Disease on EC 3.4.24.29 - aureolysin
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Abscess
Staphylokinase Promotes the Establishment of Staphylococcus aureus Skin Infections While Decreasing Disease Severity.
Anaphylaxis
Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharides.
Anemia, Dyserythropoietic, Congenital
Aberrant regulation of complement by the erythrocytes of hereditary erythroblastic multinuclearity with a positive acidified serum lysis test (HEMPAS).
Arthritis, Experimental
Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y.
Arthritis, Infectious
Impact of staphylococcal protease expression on the outcome of infectious arthritis.
Atypical Hemolytic Uremic Syndrome
A novel C3 mutation causing increased formation of the C3 convertase in familial atypical hemolytic uremic syndrome.
Atypical Hemolytic Uremic Syndrome
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome.
aureolysin deficiency
A haplotype in CFH family genes confers high risk of rare glomerular nephropathies.
Autoimmune Diseases
Intravenously applied IgG stimulates complement attenuation in a complement-dependent autoimmune disease at the amplifying C3 convertase level.
Brain Injuries
Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury.
Brain Injuries, Traumatic
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.
Brain Ischemia
Comparative effects of tissue plasminogen activator, streptokinase, and staphylokinase on cerebral ischemic infarction and pulmonary clot lysis in hamster models.
Carcinoma, Hepatocellular
Distinct CD55 Isoform Synthesis and Inhibition of Complement-Dependent Cytolysis by Hepatitis C Virus.
Cardiovascular Diseases
Purification and in vivo stability and half-life of recombinant lipid modified staphylokinase.
Chagas Disease
[Total hemolytic complement, C3 and C3 convertase levels in cardiac and indeterminate forms of Chagas' disease]
Coronary Thrombosis
Conjugation with Eight-Arm PEG Markedly Improves the In Vitro Activity and Prolongs the Blood Circulation of Staphylokinase.
Coronary Thrombosis
Effects of recombinant staphylokinase on coronary thrombosis in Chinese experimental miniature swine.
Coronary Thrombosis
[Thrombolytic effects of recombinant staphylokinase on coronary thrombosis in miniature pigs].
Craniocerebral Trauma
Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury.
Dermatitis, Atopic
[A study of the single nucleotide polymorphism fragments of the AUR gene metalloprotease strains of Staphylococcus aureus isolated from the skin of patients with atopic dermatitis].
Dermatitis, Contact
Combination treatment with lipoteichoic acids isolated from Lactobacillus plantarum and Staphylococcus aureus alleviates atopic dermatitis via upregulation of CD55 and CD59.
Embolic Stroke
Intravenous thrombolysis with recombinant staphylokinase versus tissue-type plasminogen activator in a rabbit embolic stroke model.
Embolism
Comparative fibrinolytic properties of staphylokinase and streptokinase in animal models of venous thrombosis.
Encephalomyelitis
Targeted inhibition of complement using complement receptor 2-conjugated inhibitors attenuates EAE.
Encephalomyelitis, Autoimmune, Experimental
Targeted inhibition of complement using complement receptor 2-conjugated inhibitors attenuates EAE.
Encephalomyelitis, Autoimmune, Experimental
Treatment of an encephalitogenic peptide from guinea pig myelin basic protein with alpha-protease and thermolysin. Isolation of fragments and determination of cleavage sites.
Glomerulonephritis
An inherited defect in the C3 convertase, C3b,Bb, associated with glomerulonephritis.
Glomerulonephritis
C5 nephritic factors drive the biological phenotype of C3 glomerulopathies.
Glomerulonephritis
Epstein-Barr virus transformed B cell lines derived from patients with systemic lupus erythematosus produce a nephritic factor of the classical complement pathway.
Glomerulonephritis
Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.
Glomerulonephritis
The significance of in vitro activation of guinea pig complement in glomeruli of human renal biopsy materials from varied subtypes of glomerulonephritis.
Glomerulonephritis, Membranoproliferative
A Humanized Antibody That Regulates the Alternative Pathway Convertase: Potential for Therapy of Renal Disease Associated with Nephritic Factors.
Glomerulonephritis, Membranoproliferative
Autoantibody to complement neoantigens in membranoproliferative glomerulonephritis.
Glomerulonephritis, Membranoproliferative
C3 nephritic factor (C3NeF): dissociation of cell-bound and fluid phase stabilization of alternative pathway C3 convertase.
Glomerulonephritis, Membranoproliferative
C5 nephritic factors drive the biological phenotype of C3 glomerulopathies.
Glomerulonephritis, Membranoproliferative
Management of membranoproliferative glomerulonephritis type II with plasmapheresis.
Glomerulonephritis, Membranoproliferative
Production of nephritic factor of the alternative complement pathway by Epstein Barr virus-transformed B cell lines derived from a patient with membranoproliferative glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Recurrent disseminated gonococcal infection in a patient with hypocomplementemia and membranoproliferative glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Significance of C3 nephritic factor (C3NeF) in non-hypocomplementaemic serum with membranoproliferative glomerulonephritis (MPGN).
Hemoglobinuria
Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by platelet factor H.
Hemoglobinuria, Paroxysmal
Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by platelet factor H.
Hepatitis C
Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components.
Hypersensitivity
On the immunogenicity of recombinant staphylokinase in patients and in animal models.
Hypersensitivity
Randomized coronary patency trial of double-bolus recombinant staphylokinase versus front-loaded alteplase in acute myocardial infarction.
Infections
Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection.
Infections
Distinct CD55 Isoform Synthesis and Inhibition of Complement-Dependent Cytolysis by Hepatitis C Virus.
Infections
Limitations of Staphylokinase as a Marker for Staplylococcus aureus Invasive Infections in Humans.
Infections
Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections.
Infections
Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.
Infections
Staphylococcus aureus exploits cathelicidin antimicrobial peptides produced during early pneumonia to promote staphylokinase-dependent fibrinolysis.
Infections
Staphylococcus aureus Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases.
Infections
Staphylokinase and ABO group phenotype: new players in Staphylococcus aureus implant-associated infections development.
Infections
Staphylokinase Promotes the Establishment of Staphylococcus aureus Skin Infections While Decreasing Disease Severity.
Influenza in Birds
Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinase.
Ischemic Stroke
Non-immunogenic recombinant staphylokinase versus alteplase for patients with acute ischaemic stroke 4·5 h after symptom onset in Russia (FRIDA): a randomised, open label, multicentre, parallel-group, non-inferiority trial.
Kidney Failure, Chronic
Long-term successful liver-kidney transplantation in a child with atypical hemolytic uremic syndrome caused by homozygous factor H deficiency.
Lipodystrophy
C3 nephritic factor (C3NeF): dissociation of cell-bound and fluid phase stabilization of alternative pathway C3 convertase.
Lipodystrophy
Production of nephritic factor of the alternative complement pathway by Epstein Barr virus-transformed B cell lines derived from a patient with membranoproliferative glomerulonephritis.
Lupus Erythematosus, Systemic
A circulating inhibitor of fluid-phase amplification. C3 convertase formation in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Epstein-Barr virus transformed B cell lines derived from patients with systemic lupus erythematosus produce a nephritic factor of the classical complement pathway.
Mastitis
Staphylococcus aureus stimulates urokinase-type plasminogen activator expression by bovine mammary cells.
Myocardial Infarction
A randomized trial of recombinant staphylokinase versus alteplase for coronary artery patency in acute myocardial infarction. The STAR Trial Group.
Myocardial Infarction
An enzyme-linked immunosorbent assay for host cell protein contaminants in recombinant PEGylated staphylokinase mutant SY161.
Myocardial Infarction
Clinical development of PEGylated recombinant staphylokinase (PEG-Sak) for bolus thrombolytic treatment of patients with acute myocardial infarction.
Myocardial Infarction
Collaborative Angiographic Patency Trial Of Recombinant Staphylokinase (CAPTORS II).
Myocardial Infarction
Collaborative angiographic patency trial of recombinant staphylokinase (CAPTORS).
Myocardial Infarction
Comparative immunogenicity and thrombolytic properties toward arterial and venous thrombi of streptokinase and recombinant staphylokinase in baboons.
Myocardial Infarction
Comparative time course of thrombolysis induced by intravenous boluses and infusion of staphylokinase and tissue plasminogen activator in a rabbit arterial thrombosis model.
Myocardial Infarction
Conjugation with Eight-Arm PEG Markedly Improves the In Vitro Activity and Prolongs the Blood Circulation of Staphylokinase.
Myocardial Infarction
Construction and characterization of a novel staphylokinase variant with thrombin-inhibitory activity.
Myocardial Infarction
Coronary thrombolysis with recombinant staphylokinase in patients with evolving myocardial infarction.
Myocardial Infarction
Effect of site-specific PEGylation on the fibrinolytic activity, immunogenicity, and pharmacokinetics of staphylokinase.
Myocardial Infarction
Effects of recombinant staphylokinase on coronary thrombosis in Chinese experimental miniature swine.
Myocardial Infarction
High-level secretory production of intact, biologically active staphylokinase from Bacillus subtilis.
Myocardial Infarction
Human alpha -defensins neutralize fibrinolytic activity exerted by staphylokinase.
Myocardial Infarction
Kinetic and stoichiometric analysis of the modification process for N-terminal PEGylation of staphylokinase.
Myocardial Infarction
Nuclear magnetic resonance solution structure of the plasminogen-activator protein staphylokinase.
Myocardial Infarction
On the immunogenicity of recombinant staphylokinase in patients and in animal models.
Myocardial Infarction
Phenyl linker-induced dense PEG conformation improves the efficacy of C-terminally monoPEGylated staphylokinase.
Myocardial Infarction
Polyethylene glycol-derivatized cysteine-substitution variants of recombinant staphylokinase for single-bolus treatment of acute myocardial infarction.
Myocardial Infarction
Procoagulant properties of intravenous staphylokinase versus tissue-type plasminogen activator.
Myocardial Infarction
Randomized coronary patency trial of double-bolus recombinant staphylokinase versus front-loaded alteplase in acute myocardial infarction.
Myocardial Infarction
Recombinant staphylokinase variants with altered immunoreactivity. I: Construction and characterization.
Myocardial Infarction
Staphylokinase as a plasminogen activator component in recombinant fusion proteins.
Myocardial Infarction
Staphylokinase: fibrinolytic properties and current experience in patients with occlusive arterial thrombosis.
Myocardial Infarction
Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase.
Myocardial Infarction
Thrombolytic therapy of peripheral arterial occlusion with recombinant staphylokinase.
Myocardial Infarction
Toxicology studies with recombinant staphylokinase and with SY 161-P5, a polyethylene glycol-derivatized cysteine-substitution mutant.
Myocardial Infarction
[A randomized multicenter trial comparing recombinant staphylokinase with recombinant tissue-type plasminogen activator in patients with acute myocardial infarction]
Myocardial Infarction
[Staphylokinase for a better thrombolytic treatment of heart and platelet diseases]
Myocardial Infarction
[Thrombolytic effects of recombinant staphylokinase on coronary thrombosis in miniature pigs].
Neoplasms
Synthesis and HPLC analysis of enzymatically cleavable linker consisting of poly(ethylene glycol) and dipeptide for the development of immunoconjugate.
Nephritis
Activation of the classical complement pathway by nephritic factor bound to the alternative pathway C3/C5 convertase.
Neuroinflammatory Diseases
Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury.
Pancreatitis
Synergetic effect of yihuo qingyi decoction (see text) and recombinant staphylokinase in treatment of severe acute pancreatitis of rats.
Pancreatitis
[Effect of the recombinant staphylokinase on pancreatic ischemia in severe acute pancreatitis of rats]
Paracoccidioidomycosis
Activation of human complement system Paracoccidioides brasiliensis and its deposition on the yeast form cell surface.
Pulmonary Embolism
Differential inhibition with antifibrinolytic agents of staphylokinase and streptokinase induced clot lysis.
Pulmonary Embolism
Human alpha -defensins neutralize fibrinolytic activity exerted by staphylokinase.
Renal Insufficiency
Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury.
Rheumatic Diseases
C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase.
Rhinitis
[Effectiveness and tolerance of the C3 convertase inhibitor, N-acetyl-aspartyl-magnesium glutamate in perennial rhinitis. Results of a double-blind, placebo-controlled study]
Shock, Septic
Association Between the Methicillin Resistance of Staphylococcus aureus Isolated from Slaughter Poultry, Their Toxin Gene Profiles and Prophage Patterns.
Shock, Septic
Detection and molecular characterisation of methicillin-resistant Staphylococcus aureus isolated from raw meat in the retail market.
Shock, Septic
Direct, Specific and Rapid Detection of Staphylococcal Proteins and Exotoxins Using a Multiplex Antibody Microarray.
Shock, Septic
Enterotoxin production by Staphylococcus aureus isolates from cases of septicaemia and from healthy carriers.
Shock, Septic
Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle.
Soft Tissue Infections
Staphylokinase production by clinical Staphylococcus aureus strains.
Thrombosis
A thrombosis model for evaluating thrombolytic agents in the guinea-pig: comparison of t-PA, scu-PA and a novel thrombolytic agent, staphylokinase, on thrombolytic activity.
Thrombosis
Comparative fibrinolytic properties of staphylokinase and streptokinase in animal models of venous thrombosis.
Thrombosis
Comparative immunogenicity and thrombolytic properties toward arterial and venous thrombi of streptokinase and recombinant staphylokinase in baboons.
Thrombosis
Comparative time course of thrombolysis induced by intravenous boluses and infusion of staphylokinase and tissue plasminogen activator in a rabbit arterial thrombosis model.
Thrombosis
Coronary thrombolysis with recombinant staphylokinase in patients with evolving myocardial infarction.
Thrombosis
Design, production, and characterization of an engineered biotin ligase (BirA) and its application for affinity purification of staphylokinase produced from Bacillus subtilis via secretion.
Thrombosis
Enhancement of secretion and extracellular stability of staphylokinase in Bacillus subtilis by wprA gene disruption.
Thrombosis
Feasibility study of catheter-directed thrombolysis with recombinant staphylokinase in deep venous thrombosis.
Thrombosis
High-level expression of a biologically active staphylokinase in Pichia pastoris.
Thrombosis
New derivative of staphylokinase SAK-RGD-K2-Hirul exerts thrombolytic effects in the arterial thrombosis model in rats.
Thrombosis
Nuclear magnetic resonance solution structure of the plasminogen-activator protein staphylokinase.
Thrombosis
Staphylokinase: fibrinolytic properties and current experience in patients with occlusive arterial thrombosis.
Thrombosis
Thrombolytic efficacy of native recombinant staphylokinase on femoral artery thrombus of rabbits.
Thrombosis
Two characteristics of a recombinant fusion protein composed of staphylokinase and hirudin: high thrombus affinity and thrombus-targeting release ofanticoagulant activity.
Thrombosis
[Thrombolytic effects of recombinant staphylokinase on coronary thrombosis in miniature pigs].
Uterine Cervical Neoplasms
Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease.
Vascular System Injuries
Expression and intein-mediated purification of novel staphylokinase SakSTAR with reduced immunogenicity and antiplatelet and antithrombin activation.
Vascular System Injuries
Fusion proteins with anticoagulant and fibrinolytic properties: functional studies and structural considerations.
Venous Thrombosis
Comparative fibrinolytic properties of staphylokinase and streptokinase in animal models of venous thrombosis.
Venous Thrombosis
Feasibility study of catheter-directed thrombolysis with recombinant staphylokinase in deep venous thrombosis.
html completed