillus cereus JCM 2152 (Q81DA6), Vibrio parahaemolyticus 04 (Q9AMB9), Bacillus cereus E33L (Q4V1V2), Vibrio cholerae serotype O1 ATCC 39315 (Q9KRJ0)

24754251

Rafael, S.; Diego, G.; Javier, C.

Mechanism of action of collagenase clostridium histolyticum for clinical application

Eur. J. Clin. Pharmacol.

18

263-272

2016

Hathewaya histolytica (Q46085), Hathewaya histolytica (Q9X721)

-

753702

Yi, E.; Sato, S.; Takahashi, A.; Parameswaran, H.; Blute, T.A.; Bartolak-Suki, E.; Suki, B.

Mechanical forces accelerate collagen digestion by bacterial collagenase in lung tissue strips

Front. Physiol.

7

287

2016

Hathewaya histolytica

27462275

754192

Sekiguchi, H.; Uchida, K.; Inoue, G.; Matsushita, O.; Saito, W.; Aikawa, J.; Tanaka, K.; Fujimaki, H.; Miyagi, M.; Takaso, M.

Acceleration of bone formation during fracture healing by poly(pro-hyp-gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase

J. Biomed. Mater. Res. A

104

1372-1378

2016

Hathewaya histolytica (Q46085), Hathewaya histolytica

26833780

754524

Uchida, K.; Matsushita, O.; Nishi, N.; Inoue, G.; Horikawa, K.; Takaso, M.

Enhancement of periosteal bone formation by basic fibroblast-derived growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase

J. Tissue Eng. Regen. Med.

11

1165-1172

2015

Hathewaya histolytica (Q46085), Hathewaya histolytica

25783848

755081

Velmurugan, P.; Jonnalagadda, R.R.; Nair, B.U.

Engineering D-amino acid containing collagen like peptide at the cleavage site of Clostridium histolyticum collagenase for its inhibition

PLoS ONE

10

e0124398

2015

Hathewaya histolytica

25973613