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Information on EC 3.4.24.24 - gelatinase A and Organism(s) Mus musculus and UniProt Accession P33434

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.24 gelatinase A
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This record set is specific for:
Mus musculus
UNIPROT: P33434 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
mmp-2, gelatinase, matrix metalloproteinase-2, matrix metalloproteinase 2, gelatinase a, type iv collagenase, metalloproteinase-2, progelatinase, collagenase iv, mmp 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
72 kDa Gelatinase
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-
-
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72 kDa Gelatinase type A
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-
-
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72-kDa Gelatinase
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-
-
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Collagenase IV
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-
-
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Collagenase type IV
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-
-
-
Matrix metalloproteinase 2
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-
-
-
matrix metalloproteinase-2
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-
MMP 2
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-
-
-
MMP-2
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Type IV collagen metalloproteinase
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-
-
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Type IV collagenase
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-
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Type IV collagenase/gelatinase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
146480-35-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Gelatin + H2O
?
show the reaction diagram
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-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Gelatin + H2O
?
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
curcumin
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treatment of whole cell, significant inhibition of enzyme activity after 15 days with concomitant decrease in expression of membrane type-1 matrix metalloproteinase and focal adhesion kinase to almost background level
TIMP-2
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-
-
additional information
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calreticulin-deficient null mice embryos show increased MMP-2 expression and activity, phosphatidylinositol 3 kinase inhibitor decreases the MMP-2 expression, overview
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
a complex formed by MT1-MMP, TIMP-2, and MMP-2 and located at the cell surface, is involved in MMP-2 activation, overview
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
MMP-2 activity in embryonic tissues of wild-type and caireticulin-deficient mice, overview
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene Mmp2
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
melanoma cell
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
complex formed by MT1-MMP, TIMP-2
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
in de novo formed fat pads, resulting from preadipocytes with Mmp2 knockdown, the expression of aP2, Ppar-gamma and adiponectin is significantly lower, and collagen is more preserved. The fat pad weights as well as size and density of adipocytes or blood vessels are not significantly different from controls, phenotype, overview
metabolism
expansion of adipose tissue is dependent on adipogenesis, angiogenesis and extracellular matrix remodeling by the gelatinase subfamily of the matrix metalloproteinases, overview
physiological function
the enzyme gelatinase A is involved in adipogenesis, selective modulation of MMP-2 levels affects adipogenesis
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MMP2_MOUSE
662
1
74102
Swiss-Prot
Secretory Pathway (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
calreticulin-deficient null mice embryos show increased MMP-2 expression and activity, but unaltered TIMP-2 inhibitor levels, the embryos show defects in the heart and body wall, phenotype, overview
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
MMP-2 expression analysis in embryonic tissues of wild-type and caireticulin-deficient mice, overview
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Banerji, A.; Chakrabarti, J.; Mitra, A.; Chatterjee, A.
Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells
Cancer Lett.
211
235-242
2004
Mus musculus
Manually annotated by BRENDA team
Wu, M.; Massaeli, H.; Durston, M.; Mesaeli, N.
Differential expression and activity of matrix metalloproteinase-2 and -9 in the calreticulin deficient cells
Matrix Biol.
26
463-472
2007
Mus musculus
Manually annotated by BRENDA team
Bauters, D.; Scroyen, I.; Van Hul, M.; Lijnen, H.
Gelatinase A (MMP-2) promotes murine adipogenesis
Biochim. Biophys. Acta
1850
1449-1456
2015
Mus musculus (P33434), Mus musculus, Mus musculus BALB/c (P33434)
Manually annotated by BRENDA team